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WO1997020579A3 - Novel compounds and use - Google Patents

Novel compounds and use Download PDF

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Publication number
WO1997020579A3
WO1997020579A3 PCT/EP1996/005477 EP9605477W WO9720579A3 WO 1997020579 A3 WO1997020579 A3 WO 1997020579A3 EP 9605477 W EP9605477 W EP 9605477W WO 9720579 A3 WO9720579 A3 WO 9720579A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel compounds
neurotoxins
neurotoxin
conjugates
fragments
Prior art date
Application number
PCT/EP1996/005477
Other languages
French (fr)
Other versions
WO1997020579A2 (en
Inventor
Jack Price
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of WO1997020579A2 publication Critical patent/WO1997020579A2/en
Publication of WO1997020579A3 publication Critical patent/WO1997020579A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Use of neurotoxins or fragments thereof to transport nucleic acids into the nervous system and conjugates comprising a neurotoxin or a fragment thereof and a nucleic acid.
PCT/EP1996/005477 1995-12-05 1996-12-02 Novel compounds and use WO1997020579A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9524807.6 1995-12-05
GBGB9524807.6A GB9524807D0 (en) 1995-12-05 1995-12-05 Novel compounds

Publications (2)

Publication Number Publication Date
WO1997020579A2 WO1997020579A2 (en) 1997-06-12
WO1997020579A3 true WO1997020579A3 (en) 1997-09-25

Family

ID=10784907

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/005477 WO1997020579A2 (en) 1995-12-05 1996-12-02 Novel compounds and use

Country Status (2)

Country Link
GB (1) GB9524807D0 (en)
WO (1) WO1997020579A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19856052A1 (en) * 1998-12-04 2000-06-08 Deutsches Krebsforsch Conjugate for enrichment in neuronal cells
US6306403B1 (en) 2000-06-14 2001-10-23 Allergan Sales, Inc. Method for treating parkinson's disease with a botulinum toxin
AU2003224087B2 (en) * 2002-04-18 2009-03-05 Opko Pharmaceuticals, Llc. Means and methods for the specific inhibition of genes in cells and tissue of the CNS and/or eye
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
US8734810B2 (en) 2003-10-29 2014-05-27 Allergan, Inc. Botulinum toxin treatments of neurological and neuropsychiatric disorders
US8609113B2 (en) 2003-10-29 2013-12-17 Allergan, Inc. Botulinum toxin treatments of depression
US8617572B2 (en) 2003-10-29 2013-12-31 Allergan, Inc. Botulinum toxin treatments of depression
US8609112B2 (en) 2003-10-29 2013-12-17 Allergan, Inc. Botulinum toxin treatments of depression
GB0725321D0 (en) * 2007-12-31 2008-02-06 Syntaxin Ltd Delivery vehicles
US8470792B2 (en) 2008-12-04 2013-06-25 Opko Pharmaceuticals, Llc. Compositions and methods for selective inhibition of VEGF

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991000100A2 (en) * 1989-06-29 1991-01-10 Institute For Animal Health Limited Toxin uses
WO1995032738A1 (en) * 1994-05-31 1995-12-07 Allergan, Inc. Modification of clostridial toxins for use as transport proteins
WO1996004001A1 (en) * 1994-08-05 1996-02-15 Molecular/Structural Biotechnologies, Inc. Site-specific biomolecular complexes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991000100A2 (en) * 1989-06-29 1991-01-10 Institute For Animal Health Limited Toxin uses
WO1995032738A1 (en) * 1994-05-31 1995-12-07 Allergan, Inc. Modification of clostridial toxins for use as transport proteins
WO1996004001A1 (en) * 1994-08-05 1996-02-15 Molecular/Structural Biotechnologies, Inc. Site-specific biomolecular complexes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOTTSCHALK S. ET AL.: "EFFICIENT GENE DELIVERY AND EXPRESSION IN MAMMALIAN CELLS USING DNA COUPLED WITH PERFRINGOLYSIN O.", GENE THERAPY, vol. 2, no. 7, September 1995 (1995-09-01), pages 498 - 503, XP002036157 *
JESUS FOMINAYA ET AL.: "TARGET CELL-SPECIFIC DNA TRANSFER MEDIATED BY A CHIMERIC MULTIDOMAIN PROTEIN.", JOURNAL OF BIOLOGICAL CHEMISTRY (MICROFILMS), vol. 18, 3 May 1996 (1996-05-03), MD US, pages 10560 - 10568, XP002036158 *

Also Published As

Publication number Publication date
GB9524807D0 (en) 1996-02-07
WO1997020579A2 (en) 1997-06-12

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