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WO1997019113A3 - Anticuerpos monoclonales antiidiotipos (ab2) y sus usos - Google Patents

Anticuerpos monoclonales antiidiotipos (ab2) y sus usos Download PDF

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Publication number
WO1997019113A3
WO1997019113A3 PCT/CU1996/000003 CU9600003W WO9719113A3 WO 1997019113 A3 WO1997019113 A3 WO 1997019113A3 CU 9600003 W CU9600003 W CU 9600003W WO 9719113 A3 WO9719113 A3 WO 9719113A3
Authority
WO
WIPO (PCT)
Prior art keywords
antiidiotypic antibodies
monoclonal antiidiotypic
monoclonal
antibodies
immunostimulation
Prior art date
Application number
PCT/CU1996/000003
Other languages
English (en)
French (fr)
Other versions
WO1997019113A2 (es
Inventor
Abrahan Amparo Emilia Macias
Rodriguez Rolando Perez
Obaya Teresita Rodriguez
Zamora Mercedes Ramos
Lopez Gumersinda Bombino
Marichal Orlando Pena
Original Assignee
Ct De Inmunologia Molecular Ci
Abrahan Amparo Emilia Macias
Rodriguez Rolando Perez
Obaya Teresita Rodriguez
Zamora Mercedes Ramos
Lopez Gumersinda Bombino
Marichal Orlando Pena
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct De Inmunologia Molecular Ci, Abrahan Amparo Emilia Macias, Rodriguez Rolando Perez, Obaya Teresita Rodriguez, Zamora Mercedes Ramos, Lopez Gumersinda Bombino, Marichal Orlando Pena filed Critical Ct De Inmunologia Molecular Ci
Priority to AU76904/96A priority Critical patent/AU719369B2/en
Priority to BR9606978A priority patent/BR9606978A/pt
Priority to JP9519266A priority patent/JPH11505131A/ja
Priority to EP96939804A priority patent/EP0820472A1/en
Priority to KR1019970704892A priority patent/KR19980701501A/ko
Priority to US08/875,706 priority patent/US6433148B1/en
Publication of WO1997019113A2 publication Critical patent/WO1997019113A2/es
Publication of WO1997019113A3 publication Critical patent/WO1997019113A3/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Anticuerpos monoclonales antiidiotipos de tipo IgG relativos al sistema inmunitario, capaces de ejercer una interacción con los linfocitos T y B y tener un efecto inmunoregulador, una inmunoestimulación o inmunosupresión que pueden ser utilizados en la inmunoterapía de las enfermedades autoinmunes, infecciosas y cáncer.
PCT/CU1996/000003 1995-11-17 1996-11-18 Anticuerpos monoclonales antiidiotipos (ab2) y sus usos WO1997019113A2 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU76904/96A AU719369B2 (en) 1995-11-17 1996-11-18 Monoclonal antiidiotypic antibodies (AB2) and their uses
BR9606978A BR9606978A (pt) 1995-11-17 1996-11-18 Anticorpos monoclonais antiidiótipos (ab2) e usos dos mesmos
JP9519266A JPH11505131A (ja) 1995-11-17 1996-11-18 単クローン抗イデイオタイプ抗体（ａｂ２）及びその使用
EP96939804A EP0820472A1 (en) 1995-11-17 1996-11-18 Monoclonal antiidiotypic antibodies (ab2) and uses thereof
KR1019970704892A KR19980701501A (ko) 1995-11-17 1996-11-18 모노클로널 항치매 항체 및 그 사용
US08/875,706 US6433148B1 (en) 1995-11-17 1996-11-18 Monoclonal anti-idiotypic antibodies (AB2) and their uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU1995122A CU22585A1 (es) 1995-11-17 1995-11-17 Anticuerpos monoclonales antiidiótipos (ab2) de tipo igg con alta conectividad idiotípica y composiciones farmacéuticas que los contienen. su uso como inmunoreguladores de la respuesta inmune.
CU122/95 1995-11-17

Publications (2)

Publication Number Publication Date
WO1997019113A2 WO1997019113A2 (es) 1997-05-29
WO1997019113A3 true WO1997019113A3 (es) 1997-09-25

Family

ID=5459408

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CU1996/000003 WO1997019113A2 (es) 1995-11-17 1996-11-18 Anticuerpos monoclonales antiidiotipos (ab2) y sus usos

Country Status (10)

Country Link
US (1) US6433148B1 (es)
EP (1) EP0820472A1 (es)
JP (1) JPH11505131A (es)
KR (1) KR19980701501A (es)
CN (1) CN1175958A (es)
AU (1) AU719369B2 (es)
BR (1) BR9606978A (es)
CA (1) CA2210705A1 (es)
CU (1) CU22585A1 (es)
WO (1) WO1997019113A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU22702A1 (es) * 1997-10-21 2001-07-31 Centro Inmunologia Molecular Anticuerpos monoclonales anti - idiotipo, su uso en la inmunoterapia activa de tumores malignos, hibridoma que los produce y composiciones que los contienen
US9164108B2 (en) * 2005-03-22 2015-10-20 Sri International Liposome-based microarray and methods of use thereof
US7534595B2 (en) * 2006-06-12 2009-05-19 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US7560263B2 (en) * 2007-08-17 2009-07-14 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
JP5759722B2 (ja) * 2007-08-28 2015-08-05 アッヴィ バイオテクノロジー リミテッド アダリムマブの結合蛋白質を含む組成物及び方法
US20110201022A1 (en) * 2008-07-30 2011-08-18 Biomarin Pharmaceutical Inc. Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase
CA2782444C (en) 2010-02-04 2018-10-23 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase variants and methods of using compositions thereof
JP6404821B2 (ja) * 2013-09-12 2018-10-17 国立大学法人 岡山大学 インターロイキン１０産生促進剤

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0287226A1 (en) * 1987-03-23 1988-10-19 Hiver Limited Novel vaccines
WO1991004055A1 (en) * 1989-09-15 1991-04-04 Tanox Biosystems, Inc. Treatment of autoimmune disease
US5208146A (en) * 1990-11-05 1993-05-04 The Regents Of The University Of California Murine monoclonal anti-idiotype antibodies
WO1995007096A1 (en) * 1993-09-06 1995-03-16 La Trobe University Treatment of autoimmune disease
EP0657471A1 (en) * 1993-12-09 1995-06-14 Centro de Inmunologia Molecular Anti ganglioside monoclonal antibodies and their use in the specific active immunotherapy of malignant tumours

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0287226A1 (en) * 1987-03-23 1988-10-19 Hiver Limited Novel vaccines
WO1991004055A1 (en) * 1989-09-15 1991-04-04 Tanox Biosystems, Inc. Treatment of autoimmune disease
US5208146A (en) * 1990-11-05 1993-05-04 The Regents Of The University Of California Murine monoclonal anti-idiotype antibodies
WO1995007096A1 (en) * 1993-09-06 1995-03-16 La Trobe University Treatment of autoimmune disease
EP0657471A1 (en) * 1993-12-09 1995-06-14 Centro de Inmunologia Molecular Anti ganglioside monoclonal antibodies and their use in the specific active immunotherapy of malignant tumours

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M. ALFONSO: "E1, anti-GM2 ganglioside.", HYBRIDOMA, vol. 14, no. 1, February 1995 (1995-02-01), NEW YORK, NY, USA, pages 98, XP000647509 *

Also Published As

Publication number Publication date
JPH11505131A (ja) 1999-05-18
MX9705444A (es) 1998-06-28
CU22585A1 (es) 1999-11-03
KR19980701501A (ko) 1998-05-15
WO1997019113A2 (es) 1997-05-29
BR9606978A (pt) 1997-11-04
AU719369B2 (en) 2000-05-11
AU7690496A (en) 1997-06-11
US6433148B1 (en) 2002-08-13
CA2210705A1 (en) 1997-05-29
EP0820472A1 (en) 1998-01-28
CN1175958A (zh) 1998-03-11

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