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WO1997018851A1 - Hemostasis material and apparatus - Google Patents

Hemostasis material and apparatus Download PDF

Info

Publication number
WO1997018851A1
WO1997018851A1 PCT/US1996/018747 US9618747W WO9718851A1 WO 1997018851 A1 WO1997018851 A1 WO 1997018851A1 US 9618747 W US9618747 W US 9618747W WO 9718851 A1 WO9718851 A1 WO 9718851A1
Authority
WO
WIPO (PCT)
Prior art keywords
hemostasis
ultrasound
reducing agent
bleeding
ultrasound energy
Prior art date
Application number
PCT/US1996/018747
Other languages
French (fr)
Inventor
Katsuro Tachibana
Shunro Tachibana
Original Assignee
Ekos Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ekos Corporation filed Critical Ekos Corporation
Priority to EP96940850A priority Critical patent/EP0869828A1/en
Priority to AU10810/97A priority patent/AU1081097A/en
Priority to JP09519913A priority patent/JP2000507201A/en
Publication of WO1997018851A1 publication Critical patent/WO1997018851A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B2017/12004—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for haemostasis, for prevention of bleeding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22005—Effects, e.g. on tissue
    • A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
    • A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22088—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance ultrasound absorbing, drug activated by ultrasound

Definitions

  • This invention relates generally to hemostasis, and more particularly to a method and apparatus to cause hemostasis using ultrasound and ultrasound sensitive drugs
  • FIGURES Figure 1 is a diagram illustrating the treatment of bleeding when it is difficult to use catheters or endoscopes
  • FIG. 2 is an illustration of an ultrasound therapy generator useful with the present invention
  • Figure 3 illustrates hemostasis treatment with the use of a catheter or endoscope
  • Figure 4 is a cross section view ofthe tip ofthe endoscope of Figure 3
  • An object ofthe invention is to provide a method and apparatus to provide hemostasis without the need for major surgical intervention
  • Another object ofthe invention is to provide a method and apparatus for enhancing phonophoresis
  • a further object ofthe invention is to provide a method and apparatus for enhancing phonophoresis with the introduction of a threshold reducing agent to the body
  • Still another object ofthe invention is to provide a method and apparatus to create hemostasis by introducing a cavitation threshold reducing rate and applying ultrasound energy
  • a method for enhancing phonophoresis A cavitation threshold reducing agent is introduced into the body Ultrasound energy is applied at a selected site in the body at a frequency sufficient to produce a therapeutic effect
  • a method for creating hemostasis includes introducing a cavitation threshold reducing agent to the body Ultrasound energy is applied at a selected site in the body at a frequency sufficient to create hemostasis
  • an apparatus for creating hemostasis includes a cavitation threshold lowering agent means Ultrasound energy means are coupled to the cavitation threshold lowering agent means A sufficient ultrasound energy wavelength is generated to create hemostasis at a selected site in the body.
  • the cavitation threshold lowering agent is Rose Bengal or a hematoporphryn.
  • the present provides a method for enhancing phonophoresis.
  • a cavitation threshold reducing agent is introduced to the body Ultrasound energy is applied at a selected site in the body at a frequency sufficient to produce a therapeutic effect.
  • a method is also provided for creating hemostasis with the introduction ofthe cavitation threshold reducing agent and the application of ultrasound energy
  • the present invention also is an apparatus for creating hemostasis
  • the apparatus includes a cavitation threshold lowering agent means and an ultrasound energy means that is coupled to the cavitation lowering agent means
  • An ultrasound energy wavelength is produced that is sufficient to create hemostasis at the selected site in the body.
  • An apparatus for creating hemostasis includes a hemostasis agent means The apparatus also includes an ultrasound energy means which generates an ultrasound frequency that creates hemostasis at the selected site in the body
  • cavitation threshold reducing drugs or hemostasis drugs can be used. Suitable drugs include but are not limited to Rose Bengal, hematoporphryns, and the like. In one embodiment the amount of delivered ultrasound energy can be in the range of 0.1 to 1000 Watts per square centimeter.
  • the methods and apparatus ofthe invention provide a hemostasis material that effectively and rapidly stop bleeding effectively without performing major surgical intervention such as large scale operations.
  • the methods and apparatus ofthe invention are used to treated a variety of different bleeding sites including but not limited to bleeding by organ rupture hemorrhage within the liver, and the like.
  • ultrasound device 1 can include multiple ultrasound elements lb which are attached to an interior side of a main body portion la of ultrasound device 1
  • An ultrasound vibration element lb can be a plate type ultrasound element which has an electrode on both sides.
  • Ultrasound therapy device 1 is bendable according to the shape ofthe patient A's body This permits ultrasound energy to be concentrated to the bleeding site C.
  • Diagram 3 illustrates a method of therapy where it is possible to use the catheter or endoscopy for stopping bleeding from the organs including but not limited to gastric ulcers, esophageal varices, and the like.
  • FIG 4 shows the cross section view ofthe structure of an endoscope 2 useful with the present invention.
  • the ultrasound sensitive drug is first intravenously injected to the patient
  • an esophageal or gastric endoscope 2 is introduced at bleeding site C in organ B including but not limited to the stomach as shown in Figure 3
  • hemostasis is performed by exposing ultrasound from ultrasound vibrating element 2c.
  • ultrasound vibrating element 2c is attached to the tip ofthe endoscope 2, sheath 2a.
  • the ultrasound sensitive drug in the blood is then activated by ultrasound. This produces instant coagulation which is a more effective hemostasis method than conventional methods.
  • an ultrasound vibrating element 2c is a cylinder piezo electric element in which an optical fiber 2b passes through the center and the electrode is placed on the outer and inner side.
  • the electrode receives electrical signals of ultrasound frequencies which induce ultrasound energy in the direction ofthe arrows.
  • ultrasound vibrating elements 2c are shaped in a cylinder, ultrasound energy is emitted evenly toward the radius ofthe axis of endoscope 2.
  • the shape of ultrasound vibrating element 2c is not limited to illustrated geometry .
  • a disk-like ultrasound vibrating element lb is positioned where optical fiber 2b passes through the center at the tip ofthe sheath 2a ofthe endoscope 2.
  • ultrasound is concentrated at the axis of endoscope 2.
  • the methods and apparatus ofthe present invention provide treatment of bleeding by injecting one or more ultrasound sensitive drugs to the patient along with exposure to ultrasound energy.
  • the methods and apparatus ofthe present invention are particularly useful immediately after bleeding has begun. This permits treatment and stoppage of bleeding can be stopped while the patient is transferred in an ambulance. This decreases the mortality rate of massive bleeding. Death rates from trauma are lowered by temporarily stopping the bleeding. Thereafter, major surgical intervention can be performed at the hospital. Death rates from bleeding are then reduced.
  • the methods and apparatus ofthe present invention are effective for very severe bleeding which is difficult to treat with conventional surgical methods. Additionally, because ultrasound energy can be exposed to a large area, multiple bleeding sites of different origins can be treated at the same time. Ultrasound energy can be exposed exterior to a patient's body for hemostasis.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method and apparatus for creating hemostasis includes introducing a cavitation threshold reducing agent to the body. Ultrasound energy is applied at a selected site in the body at a frequency sufficient to create hemostasis.

Description

HEMOSTASIS MATERIAL AND APPARATUS BACKGROUND OF THE INVENTION
Field ofthe Invention This invention relates generally to hemostasis, and more particularly to a method and apparatus to cause hemostasis using ultrasound and ultrasound sensitive drugs
Description of Related Art In the case of death by car accidents, gastric ulcers, ruptures of esophageal varices, massive bleeding is a frequent cause of death Particularly in emergency situations, It is important to stop bleeding as quickly as possible To increase the rate of survival, it is essential to stop the bleeding as s quickly as possible In auto accidents, strong mechanical forces frequently cause damage to internal organs in the abdomen This is a major cause of death When endoscopic fibers or catheters cannot be used for treatment of rupture of organs or intra-liver bleeding, it is difficult to stop bleeding without surgical intervention This is why it is difficult to effectively stop the bleeding at the accident site before transfer to a hospital
With bleeding from gastric ulcers or esophageal varices rupture, there are several methods of endoscopy to stop bleeding However, this is not 100% effective The current treatment used for hemostasis is laser or high radio frequency energy to burn the origin ofthe bleeding However, the success rate is not that high Current treatment methods can cause damage to locations other than the at the site of bleeding
Another method of treatment is the use of drugs as thrombin which chemically induce reactions and cause coagulation In one method, the drug is sprayed to the bleeding site and coagulation reaction is activated However, this is not completely effective to stop all bleeding BRIEF DESCRIPTION OF THF FIGURES Figure 1 is a diagram illustrating the treatment of bleeding when it is difficult to use catheters or endoscopes
Figure 2 is an illustration of an ultrasound therapy generator useful with the present invention
Figure 3 illustrates hemostasis treatment with the use of a catheter or endoscope
Figure 4 is a cross section view ofthe tip ofthe endoscope of Figure 3
SUMMARY
An object ofthe invention is to provide a method and apparatus to provide hemostasis without the need for major surgical intervention
Another object ofthe invention is to provide a method and apparatus for enhancing phonophoresis A further object ofthe invention is to provide a method and apparatus for enhancing phonophoresis with the introduction of a threshold reducing agent to the body
Still another object ofthe invention is to provide a method and apparatus to create hemostasis by introducing a cavitation threshold reducing rate and applying ultrasound energy
These and other objects ofthe invention are achieved in a method for enhancing phonophoresis A cavitation threshold reducing agent is introduced into the body Ultrasound energy is applied at a selected site in the body at a frequency sufficient to produce a therapeutic effect In one embodiment, a method for creating hemostasis includes introducing a cavitation threshold reducing agent to the body Ultrasound energy is applied at a selected site in the body at a frequency sufficient to create hemostasis
In another embodiment ofthe invention, an apparatus for creating hemostasis includes a cavitation threshold lowering agent means Ultrasound energy means are coupled to the cavitation threshold lowering agent means A sufficient ultrasound energy wavelength is generated to create hemostasis at a selected site in the body.
In one embodiment the cavitation threshold lowering agent is Rose Bengal or a hematoporphryn.
DETAILED DESCRIPTION The present provides a method for enhancing phonophoresis. A cavitation threshold reducing agent is introduced to the body Ultrasound energy is applied at a selected site in the body at a frequency sufficient to produce a therapeutic effect. A method is also provided for creating hemostasis with the introduction ofthe cavitation threshold reducing agent and the application of ultrasound energy
The present invention also is an apparatus for creating hemostasis The apparatus includes a cavitation threshold lowering agent means and an ultrasound energy means that is coupled to the cavitation lowering agent means
An ultrasound energy wavelength is produced that is sufficient to create hemostasis at the selected site in the body. An apparatus for creating hemostasis includes a hemostasis agent means The apparatus also includes an ultrasound energy means which generates an ultrasound frequency that creates hemostasis at the selected site in the body
Any number of cavitation threshold reducing drugs or hemostasis drugs can be used. Suitable drugs include but are not limited to Rose Bengal, hematoporphryns, and the like. In one embodiment the amount of delivered ultrasound energy can be in the range of 0.1 to 1000 Watts per square centimeter.
After intravenous injection ofthe ultrasound sensitive drug and delivery ofthe drug to the bleeding site, the site ofthe bleeding is exposed to ultrasound from an ultrasound device This results in activation ofthe ultrasound sensitive drug and coagulation ofthe blood In this way, hemostasis is achieved quickly and efficiently. The methods and apparatus ofthe invention provide a hemostasis material that effectively and rapidly stop bleeding effectively without performing major surgical intervention such as large scale operations.
The methods and apparatus ofthe invention are used to treated a variety of different bleeding sites including but not limited to bleeding by organ rupture hemorrhage within the liver, and the like.
Referring now to Figure 1 , there are times when it is difficult to use catheters or endoscopes to stop bleeding from organs An ultrasound sensitive drug is first intravenously injected into the patient An ultrasound diagnostic device is used (not shown in the diagram) to patient A. After locating and confirming the bleeding site C in organ B, ultrasound therapy is performed with the ultrasound therapeutic device 1 by concentrating ultrasound energy at bleeding site C for the purpose of coagulating the blood at the site ofthe damaged organ, vessel and the like. Referring now to Figure 2, a suitable therapeutic ultrasound device 1 is shown. In one embodiment, ultrasound device 1 can include multiple ultrasound elements lb which are attached to an interior side of a main body portion la of ultrasound device 1 An ultrasound vibration element lb can be a plate type ultrasound element which has an electrode on both sides. By loading the electrode with ultrasound frequency electrical signals, ultrasound is emitted in the direction ofthe arrows
Ultrasound therapy device 1 is bendable according to the shape ofthe patient A's body This permits ultrasound energy to be concentrated to the bleeding site C. Diagram 3 illustrates a method of therapy where it is possible to use the catheter or endoscopy for stopping bleeding from the organs including but not limited to gastric ulcers, esophageal varices, and the like.
Figure 4 shows the cross section view ofthe structure of an endoscope 2 useful with the present invention. In the method of treatment, the ultrasound sensitive drug is first intravenously injected to the patient Then an esophageal or gastric endoscope 2 is introduced at bleeding site C in organ B including but not limited to the stomach as shown in Figure 3 Locally or in a large area, hemostasis is performed by exposing ultrasound from ultrasound vibrating element 2c. In one embodiment, ultrasound vibrating element 2c is attached to the tip ofthe endoscope 2, sheath 2a. The ultrasound sensitive drug in the blood is then activated by ultrasound. This produces instant coagulation which is a more effective hemostasis method than conventional methods.
In one embodiment, an ultrasound vibrating element 2c is a cylinder piezo electric element in which an optical fiber 2b passes through the center and the electrode is placed on the outer and inner side. The electrode receives electrical signals of ultrasound frequencies which induce ultrasound energy in the direction ofthe arrows. When ultrasound vibrating elements 2c are shaped in a cylinder, ultrasound energy is emitted evenly toward the radius ofthe axis of endoscope 2. However, the shape of ultrasound vibrating element 2c is not limited to illustrated geometry . In other embodiments, a disk-like ultrasound vibrating element lb is positioned where optical fiber 2b passes through the center at the tip ofthe sheath 2a ofthe endoscope 2. In embodiment, ultrasound is concentrated at the axis of endoscope 2.
The methods and apparatus ofthe present invention provide treatment of bleeding by injecting one or more ultrasound sensitive drugs to the patient along with exposure to ultrasound energy. The methods and apparatus ofthe present invention are particularly useful immediately after bleeding has begun. This permits treatment and stoppage of bleeding can be stopped while the patient is transferred in an ambulance. This decreases the mortality rate of massive bleeding. Death rates from trauma are lowered by temporarily stopping the bleeding. Thereafter, major surgical intervention can be performed at the hospital. Death rates from bleeding are then reduced. The methods and apparatus ofthe present invention are effective for very severe bleeding which is difficult to treat with conventional surgical methods. Additionally, because ultrasound energy can be exposed to a large area, multiple bleeding sites of different origins can be treated at the same time. Ultrasound energy can be exposed exterior to a patient's body for hemostasis. Deep locations ofthe body including but not limited to the liver, abdominal aorta, other organs bleeding and the like, are treated without surgical intervention. Because ultrasound energy is used, body organs and structure are not damaged. This is in contrast with and will be safely used compared with laser or high radio frequency therapies where body organs and structures can be suffer damage when energy from these sources is applied to the body The foregoing description of a preferred embodiment ofthe invention has been presented for purposes of illustration and description It is not intended to be exhaustive or to limit the invention to the precise forms disclosed Obviously, many modifications and variations will be apparent to practitioners skilled in this art It is intended that the scope ofthe invention be defined by the following claims and their equivalents
What is claimed is

Claims

1 A method for enhancing phonophoresis comprising introducing a cavitation threshold reducing agent to a body, and applying ultrasound energy at a selected site in the body at a frequency sufficient to produce a therapeutic effect
2 The method of claim 1, wherein the cavitation threshold reducing agent is Rose Bengal
3 The method of claim 1 , wherein the cavitation threshold reducing agent is hematoporphryn
4 A method for creating hemostasis comprising introducing a cavitation threshold reducing agent to a body, and applying ultrasound energy at a selected site in the body at a frequency sufficient to create hemostasis
5 The method of claim 4, wherein the cavitation threshold reducing agent is Rose Bengal
6 The method of claim 4, wherein the cavitation threshold reducing agent is hematoporphryn
7 An apparatus for creating hemostasis comprising a cavitation threshold lowering agent means, and ultrasound energy means coupled to the cavitation threshold lowering agent means and generating an ultrasound energy wavelength sufficient to create hemostasis at a selected site in a body
8 The apparatus of claim 7, wherein the threshold lowering agent is Rose
Bengal 9 The apparatus of claim 7, wherein the threshold reducing agent is hematoporphryn
10 An apparatus for creating hemostasis compnsing a hemostasis agent means, and ultrasound energy means generating an ultrasound frequency that creates hemostasis at a selected site in a body
11 The apparatus of claim 10, wherein the threshold loweπng agent is Rose Bengal
12 The apparatus of claim 10, wherein the threshold reducing agent is hematoporphryn
PCT/US1996/018747 1995-11-24 1996-11-22 Hemostasis material and apparatus WO1997018851A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP96940850A EP0869828A1 (en) 1995-11-24 1996-11-22 Hemostasis material and apparatus
AU10810/97A AU1081097A (en) 1995-11-24 1996-11-22 Hemostasis material and apparatus
JP09519913A JP2000507201A (en) 1996-11-22 1996-11-22 Hemostasis method and device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30616295 1995-11-24
JP7/306162 1995-11-24

Publications (1)

Publication Number Publication Date
WO1997018851A1 true WO1997018851A1 (en) 1997-05-29

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EP (1) EP0869828A1 (en)
AU (1) AU1081097A (en)
WO (1) WO1997018851A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052609A1 (en) * 1997-05-19 1998-11-26 Nycomed Imaging As Sonodynamic therapy using an ultrasound sensitizer compound
WO1999034857A1 (en) * 1998-01-08 1999-07-15 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
EP0989822A1 (en) * 1997-06-23 2000-04-05 Focus Surgery, Inc. Methods and devices for providing acoustic hemostasis
US7066884B2 (en) 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US7432069B2 (en) 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
US8870810B2 (en) 1998-12-18 2014-10-28 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US9572527B2 (en) 2007-04-27 2017-02-21 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2167305A (en) * 1984-11-23 1986-05-29 Vernon Smith Ultrasonic transducer for dispersal of haemorrhages in eyes
EP0226740A1 (en) * 1985-12-14 1987-07-01 Dornier Medizintechnik Gmbh Apparatus for thrombosing by means of shock waves
EP0351610A2 (en) * 1988-07-01 1990-01-24 Hitachi, Ltd. Ultrasonic apparatus for therapeutical use
DE3919592A1 (en) * 1988-08-19 1990-02-22 Olympus Optical Co ULTRASONIC TREATMENT SYSTEM
US4971991A (en) * 1987-12-01 1990-11-20 Kohshiro Umemura Physiological function enhancing agents activated by ultrasonic waves for the treatment of tumors
US5053006A (en) * 1988-04-19 1991-10-01 Watson Brant D Method for the permanent occlusion of arteries
DE4020596A1 (en) * 1990-06-28 1992-01-02 Shunro Tachibana Clinical injection instrument using ultrasonic vibrating element - placed at distal end of tubular part joined to ultrasonic oscillator via coupling part
WO1994006355A1 (en) * 1992-09-14 1994-03-31 Coraje, Inc. Apparatus and method for enhanced intravascular phonophoresis including dissolution of intravascular blockage and concomitant inhibition of restenosis

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2167305A (en) * 1984-11-23 1986-05-29 Vernon Smith Ultrasonic transducer for dispersal of haemorrhages in eyes
EP0226740A1 (en) * 1985-12-14 1987-07-01 Dornier Medizintechnik Gmbh Apparatus for thrombosing by means of shock waves
US4971991A (en) * 1987-12-01 1990-11-20 Kohshiro Umemura Physiological function enhancing agents activated by ultrasonic waves for the treatment of tumors
US5053006A (en) * 1988-04-19 1991-10-01 Watson Brant D Method for the permanent occlusion of arteries
EP0351610A2 (en) * 1988-07-01 1990-01-24 Hitachi, Ltd. Ultrasonic apparatus for therapeutical use
DE3919592A1 (en) * 1988-08-19 1990-02-22 Olympus Optical Co ULTRASONIC TREATMENT SYSTEM
DE4020596A1 (en) * 1990-06-28 1992-01-02 Shunro Tachibana Clinical injection instrument using ultrasonic vibrating element - placed at distal end of tubular part joined to ultrasonic oscillator via coupling part
WO1994006355A1 (en) * 1992-09-14 1994-03-31 Coraje, Inc. Apparatus and method for enhanced intravascular phonophoresis including dissolution of intravascular blockage and concomitant inhibition of restenosis

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052609A1 (en) * 1997-05-19 1998-11-26 Nycomed Imaging As Sonodynamic therapy using an ultrasound sensitizer compound
US6498945B1 (en) 1997-05-19 2002-12-24 Amersham Health As Sonodynamic therapy using an ultrasound sensitizer compound
EP0989822A1 (en) * 1997-06-23 2000-04-05 Focus Surgery, Inc. Methods and devices for providing acoustic hemostasis
EP0989822A4 (en) * 1997-06-23 2004-07-28 Focus Surgery Inc Methods and devices for providing acoustic hemostasis
WO1999034857A1 (en) * 1998-01-08 1999-07-15 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US6190315B1 (en) 1998-01-08 2001-02-20 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US7066884B2 (en) 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US8870810B2 (en) 1998-12-18 2014-10-28 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US7432069B2 (en) 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
US9572527B2 (en) 2007-04-27 2017-02-21 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery

Also Published As

Publication number Publication date
EP0869828A1 (en) 1998-10-14
AU1081097A (en) 1997-06-11

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