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WO1997015676A3 - Candida topoisomeraseigene - Google Patents

Candida topoisomeraseigene Download PDF

Info

Publication number
WO1997015676A3
WO1997015676A3 PCT/US1996/017291 US9617291W WO9715676A3 WO 1997015676 A3 WO1997015676 A3 WO 1997015676A3 US 9617291 W US9617291 W US 9617291W WO 9715676 A3 WO9715676 A3 WO 9715676A3
Authority
WO
WIPO (PCT)
Prior art keywords
candida
topoisomeraseigene
topoisomerase
provides
present
Prior art date
Application number
PCT/US1996/017291
Other languages
French (fr)
Other versions
WO1997015676A2 (en
Inventor
Jennifer M Fostel
Kellie M Giles
Alison Taylor
Thomas P Mcgonigal
Aparna V Sarthy
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of WO1997015676A2 publication Critical patent/WO1997015676A2/en
Publication of WO1997015676A3 publication Critical patent/WO1997015676A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention provides an isolated and purified polynucleotide that encodes Candida albicans type I topoisomerase. Methods of making recombinant C. albicans topoisomerase I using those polynucleotides and host cells transformed with those polynucleotides are also provided. The present invention also provides a method for identifying compounds which inhibit the growth of fungal cells using the polynucleotide.
PCT/US1996/017291 1995-10-27 1996-10-28 Candida topoisomeraseigene WO1997015676A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US598995P 1995-10-27 1995-10-27
US60/005,989 1995-10-27

Publications (2)

Publication Number Publication Date
WO1997015676A2 WO1997015676A2 (en) 1997-05-01
WO1997015676A3 true WO1997015676A3 (en) 1997-08-28

Family

ID=21718724

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/017291 WO1997015676A2 (en) 1995-10-27 1996-10-28 Candida topoisomeraseigene

Country Status (1)

Country Link
WO (1) WO1997015676A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2223484A1 (en) * 1995-06-07 1996-12-19 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
WO2001021839A2 (en) * 1999-09-24 2001-03-29 Pharmacia & Upjohn Company Gene expression profiles
AU1073201A (en) * 1999-10-05 2001-05-10 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Tyrosine-dna phosphodiesterases (tdp) and related polypeptides, nucleic acids, vectors, tdp-producing host cells, antibodies and methods of use
US7087736B1 (en) 1999-10-05 2006-08-08 The United States Of America As Represented By The Department Of Health And Human Services Tyrosine DNA phosphodiesterases (TDP) and related polypeptides nucleic acids vectors TDP producing host cells antibodies and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009222A1 (en) * 1988-03-23 1989-10-05 The Johns Hopkins University Cloned human topoisomerase i
WO1996040886A1 (en) * 1995-06-07 1996-12-19 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009222A1 (en) * 1988-03-23 1989-10-05 The Johns Hopkins University Cloned human topoisomerase i
WO1996040886A1 (en) * 1995-06-07 1996-12-19 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANTIMICROB. AGENTS CHEMOTHER. (1992), 36(10), 2131-8 CODEN: AMACCQ;ISSN: 0066-4804 *
CHEMICAL ABSTRACTS, vol. 117, no. 21, 23 November 1992, Columbus, Ohio, US; abstract no. 207692, FOSTEL, JENNIFER M. ET AL: "Characterization of DNA topoisomerase I from Candida albicans as a target for drug discovery" XP002034941 *
CHEMICAL ABSTRACTS, vol. 125, no. 7, 12 August 1996, Columbus, Ohio, US; abstract no. 77851, TAYLOR, ALISON ET AL: "Identification of the gene encoding DNA topoisomerase I from Candida albicans" XP002034942 *
FEMS MICROBIOL. LETT. (1996), 138(2-3), 113-121 CODEN: FMLED7;ISSN: 0378-1097 *

Also Published As

Publication number Publication date
WO1997015676A2 (en) 1997-05-01

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