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WO1997015345A1 - Systeme catheter anti-infection - Google Patents

Systeme catheter anti-infection Download PDF

Info

Publication number
WO1997015345A1
WO1997015345A1 PCT/EP1996/004618 EP9604618W WO9715345A1 WO 1997015345 A1 WO1997015345 A1 WO 1997015345A1 EP 9604618 W EP9604618 W EP 9604618W WO 9715345 A1 WO9715345 A1 WO 9715345A1
Authority
WO
WIPO (PCT)
Prior art keywords
catheter
reservoirs
volume
filled
filling
Prior art date
Application number
PCT/EP1996/004618
Other languages
German (de)
English (en)
Inventor
Marion Giebel
Ülo PALM
Willehad Boemke
Original Assignee
Marion Giebel
Palm Uelo
Willehad Boemke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marion Giebel, Palm Uelo, Willehad Boemke filed Critical Marion Giebel
Priority to EP96934807A priority Critical patent/EP0961627A1/fr
Publication of WO1997015345A1 publication Critical patent/WO1997015345A1/fr
Priority to US09/299,362 priority patent/US6146363A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0017—Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings

Definitions

  • the invention relates to an infection-preventing catheter arrangement of the type specified in the preamble of the patent claim.
  • a filling and suction device is provided with at least one active substance reservoir, the total volume of which corresponds exactly to the catheter filling volume.
  • the volumes must match, since on the one hand an active substance reservoir volume that is smaller than the catheter filling volume can lead to blood penetrating into the tip of the cannula and thus to signs of coagulation and clogging, and on the other hand an active substance reservoir that is larger than the catheter filling volume can penetrate the active substance into the patient's bloodstream and thus lead to the formation of resistance.
  • their disadvantage is their assignment for only one catheter type of a certain filling volume.
  • the filling and suction device which can be attached to the rear connector of the catheter is designed in such a way that the catheter volume in the area of the cannula tip can be filled with an agent which does not damage tissue and blood cells, while the actual active substance can be filled in on the connector side, preferably at least the same volume is removable.
  • the filling volume can also exceed the catheter volume since essentially only tissue-harmless substance can be pressed into the bloodstream. It is only important that the active substance only acts within the catheter and cannot get into the patient's body. This ensures that the highest possible concentration of active ingredient can be used while avoiding the otherwise occurring side effects and development of resistance.
  • a multi-chamber system which is derived from the above, is suitable for layering the at least two substances along the cannula column.
  • WO known type The objects of claims 2 to 5 known from this WO relating to the type of active substance and 6 to 8 and 10 to 25 relating to the filling and suction device are expressly claimed as advantageous developments of the present disclosure. Only claim 9 of the WO is to be modified in such a way that the catheter-side first reservoir contains the essentially tissue-harmless agent, preferably anticoagulant, in particular heparin, and the second reservoir contains the active substance.
  • REPLACEMENT BLA ⁇ (RULE 26) The invention is explained in more detail below with the aid of two preferred exemplary embodiments. Show it:
  • FIGS 3a and 3b another embodiment in partial longitudinal section
  • Figure 3c shows a cross section according to I-I in Figure 3a.
  • FIGS la to 2b illustrate the interaction of a filling and suction device 1 with a catheter 2 in a first embodiment.
  • the filling and suction device 1 essentially consists of a cylindrical housing 3, a first membrane 4, which divides the interior of the housing into two axially successive chambers 5 and 6, and a plunger 7, which forms the end of the device 1 facing away from the catheter .
  • the device 1 has a Luer thread 8 and a plug-in cone 9, which are assigned to a connector 10 of the catheter 2.
  • the plug cone 9 is closed at its tip with a second membrane 11.
  • the first chamber 5 delimited by the second membrane 11, the plug-in cone 9, part of the cylindrical housing 3 and the first membrane 4 is filled with heparin 12, while that of the first membrane 4, another part of the housing 3
  • REPLACEMENT BLA ⁇ (RULE 26) and the front surface of the stamp 7 delimited second chamber 6 contains an active substance, in particular an antibiotic, for example gentamycin 13.
  • This two-chamber system forms a closed unit, which is completely sterile in a corresponding packaging unit (not shown) with a protective cap (also not shown) for the second membrane 11.
  • the protective cap which is fastened to the Luer thread 8 of the device 1, is removed immediately before connection to the catheter 2, so that contamination, in particular the second membrane 11, by germs which are constantly present in the air is largely avoided.
  • the connection position of the device 1 to the catheter 2 is shown in FIG. 1b.
  • the stamp 7 can be screwed into the cylinder 3 by means of a screw cap 14.
  • the screw cap 14 can also be designed as a separate cap, which causes a translatory sterile movement.
  • FIGS. 1c and 1d show the catheter arrangement during and after filling the heparin 12 and the gentamycin 13 into the catheter 1.
  • the two membranes 4 and 11 have been destroyed by the stamp pressure.
  • the heparin 12 is pressed into the area of the cannula tip 15, the filling volume being dimensioned such that no heparin 12 or only a small amount 16 of the heparin 12 can escape from the cannula tip and enter the bloodstream. This does not cause toxic reactions.
  • the heparin 12 counteracts the formation of blood clots so that cannula blockages are avoided. It also represents
  • REPLACEMENT BLA ⁇ (RULE 26) 12 is a heparin rt
  • a column buffer is compared to the Gentanycin 13 which fills the RESIZE ß th part of the catheter volume.
  • the column buffer effectively shields the gentamycin 13 from the catheterized vessel even if the interface between the heparin 12 and the gentamycin 13 is blurred by mixing processes after a long period of time. Resistance formation due to the penetration of even small amounts of gentamycin 13 into the blood is therefore excluded.
  • a single device 1 of a certain size can be used for several types of catheter.
  • the antibiotic solution By screwing the cap 14 back, the antibiotic solution can be sucked back into the reservoir of the device 1.
  • the screw-back path can be somewhat longer than the screw-in path.
  • some body fluid is sucked out of the catheterized vessel, in particular blood, beyond the pure filling volume.
  • it is almost doubly ensured that no drug residues remain in the catheter that could be washed into the patient's body by a subsequent infusion.
  • the device 1 can also be examined for its germ content, for example.
  • the filling and suction device 1 is closed with a sterile cap 17 immediately after the disconnection from the catheter 2, as can be seen in FIG. 2b.
  • REPLACEMENT BLA ⁇ (RULE 26) A second embodiment is shown in Figures 3a, 3b and 3c.
  • the two chambers 5 'and 6' for heparin 12 and gentamycin 13 are not arranged axially one behind the other, but next to each other as parallel bores in a cylinder 3 '.
  • a modified stamp 7 'with two parallel push rods 18 and 19 ensures that the heparin-filled chamber 5' is emptied first and then the gentamycin-filled chamber 6 '.
  • a screw cap 14 ' is placed on the cylinder 3' and, in operative connection with the plunger 7 ', causes its translatory displacement.
  • a connecting element of high rigidity for example a coil spring 20, and a driver 22 provided with a seal 22 pushes the heparin 12 out of the filling and suction device via the push rod 18.
  • the push rod 19 also moves within a similar seal 21, whereby, however, no influence is exerted on the chamber 6 ′ filled with gentamycing, since this push rod 19 is provided with a driver 23 which is free inside the seal 21 in accordance with the depth of the heparin column Game.
  • the screw spring 20 is compressed, while the chamber 6' is emptied with the gentamycin 13.
  • 3b shows the end position after filling.
  • the two drivers 22 and 23 act in the opposite direction.
  • a stop 24 prevents the punch 7 'from being screwed out of the cylinder 3'.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un système cathéter anti-infection comportant un cathéter (2) qui présente un tube à canule rigide ou souple avec un élément de raccordement (10) prévu à une extrémité arrière. Un dispositif de remplissage et d'aspiration (1) comportant un ou plusieurs réservoirs de principe actif peut être fixé sur l'élément de raccordement (10). Au moins un des réservoirs est rempli d'une substance contenant au moins un antibiotique ou un agent chimiothérapeutique ou antiviral, de préférence de l'aminoglycoside, de préférence de la gentamycine (13), au moins en concentration efficace minimale. Un autre réservoir est rempli d'une autre substance contenant ou produisant au moins un agent n'altérant sensiblement ni les cellules tissulaires ni les cellules sanguines, de préférence un anticoagulant, notamment de l'héparine (12). Cette substance peut être introduite essentiellement dans la zone de la pointe (15) de la canule. Le volume total des réservoirs correspond au moins au volume de remplissage du cathéter, plus éventuellement le volume de pièces intermédiaires, notamment celui d'un robinet à trois voies.
PCT/EP1996/004618 1995-10-26 1996-10-24 Systeme catheter anti-infection WO1997015345A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP96934807A EP0961627A1 (fr) 1995-10-26 1996-10-24 Systeme catheter anti-infection
US09/299,362 US6146363A (en) 1996-10-24 1999-04-26 Anti-infection catheter

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1995139785 DE19539785A1 (de) 1995-10-26 1995-10-26 Infektvorbeugende Katheteranordnung
DE19539785.1 1995-10-26

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/299,362 Continuation-In-Part US6146363A (en) 1996-10-24 1999-04-26 Anti-infection catheter

Publications (1)

Publication Number Publication Date
WO1997015345A1 true WO1997015345A1 (fr) 1997-05-01

Family

ID=7775780

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/004618 WO1997015345A1 (fr) 1995-10-26 1996-10-24 Systeme catheter anti-infection

Country Status (3)

Country Link
EP (1) EP0961627A1 (fr)
DE (1) DE19539785A1 (fr)
WO (1) WO1997015345A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7481837B2 (en) 1999-12-10 2009-01-27 Advanced Cardiovascular Systems, Inc. Bifurcated stent delivery system having retractable sheath

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613025B1 (en) 2000-05-25 2003-09-02 Scimed Life Systems, Inc. Method and apparatus for diagnostic and therapeutic agent delivery
DE10100069C1 (de) * 2001-01-02 2003-06-18 Klaus Affeld Infektionsschutzsystem für implantierte Fremdkörper

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3930039A1 (de) * 1989-09-06 1991-03-07 Palm Uelo Aarne Infektvorbeugende katheteranordnung
WO1991006329A1 (fr) * 1990-11-02 1991-05-16 Marion Giebel Agencement de catheter anti-infection

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3930039A1 (de) * 1989-09-06 1991-03-07 Palm Uelo Aarne Infektvorbeugende katheteranordnung
WO1991006329A1 (fr) * 1990-11-02 1991-05-16 Marion Giebel Agencement de catheter anti-infection

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7481837B2 (en) 1999-12-10 2009-01-27 Advanced Cardiovascular Systems, Inc. Bifurcated stent delivery system having retractable sheath

Also Published As

Publication number Publication date
DE19539785A1 (de) 1996-07-18
EP0961627A1 (fr) 1999-12-08

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