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WO1997013776A3 - Nouveaux derives amines de 2', 3' didesoxyglycosides d'epipodophyllotoxine, leur procede de preparation, leur utilisation comme medicament et leur utilisation destinee aux traitements anticancereux - Google Patents

Nouveaux derives amines de 2', 3' didesoxyglycosides d'epipodophyllotoxine, leur procede de preparation, leur utilisation comme medicament et leur utilisation destinee aux traitements anticancereux Download PDF

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Publication number
WO1997013776A3
WO1997013776A3 PCT/FR1996/001588 FR9601588W WO9713776A3 WO 1997013776 A3 WO1997013776 A3 WO 1997013776A3 FR 9601588 W FR9601588 W FR 9601588W WO 9713776 A3 WO9713776 A3 WO 9713776A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug
preparation
treating cancer
dideoxyglycosides
epipodophyllotoxin
Prior art date
Application number
PCT/FR1996/001588
Other languages
English (en)
Other versions
WO1997013776A2 (fr
Inventor
Claude Monneret
Laurent Daley
Yves Guminski
Thierry Imbert
Bridget Hill
Original Assignee
Pf Medicament
Claude Monneret
Laurent Daley
Yves Guminski
Thierry Imbert
Bridget Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament, Claude Monneret, Laurent Daley, Yves Guminski, Thierry Imbert, Bridget Hill filed Critical Pf Medicament
Priority to NZ320323A priority Critical patent/NZ320323A/xx
Priority to AU73040/96A priority patent/AU7304096A/en
Priority to JP9514777A priority patent/JP2000505053A/ja
Priority to BR9610851A priority patent/BR9610851A/pt
Priority to EP96934895A priority patent/EP0873347A2/fr
Priority to KR1019980702647A priority patent/KR19990064166A/ko
Publication of WO1997013776A2 publication Critical patent/WO1997013776A2/fr
Publication of WO1997013776A3 publication Critical patent/WO1997013776A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne un composé de formule générale (I), X, Y, R1 et R2 étant définis dans la description, leur procédé de préparation, leur utilisation comme médicament et leur utilisation destinée aux traitements anticancéreux.
PCT/FR1996/001588 1995-10-12 1996-10-11 Nouveaux derives amines de 2', 3' didesoxyglycosides d'epipodophyllotoxine, leur procede de preparation, leur utilisation comme medicament et leur utilisation destinee aux traitements anticancereux WO1997013776A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
NZ320323A NZ320323A (en) 1995-10-12 1996-10-11 Amine derivatives of epipodophyllotoxin 2", 3"- dideoxyglycosides, preparation and use thereof as a drug and for treating cancer
AU73040/96A AU7304096A (en) 1995-10-12 1996-10-11 Novel amine derivatives of epipodophyllotoxin 2", 3"-dideoxyglycosides, preparation method therefor and use thereof as a drug and for treating cancer
JP9514777A JP2000505053A (ja) 1995-10-12 1996-10-11 エピポドフイロトキシン２”，３”−ジデオキシグリコシドの新規アミン誘導体、その調製方法、ならびに薬剤用および抗がん治療用としてのその使用
BR9610851A BR9610851A (pt) 1995-10-12 1996-10-11 Composto processo de preparação de composto medicamento composição farmacêuticas e utilização do composto
EP96934895A EP0873347A2 (fr) 1995-10-12 1996-10-11 Nouveaux derives amines de 2", 3" didesoxyglycosides d'epipodophyllotoxine, leur procede de preparation, leur utilisation comme medicament et leur utilisation destinee aux traitements anticancereux
KR1019980702647A KR19990064166A (ko) 1995-10-12 1996-10-11 에피포도필로톡신 2",3"-디데옥시글리코시드의 신규한 아민 유도체, 그것의 제조방법, 및 약물로서 사용하는 방법 및 암 치료에 사용하는 방법<

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9511978A FR2739857B1 (fr) 1995-10-12 1995-10-12 Nouveaux derives amines de 2",3"-didesoxyglycosides d'epipodophyllotoxine, leur procede de preparation, leur utilisation comme medicament et leur utilisation destinee aux traitements anticancereux
FR95/11978 1995-10-21

Publications (2)

Publication Number Publication Date
WO1997013776A2 WO1997013776A2 (fr) 1997-04-17
WO1997013776A3 true WO1997013776A3 (fr) 1997-06-05

Family

ID=9483465

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1996/001588 WO1997013776A2 (fr) 1995-10-12 1996-10-11 Nouveaux derives amines de 2', 3' didesoxyglycosides d'epipodophyllotoxine, leur procede de preparation, leur utilisation comme medicament et leur utilisation destinee aux traitements anticancereux

Country Status (10)

Country Link
EP (1) EP0873347A2 (fr)
JP (1) JP2000505053A (fr)
KR (1) KR19990064166A (fr)
CN (1) CN1202173A (fr)
AU (1) AU7304096A (fr)
BR (1) BR9610851A (fr)
CA (1) CA2234484A1 (fr)
FR (1) FR2739857B1 (fr)
NZ (1) NZ320323A (fr)
WO (1) WO1997013776A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2800374B1 (fr) 1999-10-28 2002-06-28 Adir Nouveaux derives de 9-(3,5-dimethoxyphenyl)-5,8,8a,9- tetrahydrofuro[3',4':6,7]naphto[2,3-d] [1,3]dioxol-6(5ah)- one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
TWI307341B (en) * 2002-10-11 2009-03-11 Plantaceutica Inc Anticancer compounds
FR2859208B1 (fr) 2003-09-02 2006-01-21 Servier Lab Nouveaux derives de 9-amino-podophyllotoxine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN102115483B (zh) * 2009-12-30 2014-12-17 苏州天人合生物技术有限公司 卤代双去氧糖衍生物及其制备方法与应用
CN109369667B (zh) * 2018-12-05 2021-04-13 南通大学 2，3，6-三脱氧糖基去甲表鬼臼毒素化合物及其制备方法和用途
CN110294764B (zh) * 2019-07-15 2021-04-20 中国科学院兰州化学物理研究所 一种偶氮键连接的鬼臼毒素衍生物及其制备方法
CN112079879B (zh) * 2020-08-21 2022-01-14 华润双鹤药业股份有限公司沧州分公司 一种替尼泊苷中间体的合成新方法及替尼泊苷的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547567A (en) * 1983-07-29 1985-10-15 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Derivatives of 4'-demethyl-4-epipodophyllotoxin
EP0415453A2 (fr) * 1989-09-01 1991-03-06 Bristol-Myers Squibb Company Derivés d'epipodophyllotoxin altroside

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547567A (en) * 1983-07-29 1985-10-15 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Derivatives of 4'-demethyl-4-epipodophyllotoxin
EP0415453A2 (fr) * 1989-09-01 1991-03-06 Bristol-Myers Squibb Company Derivés d'epipodophyllotoxin altroside

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SAITO H ET AL: "Studies on lignan lactone antitumor agents. I. Synthesis of aminoglycosidic lignan variants related to podophyllotoxin", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 34, no. 9, 1986, TOKYO JP, pages 3733 - 3740, XP002005524 *

Also Published As

Publication number Publication date
WO1997013776A2 (fr) 1997-04-17
CA2234484A1 (fr) 1997-04-17
KR19990064166A (ko) 1999-07-26
AU7304096A (en) 1997-04-30
JP2000505053A (ja) 2000-04-25
EP0873347A2 (fr) 1998-10-28
MX9802933A (es) 1998-11-29
NZ320323A (en) 1999-07-29
FR2739857B1 (fr) 1998-01-02
BR9610851A (pt) 1999-07-13
CN1202173A (zh) 1998-12-16
FR2739857A1 (fr) 1997-04-18

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