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WO1997013505A3 - UTILISATION D'UN LIGAND AGONISTE SPECIFIQUE RAR-η POUR AUGMENTER LE TAUX D'APOPTOSE - Google Patents

UTILISATION D'UN LIGAND AGONISTE SPECIFIQUE RAR-η POUR AUGMENTER LE TAUX D'APOPTOSE Download PDF

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Publication number
WO1997013505A3
WO1997013505A3 PCT/FR1996/001568 FR9601568W WO9713505A3 WO 1997013505 A3 WO1997013505 A3 WO 1997013505A3 FR 9601568 W FR9601568 W FR 9601568W WO 9713505 A3 WO9713505 A3 WO 9713505A3
Authority
WO
WIPO (PCT)
Prior art keywords
rar
apoptosis
specific agonist
agonist ligand
composition
Prior art date
Application number
PCT/FR1996/001568
Other languages
English (en)
Other versions
WO1997013505A2 (fr
Inventor
Laszlo Fesus
Zsuzsa Szondy
Uwe Reichert
Original Assignee
Cird
Laszlo Fesus
Zsuzsa Szondy
Uwe Reichert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cird, Laszlo Fesus, Zsuzsa Szondy, Uwe Reichert filed Critical Cird
Priority to NZ319646A priority Critical patent/NZ319646A/xx
Priority to US09/051,407 priority patent/US6593359B1/en
Priority to PL96326077A priority patent/PL185826B1/pl
Priority to AU72209/96A priority patent/AU705993B2/en
Priority to KR1019980702620A priority patent/KR19990064139A/ko
Priority to BR9610967A priority patent/BR9610967A/pt
Priority to JP09514767A priority patent/JP3135266B2/ja
Priority to EP96933502A priority patent/EP0854710A2/fr
Publication of WO1997013505A2 publication Critical patent/WO1997013505A2/fr
Publication of WO1997013505A3 publication Critical patent/WO1997013505A3/fr
Priority to NO981592A priority patent/NO981592L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Utilisation d'au moins un ligand agoniste spécifique aux récepteurs de type RAR-η dans la préparation d'une composition pharmaceutique destinée à augmenter le taux d'apoptose dans au moins une population cellulaire pour laquelle l'apoptose peut être induite par activation des récepteurs de type RAR-η. Cette composition peut servir notamment à traiter une maladie ou un désordre lié à une insuffisance du taux d'apoptose dans au moins une population cellulaire pour laquelle l'apoptose peut être induite par activation des récepteurs de type RAR-η. Utilisation d'au moins un ligand agoniste spécifique aux récepteurs de type RAR-η dans une composition cosmétique en tant qu'inducteur d'apoptose. Cette composition peut permettre de prévenir et/ou de lutter contre le vieillissement photoinduit ou chronologique de la peau.
PCT/FR1996/001568 1995-10-09 1996-10-08 UTILISATION D'UN LIGAND AGONISTE SPECIFIQUE RAR-η POUR AUGMENTER LE TAUX D'APOPTOSE WO1997013505A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
NZ319646A NZ319646A (en) 1995-10-09 1996-10-08 Use of a rar-y-specific agonist ligand for increasing the rate of apoptosis
US09/051,407 US6593359B1 (en) 1995-10-09 1996-10-08 Use of a RAR-γ-specific agonist ligand for increasing the rate of apoptosis
PL96326077A PL185826B1 (pl) 1995-10-09 1996-10-08 Zastosowanie specyficznego ligandu agonistycznegoZastosowanie specyficznego ligandu agonistycznegoRAR-y do zwiększenia stopnia apoptozyRAR-y do zwiększenia stopnia apoptozy
AU72209/96A AU705993B2 (en) 1995-10-09 1996-10-08 Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis
KR1019980702620A KR19990064139A (ko) 1995-10-09 1996-10-08 세포 소멸 속도를 증가시키는 감마-알에이알-특이성 작용 물질리간드의 용도
BR9610967A BR9610967A (pt) 1995-10-09 1996-10-08 Utilização de pelo menos um ligante agonista específico aos receptores de tipo rar e processo cosmético para previnir e/ou combater o envelhecimento fotoinduzido ou cronológico da pele
JP09514767A JP3135266B2 (ja) 1995-10-09 1996-10-08 アポプトシス速度向上のためのＲＡＲ−γ−特異的アゴニストリガンドの使用
EP96933502A EP0854710A2 (fr) 1995-10-09 1996-10-08 UTILISATION D'UN LIGAND AGONISTE SPECIFIQUE RAR-$g(g) POUR AUGMENTER LE TAUX D'APOPTOSE
NO981592A NO981592L (no) 1995-10-09 1998-04-07 Anvendelse av <gamma>-RAR-spesifikk agonistligand for Õ °ke apoptosisraten

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR95/12179 1995-10-09
FR9512179A FR2739557B1 (fr) 1995-10-09 1995-10-09 Utilisation d'un ligand agoniste specifique rar-gamma

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US09/051,407 A-371-Of-International US6593359B1 (en) 1995-10-09 1996-10-08 Use of a RAR-γ-specific agonist ligand for increasing the rate of apoptosis
US09/431,920 Division US6686386B1 (en) 1995-10-09 1999-11-02 Use of a RAR-γ-specific agonist ligand for increasing the rate of apoptosis
US09/624,771 Division US6506796B1 (en) 1995-10-09 2000-07-25 Use of a RAR-γ-specific agonist ligand for increasing the rate of apoptosis
US09/801,664 Continuation US20010018456A1 (en) 1995-10-09 2001-03-09 Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis
US10/183,518 Continuation-In-Part US20030092758A1 (en) 1995-10-09 2002-06-28 Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis

Publications (2)

Publication Number Publication Date
WO1997013505A2 WO1997013505A2 (fr) 1997-04-17
WO1997013505A3 true WO1997013505A3 (fr) 1997-05-29

Family

ID=9483613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1996/001568 WO1997013505A2 (fr) 1995-10-09 1996-10-08 UTILISATION D'UN LIGAND AGONISTE SPECIFIQUE RAR-η POUR AUGMENTER LE TAUX D'APOPTOSE

Country Status (16)

Country Link
US (4) US6593359B1 (fr)
EP (1) EP0854710A2 (fr)
JP (1) JP3135266B2 (fr)
KR (1) KR19990064139A (fr)
CN (1) CN1121857C (fr)
AU (1) AU705993B2 (fr)
BR (1) BR9610967A (fr)
CA (1) CA2231561A1 (fr)
FR (1) FR2739557B1 (fr)
HU (1) HUP9900453A3 (fr)
NO (1) NO981592L (fr)
NZ (1) NZ319646A (fr)
PL (1) PL185826B1 (fr)
RU (1) RU2188037C2 (fr)
TR (1) TR199800645T1 (fr)
WO (1) WO1997013505A2 (fr)

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GB9907461D0 (en) * 1999-03-31 1999-05-26 King S College London Neurite regeneration
US20070213290A1 (en) * 1996-10-17 2007-09-13 Kingsman Alan J Neurite regeneration
US20030053991A1 (en) * 2000-10-04 2003-03-20 Kingsman Alan John Retinoic acid receptor beta-2, its agonists, and gene theraphy vectors for the treatment of neurological disorders
US20040266715A1 (en) * 1999-03-31 2004-12-30 Wong Liang Fong Neurite regeneration
FR2757852B1 (fr) 1996-12-31 1999-02-19 Cird Galderma Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations
TR200001228T2 (tr) * 1997-11-12 2001-01-22 F.Hoffmann-La Roche Ag T yardımcı hücre tür 2 kökenli bağışıklık hastalıklarının retinoit antagonistlerle tedavisi
US6083973A (en) * 1998-03-09 2000-07-04 Syntex (U.S.A.) Inc. Methods for inhibiting mucin secretion using RAR α selective antagonists
US6949528B1 (en) * 1998-03-18 2005-09-27 Goddard John G Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
JO2178B1 (en) * 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of invasive diseases, using selected anti-PAR materials
AU2003294757A1 (en) * 2002-11-29 2004-06-23 Axxima Pharmaceuticals Ag Formulations useful against hepatitis c virus infections
US20050202055A1 (en) * 2004-03-11 2005-09-15 Koichi Shudo, Tokyo, Japan Anti-wrinkle agent
CN1933802B (zh) * 2004-03-26 2011-07-06 帝斯曼知识产权资产管理有限公司 包含hdac抑制剂和类维生素a的组合的组合物
US7713266B2 (en) 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US7850683B2 (en) * 2005-05-20 2010-12-14 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US9254162B2 (en) 2006-12-21 2016-02-09 Myoscience, Inc. Dermal and transdermal cryogenic microprobe systems
US8409185B2 (en) 2007-02-16 2013-04-02 Myoscience, Inc. Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling
WO2009065061A1 (fr) 2007-11-14 2009-05-22 Myoscience, Inc. Gestion de la douleur à l'aide du remodelage cryogénique
EP2373239B1 (fr) 2008-12-22 2013-08-14 Myoscience, Inc. Système de cryochirurgie intégré avec fluide frigorigène et source d'énergie électrique
CA2809374C (fr) 2010-09-01 2021-02-23 Thomas Jefferson University Une composition renfermant un agoniste du recepteur gamma d'acide retinoique et son utilisation pour la reparation et la regeneration de muscles
BR112013033309B1 (pt) * 2011-06-24 2022-07-05 Gri Bio, Inc Uso de tazaroteno e método in vitro para inibição de ativação de células nkt tipo i
US9314290B2 (en) 2012-01-13 2016-04-19 Myoscience, Inc. Cryogenic needle with freeze zone regulation
US9155584B2 (en) 2012-01-13 2015-10-13 Myoscience, Inc. Cryogenic probe filtration system
EP2802280B1 (fr) 2012-01-13 2016-11-30 Myoscience, Inc. Protection de la peau pour le remodelage sous-cutané cryogénique dans le cadre de soins cosmétiques et autres traitements
US9017318B2 (en) 2012-01-20 2015-04-28 Myoscience, Inc. Cryogenic probe system and method
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
US10016229B2 (en) 2013-03-15 2018-07-10 Myoscience, Inc. Methods and systems for treatment of occipital neuralgia
CN105208954B (zh) 2013-03-15 2019-06-04 肌肉科技股份有限公司 低温钝性解剖方法和设备
US10130409B2 (en) 2013-11-05 2018-11-20 Myoscience, Inc. Secure cryosurgical treatment system
US10940127B2 (en) 2015-11-25 2021-03-09 Io Therapeutics, Inc. Use of CYP26-resistant RAR alpha selective agonists in the treatment of cancer
WO2017197323A1 (fr) 2016-05-13 2017-11-16 Lee Ann S Procédés et systèmes de localisation et de traitement par une thérapie à froid
CN115671292A (zh) * 2016-06-10 2023-02-03 Io治疗公司 用于癌症免疫疗法的受体选择性类视黄醇和rexinoid化合物和免疫调节剂
US10231944B2 (en) * 2017-07-13 2019-03-19 Io Therapeutics, Inc. Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy
SG11202001479RA (en) 2017-08-31 2020-03-30 Io Therapeutics Inc Rar selective agonists in combination with immune modulators for cancer immunotherapy
US11134998B2 (en) 2017-11-15 2021-10-05 Pacira Cryotech, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
US11135236B2 (en) * 2018-04-10 2021-10-05 Northwestern University Retinoic acid receptor gamma agonists to attenuate anthracycline-induced cardiotoxicity

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US5786391A (en) * 1995-01-11 1998-07-28 Cornell Research Foundation, Inc. Regulating gene expression using retinoids with Ch2 OH or related groups at the side chain terminal position

Patent Citations (1)

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WO1997003682A1 (fr) * 1995-07-17 1997-02-06 Centre International De Recherches Dermatologiques C.I.R.D. Galderma Procedes de traitement de cancers a l'aide de 6-[3-[1-adamantyl]-4-hydroxyphenyl]

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Also Published As

Publication number Publication date
TR199800645T1 (xx) 1998-06-22
JPH11501661A (ja) 1999-02-09
JP3135266B2 (ja) 2001-02-13
NZ319646A (en) 2000-08-25
FR2739557A1 (fr) 1997-04-11
CA2231561A1 (fr) 1997-04-17
AU7220996A (en) 1997-04-30
US20010018456A1 (en) 2001-08-30
US6593359B1 (en) 2003-07-15
CN1203528A (zh) 1998-12-30
AU705993B2 (en) 1999-06-03
US6506796B1 (en) 2003-01-14
HUP9900453A2 (hu) 1999-05-28
FR2739557B1 (fr) 1997-11-14
CN1121857C (zh) 2003-09-24
EP0854710A2 (fr) 1998-07-29
BR9610967A (pt) 1999-03-02
WO1997013505A2 (fr) 1997-04-17
US6686386B1 (en) 2004-02-03
RU2188037C2 (ru) 2002-08-27
NO981592D0 (no) 1998-04-07
NO981592L (no) 1998-06-09
PL185826B1 (pl) 2003-08-29
KR19990064139A (ko) 1999-07-26
PL326077A1 (en) 1998-08-17
HUP9900453A3 (en) 1999-11-29

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