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WO1997013490A3 - Kontrastmittel für die nahinfrarot-diagnostik, enthaltend mit polymethinfarbstoffen beladene kolloidale systeme - Google Patents

Kontrastmittel für die nahinfrarot-diagnostik, enthaltend mit polymethinfarbstoffen beladene kolloidale systeme Download PDF

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Publication number
WO1997013490A3
WO1997013490A3 PCT/DE1996/001878 DE9601878W WO9713490A3 WO 1997013490 A3 WO1997013490 A3 WO 1997013490A3 DE 9601878 W DE9601878 W DE 9601878W WO 9713490 A3 WO9713490 A3 WO 9713490A3
Authority
WO
WIPO (PCT)
Prior art keywords
near infrared
polymethine dyes
colloidal systems
contrasting agents
containing colloidal
Prior art date
Application number
PCT/DE1996/001878
Other languages
English (en)
French (fr)
Other versions
WO1997013490A2 (de
Inventor
Kai Licha
Bjoern Riefke
Werner Weitschiess
Dieter Heldmann
Violetta Sudmann
Original Assignee
Diagnostikforschung Inst
Kai Licha
Bjoern Riefke
Werner Weitschiess
Dieter Heldmann
Violetta Sudmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagnostikforschung Inst, Kai Licha, Bjoern Riefke, Werner Weitschiess, Dieter Heldmann, Violetta Sudmann filed Critical Diagnostikforschung Inst
Priority to KR1019980701830A priority Critical patent/KR100290240B1/ko
Priority to EP96945477A priority patent/EP0854732A2/de
Priority to US09/051,511 priority patent/US6319488B1/en
Priority to JP9514616A priority patent/JPH11504656A/ja
Priority to AU15892/97A priority patent/AU711266B2/en
Publication of WO1997013490A2 publication Critical patent/WO1997013490A2/de
Publication of WO1997013490A3 publication Critical patent/WO1997013490A3/de
Priority to NO981586A priority patent/NO981586L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0078—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion microemulsion, nanoemulsion

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Nanotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

Die Erfindung betrifft mit Polymethinfarbstoffen beladene kolloidale Systeme mit geeigneten photophysikalischen und pharmakologischen Eigenschaften, deren Verwendung als Kontrastmittel in der Fluoreszenz- und Transilluminationsdiagnostik im nahinfraroten Spektralbereich sowie Verfahren zu ihrer Herstellung.
PCT/DE1996/001878 1995-10-11 1996-09-26 Kontrastmittel für die nahinfrarot-diagnostik, enthaltend mit polymethinfarbstoffen beladene kolloidale systeme WO1997013490A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1019980701830A KR100290240B1 (ko) 1995-10-11 1996-09-26 폴리메틴 염료가 포함된 콜로이드계를 함유한 근적외선 진단용 조영제
EP96945477A EP0854732A2 (de) 1995-10-11 1996-09-26 Kontrastmittel für die nahinfrarot-diagnostik
US09/051,511 US6319488B1 (en) 1995-10-11 1996-09-26 Contrast medium for near infrared diagnosis
JP9514616A JPH11504656A (ja) 1995-10-11 1996-09-26 ポリメチン染料をロードされたコロイド系を含有する近赤外線診断のための造影剤
AU15892/97A AU711266B2 (en) 1995-10-11 1996-09-26 Contrasting agents for near infrared diagnosis
NO981586A NO981586L (no) 1995-10-11 1998-04-07 Kontrastmiddel for nµrinfrar÷d-diagnostikken, inneholdende systemer som er anriket med polymetinfarvestoffer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19539409A DE19539409C2 (de) 1995-10-11 1995-10-11 Kontrastmittel für die Nahinfrarot-Diagnostik
DE19539409.7 1995-10-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/051,511 A-371-Of-International US6319488B1 (en) 1995-10-11 1996-09-26 Contrast medium for near infrared diagnosis
US09/962,788 Division US20020022004A1 (en) 1995-10-11 2001-09-25 Contrast medium for near infrared diagnosis

Publications (2)

Publication Number Publication Date
WO1997013490A2 WO1997013490A2 (de) 1997-04-17
WO1997013490A3 true WO1997013490A3 (de) 1997-10-23

Family

ID=7775535

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1996/001878 WO1997013490A2 (de) 1995-10-11 1996-09-26 Kontrastmittel für die nahinfrarot-diagnostik, enthaltend mit polymethinfarbstoffen beladene kolloidale systeme

Country Status (13)

Country Link
US (2) US6319488B1 (de)
EP (1) EP0854732A2 (de)
JP (1) JPH11504656A (de)
KR (1) KR100290240B1 (de)
CN (1) CN1075951C (de)
AU (1) AU711266B2 (de)
CA (1) CA2233995A1 (de)
DE (1) DE19539409C2 (de)
HU (1) HUP9900458A3 (de)
IL (1) IL119365A (de)
NO (1) NO981586L (de)
WO (1) WO1997013490A2 (de)
ZA (1) ZA968229B (de)

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US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
JP2000095758A (ja) * 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US20030180221A1 (en) * 1998-09-18 2003-09-25 Schering Ag Near infrared fluorescent contrast agent and fluorescence imaging
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DE10046215B4 (de) * 2000-09-19 2004-04-15 Institut für Chemo- und Biosensorik Münster e.V. i.Ins. Fluorochrome und deren Verwendung
US7139122B1 (en) * 2000-10-17 2006-11-21 Lucid, Inc. System and method for enhancing confocal reflectance images of tissue specimens
US7003345B1 (en) 2000-10-17 2006-02-21 Lucid, Inc. System and method for enhancing microscope images of tissue using citric acid and agents of the like
TWI284539B (en) 2001-07-30 2007-08-01 Epix Pharm Inc A method for making a magnetic resonance (MR) imaging agent, a MR imaging contrast agent, a method for altering stability of a peptide and a modified peptide
JP2003261464A (ja) * 2002-03-07 2003-09-16 Fuji Photo Film Co Ltd 近赤外蛍光造影剤および蛍光造影法
US20040133112A1 (en) * 2002-03-08 2004-07-08 Milind Rajadhyaksha System and method for macroscopic and confocal imaging of tissue
AU2003248747A1 (en) 2002-06-27 2004-01-19 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
WO2004005289A2 (en) 2002-07-02 2004-01-15 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
WO2004068405A2 (en) * 2003-01-25 2004-08-12 Oraevsky Alexander A High contrast optoacoustical imaging using nanoparticles
JP2004269439A (ja) * 2003-03-10 2004-09-30 Motohiro Takeda センチネルリンパ節検出剤及び検出方法
WO2005082423A2 (en) * 2003-11-18 2005-09-09 Beth Israel Deaconess Medical Center Serum albumin conjugated to fluorescent substances for imaging
JP2005145921A (ja) * 2003-11-19 2005-06-09 Konica Minolta Medical & Graphic Inc 診断用蛍光造影剤及び蛍光造影診断方法
WO2006009786A2 (en) 2004-06-18 2006-01-26 Elmaleh David R Intravascular imaging device and uses thereof
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
JP2008043396A (ja) * 2006-08-11 2008-02-28 Olympus Corp 内視鏡システム
GB2440910A (en) * 2006-08-18 2008-02-20 Robert Charles Wilson A marker for studying drug dynamics in vivo
KR100825939B1 (ko) * 2006-08-28 2008-04-29 한국과학기술연구원 근적외선 형광체가 결합된 양친성 고분자의 나노 입자를포함하는 암 진단용 조영제
JP2008148791A (ja) * 2006-12-14 2008-07-03 Olympus Corp 内視鏡システム
CN101723874B (zh) * 2008-10-31 2013-09-11 深圳迈瑞生物医疗电子股份有限公司 花菁类化合物及其在生物样品染色中的用途
CN101750476B (zh) * 2008-12-08 2015-06-03 深圳迈瑞生物医疗电子股份有限公司 血液分析试剂及其使用方法
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Also Published As

Publication number Publication date
NO981586D0 (no) 1998-04-07
IL119365A (en) 2000-07-26
HUP9900458A3 (en) 1999-11-29
EP0854732A2 (de) 1998-07-29
CN1075951C (zh) 2001-12-12
DE19539409A1 (de) 1997-04-17
JPH11504656A (ja) 1999-04-27
NO981586L (no) 1998-04-07
CN1199341A (zh) 1998-11-18
ZA968229B (en) 1997-05-14
WO1997013490A2 (de) 1997-04-17
KR100290240B1 (ko) 2001-05-15
US6319488B1 (en) 2001-11-20
HUP9900458A2 (hu) 1999-06-28
AU711266B2 (en) 1999-10-07
DE19539409C2 (de) 1999-02-18
KR19990044581A (ko) 1999-06-25
IL119365A0 (en) 1997-01-10
AU1589297A (en) 1997-04-30
US20020022004A1 (en) 2002-02-21
CA2233995A1 (en) 1997-04-17

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