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WO1997012563A1 - Procede de recouvrement d'une attelle a l'aide d'une matrice acellulaire - Google Patents

Procede de recouvrement d'une attelle a l'aide d'une matrice acellulaire Download PDF

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Publication number
WO1997012563A1
WO1997012563A1 PCT/CA1996/000663 CA9600663W WO9712563A1 WO 1997012563 A1 WO1997012563 A1 WO 1997012563A1 CA 9600663 W CA9600663 W CA 9600663W WO 9712563 A1 WO9712563 A1 WO 9712563A1
Authority
WO
WIPO (PCT)
Prior art keywords
stent
biomaterial
acellular matrix
catheter
distal
Prior art date
Application number
PCT/CA1996/000663
Other languages
English (en)
Inventor
Malcolm Rawlings
Allan Adelman
Original Assignee
Malcolm Rawlings
Allan Adelman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Malcolm Rawlings, Allan Adelman filed Critical Malcolm Rawlings
Publication of WO1997012563A1 publication Critical patent/WO1997012563A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/88—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/062—Apparatus for the production of blood vessels made from natural tissue or with layers of living cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/88—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
    • A61F2/885—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils comprising a coil including a plurality of spiral or helical sections with alternate directions around a central axis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9505—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
    • A61F2002/9511—Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument the retaining means being filaments or wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable

Definitions

  • This invention relates to a method of covering a stent with biomaterial.
  • this invention relates to a method of covering a stent with acellular matrix.
  • Stents consisting of an "open" metal scaffolding, are now widely used for
  • the stent is deployed to its target location within a vessel by
  • the stent is then expanded either on its own accord or by
  • Balloon expandable stents are typically metal mesh that are mounted on balloon
  • Self-expanding stents are made of an alloy having a "memory" that expand to the desired size after being placed at the target site of the vessel. Examples of such stents are
  • the double helix is advantageous because by narrowing and widening the gaps between the parallel struts, it can be contracted and expanded in diameter without
  • All intravascular stents consist of an open metal scaffolding.
  • space to stent material varies from 80/20 to about 90/10.
  • the healing response is triggered.
  • the healing response is a proliferation of smooth muscles cells from
  • the gaps in the metal provide an opportunity for ensuing smooth muscle cell proliferation to grow through the open spaces of the stent.
  • sleeved stent is allowed to expand, pressing the flexible sleeve against the walls of the
  • the sleeve is intended to prevent tissue growth between the gaps defined by
  • nylon and other synthetic materials probably will not provide a long
  • Acellular matrix is a biomaterial derived from
  • tissue extracted from mammalians which is processed to remove all cells and soluble
  • Acellular matrix comprises a framework of largely insoluble collagen and elastin, which
  • biomaterial covering for implantation wherein the stent is prepared by inserting
  • biomaterial through the stent when the stent.
  • the combined biomaterial and stent is
  • the covering is non-thrombogenic and inhibits tissue ingrowth when
  • acellular matrix or other biomaterial covering which can form a barrier between an implanted stent and the wall of the host blood vessel, duct,
  • a stent covered with acellular matrix or other biomaterial for use as a stent or graft for other ducts or conduits within a living body.
  • the biomaterial is attached to the stent by
  • suturing surgically stapling, taping, gluing or other suitable means.
  • biomaterial is attached to itself by suturing, surgically stapling, taping, gluing or other suitable means.
  • the acellular matrix or other biomaterial is
  • the biomaterial may be seeded before or after it is placed
  • the stent and biomaterial is covered by a protective sheath and delivered to a target site and expanded by removing the protective
  • the use comprises the steps
  • tubular acellular matrix on the distal end of the catheter sliding a self-expanding stent over
  • the matrix the self-expanding stent having a protective sheath; extending the distal and
  • distal and proximal ends of the tubular acellular matrix may be attached together.
  • the acellular matrix or other biomaterial is provided.
  • the acellular matrix or other biomaterial is
  • the biomaterial may be seeded with endothelial
  • a stent with an inner tubular lining is provided.
  • the inner lining has open ends for rolling about ends of the stent.
  • the open ends of the inner tubular lining are attached to the tube or to each other.
  • the acellular matrix may be seeded with endothelial cells.
  • Figure 1 is a perspective view of an embodiment of the stent and biomaterial
  • Figure 2 is a side sectional view of the self-expanding stent and acellular
  • Figure 3 is a sectional view of the self-expanding stent of Figure 2 partially
  • Figure 4 is a sectional view of the self-expanding stent of Figure 2 fully
  • Figure 5 is a perspective view of another self-expanding stent which can be
  • Figure 6 is a sectional view of another embodiment of the stent and biomaterial covering of the present invention mounted on a catheter.
  • a stent to be used with the present invention is illustrated in Figure 1.
  • Stent 12 is
  • stent 12 is self-expanding.
  • FIGs 1 and 6 are illustrations of self-expandable stents.
  • the stent 12 is illustrated mounted on a catheter 14.
  • Acellular matrix 16 is mounted between the catheter 14 and the stent 12, presenting an inner lining for the stent 12.
  • Acellular matrix 16 of the preferred embodiments is derived from mammalian,
  • a human vessel including blood vessels, namely arteries and veins, ducts, or
  • conduits and are therefore, tubular in shape having open ends.
  • acellular matrix 16 is extracted from human sources.
  • human sources bovine, bovine, and
  • porcine, canine or similar mammalian sources may also be suitable.
  • cryo- preserved human veins or other ducts or conduits are contemplated as being a suitable
  • the acellular matrix material may be seeded by placing it in a high density culture
  • the acellular matrix material may be seeded with endothelial cells before or after the
  • acellular matrix is placed inside the stent by placing it in a high density culture medium.
  • the seeding may be done in situ.
  • Methods of endothelial seeding are known
  • the endothelial cells may be seeded in a monolayer or layers on the acellular
  • Stent 12 may have an internal protective sheath or sleeve 18.
  • Sheath 18 has a
  • Slot 20 allows access for distal end 22 and proximal end
  • the distal end 22 is wound down to compact the stent 12. The distal end 22 is then looped
  • Release wire 30 extends internally within the catheter
  • the protective sheath 18 is withdrawn, the distal end 32 of acellular matrix 16 is rolled
  • proximal end 34 is rolled
  • the distal end 32 is rolled back to cover only a portion of the
  • proximal end 34 is rolled back a portion
  • the distal end 32 and the proximal end 34 are attached to the inner tubular body of the acellular matrix 16 by suturing, surgical stapling, gluing, taping, or any other method for attaching biomaterial to itself.
  • the stent 12 and acellular matrix 16 can now be deployed using techniques and methods well known in the art.
  • the stent 12 and acellular matrix 16 of the present invention could be mounted on such cylinder and later transferred to a stent for
  • a continuous suture line may be used around the circumferential seam for joining the ends 32 and 34 together.
  • the stent 12 is fully covered, both internally and externally and may be
  • distal end 22 and proximal end 24 of stent 12 extend through the
  • the stent 12 and acellular matrix 16 are also useful in grafting.
  • acellular matrix 16 may be implanted on ends of a blood vessel which are to be joined.
  • the stent 12 will provide improved structural support for the vessel over conventional prior art grafts. This improved support will reduce the risk of aneurysms. Additionally, the stent 12 and acellular matrix 16 can be made of a larger diameter
  • the stent 12 to operate as a graft for larger ducts within the human body.
  • the stent 12 is configured to operate as a graft for larger ducts within the human body.
  • the stent 12 is configured to operate as a graft for larger ducts within the human body.
  • the stent 12 is configured to operate as a graft for larger ducts within the human body.
  • acellular matrix 16 of the present invention has applications as a prothesis for the trachea, oesophagus, alimentary canal, genitourinary or other similar bodily ducts.
  • acellular matrix 16 is attached to the stent 12 when stent 12 is in the expanded state.
  • Stent 12 is then collapsed and mounted on the catheter 14.
  • Guide wire 36 is inserted
  • the acellular matrix 16 may be attached to stent 12 by suturing, surgical stapling, taping, gluing or by any other suitable method for attaching the biomaterial which would
  • acellular matrix 16 may be seeded with mammalian endothelial
  • stent cells preferably human endothelial cells. before or after it is mounted on the catheter 14 or in situ once the stent 12 is delivered to the target site.
  • the stent 12 and acellular matrix 16 can now be deployed to the target site by

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Prostheses (AREA)

Abstract

On décrit une attelle présentant un revêtement tubulaire intérieur, réalisé à l'aide d'un biomatériau et qui présente des extrémités ouvertes que l'on peut rouler autour des extrémités de l'attelle. On attache ensuite les extrémités du tube sur le tube lui-même. Dans un autre mode de réalisation, on fixe directement le revêtement intérieur sur l'attelle. Un procédé de recouvrement d'une attelle consiste à monter un tube d'un biomatériau sur une extrémité distale d'un cathéter, puis à monter l'attelle sur le biomatériau, lequel peut être ensemencé à l'aide de cellules endothéliales.
PCT/CA1996/000663 1995-10-03 1996-10-03 Procede de recouvrement d'une attelle a l'aide d'une matrice acellulaire WO1997012563A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US470095P 1995-10-03 1995-10-03
US60/004,700 1995-10-03

Publications (1)

Publication Number Publication Date
WO1997012563A1 true WO1997012563A1 (fr) 1997-04-10

Family

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Country Status (2)

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CA (1) CA2181522A1 (fr)
WO (1) WO1997012563A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015105A1 (fr) * 1997-09-23 1999-04-01 Carlos Vonderwalde Freidberg Gaine non thrombogene pour stent
WO1999015104A1 (fr) * 1997-09-23 1999-04-01 Carlos Vonderwalde Freidberg Gaine de prothese endovasculaire non thrombogene
WO2000033768A1 (fr) * 1998-12-04 2000-06-15 Bio-Vascular, Inc. Enveloppe de stent
US6468300B1 (en) 1997-09-23 2002-10-22 Diseno Y Desarrollo Medico, S.A. De C.V. Stent covered heterologous tissue
US6602285B1 (en) 1998-09-05 2003-08-05 Jomed Gmbh Compact stent
US6682554B2 (en) 1998-09-05 2004-01-27 Jomed Gmbh Methods and apparatus for a stent having an expandable web structure
US6733525B2 (en) 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
US6755856B2 (en) 1998-09-05 2004-06-29 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for stenting comprising enhanced embolic protection, coupled with improved protection against restenosis and thrombus formation
EP1440673A1 (fr) * 2003-01-24 2004-07-28 Medtronic Vascular, Inc. Système de pose d'un drain tuteur-grefon
EP1608299A2 (fr) * 2003-03-26 2005-12-28 Cardiomind, Inc. Technologies de distribution d'implants
US7374571B2 (en) 2001-03-23 2008-05-20 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of manufacture
US7556646B2 (en) 2001-09-13 2009-07-07 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
EP2298241A3 (fr) * 1996-12-03 2011-11-02 Atrium Medical Corporation Prothèse à plusieurs étages
US8900285B2 (en) 2005-11-02 2014-12-02 Biosensors International Group, Ltd. Covering electrolytic restraint implant delivery systems
US8920488B2 (en) 2007-12-20 2014-12-30 Abbott Laboratories Vascular Enterprises Limited Endoprosthesis having a stable architecture
US9320627B2 (en) 2007-05-23 2016-04-26 Abbott Laboratories Vascular Enterprises Limited Flexible stent with torque-absorbing connectors

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EP0119688A2 (fr) * 1983-01-25 1984-09-26 Alexander Balko Appareil pour la remise en état des vaisseaux corporels
EP0282175A1 (fr) * 1987-03-13 1988-09-14 Cook Incorporated Dilatateur endovasculaire et sa méthode de fabrication
US5336615A (en) * 1992-01-06 1994-08-09 Yale University Genetically engineered endothelial cells exhibiting enhanced migration and plasminogen activator activity
WO1995021592A1 (fr) * 1994-02-09 1995-08-17 Boston Scientific Technology Inc. Prothese endoluminale a deux branches
WO1996010375A1 (fr) * 1994-10-04 1996-04-11 Cardiovascular Concepts, Inc. Ensemble pour le traitement de vaisseaux sanguins, et procede associe
WO1996022745A1 (fr) * 1995-01-23 1996-08-01 Schneider (Usa) Inc. Greffe-prothese endovasculaire percutanee et leur procede de mise en place
WO1996027347A1 (fr) * 1995-03-08 1996-09-12 Board Of Governers Of Wayne State University Greffe intraluminale composite

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0119688A2 (fr) * 1983-01-25 1984-09-26 Alexander Balko Appareil pour la remise en état des vaisseaux corporels
EP0282175A1 (fr) * 1987-03-13 1988-09-14 Cook Incorporated Dilatateur endovasculaire et sa méthode de fabrication
US5336615A (en) * 1992-01-06 1994-08-09 Yale University Genetically engineered endothelial cells exhibiting enhanced migration and plasminogen activator activity
WO1995021592A1 (fr) * 1994-02-09 1995-08-17 Boston Scientific Technology Inc. Prothese endoluminale a deux branches
WO1996010375A1 (fr) * 1994-10-04 1996-04-11 Cardiovascular Concepts, Inc. Ensemble pour le traitement de vaisseaux sanguins, et procede associe
WO1996022745A1 (fr) * 1995-01-23 1996-08-01 Schneider (Usa) Inc. Greffe-prothese endovasculaire percutanee et leur procede de mise en place
WO1996027347A1 (fr) * 1995-03-08 1996-09-12 Board Of Governers Of Wayne State University Greffe intraluminale composite

Cited By (29)

* Cited by examiner, † Cited by third party
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