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WO1997011683A3 - Stabilised phospholipid compositions - Google Patents

Stabilised phospholipid compositions Download PDF

Info

Publication number
WO1997011683A3
WO1997011683A3 PCT/GB1996/002364 GB9602364W WO9711683A3 WO 1997011683 A3 WO1997011683 A3 WO 1997011683A3 GB 9602364 W GB9602364 W GB 9602364W WO 9711683 A3 WO9711683 A3 WO 9711683A3
Authority
WO
WIPO (PCT)
Prior art keywords
stabilised
phospholipid compositions
phospholipid
compositions
ammonia
Prior art date
Application number
PCT/GB1996/002364
Other languages
French (fr)
Other versions
WO1997011683A2 (en
Inventor
Kari Dyvik
Harald Dugstad
Roald Skurtveit
Jo Klaveness
Jonny Oestensen
Kiyoto Yachi
Original Assignee
Nycomed Imaging As
Daiichi Seiyaku Co
Cockbain Julian
Kari Dyvik
Harald Dugstad
Roald Skurtveit
Jo Klaveness
Jonny Oestensen
Kiyoto Yachi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As, Daiichi Seiyaku Co, Cockbain Julian, Kari Dyvik, Harald Dugstad, Roald Skurtveit, Jo Klaveness, Jonny Oestensen, Kiyoto Yachi filed Critical Nycomed Imaging As
Priority to EP96931893A priority Critical patent/EP0857070A2/en
Priority to JP09513213A priority patent/JP2000515487A/en
Publication of WO1997011683A2 publication Critical patent/WO1997011683A2/en
Publication of WO1997011683A3 publication Critical patent/WO1997011683A3/en
Priority to NO981340A priority patent/NO981340D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Colloid Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

The stability of phospholipid compositions is enhanced by the inclusion of a buffer system comprising ammonia or a water soluble amine having a pH at 15 °C of less than or equal to 9.5.
PCT/GB1996/002364 1995-09-27 1996-09-25 Stabilised phospholipid compositions WO1997011683A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP96931893A EP0857070A2 (en) 1995-09-27 1996-09-25 Stabilised phospholipid compositions
JP09513213A JP2000515487A (en) 1995-09-27 1996-09-25 Stabilized phospholipid composition
NO981340A NO981340D0 (en) 1995-09-27 1998-03-24 Stabilized phospholipid compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9519654.9 1995-09-27
GBGB9519654.9A GB9519654D0 (en) 1995-09-27 1995-09-27 Stabilised phospholipid compositions

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09043575 A-371-Of-International 1998-07-13
US09/982,196 Continuation US20020039556A1 (en) 1995-09-27 2001-10-19 Stabilised phospholipid compositions

Publications (2)

Publication Number Publication Date
WO1997011683A2 WO1997011683A2 (en) 1997-04-03
WO1997011683A3 true WO1997011683A3 (en) 1997-06-26

Family

ID=10781317

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/002364 WO1997011683A2 (en) 1995-09-27 1996-09-25 Stabilised phospholipid compositions

Country Status (7)

Country Link
EP (1) EP0857070A2 (en)
JP (1) JP2000515487A (en)
CN (1) CN1202830A (en)
CA (1) CA2233135A1 (en)
GB (1) GB9519654D0 (en)
NO (1) NO981340D0 (en)
WO (1) WO1997011683A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4752987B2 (en) * 2000-10-12 2011-08-17 ライオン株式会社 External preparation composition
WO2007129311A2 (en) * 2006-05-04 2007-11-15 Pan Sci Tech S.A. Nano-particles with contrast agents for diagnostic delivery system for x-ray and ct
BRPI0821158A2 (en) * 2007-12-20 2015-06-16 Novartis Ag Method for Making Contact Lenses
JP5299449B2 (en) * 2011-02-23 2013-09-25 ライオン株式会社 External preparation composition
CN104561156B (en) * 2013-10-28 2020-07-07 丰益(上海)生物技术研发中心有限公司 Process for preparing saturated phospholipids
GB201821049D0 (en) * 2018-12-21 2019-02-06 Ge Healthcare As Ultrasound contrast agent and methods for use therof
WO2024199424A1 (en) * 2023-03-30 2024-10-03 上海济煜医药科技有限公司 Phospholipid composition, preparation method therefor and use of nitrogen-containing compound

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0260811A2 (en) * 1986-08-21 1988-03-23 Vestar, Inc. Phospholipid particles encapsulating polyene antibiotics for the treatment of systemic fungal infections
US4962022A (en) * 1986-09-22 1990-10-09 Becton Dickinson And Company Storage and use of liposomes
WO1990014074A1 (en) * 1989-05-22 1990-11-29 Vical, Inc. Improved liposomal formulations of nucleotides and nucleotide analogues
WO1995026205A1 (en) * 1994-03-28 1995-10-05 Nycomed Imaging A/S Liposomes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0260811A2 (en) * 1986-08-21 1988-03-23 Vestar, Inc. Phospholipid particles encapsulating polyene antibiotics for the treatment of systemic fungal infections
US4962022A (en) * 1986-09-22 1990-10-09 Becton Dickinson And Company Storage and use of liposomes
WO1990014074A1 (en) * 1989-05-22 1990-11-29 Vical, Inc. Improved liposomal formulations of nucleotides and nucleotide analogues
WO1995026205A1 (en) * 1994-03-28 1995-10-05 Nycomed Imaging A/S Liposomes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M. GRIT ET LA: "Hydrolysis of Partially saturated Egg Phosphatidylcholine in Aqueous Liposome Dispersions and the Effect of Cholesterol Incorporation on Hydrolysis Kinetics", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 45, no. 6, June 1993 (1993-06-01), pages 490 - 495, XP000196747 *

Also Published As

Publication number Publication date
WO1997011683A2 (en) 1997-04-03
NO981340L (en) 1998-03-24
NO981340D0 (en) 1998-03-24
CA2233135A1 (en) 1997-04-03
JP2000515487A (en) 2000-11-21
CN1202830A (en) 1998-12-23
EP0857070A2 (en) 1998-08-12
GB9519654D0 (en) 1995-11-29

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