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WO1997009976A3 - Procede d'attenuation de troubles dus a des neurotoxines par des chelatants du zinc - Google Patents

Procede d'attenuation de troubles dus a des neurotoxines par des chelatants du zinc Download PDF

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Publication number
WO1997009976A3
WO1997009976A3 PCT/IB1996/000981 IB9600981W WO9709976A3 WO 1997009976 A3 WO1997009976 A3 WO 1997009976A3 IB 9600981 W IB9600981 W IB 9600981W WO 9709976 A3 WO9709976 A3 WO 9709976A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurotoxic injury
zinc chelators
reducing neurotoxic
reducing
injury
Prior art date
Application number
PCT/IB1996/000981
Other languages
English (en)
Other versions
WO1997009976A2 (fr
Inventor
Dennis Wonkyu Choi
Jae-Young Koh
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Priority to AU68879/96A priority Critical patent/AU6887996A/en
Publication of WO1997009976A2 publication Critical patent/WO1997009976A2/fr
Publication of WO1997009976A3 publication Critical patent/WO1997009976A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur des composés chélatants du zinc pharmaceutiquement acceptables, utilisés dans la fabrication de médicaments destinés au traitement de troubles dus à des neurotoxines.
PCT/IB1996/000981 1995-09-01 1996-08-23 Procede d'attenuation de troubles dus a des neurotoxines par des chelatants du zinc WO1997009976A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU68879/96A AU6887996A (en) 1995-09-01 1996-08-23 Method of reducing neurotoxic injury with zinc chelators

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US313495P 1995-09-01 1995-09-01
US60/003,134 1995-09-01
US735695P 1995-11-20 1995-11-20
US60/007,356 1995-11-20

Publications (2)

Publication Number Publication Date
WO1997009976A2 WO1997009976A2 (fr) 1997-03-20
WO1997009976A3 true WO1997009976A3 (fr) 1997-05-22

Family

ID=26671370

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1996/000981 WO1997009976A2 (fr) 1995-09-01 1996-08-23 Procede d'attenuation de troubles dus a des neurotoxines par des chelatants du zinc

Country Status (2)

Country Link
AU (1) AU6887996A (fr)
WO (1) WO1997009976A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7244764B2 (en) 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US8835654B2 (en) 2004-12-22 2014-09-16 Bhi Limited Partnership Method and compositions for treating amyloid-related diseases

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834457A (en) * 1996-01-26 1998-11-10 The Regents Of The University Of California Method of modulating radical formation by mutant cuznsod enzymes
US7045531B1 (en) 1997-03-11 2006-05-16 The General Hospital Corporation Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator
US6323218B1 (en) * 1998-03-11 2001-11-27 The General Hospital Corporation Agents for use in the treatment of Alzheimer's disease
US6638711B1 (en) 1999-04-29 2003-10-28 The General Hospital Corporation Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation
US6562836B1 (en) 1999-05-24 2003-05-13 Queen's University Of Kingston Methods and compounds for inhibiting amyloid deposits
US6407090B1 (en) 1999-06-23 2002-06-18 Zinc Therapeutics Canada, Inc. Zinc ionophores as anti-apoptotic agents
ES2686625T3 (es) * 2001-12-06 2018-10-18 Fibrogen, Inc. Métodos para el tratamiento o prevención de la anemia
AU2002950217A0 (en) * 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
IL151921A0 (en) 2002-09-25 2003-04-10 Pharma Ltd D Liphopilic diesters of chelating agent for inhibition of enzyme activity
CA2520259A1 (fr) 2003-04-11 2004-10-28 Anormed Inc. Composes de liaison aux recepteurs de chimiokine cxcr4
DK3851447T3 (da) 2006-10-12 2023-12-04 Bellus Health Inc Fremgangsmåder, forbindelser, sammensætninger og vehikler til administration af 3-amino-1-propansulfonsyre
WO2014152207A1 (fr) 2013-03-15 2014-09-25 Mylan Laboratories, Inc. Formulations de granulation par fusion de principes actifs faiblement hydrosolubles
WO2016164685A1 (fr) * 2015-04-10 2016-10-13 Ohio University Compositions et méthodes destinées à des tissus traumatisés, comprenant des chélateurs du zinc
WO2016179217A1 (fr) * 2015-05-06 2016-11-10 Ohio University Chélation d'ions métalliques pour améliorer l'effet d'un activateur tissulaire du plasminogène (tpa) dans le cadre de la thrombolyse
WO2017106328A1 (fr) 2015-12-14 2017-06-22 X4 Pharmaceuticals, Inc. Méthodes de traitement du cancer
US11357742B2 (en) 2015-12-14 2022-06-14 X4 Pharmaceuticals, Inc. Methods for treating cancer
SI3393468T1 (sl) 2015-12-22 2023-01-31 X4 Pharmaceuticals, Inc. Postopki za zdravljenje bolezni imunske pomanjkljivosti
CN109153722A (zh) 2016-04-08 2019-01-04 X4 制药有限公司 用于治疗癌症的方法
US10988465B2 (en) 2016-06-21 2021-04-27 X4 Pharmaceuticals, Inc. CXCR4 inhibitors and uses thereof
JP6994767B2 (ja) 2016-06-21 2022-01-14 エックス４ ファーマシューティカルズ， インコーポレイテッド Ｃｘｃｒ４阻害剤およびその使用
CA3027498A1 (fr) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Inhibiteurs de cxcr4 et leurs utilisations
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3932338A1 (de) * 1989-09-28 1991-04-11 Nmi Naturwissenschaftl U Mediz Verfahren zur praeventiven therapie von morbus alzheimer
US5206264A (en) * 1991-11-04 1993-04-27 Cypros Pharmaceutical Corporation Use of disulfiram to prevent cardiovascular damage
WO1993010459A1 (fr) * 1991-11-12 1993-05-27 The University Of Melbourne Procede de diagnostic et de traitement de la maladie d'alzheimer
EP0656362A1 (fr) * 1993-12-03 1995-06-07 Lilly Industries Limited Composés chimiques
WO1996006639A2 (fr) * 1994-09-01 1996-03-07 Medico Pharma Vertriebs Gmbh Nouveaux medicaments contenant des agents formant des chelates

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3932338A1 (de) * 1989-09-28 1991-04-11 Nmi Naturwissenschaftl U Mediz Verfahren zur praeventiven therapie von morbus alzheimer
US5206264A (en) * 1991-11-04 1993-04-27 Cypros Pharmaceutical Corporation Use of disulfiram to prevent cardiovascular damage
US5373021A (en) * 1991-11-04 1994-12-13 Cypros Pharmaceutical Corporation Use of disulfiram for Neuronal Protection
WO1993010459A1 (fr) * 1991-11-12 1993-05-27 The University Of Melbourne Procede de diagnostic et de traitement de la maladie d'alzheimer
EP0656362A1 (fr) * 1993-12-03 1995-06-07 Lilly Industries Limited Composés chimiques
WO1996006639A2 (fr) * 1994-09-01 1996-03-07 Medico Pharma Vertriebs Gmbh Nouveaux medicaments contenant des agents formant des chelates

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ARISPE ET AL: "zn2+ interaction with alzheimer amyloid beta protein calcium channels", P.N.A.S, vol. 93, no. 4, February 1996 (1996-02-01), pages 1710 - 1715, XP002028934 *
CUAJUNGCO ET AL: "prevention of zinc neurotoxicity in vivo by tpen", NEUROREPORT, vol. 7, no. 7, 17 May 1996 (1996-05-17), pages 1301 - 1304, XP000670010 *
DATABASE DISSERTATION ABSTRACTS umi; 1995, LEE P.J.: "modulation of central cholinergic excitotoxicity by zinc chelating agents", XP002028935 *
KOH ET AL: "the role of zinc in selective neuronal death after transient global cerebral ischemia", SCIENCE, vol. 272, no. 5264, 17 May 1996 (1996-05-17), pages 1013 - 1016, XP002028933 *
KOH ET AL: "zinc toxicity on cultured cortical neurons", NEUROSCIENCE, vol. 60, no. 4, 1994, pages 1049 - 1057, XP000670025 *
LEE P.J.: "idem", MASTERS ABSTRACTS, vol. 34, no. 04, 1995, pages 1564 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7244764B2 (en) 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7598269B2 (en) 2003-06-23 2009-10-06 Bellus Health (International) Limited Methods and compositions for treating amyloid-related diseases
US8835654B2 (en) 2004-12-22 2014-09-16 Bhi Limited Partnership Method and compositions for treating amyloid-related diseases

Also Published As

Publication number Publication date
WO1997009976A2 (fr) 1997-03-20
AU6887996A (en) 1997-04-01

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