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WO1997006824A3 - Bioconjugues de complexes de manganese et leur application comme catalyseurs - Google Patents

Bioconjugues de complexes de manganese et leur application comme catalyseurs Download PDF

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Publication number
WO1997006824A3
WO1997006824A3 PCT/US1996/012767 US9612767W WO9706824A3 WO 1997006824 A3 WO1997006824 A3 WO 1997006824A3 US 9612767 W US9612767 W US 9612767W WO 9706824 A3 WO9706824 A3 WO 9706824A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioconjugates
catalysts
application
manganese complexes
injury
Prior art date
Application number
PCT/US1996/012767
Other languages
English (en)
Other versions
WO1997006824A2 (fr
Inventor
William L Neumann
Dennis P Riley
Randy H Weiss
Susan L Henke
Patrick J Lennon
Karl W Aston
Original Assignee
Monsanto Co
William L Neumann
Dennis P Riley
Randy H Weiss
Susan L Henke
Patrick J Lennon
Karl W Aston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co, William L Neumann, Dennis P Riley, Randy H Weiss, Susan L Henke, Patrick J Lennon, Karl W Aston filed Critical Monsanto Co
Priority to PL96324993A priority Critical patent/PL324993A1/xx
Priority to BR9610347A priority patent/BR9610347A/pt
Priority to AU67655/96A priority patent/AU700958B2/en
Priority to EP96928057A priority patent/EP0844886A2/fr
Priority to JP09509336A priority patent/JP2000513322A/ja
Priority to IL12304096A priority patent/IL123040A0/xx
Publication of WO1997006824A2 publication Critical patent/WO1997006824A2/fr
Priority to CZ982711A priority patent/CZ271198A3/cs
Priority to IL12588997A priority patent/IL125889A0/xx
Priority to EP97907685A priority patent/EP0891338A1/fr
Priority to CA002249011A priority patent/CA2249011A1/fr
Priority to AU19624/97A priority patent/AU1962497A/en
Priority to PCT/US1997/002566 priority patent/WO1997033877A1/fr
Priority to BR9708179A priority patent/BR9708179A/pt
Priority to JP9532611A priority patent/JP2000508625A/ja
Priority to CN97194351A priority patent/CN1225631A/zh
Publication of WO1997006824A3 publication Critical patent/WO1997006824A3/fr
Priority to NO980649A priority patent/NO980649L/no
Priority to MXPA/A/1998/001322A priority patent/MXPA98001322A/xx
Priority to NO984164A priority patent/NO984164L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Bioconjugués d'imitateurs de mimétiques à faible poids moléculaire de superoxyde-dismutase (S.O.D.) représentés par la formule (I) dans laquelle R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, X, Y, Z et n sont tels que définis dans la description. Ces substances s'avèrent bénéfiques comme agents thérapeutiques dans le traitement de pathologies inflammatoires et des troubles tels que les lésions ischémiques/de perfusion répétée, les accidents cérébrovasculaires, l'athérosclérose, et dans toutes les autres formes de destructions ou de lésions tissulaires induites par oxydation.
PCT/US1996/012767 1995-08-17 1996-08-14 Bioconjugues de complexes de manganese et leur application comme catalyseurs WO1997006824A2 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
PL96324993A PL324993A1 (en) 1995-08-17 1996-08-14 Bioconjugates of macrocyclic, nitrogen containing manganese complex ligands efficiently acting as catalysts of the superoxidic dismutation reaction
BR9610347A BR9610347A (pt) 1995-08-17 1996-08-14 Bioconjugados de complexos de manganés de ligantes macrocíclicos contendo nitrogénio efetivos como catalisadores para a dismutação de superóxido
AU67655/96A AU700958B2 (en) 1995-08-17 1996-08-14 Bioconjugates of manganese complexes and their application as catalysts
EP96928057A EP0844886A2 (fr) 1995-08-17 1996-08-14 Bioconjugues de complexes de manganese et leur application comme catalyseurs
JP09509336A JP2000513322A (ja) 1995-08-17 1996-08-14 スーパーオキシドをジスムテートする触媒として有効な窒素含有大環状リガンドのマンガン錯体の生体分子結合体
IL12304096A IL123040A0 (en) 1995-08-17 1996-08-14 Manganese complexes pharmaceutical compositions containg them and their use
CN97194351A CN1225631A (zh) 1996-03-13 1997-03-04 有歧化过氧化物催化剂效果的含氮大环配位体锰或铁配合物的生物缀合物
EP97907685A EP0891338A1 (fr) 1996-03-13 1997-03-04 Bioconjugues de complexes de manganese ou de fer de ligands macrocycliques contenant de l'azote, efficaces comme catalyseurs pour la dismutation du superoxyde
IL12588997A IL125889A0 (en) 1996-03-13 1997-03-04 Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
CZ982711A CZ271198A3 (cs) 1996-03-13 1997-03-04 Biokonjugáty manganu nebo komplexy železa makrocyklických ligandů obsahujících dusík, působící jako katalyzátory pro dismutaci superoxidu
CA002249011A CA2249011A1 (fr) 1996-03-13 1997-03-04 Bioconjugues de complexes de manganese ou de fer de ligands macrocycliques contenant de l'azote, efficaces comme catalyseurs pour la dismutation du superoxyde
AU19624/97A AU1962497A (en) 1996-03-13 1997-03-04 Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
PCT/US1997/002566 WO1997033877A1 (fr) 1996-03-13 1997-03-04 Bioconjugues de complexes de manganese ou de fer de ligands macrocycliques contenant de l'azote, efficaces comme catalyseurs pour la dismutation du superoxyde
BR9708179A BR9708179A (pt) 1996-03-13 1997-03-04 Bioconjugados de complexos de manganês ou ferro de ligantes macrociclicos contendo nitrogênio eficazes como catalizadores para desmutar superoxidos
JP9532611A JP2000508625A (ja) 1996-03-13 1997-03-04 スーパーオキシドをジスムテートする触媒として有効な窒素含有大環状リガンドのマンガンまたは鉄錯体の生体分子結合体
NO980649A NO980649L (no) 1995-08-17 1998-02-16 Biokonjugater av mangankoplekser og anvendelse derav som katalysatorer
MXPA/A/1998/001322A MXPA98001322A (en) 1995-08-17 1998-02-17 Bioconjugados de complejos de manganeso de ligandos macrociclicos containing nitrogen, effective as catalysts to dismute superox
NO984164A NO984164L (no) 1996-03-13 1998-09-10 Biokonjugater av mangan eller jernkomplekser bestÕende av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismutering av superoksid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US242195P 1995-08-17 1995-08-17
US60/002,421 1995-08-17

Publications (2)

Publication Number Publication Date
WO1997006824A2 WO1997006824A2 (fr) 1997-02-27
WO1997006824A3 true WO1997006824A3 (fr) 1997-07-03

Family

ID=21700675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/012767 WO1997006824A2 (fr) 1995-08-17 1996-08-14 Bioconjugues de complexes de manganese et leur application comme catalyseurs

Country Status (12)

Country Link
EP (1) EP0844886A2 (fr)
JP (1) JP2000513322A (fr)
KR (1) KR19990037647A (fr)
CN (1) CN1200039A (fr)
AU (1) AU700958B2 (fr)
BR (1) BR9610347A (fr)
CA (1) CA2229799A1 (fr)
CZ (1) CZ39898A3 (fr)
IL (1) IL123040A0 (fr)
NO (1) NO980649L (fr)
PL (1) PL324993A1 (fr)
WO (1) WO1997006824A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7470677B2 (en) 1993-10-15 2008-12-30 Aeolus Pharmaceuticals, Inc. Oxidant scavengers
US7485721B2 (en) 2002-06-07 2009-02-03 Duke University Substituted porphyrins
US8975082B2 (en) 2008-05-13 2015-03-10 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2198767T3 (es) 1997-11-03 2004-02-01 Duke University Porfirinas sustituidas.
MXPA01007451A (es) 1999-01-25 2004-03-10 Nat Jewish Med & Res Center Porfirinas sustituidas.
US6749832B2 (en) 1999-12-23 2004-06-15 Amersham Plc Labelled ascorbic acid derivatives
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
CA2449024A1 (fr) 2001-06-01 2002-12-12 National Jewish Medical And Research Center Capteurs oxydants destines au traitement du diabete ou a etre utilises dans une transplantation ou a induire une tolerance immunitaire
ES2464728T3 (es) 2008-05-23 2014-06-03 National Jewish Health Compuestos para su uso en el tratamiento de lesiones asociadas con la exposición a una especie química alquilante
JP6267638B2 (ja) * 2011-09-26 2018-01-24 ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーＧａｌｅｒａ Ｌａｂｓ， Ｌｌｃ 疾患の治療方法
CN110520107A (zh) * 2017-02-15 2019-11-29 加莱拉实验室有限责任公司 用于局部肠递送的五氮杂大环状环配合物
CN108752383B (zh) * 2018-05-02 2020-10-30 江苏理工学院 一种具有sod活性的吡唑羧酸酯锰配合物及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0281463A2 (fr) * 1987-03-06 1988-09-07 Sumitomo Pharmaceuticals Company, Limited Complexe de platine, son procédé de préparation et composition pharmaceutique comportant ce complexe
EP0524161A1 (fr) * 1991-07-19 1993-01-20 Monsanto Company Complexes de manganèse avec des ligands macrocycliques contenant de l'azote, effectifs comme catalyseurs pour la dismutation de superoxide
WO1994015925A1 (fr) * 1993-01-14 1994-07-21 Monsanto Company Complexes manganesiens de ligands macrocycliques contenant de l'azote et efficaces comme catalyseurs pour la dismutation du superoxyde
WO1995028968A1 (fr) * 1994-04-22 1995-11-02 Monsanto Company Analyse d'image de diagnostic utilisant des complexes metalliques
WO1996039396A1 (fr) * 1995-06-06 1996-12-12 Monsanto Company Complexes de manganese ou de fer de coordinats macrocycliques contenant de l'azote, efficaces comme catalyseurs pour la dismutation de superoxydes
WO1996040658A1 (fr) * 1995-06-07 1996-12-19 Monsanto Company Procede de preparation de polyazamacrocycles substitues

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0281463A2 (fr) * 1987-03-06 1988-09-07 Sumitomo Pharmaceuticals Company, Limited Complexe de platine, son procédé de préparation et composition pharmaceutique comportant ce complexe
EP0524161A1 (fr) * 1991-07-19 1993-01-20 Monsanto Company Complexes de manganèse avec des ligands macrocycliques contenant de l'azote, effectifs comme catalyseurs pour la dismutation de superoxide
WO1994015925A1 (fr) * 1993-01-14 1994-07-21 Monsanto Company Complexes manganesiens de ligands macrocycliques contenant de l'azote et efficaces comme catalyseurs pour la dismutation du superoxyde
WO1995028968A1 (fr) * 1994-04-22 1995-11-02 Monsanto Company Analyse d'image de diagnostic utilisant des complexes metalliques
WO1996039396A1 (fr) * 1995-06-06 1996-12-12 Monsanto Company Complexes de manganese ou de fer de coordinats macrocycliques contenant de l'azote, efficaces comme catalyseurs pour la dismutation de superoxydes
WO1996040658A1 (fr) * 1995-06-07 1996-12-19 Monsanto Company Procede de preparation de polyazamacrocycles substitues

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CANCER LETT., 1993, VOL. 70, NO. 1-2, PAGES 57-64 *
DATABASE CHEMABS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MAEDA, MITSUAKI ET AL: "Antitumor activity and tissue distribution of bis(bilato)-1,2- cyclohexanediammineplatinum(II) complexes in BDF1 mice with murine reticulum cell sarcoma (M5076)", XP002030621 *
HARDY M M ET AL: "Superoxide dismutase mimetics inhibit neutrophil-mediated human aortic endothelial cell injury in vitro", J. BIOL. CHEM., 1994, VOL. 269, NO. 28, PAGE(S) 18535-40, XP002030616 *
TSUCHIDA, EISHUN ET AL: "Amphiphilic porphinatoirons having steroid groups and their oxygen-adduct formation in an aqueous medium", BULL. CHEM. SOC. JPN., 1990, VOL. 63, NO. 8, PAGE(S) 2323-7, XP002030617 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7470677B2 (en) 1993-10-15 2008-12-30 Aeolus Pharmaceuticals, Inc. Oxidant scavengers
US7485721B2 (en) 2002-06-07 2009-02-03 Duke University Substituted porphyrins
US8975082B2 (en) 2008-05-13 2015-03-10 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9096652B2 (en) 2008-05-13 2015-08-04 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity

Also Published As

Publication number Publication date
AU700958B2 (en) 1999-01-14
NO980649L (no) 1998-04-02
BR9610347A (pt) 1999-06-01
EP0844886A2 (fr) 1998-06-03
JP2000513322A (ja) 2000-10-10
WO1997006824A2 (fr) 1997-02-27
PL324993A1 (en) 1998-07-06
NO980649D0 (no) 1998-02-16
CN1200039A (zh) 1998-11-25
IL123040A0 (en) 1998-09-24
CZ39898A3 (cs) 1998-07-15
CA2229799A1 (fr) 1997-02-27
KR19990037647A (ko) 1999-05-25
MX9801322A (es) 1998-05-31
AU6765596A (en) 1997-03-12

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