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WO1997000063A3 - Peptides d'urocortine - Google Patents

Peptides d'urocortine Download PDF

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Publication number
WO1997000063A3
WO1997000063A3 PCT/US1996/010240 US9610240W WO9700063A3 WO 1997000063 A3 WO1997000063 A3 WO 1997000063A3 US 9610240 W US9610240 W US 9610240W WO 9700063 A3 WO9700063 A3 WO 9700063A3
Authority
WO
WIPO (PCT)
Prior art keywords
ucn
leu
arg
ser
crf
Prior art date
Application number
PCT/US1996/010240
Other languages
English (en)
Other versions
WO1997000063A2 (fr
Inventor
Wylie W Vale Jr
Joan Vaughan
Cynthia J Donaldson
Kathy A Lewis
Paul Sawchenko
Jean E F Rivier
Marilyn H Perrin
Original Assignee
Salk Inst For Biological Studi
Wylie W Vale Jr
Joan Vaughan
Cynthia J Donaldson
Kathy A Lewis
Paul Sawchenko
Jean E F Rivier
Marilyn H Perrin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi, Wylie W Vale Jr, Joan Vaughan, Cynthia J Donaldson, Kathy A Lewis, Paul Sawchenko, Jean E F Rivier, Marilyn H Perrin filed Critical Salk Inst For Biological Studi
Priority to US08/981,189 priority Critical patent/US6214797B1/en
Priority to JP50331297A priority patent/JP2002504802A/ja
Priority to AU62777/96A priority patent/AU6277796A/en
Priority to EP96921584A priority patent/EP0845035A2/fr
Publication of WO1997000063A2 publication Critical patent/WO1997000063A2/fr
Publication of WO1997000063A3 publication Critical patent/WO1997000063A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)

Abstract

L'urocortine (Ucn) est un peptide de mammifère natif généralement lié à l'Urotensine I et au facteur libérateur de corticotropine (CRF). L'Ucn humain présente la formule suivante: Asp-Asn-Pro-Ser-Leu-Ser-Ile-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Aer-Ile-Ile-Phe-Asp-Ser-Val-NH2 (SEQ ID NO:15). L'Ucn dérivé de rat est identique à l'exception de deux substitutions, Asp2 pour Asn?2 et Pro4¿ pour Ser4. L'Ucn ou les analogues de ce dernier ou des sels pharmaceutiquement acceptables peuvent être administrés à l'homme ou à d'autres mammifères pour élever les taux d'ACTH, de β-endorphine, β-lipotropine, d'autres produits du gène de la pro-opiomélanocortine et de la corticostérone. Ils peuvent également permettre d'abaisser la tension artérielle sur un laps de temps prolongé, de stimuler l'humeur et d'améliorer la mémoire et la performance d'apprentissage. Ils peuvent également avoir une application diagnostique. Des fragments raccourcis peuvent être administrés pour libérer le CFR endogène et/ou l'Ucn, dans le cerveau et dans le système périphérique. Des agonistes et des antagonistes d'Ucn marqués peuvent être utilisés dans des dosages avec des récepteurs du CFR. Ils peuvent également avoir une utilisation diagnostique avec les anticorps d'Ucn.
PCT/US1996/010240 1995-06-13 1996-06-12 Peptides d'urocortine WO1997000063A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US08/981,189 US6214797B1 (en) 1995-06-13 1996-06-12 Urocortin peptides, nucleic acid encoding same methods for using same
JP50331297A JP2002504802A (ja) 1995-06-13 1996-06-12 ウロコルチンペプチド
AU62777/96A AU6277796A (en) 1995-06-13 1996-06-12 Urocortin peptides
EP96921584A EP0845035A2 (fr) 1995-06-13 1996-06-12 Peptides d'urocortine

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49031495A 1995-06-13 1995-06-13
US222395P 1995-08-11 1995-08-11
US60/002,223 1995-08-11
US08/490,314 1995-08-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US08/981,189 A-371-Of-International US6214797B1 (en) 1995-06-13 1996-06-12 Urocortin peptides, nucleic acid encoding same methods for using same
US09/818,009 Division US20030032587A1 (en) 1995-06-13 2001-03-26 Urocortin peptides

Publications (2)

Publication Number Publication Date
WO1997000063A2 WO1997000063A2 (fr) 1997-01-03
WO1997000063A3 true WO1997000063A3 (fr) 1997-01-23

Family

ID=26670100

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/010240 WO1997000063A2 (fr) 1995-06-13 1996-06-12 Peptides d'urocortine

Country Status (5)

Country Link
EP (1) EP0845035A2 (fr)
JP (1) JP2002504802A (fr)
AU (1) AU6277796A (fr)
CA (1) CA2223792A1 (fr)
WO (1) WO1997000063A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9807504D0 (en) * 1998-04-07 1998-06-10 Univ London Use of corticotropin releasing hormone and like polypeptides in therapy
WO2001072326A1 (fr) * 2000-03-31 2001-10-04 Smithkline Beecham Plc Utilisation d'agonistes des recepteurs de crf pour le traitement ou la prevention de maladies, notamment de maladies neurodegeneratives
PT1305334E (pt) 2000-08-04 2008-12-30 Res Dev Foundation Proteínas de urocortina e suas utilizações
US20020082409A1 (en) * 2000-10-26 2002-06-27 Hsu Sheau Yu Stresscopins and their uses
US6670140B2 (en) 2001-03-06 2003-12-30 The Procter & Gamble Company Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
IL154553A0 (en) 2001-03-15 2003-09-17 Res Dev Foundation Urocortin-iii and uses thereof
US7491702B2 (en) 2001-04-18 2009-02-17 The Open University Polypeptides related to amyloid precursor protein, pharmaceutical compositions thereof, and methods of treatment using the same
EP2228387A2 (fr) * 2001-04-18 2010-09-15 The Open University Polypeptides dérivés de l'APP (Protéine Précurseur Amyloide), et leurs utilisations
US7622446B2 (en) 2001-04-18 2009-11-24 The Open University Polypeptides, derivatives and uses thereof
US7192924B2 (en) 2002-01-16 2007-03-20 The Procter & Gamble Company Corticotropin releasing factor 2 receptor agonists
US7982018B2 (en) 2006-10-16 2011-07-19 Conjuchem, Llc Modified corticotropin releasing factor peptides and uses thereof
EP2197465A2 (fr) * 2007-09-11 2010-06-23 Mondobiotech Laboratories AG Utilisation de l'angiotensine ii comme agent therapeutique, p.e. pour le traitement des infections de s. pneumoniae
WO2009043521A2 (fr) * 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Utilisation d'un peptide en tant qu'agent thérapeutique
JOP20170153A1 (ar) * 2016-07-15 2019-01-30 Lilly Co Eli نظائر urocortin-2 جديدة معدلة بحمض دهني لعلاج داء السكري وأمراض الكلى المزمنة
AU2017345785A1 (en) * 2016-10-20 2019-05-16 Cortene Inc. Methods of treating diseases resulting from a maladapted stress response

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989012646A1 (fr) * 1988-06-21 1989-12-28 The Salk Institute For Biological Studies Analogues de crf
US4908352A (en) * 1987-09-28 1990-03-13 The Salk Institute For Biological Studies Urotensin peptides
WO1990003392A1 (fr) * 1988-09-23 1990-04-05 The Salk Institute For Biological Studies Antagonistes de crf
WO1992022576A1 (fr) * 1991-06-14 1992-12-23 The Salk Institute For Biological Studies Analogues de facteur de liberation de corticotropine (crf)
WO1995034651A2 (fr) * 1994-06-14 1995-12-21 Neurocrine Biosciences, Inc. Recepteurs du facteur2 liberant la corticotropine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908352A (en) * 1987-09-28 1990-03-13 The Salk Institute For Biological Studies Urotensin peptides
WO1989012646A1 (fr) * 1988-06-21 1989-12-28 The Salk Institute For Biological Studies Analogues de crf
WO1990003392A1 (fr) * 1988-09-23 1990-04-05 The Salk Institute For Biological Studies Antagonistes de crf
WO1992022576A1 (fr) * 1991-06-14 1992-12-23 The Salk Institute For Biological Studies Analogues de facteur de liberation de corticotropine (crf)
WO1995034651A2 (fr) * 1994-06-14 1995-12-21 Neurocrine Biosciences, Inc. Recepteurs du facteur2 liberant la corticotropine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
T.W. LOVENBERG ET AL.: "Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 92, January 1995 (1995-01-01), WASHINGTON US, pages 836 - 840, XP002019808 *
VAUGHAN, JOAN ET AL: "Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor", NATURE (LONDON) (1995), 378(6554), 287-92 CODEN: NATUAS;ISSN: 0028-0836, 16 November 1995 (1995-11-16), XP002019807 *

Also Published As

Publication number Publication date
AU6277796A (en) 1997-01-15
EP0845035A2 (fr) 1998-06-03
WO1997000063A2 (fr) 1997-01-03
JP2002504802A (ja) 2002-02-12
CA2223792A1 (fr) 1997-01-03

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