+

WO1997049385B1 - Procedes et compositions utilisant des excipients organiques pour renforcer les proprietes bioadhesives de polymeres - Google Patents

Procedes et compositions utilisant des excipients organiques pour renforcer les proprietes bioadhesives de polymeres

Info

Publication number
WO1997049385B1
WO1997049385B1 PCT/US1997/010256 US9710256W WO9749385B1 WO 1997049385 B1 WO1997049385 B1 WO 1997049385B1 US 9710256 W US9710256 W US 9710256W WO 9749385 B1 WO9749385 B1 WO 9749385B1
Authority
WO
WIPO (PCT)
Prior art keywords
microsphere
polymer
composition
anhydride
polymers
Prior art date
Application number
PCT/US1997/010256
Other languages
English (en)
Other versions
WO1997049385A1 (fr
Filing date
Publication date
Priority claimed from US08/670,326 external-priority patent/US5955096A/en
Application filed filed Critical
Priority to JP10503153A priority Critical patent/JP2000513355A/ja
Priority to AT97929973T priority patent/ATE230978T1/de
Priority to EP97929973A priority patent/EP0912166B1/fr
Priority to DE69718470T priority patent/DE69718470T2/de
Publication of WO1997049385A1 publication Critical patent/WO1997049385A1/fr
Publication of WO1997049385B1 publication Critical patent/WO1997049385B1/fr

Links

Abstract

La présente invention concerne des procédés et compositions permettant de renforcer les propriétés bioadhésives de polymères utilisés dans les systèmes d'administration de médicaments. En incorporant un oligomère d'anhydride dans le polymère on renforce ses propriétés bioadhésives ce qui fait que ce polymère adhère plus facilement à la surface d'un tissu tel qu'une membrane de muqueuse. Parmi les oligomères d'anhydrides qui renforcent les propriétés bioadhésives d'un polymère, on trouve des oligomères synthétisés à partir de monomères d'acide dicarboxylique, de préférence les monomères que l'on trouve dans le cycle de glycolyse de Krebs, et notamment l'acide fumarique. Ces oligomères peuvent s'incorporer dans une large gamme de polymères, y compris des protéines, des polyosides et des polymères biocompatibles synthétiques. Selon une réalisation, les oligomères d'anhydrides peuvent s'incorporer dans des polymères utilisés pour former ou enrober les systèmes d'administration de médicaments, tels que les microsphères, qui contiennent un médicament ou un agent de diagnostic. De tels polymères, par exemple ceux qui se trouvent sous forme de microsphères, sont plus aptes à adhérer aux membranes des muqueuses. Ils conviennent donc à l'administration d'un médicament ou d'un agent de diagnostic via diverses surfaces de membranes de muqueuses, et notamment celles des voies gastro-intestinales, respiratoires, excrétrices et génitales.
PCT/US1997/010256 1996-06-25 1997-06-12 Procedes et compositions utilisant des excipients organiques pour renforcer les proprietes bioadhesives de polymeres WO1997049385A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP10503153A JP2000513355A (ja) 1996-06-25 1997-06-12 有機賦型剤を使用する、ポリマーの生体接着特性を増強するための方法および組成物
AT97929973T ATE230978T1 (de) 1996-06-25 1997-06-12 Verfahren und zubereitungen zum verbessern der bioadhäsiv-eigenschaften von polymeren unter verwendung organischer excipienten
EP97929973A EP0912166B1 (fr) 1996-06-25 1997-06-12 Procedes et compositions utilisant des excipients organiques pour renforcer les proprietes bioadhesives de polymeres
DE69718470T DE69718470T2 (de) 1996-06-25 1997-06-12 Verfahren und zubereitungen zum verbessern der bioadhäsiv-eigenschaften von polymeren unter verwendung organischer excipienten

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US670,326 1996-06-25
US08/670,326 US5955096A (en) 1996-06-25 1996-06-25 Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients

Publications (2)

Publication Number Publication Date
WO1997049385A1 WO1997049385A1 (fr) 1997-12-31
WO1997049385B1 true WO1997049385B1 (fr) 1998-02-26

Family

ID=24689975

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/010256 WO1997049385A1 (fr) 1996-06-25 1997-06-12 Procedes et compositions utilisant des excipients organiques pour renforcer les proprietes bioadhesives de polymeres

Country Status (6)

Country Link
US (3) US5955096A (fr)
EP (1) EP0912166B1 (fr)
JP (1) JP2000513355A (fr)
AT (1) ATE230978T1 (fr)
DE (1) DE69718470T2 (fr)
WO (1) WO1997049385A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9108070B2 (en) 2006-09-13 2015-08-18 Polymerix Corporation Active agents and their oligomers and polymers

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US6368586B1 (en) 1996-01-26 2002-04-09 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US20030077317A1 (en) * 1996-06-25 2003-04-24 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
IT1284874B1 (it) * 1996-08-02 1998-05-22 Farmigea Spa Complessi bioadesivi di polycarbophil e farmaci antifungini o antiprotozoari azolici
US6284375B1 (en) * 1996-10-18 2001-09-04 Tuo Jin Lipid vesicle system
DE19646392A1 (de) * 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
GB9710699D0 (en) * 1997-05-24 1997-07-16 Danbiosyst Uk Gastro-retentive controlled release system
US20050074495A1 (en) * 1997-06-17 2005-04-07 Fziomed, Inc. Compositions of polyacids and methods for their use in reducing adhesions
US7192984B2 (en) * 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US20040096422A1 (en) * 1997-06-17 2004-05-20 Schwartz Herbert E. Compositions of polyacids and polyethers and methods for their use in reducing pain
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US7122615B1 (en) 1998-09-10 2006-10-17 Rutgers, The State University Of New Jersey Polyanhydrides with therapeutically useful degradation products
US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US7637948B2 (en) * 1997-10-10 2009-12-29 Senorx, Inc. Tissue marking implant
US7343710B2 (en) * 1998-07-03 2008-03-18 I.D.A Limited Method and apparatus for controlling pests
GB9814507D0 (en) * 1998-07-03 1998-09-02 Univ Southampton A method and apparatus for controlling pests
WO2000046147A2 (fr) * 1999-02-03 2000-08-10 Biosante Pharmaceuticals, Inc. Particules therapeutiques de phosphate de calcium et procedes de fabrication et d'utilisation associes
US20020054914A1 (en) * 1999-02-03 2002-05-09 Tulin Morcol Compositions and methods for therapuetic agents complexed with calcium phosphate and encased by casein
US20040258763A1 (en) * 1999-02-03 2004-12-23 Bell Steve J.D. Methods of manufacture and use of calcium phosphate particles containing allergens
WO2000059516A1 (fr) * 1999-04-02 2000-10-12 Fziomed, Inc. Compositions de polyacides et polyethers et procedes d'utilisation destines a la reduction d'adhesions
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
AU2001259177A1 (en) * 2000-04-28 2001-11-12 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
WO2002002189A2 (fr) * 2000-06-30 2002-01-10 Polydex Pharmaceuticals Limited Sulfate de cellulose et autres polysaccharides sulfates utilises dans la prevention ou le traitement de nombreuses infections, notamment l'infection par le virus du papillome
ES2306698T3 (es) * 2000-10-24 2008-11-16 L'oreal Dispositivo de pulverizacion que comprende por lo menos dos orificios de salida de gas vector.
US20060062855A1 (en) * 2001-02-27 2006-03-23 Bell Steve J D Therapeutic calcium phosphate particles for use in inhibiting expression of a gene
US20040126900A1 (en) * 2001-04-13 2004-07-01 Barry Stephen E High affinity peptide- containing nanoparticles
US8815793B2 (en) * 2001-07-20 2014-08-26 Northwestern University Polymeric compositions and related methods of use
US7618937B2 (en) * 2001-07-20 2009-11-17 Northwestern University Peptidomimetic polymers for antifouling surfaces
US7858679B2 (en) * 2001-07-20 2010-12-28 Northwestern University Polymeric compositions and related methods of use
WO2003011311A1 (fr) * 2001-07-27 2003-02-13 Merck Patent Gmbh Extraits de bauhinia
WO2003013683A1 (fr) * 2001-08-08 2003-02-20 Brown University Research Foundation Procedes de micronisation de medicaments hydrophobes
US20030124196A1 (en) * 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
US20030083286A1 (en) * 2001-08-22 2003-05-01 Ching-Leou Teng Bioadhesive compositions and methods for enhanced intestinal drug absorption
ATE457328T1 (de) * 2001-10-09 2010-02-15 Genzyme Corp Verfahren zur reinigung und trocknung von polymer-hydrogelen
US6600011B2 (en) * 2001-10-09 2003-07-29 Genzyme Corporation Process for purification and drying of polymer hydrogels
US8425892B2 (en) 2001-10-29 2013-04-23 Columbia Laboratories, Inc. Extended, controlled-release pharmaceutical compositions using charged polymers
US8563592B2 (en) 2001-11-01 2013-10-22 Spectrum Pharmaceuticals, Inc. Bladder cancer treatment and methods
ATE455545T1 (de) * 2001-11-01 2010-02-15 Spectrum Pharmaceuticals Inc Medizinische zusammensetzungen zur intravesikalen behandlung von blasenkrebs
WO2003049701A2 (fr) * 2001-12-10 2003-06-19 Spherics, Inc. Procedes et produits utiles dans la formation et l'isolation de microparticules
US20050064027A1 (en) * 2001-12-15 2005-03-24 Spherics, Inc. Bioadhesive drug delivery system with enhanced gastric retention
JP2005530695A (ja) * 2002-02-15 2005-10-13 ザイコス インク． 生理活性物質を細胞内に導入するエレクトロポレーション法
US8911831B2 (en) * 2002-07-19 2014-12-16 Northwestern University Surface independent, surface-modifying, multifunctional coatings and applications thereof
AU2003270802A1 (en) * 2002-09-20 2004-04-08 The Children's Hospital Of Philadelphia Engineering of material surfaces
AU2003277023B2 (en) * 2002-09-26 2009-02-26 Endovascular Devices, Inc. Apparatus and method for delivery of mitomycin through an eluting biocompatible implantable medical device
US20060018973A1 (en) * 2002-09-30 2006-01-26 In-San Kim Composition for stimulating bone-formation and bone consolidation
WO2004098570A1 (fr) * 2002-10-30 2004-11-18 Spherics, Inc. Agents bioactifs nanoparticulaires
AU2004296404A1 (en) * 2003-12-09 2005-06-23 Spherics, Inc. Bioadhesive polymers with catechol functionality
US20050181050A1 (en) * 2004-01-28 2005-08-18 Collegium Pharmaceutical, Inc. Dosage forms using drug-loaded ion exchange resins
EP1729741A2 (fr) * 2004-03-03 2006-12-13 Spherics, Inc. Systeme d'administration de medicaments polymeres pour des medicaments hydrophobes
US8980300B2 (en) * 2004-08-05 2015-03-17 Advanced Cardiovascular Systems, Inc. Plasticizers for coating compositions
CN1736484A (zh) * 2004-08-19 2006-02-22 张阳德 半乳糖化海藻酸钠－多聚赖氨酸纳米粒的制备方法
US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
US20080311191A1 (en) * 2004-08-27 2008-12-18 Avinash Nangia Multi-Layer Tablets and Bioadhesive Dosage Forms
AU2005285298A1 (en) * 2004-08-27 2006-03-23 Spherics, Inc. Multi-layer tablets and bioadhesive dosage forms
US20070281007A1 (en) * 2004-08-27 2007-12-06 Jacob Jules S Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs
US8110211B2 (en) * 2004-09-22 2012-02-07 Advanced Cardiovascular Systems, Inc. Medicated coatings for implantable medical devices including polyacrylates
WO2006050368A2 (fr) 2004-11-01 2006-05-11 Biosante Pharmaceuticals, Inc. Particules therapeutiques de phosphate de calcium destinees a la medecine esthetique ou cosmetique, et procedes de fabrication et d'utilisation
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
CA2596035A1 (fr) * 2005-01-28 2006-08-03 Collegium Pharmaceutical, Inc. Excipients non aqueux non ioniques pour administration topique et par voie orale d'agents actifs lies a un support
US8722071B2 (en) * 2005-02-28 2014-05-13 Council Of Scientific & Industrial Research Microcapsules containing biocide and preparation thereof by solvent evaporation technique
US9101436B2 (en) * 2005-10-21 2015-08-11 Ada Foundation Dental and endodontic filling materials and methods
SI1978925T1 (sl) * 2005-12-23 2010-01-29 Medidom Lab Termoreaktiven nevtraliziran sestavek hitozana, ki tvori hidrogel, liofilizat in postopek za izdelavo le-tega
US8252333B2 (en) * 2006-01-26 2012-08-28 Jorge Cueto-Garcia Biodegradable, non-toxic biological adhesive for use in abdominal surgery
US7732539B2 (en) * 2006-02-16 2010-06-08 National Science Foundation Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives
US8703167B2 (en) * 2006-06-05 2014-04-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug
US20080008736A1 (en) * 2006-07-06 2008-01-10 Thierry Glauser Random copolymers of methacrylates and acrylates
US8563117B2 (en) * 2006-08-04 2013-10-22 Phillip B. Messersmith Biomimetic modular adhesive complex: materials, methods and applications therefore
AU2007283772B2 (en) 2006-08-04 2013-03-07 Kensey Nash Corporation Biomimetic compounds and synthetic methods therefor
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
KR20090065519A (ko) 2006-08-30 2009-06-22 자고텍 아게 니솔디핀을 포함하는 방출 제어형 고형 경구 투여 제제
US9744137B2 (en) 2006-08-31 2017-08-29 Supernus Pharmaceuticals, Inc. Topiramate compositions and methods of enhancing its bioavailability
JP5489719B2 (ja) * 2006-11-17 2014-05-14 スパーナス ファーマシューティカルズ インコーポレイテッド トピラマートの徐放性配合物
WO2008089032A1 (fr) * 2007-01-11 2008-07-24 Northwestern University Revêtement résistant aux salissures et procédés de fabrication de ceux-ci
CN101668518B (zh) * 2007-02-14 2014-05-07 尼尔·A·所罗门 乳糖酶制剂
US8383092B2 (en) * 2007-02-16 2013-02-26 Knc Ner Acquisition Sub, Inc. Bioadhesive constructs
US8673286B2 (en) 2007-04-09 2014-03-18 Northwestern University DOPA-functionalized, branched, poly(aklylene oxide) adhesives
US20080300526A1 (en) * 2007-06-01 2008-12-04 Yulex Corporation Guayule rubber and resin wet-stick bioadhesives
JP2011503183A (ja) * 2007-11-13 2011-01-27 サーモディクス ファーマシューティカルズ， インコーポレイテッド 薬物送達のプラットホームとしての粘稠なターポリマー
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
US8951546B2 (en) 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US20100158978A1 (en) * 2008-12-23 2010-06-24 Peter Markland Bioactive spray coating compositions and methods of making and uses thereof
US8974808B2 (en) * 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US9415197B2 (en) 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
CN104434136A (zh) 2009-03-02 2015-03-25 第七感生物系统有限公司 用于抽出血液的装置
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
WO2010101625A2 (fr) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Capteur de mesure d'oxygène
US20110130465A1 (en) * 2009-12-01 2011-06-02 Nerites Corporation Coatings for prevention of biofilms
WO2011094573A1 (fr) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Systèmes et procédés de surveillance ou de rétroaction
EP2593014B1 (fr) 2010-07-16 2015-11-04 Seventh Sense Biosystems, Inc. Environnement basse pression pour dispositifs à transfert de fluide
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
WO2012021801A2 (fr) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systèmes et procédés adaptés pour surveiller des sujets
WO2012030821A1 (fr) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Mélanges de terpolymères et leur utilisation comme adhésifs sensibles à la pression
CN103370007B (zh) 2010-11-09 2018-12-18 第七感生物系统有限公司 用于采血的系统和界面
WO2012064821A2 (fr) 2010-11-09 2012-05-18 Knc Ner Acquisition Sub, Inc. Composés adhésifs et leurs procédés d'utilisation pour la réparation d'hernies
ES2643291T3 (es) 2010-12-22 2017-11-22 Purdue Pharma L.P. Formas de dosificación de liberación controlada con cierre inviolable recubiertas
AU2012249683A1 (en) 2011-04-29 2013-11-14 Seventh Sense Biosystems, Inc. Devices and methods for collection and/or manipulation of blood spots or other bodily fluids
CN103874460B (zh) 2011-04-29 2016-06-22 第七感生物系统有限公司 一种用于从受验者的皮肤接收血液或其它物质的装置
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
EP3106092A3 (fr) 2011-04-29 2017-03-08 Seventh Sense Biosystems, Inc. Systèmes et procédés pour recueillir un fluide provenant d'un sujet
US20140120162A1 (en) 2011-06-06 2014-05-01 Perosphere Inc. Bioadhesive Drug Delivery Compositions
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
WO2014194055A1 (fr) 2013-05-29 2014-12-04 Rutgers, The State University Of New Jersey Poly(anhydride-esters) à base d'antioxydants
WO2015191742A1 (fr) 2014-06-13 2015-12-17 Rutgers, The State University Of New Jersey Procédé et intermédiaires pouvant être utilisés pour la préparation de polyanhydride-polyesters
WO2016164898A1 (fr) 2015-04-10 2016-10-13 Rutgers, The State University Of New Jersey Polymères d'acide kojique
WO2017141262A1 (fr) 2016-02-19 2017-08-24 Indian Institute Of Technology, Bombay Préparation pharmaceutique à administration orale contenant une protéine
CN115845119B (zh) * 2022-12-15 2024-06-07 湖南中腾湘岳生物科技有限公司 一种改性淀粉微球止血材料及其制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128245C (fr) * 1951-05-31
US2675619A (en) * 1952-05-31 1954-04-20 Mcbee Co Drafting instrument
US3036118A (en) * 1957-09-11 1962-05-22 Wyandotte Chemicals Corp Mixtures of novel conjugated polyoxyethylene-polyoxypropylene compounds
US2979578A (en) * 1958-10-30 1961-04-11 Litton Systems Inc Omnipositional rotary switch
NL130291C (fr) * 1964-01-02
US3829506A (en) * 1971-06-01 1974-08-13 Basf Wyandotte Corp Biodegradable surface active agents having good foam properties and foam stabilizing characteristics
US4757128A (en) * 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US4861627A (en) * 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
US4933431A (en) * 1987-07-31 1990-06-12 Massachusetts Institute Of Technology One step preparation of poly(amide-anhydride)
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US4976968A (en) * 1989-02-24 1990-12-11 Clinical Technologies Associates, Inc. Anhydrous delivery systems for pharmacological agents
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
US4997904A (en) * 1989-08-25 1991-03-05 Nova Pharmaceutical Corporation Aromatic polyanhydride compositions
EP0431719B1 (fr) * 1989-10-31 1994-11-09 Columbia Laboratories, Inc. Composition pour hydrater le tissu vaginal
JPH04506931A (ja) * 1989-11-06 1992-12-03 アルカーメス　コントロールド　セラピューティクス，インコーポレイテッド タンパク質マイクロスフェアを生産する方法
JP2571874B2 (ja) * 1989-11-06 1997-01-16 アルカーメス コントロールド セラピューティクス，インコーポレイテッド タンパク質マイクロスフェア組成物
US5271961A (en) * 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5175235A (en) * 1990-06-04 1992-12-29 Nova Pharmaceutical Corporation Branched polyanhydrides
US5173298A (en) * 1990-09-27 1992-12-22 Allergan, Inc. Nonaqueous fluorinated drug delivery vehicle suspensions
US5518731A (en) * 1990-09-27 1996-05-21 Allergan, Inc. Nonaqueous fluorinated drug delivery vehicle suspensions
US5275820A (en) * 1990-12-27 1994-01-04 Allergan, Inc. Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin particles
US6197346B1 (en) * 1992-04-24 2001-03-06 Brown Universtiy Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
US5518730A (en) * 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
CA2187353C (fr) * 1994-04-08 2007-05-22 Gerald L. Yewey Compositions liquides a diffusion
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9108070B2 (en) 2006-09-13 2015-08-18 Polymerix Corporation Active agents and their oligomers and polymers

Similar Documents

Publication Publication Date Title
WO1997049385B1 (fr) Procedes et compositions utilisant des excipients organiques pour renforcer les proprietes bioadhesives de polymeres
EP0952171B1 (fr) Copolymères de polyesters, formateurs d'hydrogels, auto-solvatants et absorbables ainsi que leurs procédés d'utilisation
CA2485977A1 (fr) Polymere a chaine courte permettant de renforcer la bioadherence de polymeres sur une membrane muqueuse
US6890560B2 (en) Negatively charged amphiphilic block copolymer as drug carrier
EP0877603B1 (fr) Procedes et compositions permettant de renforcer les proprietes bioadhesives de polymeres
EP1257257B1 (fr) Procédé de fabrication de systèmes d'administration utilisant des compositions polymères biodegradables préformées
TWI302838B (en) Polymer coated microparticles for sustained release
US5955096A (en) Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US20030059469A1 (en) Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
JP5445130B2 (ja) 眼の外部または内部への眼科用薬剤の送達法
JP2005533022A5 (fr)
AU2002303027A1 (en) Negatively charged amphiphilic block copolymer as drug carrier and complex thereof with positively charged drug
JP2002512947A5 (fr)
JP2000512519A (ja) 医療用具をコーティングするための組成物及び方法
AU2296699A (en) Process for making absorbable microparticles
EP1406946B1 (fr) Copolymere bloc amphiphile positivement charge comme vecteur de medicament et complexe de celui-ci dote d'un medicament negativement charge
Ranade Drug delivery systems: 3A. Role of polymers in drug delivery
JPS62297325A (ja) デポ製剤用の生物学的分解性重合体およびその製法
CN1194704C (zh) 含有活性药物、主链中具有氨基酸的聚酯及其制备方法
CA2522179A1 (fr) Composition pharmaceutique contenant des proteines et/ou des polypeptides et des particules colloidales
US20060286138A1 (en) Novel biodegradable aliphatic polyesters and pharmaceutical compositions and applications thereof
US8246994B2 (en) Method for delivering an active agent using a hydrogel composition
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载