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WO1997044088A1 - Sonde ureterale - Google Patents

Sonde ureterale Download PDF

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Publication number
WO1997044088A1
WO1997044088A1 PCT/DE1997/000979 DE9700979W WO9744088A1 WO 1997044088 A1 WO1997044088 A1 WO 1997044088A1 DE 9700979 W DE9700979 W DE 9700979W WO 9744088 A1 WO9744088 A1 WO 9744088A1
Authority
WO
WIPO (PCT)
Prior art keywords
catheter
ureteral catheter
electrodes
ureteral
electrode
Prior art date
Application number
PCT/DE1997/000979
Other languages
German (de)
English (en)
Inventor
Uwe Friedrich
Ralph Erich Vetter
Manuela Muhr
Sándor LOVASZ
Original Assignee
WILLY RüSCH AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19701840A external-priority patent/DE19701840A1/de
Application filed by WILLY RüSCH AG filed Critical WILLY RüSCH AG
Publication of WO1997044088A1 publication Critical patent/WO1997044088A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/008—Implant devices for drainage of body fluids from one part of the body to another pre-shaped, for use in the urethral or ureteral tract
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1485—Probes or electrodes therefor having a short rigid shaft for accessing the inner body through natural openings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B2018/1246—Generators therefor characterised by the output polarity
    • A61B2018/126—Generators therefor characterised by the output polarity bipolar

Definitions

  • the invention is based on a ureteral catheter
  • kidney pelvis merging into a rollable shaft section with a plurality of passage openings which are connected to the lumen and
  • Such a ureteral catheter has become known from EP-A-208841.
  • Known ureteral catheters have two roll-in shaft ends that fix the catheter in position and prevent uncontrollable migration into the kidney pelvis or into the bladder.
  • the bladder-side end of such ureteral catheters can alternatively be provided with a valve mechanism, which likewise prevents uncontrolled migration of the ureteral catheter and, above all, vesico-ureteral reflux.
  • the ureteral catheters bridge the ureter and ensure a safe flow of urine from the renal pelvis into the bladder.
  • the known ureteral catheters cannot solve the problem requiring treatment alone.
  • terperistalsis for example in connection with the forced expulsion of stone fragments after shock wave lithotrypsia, can be used.
  • At the end of the ureteral catheter on the kidney side at least one electrode which can be coupled or is connected to a current source is designed such that it can at least emit electrical pulses to an adjacent tissue, or that the open end
  • a body-free end is that the passage openings are limited to the end of the kidney pelvis and that at the end of the catheter at the kidney pelvis at least one electrode which can be coupled or is connected to a current source is designed such that it can at least emit electrical pulses to an adjacent tissue .
  • the ureteral catheter according to the invention thus has the essential advantage that it can stimulate the pacemaker centers (pacemaker centers) located in the upper urinary tract in such a way that the ureter is stimulated to rhythmic contractions which are necessary for regulated urinary transport from the kidney pelvis to the bladder.
  • pacemaker centers pacemaker centers located in the upper urinary tract in such a way that the ureter is stimulated to rhythmic contractions which are necessary for regulated urinary transport from the kidney pelvis to the bladder.
  • the different pacemaker centers (middle cup group, cone of the kidney pelvis, upper, middle or lower ureter) can be stimulated with different frequencies and / or current strengths.
  • the middle calyx group is preferably stimulated.
  • the peristalsis of the ureter is restarted by topical irritation by means of electrical current pulses in the area of one of these pacemaker centers. If the ureteral catheter according to the invention is used, this leads to a general improvement in the urodynamics of the decompensated upper urinary tract, so that primarily an operative intervention can be avoided or, however, in previously operated children, e.g. B. in cutan ureterostomy in megaureters or in operations of a decompensated ureteral stenosis with hydronephrosis and spontaneous pacemaker loss and renal parenchymal damage to the urinary flow is further improved.
  • the open end is a body-free end
  • a spontaneous emptying and relief of the renal pelvis via the catheter into the body-free area can take place.
  • a retrograde filling of the hollow kidney system with a liquid from the outside is possible.
  • An optimal bolus can be achieved via the retrograde artificial filling of the pyelon.
  • the peristaltic activity of the ureter can be stimulated and the transport activity of the ureter can be promoted by the electrode in the area of the pacemaker centers.
  • Kidney stones which are present in large numbers as stone fragments in the ureter, for example after a shock wave lithotrypsia (extra-corporeal shock wave lithotripsy [ESWL]), may block, at least partially, these and / or possibly a kidney basin. Causing overpressure can be improved with a liquid supplied from outside and, above all, can be flushed out safely and completely into the bladder in a shorter time.
  • ESWL extra-corporeal shock wave lithotripsy
  • the body-free end is led directly outwards via a percutaneous nephrotomy.
  • this has the advantage that the ureter itself is not loaded with a catheter system.
  • electrical stimulation takes place via the electrode on the side of the kidney. Liquids of higher viscosity than urine applied in antigrad support the forced expulsion of stone fragments via the ureters.
  • Colic infections and inflammation of the kidneys that cannot be excluded can be prevented.
  • This flushing can also be carried out with liquids of higher viscosity.
  • the effectiveness of the electrostimulation can be ascertained via the amount of liquid supplied and removed, and known radiographic or electromyographic methods can be dispensed with.
  • two electrodes are provided at the end of the catheter on the kidney side.
  • the ureteral catheter according to the invention can be operated not only unipolar but also bipolar.
  • the bipolar mode of operation is more effective, safer and less stressful for the patient.
  • the electrode or the electrodes are made of an electrically conductive material, preferably platinum, and are helically attached to the outer circumference of the ureteral catheter, or the electrode or the electrodes are in the form of axially extending metallic tube pieces Integrated outer surface of the ureteral catheter.
  • the electrode or the electrodes are designed as tube pieces, they can be incorporated into the catheter shaft and the lines run in the catheter shaft up to the free end of the catheter in the body-free area. There, the line or lines can again lead into one or more stirring pieces attached to the outer surface of the catheter, which are to be provided as connection contacts for a current source to be connected.
  • the electrode or the electrodes are worked into the outer surface of the catheter without a step.
  • ureteral catheter according to the invention can be advanced as gently as possible on the inner walls of the hollow organs when inserted through the urethra into the ureter.
  • these can additionally be covered with an electrically conductive protective film.
  • the electrode or electrodes are formed from an electrically conductive plastic which is incorporated as a shaft section in the ureteral catheter.
  • the entire shaft surface can be given a uniform surface quality, and the flexibility of the ureteral catheter does not differ significantly from the other shaft regions in the area of the electrodes.
  • the electrodes or the electrodes are connected to lines which run in the catheter wall and exit at the end of the catheter on the bladder side.
  • the lines are provided with an insulating sheath at least outside the catheter, and the free ends of the lines are equipped with connecting means for a current source to be connected.
  • the ureteral catheter according to the invention can be operated safely.
  • the electrode or electrodes are connected to a current source which is provided in the catheter wall or on the bladder-side free end of the catheter.
  • a current source which is provided in the catheter wall or on the bladder-side free end of the catheter.
  • the electrode or electrodes are coupled to connections of a coil or coils which inductively supply the electrode or electrodes with current.
  • the current source can be implanted under the skin or carried on the skin.
  • the stimulation frequency, intensity, etc. can be influenced in a line-less manner via such an operating mode.
  • the electrode or electrodes are connected to means which supply the electrode or the electrodes with freely selectable current and voltage strengths, with a pulse duration and pulse frequency being specified.
  • the ureteral catheter has a length such that the ureteral catheter extends outward from the kidney via the ureter, bladder or urethra into an area outside the body extends.
  • a body-free end is provided with a Luer lock connection.
  • liquid systems can be coupled to the ureteral catheter according to the invention in a liquid-tight and quickly detachable manner.
  • the outer surface of the ureteral catheter has a hydrophilic property, which is achieved in particular by means of a hydrophilic coating. Due to the hydrophilic coating, stone fragments can be removed more easily in the space between the ureteral catheter according to the invention and the adjacent inner surface wall of the ureter.
  • an end of the ureteral catheter on the kidney pelvis can be fixed in the kidney pelvis via a synthetic fiber. This has the advantage that a placed ureteral catheter cannot move unintentionally.
  • the ureter catheters according to the invention are preferably provided with an outer marking so that the endoscopic placement of these catheters is facilitated.
  • the invention is shown in the drawing. It shows:
  • FIG. 1 shows a ureter catheter according to the invention with shaft ends that can be rolled up at both ends, two electrodes being provided at the shaft end on the renal pelvis;
  • FIG. 2 shows a ureteral catheter according to the invention with an inserted guide wire, via which the free ends can be axially aligned;
  • FIG. 3 shows an end of an ureteral catheter according to the invention, partially in cross section, with helix-shaped electrodes
  • FIG. 4 shows an end of an ureteral catheter according to the invention, partly in cross section, with electrodes incorporated into the catheter shaft and made of an electrically conductive plastic material;
  • Fig. 5 is a view according to V-V of Fig. 1;
  • Fig. 6 is a view according to VI-VI of Fig. 1;
  • Fig. 7 is a view according to VII-VII of Fig. 1; 8 shows a cross section through a catheter shaft of a ureter catheter according to the invention with incorporated current sources in the catheter wall;
  • FIG. 9 shows a section of a ureteral catheter according to the invention, which shows a passage opening, line lumens and a drainage lumen;
  • FIG. 10 shows a further embodiment of a ureteral catheter according to the invention with a shaft end on the kidney side and a body-free shaft end.
  • kidney-side end 11 and the bladder-side end 12 are designed as roll-in shaft ends which, in the placed state, fix the ureteral catheter both in the kidney pelvis and in the bladder.
  • the ureteral catheter 10 is made of a flexible, yet dimensionally stable plastic material that is compatible with the tissue.
  • a tip 13 of the kidney-side end 11 is closed.
  • One end 14 of the end 12 on the bladder side is open and opens into a lumen 15 which extends the entire catheter shaft 16 of the ureteral catheter 10 to the closed tip.
  • ze 13 passes through.
  • the tip 13 itself is rounded.
  • the catheter shaft 16 is penetrated by numerous through openings 17 which are connected to the lumen 15.
  • the passage openings 17 are shown in the exemplary embodiment along the entire catheter shaft 16, but they can also be formed only in sections on the ureter catheter 10.
  • the passage openings 17 can be formed on one side but also on both sides of the ureter catheter 10.
  • Markings 18 are further provided on the catheter shaft 16, which facilitate placement of the ureter catheter 10.
  • An X-ray-tight strip can also be incorporated into the catheter shaft 16, so that the placement of the ureter catheter 10 can be checked on the one hand and on the other hand to recognize the direction in which the free shaft ends curl.
  • two electrodes 19, 20 are attached to the outer circumference of the catheter shaft 16.
  • the electrodes 19, 20 have an electrical connection which leads into the catheter wall and connects there to lines 21, 22.
  • the lines 21, 22, starting from the electrodes 19, 20, are led through the entire longitudinal extent of the ureteral catheter 10 and exit at the bladder-side end 12 of the ureteral catheter 10.
  • the lines 21, 22 can be guided in a wedge shape in the catheter wall over the entire longitudinal extent of the ureteral catheter 10.
  • Corresponding connection means for a current source must be provided at the free ends of the lines 21, 22.
  • the electrodes 19, 20 are wound helically on the outer circumference of the catheter shaft 16.
  • the electrodes 19, 20 can be made from any electrically conductive material that is tissue compatible.
  • the electrodes 19, 20 are preferably at a distance of 1 cm to 1.5 cm from one another, so that an adequately delimited electric field for triggering contraction is built up in the area of the electrodes 19, 20 (bipolar operation).
  • sensors can also be provided on the ureteral catheter 10 which recognize the body's own electrical signals for activating the peristalsis. By means of the electrodes 19, 20, the body's own signals can be amplified and / or synchronized if necessary.
  • the electrodes 19, 20 can also perform the function of the sensors in a double function.
  • Electrodes are operated unipolarly on the ureteral catheter, these electrodes work together with further electrodes attached to the patient's skin.
  • Fig. 2 shows a ureteral catheter 10, which does not necessarily have to correspond in all of the objective features to the ureteral catheter from Fig. 1, with a guide wire 25 which can be inserted into the lumen 15 of the ureteral catheter 10 shown in dashed lines, and which is in itself the kidney-side and bladder-side rolled ends 11, 12 can stretch straight. If the guide wire 25 is removed from the ureteral catheter 10, rolled-up ends 11, 12 on the renal pelvis and bladder side are formed again. The ends of the ureter catheter 10 are shaped by a plastic material that has a memory effect.
  • the electrodes 19, 20 and the passage openings are also shown in FIG. 2.
  • the markings 18 are applied between the passage openings 17.
  • the lines 21, 22 connect the electrodes 19, 20 to a current source.
  • 3 shows the end 11 of a ureteral catheter according to the invention with an inserted guide wire 25.
  • the guide wire 25 is inserted into the lumen 15 up to the tip 13. With the guide wire 25, the rolled-up end 11 on the kidney side is stretched and aligned in a straight line.
  • the electrodes 19, 20 are made of a bendable metallic material, in the exemplary embodiment platinum wire, which can change the direction shown without damaging the electrical connection.
  • the end 11 of the kidney is shown in cross section, and it can be seen that the passage opening 17 opens up free access to the lumen 15.
  • the lines 21, 22 are guided in the catheter wall.
  • FIG. 4 shows a further embodiment of an end 11 of the ureter catheter 10 on the kidney side.
  • the end 11 on the kidney side is stretched in a straight line through the guide wire 25.
  • electrodes 27, 28 are incorporated into the catheter material.
  • the electrodes 27, 28 can for example be made of a graphite plastic mass. Electrically conductive particles are, for example, mixed into the plastic material in some areas and form the electrodes.
  • the electrodes 27, 28 are in turn connected to the lines 21, 22 which connect the electrodes 27, 28 to a power source.
  • the passage openings 17 are connected to the lumen 15, so that drainage can take place via the passage openings 17 as soon as the guide wire 25 is removed from the lumen 15.
  • FIG. 5 shows a cross section of the ureteral catheter 10 of FIG. 1 in the area of the tip 13.
  • the cross section shows that the ureteral catheter 10 m in this area consists of a solid material
  • FIG. 6 shows a section according to VI-VI of FIG. 1. It can be seen that the ureteral catheter 10 has the lumen 15 in this area, and a catheter wall is provided with a line lumen 31 which receives a line which receives the electrode is electrically connected to a current source.
  • FIG. 7 shows a cross-section VII-VII of FIG. 1.
  • This cross-section shows that the ureteral catheter 10 has the line lumen 31 and a further line lumen 32 in this area in addition to the lumen 15.
  • the lead lumens 31, 32 connect the electrodes to a current source.
  • further lumens can be guided for further lines to further electrodes.
  • FIG. 8 shows a further cross section through the catheter shaft 16 of the ureter catheter 10, which in this exemplary embodiment is equipped with energy sources 33, 34, miniaturized batteries, which are accommodated in the catheter shaft wall 30.
  • the lumen 15 is kept completely open with respect to its free cross-sectional area.
  • These energy sources 33, 34 do not create a constriction. If 30 energy sources 33, 34 are incorporated in the catheter shaft, no lines have to be led out of the catheter shaft 16. Further processors can also be incorporated into the catheter shaft 30, which control and regulate the intensity of stimulation by the electrodes. If the energy sources 33, 34 are accumulators, they can be charged from outside without a wire.
  • 9 shows a short section of a shaft of the ureteral catheter 10 in the area of a passage opening 17. In this shaft section area, in addition to the lumen 15, the line lumens 31, 32 for current-carrying lines are also provided, which connect the electrodes to a current source.
  • FIG. 10 shows a ureteral catheter 40 with an end 41 on the side of the kidney and a body-free end 42.
  • a tip 43 of the end 41 on the side of the kidney is closed.
  • One end 44 of the body-free end 42 is open and opens into a lumen 45 which runs through the entire catheter shaft 46 of the body-free 40 up to the closed tip 43.
  • Passage openings 47 are provided only in the region of the end 41 on the inside of the pool. The passage openings 47 are connected to the lumen 45. Markings can be provided along the catheter shaft 46 on the catheter shaft 46 so that endoscopic placement of the ureter catheter 40 is facilitated.
  • An electrode 49 is formed in the region of the end 41 on the kidney pelvis on the ureter catheter 40.
  • the electrode 49 is connected to a line 51 which runs in the catheter shaft 46 and opens into an electrical connection 52 at the body-free end 42.
  • the line 51 can extend helically in the catheter shaft 46.
  • Both the electrical connection 52 and the electrode 49 can be made from a metallic piece of pipe.
  • the axial length of the ureteral catheter 40 is designed such that it can be guided from the kidney 53 via the ureter 54 and the bladder 55 to the outside into the body-free area.
  • the body-free end 42 is provided with a Luer lock connection 56 so that liquid Systems can be securely coupled to the ureteral catheter 40.
  • the kidney pelvis can be filled with a liquid from the outside via the liquid systems not shown in the figure, so that stone fragments 57 located in the ureter 54 can be improved and washed out more easily.
  • a ureteral catheter 10 has an elongated shaft and a lumen 15 for drainage between the kidney pelvis and bladder and / or for the supply of liquids into the kidney pelvis.
  • the end 11 of the ureteral catheter 10 on the side of the kidney is closed and a plurality of passage openings 17 ensure access to the lumen 15.
  • the end 12 of the ureteral catheter 10 on the bladder side is open.
  • the ureteral catheter can extend from the kidney to the outside into a region free of the body, and the passage openings are only provided at the end of the ureteral catheter on the kidney side.
  • the kidney pelvis can be filled with a liquid from outside via the ureteral catheter and stone fragments located in the ureter can be washed out more easily.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
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  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
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  • Radiology & Medical Imaging (AREA)
  • External Artificial Organs (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Endoscopes (AREA)

Abstract

L'invention concerne une sonde urétérale (10) présentant une tige allongée et une lumière (15) servant à effectuer un drainage dans la zone comprise entre le bassinet et la vessie et/ou à activer les contractions péristaltiques de l'uretère. L'extrémité (11) de la sonde urétérale (10) située côté bassinet est fermée et plusieurs ouvertures de passage (17) garantissent l'accès à la lumière (15). L'extrémité (12) de la sonde urétérale (10) située côté vessie est ouverte. L'extrémité (11) de la sonde (10) située côté bassinet comporte au moins une électrode (19) reliée à une source de courant, laquelle peut au moins délivrer une impulsion électrique à un tissu contigu. Dans un mode de réalisation, la sonde urétérale peut s'étendre depuis le rein vers l'extérieur, dans une zone externe du corps et seulement l'extrémité de la sonde urétérale située côté bassinet comporte des ouvertures de passage. Dans un tel mode de réalisation, le bassinet peut être rempli depuis l'extérieur et par l'intermédiaire de la sonde urétérale, avec un liquide, et les fragments de calculs se trouvant dans l'uretère peuvent être évacués plus facilement.
PCT/DE1997/000979 1996-05-21 1997-05-15 Sonde ureterale WO1997044088A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19620388.0 1996-05-21
DE19620388 1996-05-21
DE19701840.8 1997-01-21
DE19701840A DE19701840A1 (de) 1996-05-21 1997-01-21 Ureterkatheter

Publications (1)

Publication Number Publication Date
WO1997044088A1 true WO1997044088A1 (fr) 1997-11-27

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PCT/DE1997/000979 WO1997044088A1 (fr) 1996-05-21 1997-05-15 Sonde ureterale

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WO (1) WO1997044088A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010067360A2 (fr) 2008-12-09 2010-06-17 Nephera Ltd. Stimulation de l'appareil urinaire
US8725249B2 (en) 2008-12-09 2014-05-13 Nephera Ltd. Stimulation of the urinary system
US8923970B2 (en) 2008-12-09 2014-12-30 Nephera Ltd. Stimulation of the urinary system
EP2717795A4 (fr) * 2011-06-06 2015-01-28 St Jude Medical Système et procédé de dénervation rénale
CN106572875A (zh) * 2014-02-07 2017-04-19 沃夫医药公司 用于肾盂消融的方法和系统
CN109953814A (zh) * 2017-12-25 2019-07-02 四川锦江电子科技有限公司 一种组合式消融穿刺装置
US12161379B2 (en) 2011-07-12 2024-12-10 Verve Medical, Inc. Treatment of kidney disease using renal nerve denervation via the renal pelvis
US12194001B2 (en) 2014-02-07 2025-01-14 Verve Medical, Inc. Treatment of kidney disease by renal pelvis ablation

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Publication number Priority date Publication date Assignee Title
SU1107866A1 (ru) * 1982-07-12 1984-08-15 Первый Московский Ордена Ленина И Ордена Трудового Красного Знамени Медицинский Институт Им.И.М.Сеченова Способ лечени больных хроническим пиелонефритом
EP0208841A2 (fr) * 1985-07-13 1987-01-21 B. Braun-SSC AG Cathéter urétéral
EP0346058A1 (fr) * 1988-06-07 1989-12-13 Btg International Limited Appareils médicaux
WO1992007605A1 (fr) * 1990-11-05 1992-05-14 Ravi Xavier Catheter implantable a plusieurs electrodes servant a administrer un medicament
US5249585A (en) * 1988-07-28 1993-10-05 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1107866A1 (ru) * 1982-07-12 1984-08-15 Первый Московский Ордена Ленина И Ордена Трудового Красного Знамени Медицинский Институт Им.И.М.Сеченова Способ лечени больных хроническим пиелонефритом
EP0208841A2 (fr) * 1985-07-13 1987-01-21 B. Braun-SSC AG Cathéter urétéral
EP0346058A1 (fr) * 1988-06-07 1989-12-13 Btg International Limited Appareils médicaux
US5249585A (en) * 1988-07-28 1993-10-05 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
WO1992007605A1 (fr) * 1990-11-05 1992-05-14 Ravi Xavier Catheter implantable a plusieurs electrodes servant a administrer un medicament

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 8509, Derwent World Patents Index; AN 85-055408, XP002039970 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010067360A2 (fr) 2008-12-09 2010-06-17 Nephera Ltd. Stimulation de l'appareil urinaire
US8725249B2 (en) 2008-12-09 2014-05-13 Nephera Ltd. Stimulation of the urinary system
US8923970B2 (en) 2008-12-09 2014-12-30 Nephera Ltd. Stimulation of the urinary system
US9498624B2 (en) 2008-12-09 2016-11-22 Nephera Ltd. Stimulation of the urinary system
EP2717795A4 (fr) * 2011-06-06 2015-01-28 St Jude Medical Système et procédé de dénervation rénale
US12161379B2 (en) 2011-07-12 2024-12-10 Verve Medical, Inc. Treatment of kidney disease using renal nerve denervation via the renal pelvis
CN106572875A (zh) * 2014-02-07 2017-04-19 沃夫医药公司 用于肾盂消融的方法和系统
EP3102132A4 (fr) * 2014-02-07 2017-11-01 Verve Medical, Inc. Procédés et systèmes pour l'ablation du bassinet du rein
US12194001B2 (en) 2014-02-07 2025-01-14 Verve Medical, Inc. Treatment of kidney disease by renal pelvis ablation
CN109953814A (zh) * 2017-12-25 2019-07-02 四川锦江电子科技有限公司 一种组合式消融穿刺装置

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