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WO1997043369A1 - Compositions repulsives pour les insectes comprenant des agents antimicrobiens et des tensio-actifs non ioniques - Google Patents

Compositions repulsives pour les insectes comprenant des agents antimicrobiens et des tensio-actifs non ioniques Download PDF

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Publication number
WO1997043369A1
WO1997043369A1 PCT/EP1997/002495 EP9702495W WO9743369A1 WO 1997043369 A1 WO1997043369 A1 WO 1997043369A1 EP 9702495 W EP9702495 W EP 9702495W WO 9743369 A1 WO9743369 A1 WO 9743369A1
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WO
WIPO (PCT)
Prior art keywords
polymer
insect repellent
nonionic surfactant
composition according
benzoic acid
Prior art date
Application number
PCT/EP1997/002495
Other languages
English (en)
Inventor
Alexander Allan
Timothy David Finch
Christopher Maddison
Kenneth Leslie Rabone
Martin Sharples
Original Assignee
Unilever Plc
Unilever N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Plc, Unilever N.V. filed Critical Unilever Plc
Priority to AU29558/97A priority Critical patent/AU2955897A/en
Publication of WO1997043369A1 publication Critical patent/WO1997043369A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N27/00—Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
    • A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/18—Hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2041—Dihydric alcohols
    • C11D3/2062—Terpene
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2075—Carboxylic acids-salts thereof
    • C11D3/2082—Polycarboxylic acids-salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2075—Carboxylic acids-salts thereof
    • C11D3/2086—Hydroxy carboxylic acids-salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2093—Esters; Carbonates
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/50—Perfumes

Definitions

  • insect-repellent Compoaitiona Comprising Antimicrobial A ⁇ ents and Nonionic Surfactant
  • the present invention relates to disinfecting and insect- repellent compositions comprising nonionic surfactant .
  • Cleaning compositions generally comprise one or more surfactants, and, optionally, one or more hygiene agents. These compositions function to keep surfaces free from microbial contamination in two ways, firstly by removing soils and secondly by killing bacteria and other microbes which live in an upon these soils.
  • Typical surfactants are selected from anionic, nonionic, amphoteric and cationic surfactants. With nonionics being very commonly used due to their effectiveness on fatty soils and low foaming. Of these surfactants, nonionics show low biocidal activity, whereas certain anionic, cationic and amphoteric surfactants show biocidal activity under specific conditions of, for example, pH and concentration.
  • Known hygiene agents in common use include, strong acids, alkali's, phenolics, peracids and hypohalides. These are generally highly reactive species which exhibit this reactivity in terms of one or more of, short shelf life, toxic, corrosive and irritant properties. In general, these components are required at relatively high levels in formulations.
  • preservatives in cosmetics and some foods. These preservatives generally show lower biocidal activity than the above-mentioned hygiene agents when used at the same level.
  • a hygiene agent is preferably an agent which shows a 100,000 fold or better reduction in the number of viable microorganisms in a specified culture when used at a level of around 0.5%. This is generally known as a 'log 5 kill' .
  • salicylic acid is generally regarded as the most effective biocide against common bacteria, but it's activity falls far short of that required of a hygiene agent.
  • EP 0619363 relates to aqueous liquid detergents which comprise a surfactant, at least 50% water and an effective amount of an insect repellent material.
  • the compositions are free of insecticides.
  • insect-repellents mentioned are materials which are known insect repellents per se and also perfumes. Other materials can be present in the composition and these include soil release promoting agents, which may be polymers .
  • Insect repellents are chemically sensitive to oxidising agents such as hypochlorite and other common hygiene agents such as peroxy-compounds .
  • oxidising agents such as hypochlorite
  • other common hygiene agents such as peroxy-compounds .
  • GB 718050 (Miles Labs: 1951) relates to a germicidal, fungicidal and deodorant composition for topical application to skin which comprises fungicide, ethanol, menthol, camphor or other essential oils and chlorothymol and a nonionic surfactant.
  • the levels of the surfactants in the compositions disclosed are so low (around 0.35%wt) that they would not provide an effective cleaning composition for hard surfaces.
  • GB 431344 (ICI: 1935) relates to a treatment for protecting wood against fungus which comprises in addition to a fungicide, surfactant and an essential oil.
  • the levels of surfactant in this composition is again far too low for it to be considered as a hard surface cleaning composition.
  • JP 89263738 (Nitto Denko Corp: 1989) relates to a medical composition which comprises nonionic surfactant, limonene and a medicated component which can be sodium salicylate.
  • the present invention provides a hard surface cleaning composition
  • a hard surface cleaning composition comprising: a) at least 0.5% of a nonionic surfactant, b) 0.1-15%wt on product of an antimicrobial agent selected from the group comprising: benzoic acid derivatives, dicarboxylic acids, and mixtures thereof, and, c) an insect repellent.
  • the antimicrobial agents described above which exhibit a synergy with the nonionic surfactant, are compatible with insect repellents.
  • the synergy between the selected antimicrobial agent and the nonionic surfactant provides an effective antimicrobial action without requiring the presence of strongly reactive species which would otherwise react chemically with the insect repellent material.
  • the compositions provide both a hygiene and a cleaning benefit while also providing an effective insect-repellency which assists in preventing re- contamination of the surface by microbes carried on insect vectors.
  • the invention also extends to a method for cleaning hard surfaces and repelling insects therefrom which comprises the step of treating the surface with a composition comprising: a) at least 0.5% of a nonionic surfactant, b) 0.1-15%wt on product of an antimicrobial agent selected from the group comprising: benzoic acid derivatives, dicarboxylic acids, and mixtures thereof, and, c) an insect repellent.
  • a composition comprising: a) at least 0.5% of a nonionic surfactant, b) 0.1-15%wt on product of an antimicrobial agent selected from the group comprising: benzoic acid derivatives, dicarboxylic acids, and mixtures thereof, and, c) an insect repellent.
  • Nonionic surfactants are an essential component of the compositions according to the invention.
  • the surfactants are preferably, alkoxylated alcohols or amine oxides. Alkoxylated alcohols are preferred as surfactants, with ethoxylated alcohols being the most preferred.
  • Suitable nonionic detergent active compounds can be broadly described as compounds produced by the condensation of alkylene oxide groups, which are hydrophilic in nature, with an organic hydrophobic compound which may be aliphatic or alkyl aromatic in nature.
  • the length of the hydrophilic or polyoxyalkylene radical which is condensed with any particular hydrophobic group can be readily adjusted to yield a water-soluble compound having the desired degree of balance between hydrophilic and hydrophobic elements.
  • Particular examples include the condensation product of aliphatic alcohols having from 8 to 22 carbon atoms in either straight or branched chain configuration with ethylene oxide, such as a coconut oil ethylene oxide condensate having from 1 to 15 moles of ethylene oxide per mole of coconut alcohol; condensates of alkylphenols whose alkyl group contains from 6 to 12 carbon atoms with 1 to 25 moles of ethylene oxide per mole of alkylphenol.
  • Particularly preferred nonionic surfactants include the condensation products of C 8 -C 18 alcohols with 2-12 moles of ethylene oxide.
  • the most preferred alkoxylated alcohol nonionic surfactants are ethoxylated alcohols having a chain length of C,-C n and an EO value of at least 5 but less than 10.
  • Particularly preferred nonionic surfactants include the condensation products of C 10 alcohols with 5-8 moles of ethylene oxide.
  • the preferred ethoxylated alcohols have a calculated HLB of 10-16. While mixtures of nonionic surfactants can be used it is preferred to use a single commercially available surfactant .
  • the amount of nonionic detergent active to be employed in the composition of the invention will generally be from 0.5 to
  • Concentrated products will generally have 7-20%wt nonionic surfactant present, whereas dilute products suitable for spraying will generally have 0.5-10%wt nonionic surfactant present.
  • compositions of the present invention are essentially free of anionic surfactant.
  • the amount of anionic detergent active to be employed in the detergent composition of this invention will generally be from 0.5 to 25%wt (on total active) , preferably less than 10%wt (on total active) most preferably less than 5%wt.
  • Typical levels of the antimicrobial agent in formulations range from 0.01 to 8%, with levels of 0.05-4wt%, particularly around 2% being preferred for normal compositions and up to two or four times that concentration being present in so called, concentrated products.
  • concentration of the antimicrobial agent will be in the range 0.05-0.5%wt .
  • the ratio of the nonionic surfactant to the antimicrobial agent will preferably be in the range 50:1 to >1:1, more preferably 30:1 to >1: 1 i.e. an excess of nonionic will be present.
  • 'benzoic acid derivatives' includes benzoic acid and derivatives thereof. In particular it includes ortho- hydroxy benzoic acid derivatives including salicylic acid. Surprisingly, we have determined that the presence of a benzoic acid derivative also improves the cleaning performance of the compositions. Benzoic acid derivatives are the preferred antimicrobials.
  • the preferred antimicrobial agent is salicylic acid, which gives better hygiene results than benzoic and shows a very marked improvement as compared with sorbic acid.
  • Alternative acids are the polyhydroxyl carboxylic acids in which at least one of the hydroxyl groups is ortho- to the carboxylic acid group. The remaining hydroxyl group or groups can be in the remaining ortho-, para- or meta- configurations.
  • the polyhydroxyl carboxylic acids exhibit the same synergy as the mono hydroxylic acid derivative (salicylic acid) but are believed to be less irritant.
  • salicylic acid derivatives methylated at positions 3-6 exhibit an additional antimicrobial action over that obtained with salicylic acid. This was particularly true for gram positive bacteria and yeasts. In contrast hydroxylation at these sites was found to decrease the synergistic effect.
  • the preferred alkyl substituted ortho-hydroxy aromatic carboxylic acid is of the general formula:
  • R j is C j 12 alkyl, and the hydroxyl group is ortho to the carboxyl group.
  • the alkyl substituted ortho-hydroxy aromatic carboxylic acids are substituted at the 3, 4 or 5-position, relative to the carboxyl group.
  • Preferred chain lengths for the alkyl group are C ]-6 , with methyl substituted acids being particularly preferred.
  • Particularly preferred acids are 2 - hydroxy 5-methyl benzoic acid, 2-hydroxy 4-methyl benzoic acid and 2-hydroxy 3-methyl benzoic acid.
  • alkyl substituted ortho-hydroxy aromatic carboxylic acid mentioned above is the most preferred antimicrobial agent, dicarboxylic acids can be used in addition to or instead of them.
  • suitable dicarboxylic acids include succinic acid, malic acid and ascorbic acid.
  • the dicarboxylic acid mixture present in the formulation include adipic, glutaric and succinic acid and mixtures thereof.
  • the mixtures are preferred as these are commercially available.
  • Typical mixtures which can be found in the marketplace comprise 30-35% adipic acid, 45-50% glutaric acid and 10-18% succinic acid.
  • Such a mixture is available in the marketplace as Sokalan DCS (TM, ex. BASF) .
  • Another suitable mixture is available as Radimix (TM, ex. Radici) .
  • the use of essentially pure acids is not excluded but these have limited commercial availability.
  • These compositions have the further advantage that they assist in the removal of limescale and other calcinareous deposits, while these deposits are themselves unsightly they also can provide a haven for microbes.
  • Mixtures of benzoic acid derivatives and the dicarboxylics are preferred to the use of the dicarboxylic acids as the sole antimicrobial component.
  • An effective level of insect repellent is an essential component of the compositions of the present invention.
  • Particularly suitable insect repellents include essential oils such as those of genus Mentha, particularly Mentha arvensis, mentha piperita, Mentha spicata and Mentha cardica; Lemongrass East Indian oil. Lemon oil, Citronella, Cedarwood and Pine oil; terpenoids, particularly limonene, carvone, cineole, linalool, Gum Camphor, citronellal, alpha and beta terpenol, fencholic acid, borneol, iso borneol, bornyl acetate and iso bornyl acetate.
  • essential oils such as those of genus Mentha, particularly Mentha arvensis, mentha piperita, Mentha spicata and Mentha cardica
  • Lemongrass East Indian oil Lemon oil, Citronella, Cedarwood and Pine oil
  • terpenoids particularly limonene, carvone, cineole, linalool, Gum Camphor, citronellal, alpha and
  • the most preferred insect repellents are the terpenoids, particularly limonene. Many of the terpenoids are not unpleasant-smelling to humans and consequently the insect repellent material while fulfilling its primary function also can have the secondary function of lending a pleasing smell to the composition.
  • insect repellent required will vary with the nature of the material used. For essential oils and terpenoids, preferred levels are 0.1-5% on product.
  • the ratio of surfactant to insect repellent does not exceed 10:lwt% and more preferably that the ratio of surfactant to insect repellent falls in the range 8-2:1.
  • the ratio of insect repellent to polymer is in the range less than 5:1 but more than 0.5:1. We have found that ratios of 4:1 of a perfume containing 54% insect repellent to polymer were effective.
  • the presence of the insect repellent perfume acts synergistically with the antimicrobial agent, particularly when this is a benzoic acid derivative, allowing effective disinfection over a broader pH range.
  • Polymers are an optional component of compositions according to the present invention. It is preferable that these polymers are carboxylate polymers.
  • a carboxylate polymer is one formed from monomers which comprise a carboxy-functional group. This group of polymers excludes polymers such as silicone oils and mineral oils.
  • the preferred polymers in embodiments of the present invention are polymers of acrylic or methacrylic acid or maleic anhydride, or a co-polymer of one or more of the same either together or with other monomers.
  • Particularly suitable polymers include polyacrylic acid, polymaleic anhydride and copolymers of either of the aforementioned with ethylene, styrene and methyl vinyl ether.
  • the most preferred polymers are maleic anhydride co-polymers, preferably those formed with styrene, acrylic acid, methyl vinyl ether and ethylene.
  • the molecular weight of the polymer is at least, 5000, more preferably at least 50,000 and most preferably in excess of 100,000.
  • the molecular weight of the polymer is preferably below 1,000,000 Dalton.
  • the compositions comprise at least 0.01wt% polymer, on product.
  • the level of polymer is 0.05-5.0wt%. More preferably 0.1-4.0wt% of polymer is present.
  • the initial polymer level can be as high as 5%wt .
  • the polymer assists in transporting the insect repellent to the surface and maintaining the repellent on the surface during the cleaning operation. Consequently, despite the presence of surfactants in the compositions of the invention and the oily nature of many insect repellents, the insect repellent is not removed from the surface by the surfactant.
  • insect repellent in the presence of polymer the insect repellent is released from the surface over a prolonged period of time. This is advantageous as the reinfection of the surface through insect vectors is further delayed as the period over which insects are effectively repelled is extended.
  • a further advantage of the polymer is believed to be a reduction of the energy required to clean the surface both in initial (primary) and in second and subsequent (secondary ) cleaning operations. This is believed to be due to the deposition of components of the composition at the surface which increase the surfactant concentration at the surface and form a protective film which retards the attachment of soils to the surface when the surface is resoiled.
  • compositions of the present invention preferably contain perfume components other than the insect repellent perfume components mentioned above. Typical levels being 0.1-5%wt on product.
  • perfume components are deposited at the surface in the same manner as the insect repellent components and consequently released over a prolonged period of time to give a persistent pleasant smell to surfaces which have been cleaned with the compositions according to the invention.
  • Fully formulated compositions according to the invention therefore effectively remove soil and kill bacteria while depositing both a surface-protective polymer and a long- lasting, pleasant smelling, insect repellent on the surface, to prevent both resoiling and re-contamination of the surface.
  • compositions according to the invention are advantageous to employ a single insect-repellent and perfuming component in compositions according to the invention.
  • a suitable insect repellent, pleasant smelling perfume is commercially available as 'Stay Away 2001' (TM) ex. Givaudan Roure. This will generally be used in compositions according to the invention at levels of 0.5-3%wt.
  • composition according to the invention can contain other minor, unessential ingredients which aid in their cleaning performance and maintain the physical and chemical stability of the product.
  • the composition can contain detergent builders.
  • the builder when employed, preferably will form from 0.1 to 25% by weight of the composition.
  • Metal ion sequestrants such as ethylene-diamine-tetra- acetates, amino-polyphosphonates (such as those in the DEQUEST R range) and phosphates and a wide variety of other poly-functional organic acids and salts, can also optionally be employed.
  • Citrate is particularly preferred as this functions as a buffer maintaining the composition at a pH in the range 3-5 on dilution. Typical levels of citrate range from 0.5-5%, with higher levels of 5-10% being used in concentrates and lower levels of 0.1-1% being used in sprayable products. Citric can be replaced by other suitable buffering agents to maintain the pH in this range. Citric is preferred for environmental reasons and a lack of residues.
  • Hydrotropes are useful optional components. It is believed that the use of hydrotropes enables the cloud point of the compositions to be raised without requiring the addition of anionic surfactants.
  • the formations according to the invention are free of anionics, or contain low levels of anionics, i.e. less than 50% of the level of the betaine.
  • Suitable hydrotropes include, alkali metal toluene sulphonates, urea, alkali metal xylene and cumene sulphonates, short chain, preferably C 2 -C 5 alcohols and glycols. Preferred amongst these hydrotropes are the sulphonates, particularly the cumene and toluene sulphonates.
  • Typical levels of hydrotrope range from 0-5% for the sulphonates. Correspondingly higher levels of urea and alcohols are required. Hydrotropes are not required for dilute products.
  • compositions according to the invention can also contain, in addition to the ingredients already mentioned, various other optional ingredients such as, solvents, colourants, optical brighteners, soil suspending agents, detersive enzymes, compatible bleaching agents (such as reducing bleaches) , gel- control agents, freeze-thaw stabilisers, further bactericides, additional perfume components and opacifiers.
  • various other optional ingredients such as, solvents, colourants, optical brighteners, soil suspending agents, detersive enzymes, compatible bleaching agents (such as reducing bleaches) , gel- control agents, freeze-thaw stabilisers, further bactericides, additional perfume components and opacifiers.
  • the composition has a pH of 3.2-4.5. It is believed that the above pH 4.5 the hygiene benefit of the compositions is less pronounced and below pH 3.0 surface damage may occur.
  • the most preferred pH is around 3.5-3.8. Compositions having a pH of less than 3.0 will damage enamel surfaces.
  • compositions having a pH significantly above 4.5 will show reduced kill against micro-organisms.
  • citrate at a level of 3.5% will be sufficient to reduce the pH on addition of the product of the present invention at 3.3g/l to a pH below 4.0.
  • For sprayable products less steps need be taken to maintain the pH. It is believed that the relatively low pH of the composition is important in achieving both the cleaning and the antimicrobial synergies which are exhibited by the products according to the invention.
  • compositions vary with the ratio of the components present. As mentioned above it is preferred that the ratio of surfactant to insect repellent does not exceed 10:lwt%.
  • compositions according to the invention comprise: a) l-10%wt of an ethoxylated alcohol, b) 0.01 to 8%wt of an antimicrobial agent selected from the group comprising: benzoic acid derivatives, dicarboxylic acids, and mixtures thereof, and, c) 0.2-4%wt of a terpenoid insect repellent material
  • More particularly preferred compositions according to the invention comprise: a) l-10%wt of an ethoxylated alcohol, b) 0.01 to 8%wt of an antimicrobial agent selected from the group comprising: benzoic acid derivatives, dicarboxylic acids, and mixtures thereof, c) 0.2-4%wt of a terpenoid insect repellent material, and, d) 0.01-5.0wt% of a carboxylate polymer.
  • compositions according to the invention have a pH of 3.2-4.5 and comprise: a) l-10%wt of an C8-C12 3-8EO ethoxylated alcohol nonionic surfactant, b) 0.01 to 8%wt a 2-hydroxy benzoic acid derivative, preferably salicylic acid, c) 0.2-4%wt of a terpenoid insect repellent material said insect repellent material comprising limonene d) 0.01-5.0wt% of a polyacrylic acid polymer, e) 0.1-2% of a betaine or amine oxide.
  • nonionic surfactant In the presence of nonionic surfactant, polymer, antimicrobial agent and the insect repellent a series of synergistic interactions are believed to take place which greatly enhance the effectiveness of this simple composition.
  • the synergy between the selected antimicrobial agent and the nonionic surfactant provides an effective antimicrobial action without requiring the presence of strongly reactive species which would otherwise react chemically with the insect repellent material.
  • the polymer and the nonionic surfactant interact to give both a reduced effort requirement for both primary and secondary cleaning and promote the deposition and retention of the insect repellent at the surface.
  • the insect repellent and the antimicrobial agent are believed to interact so as to improve the antimicrobial activity over the pH range of the product.
  • Perfume 1.0% A perfume comprising at least 50% limonene *Coco-Amido Propyl Betaine
  • compositions of examples were prepared by mixing the components in the proportions given above.
  • Perfume A perfume comprising at least 50% limonene
  • compositions of examples were prepared by mixing the components in the proportions given below in Table 4.
  • the cloud point of each formulation has been adjusted to 50 degrees C. using the hydrotrope (SCS) .
  • the pH of each formulation was been adjusted to 3.5 using NaOH.
  • Antimicrobial 2. .0 2. .0 0. .0 0. .0
  • example 3 the same formulations as used in example 2 were tested for their hygiene properties in a 96 well (8x12) microtitre plate, using a test related to the 'European Suspension Test ' .
  • lml of formulation was diluted into 14ml of water. 5ml of the diluted solution was added to 4ml of distilled water and 270 ⁇ l of the product dosed into one well of the microtitre plate. This was repeated for the remaining 7 formulations being tested on this plate. 8 wells were simultaneously inoculated with 30 ⁇ l bacterial suspension using a multipipette and agitated. After a 5mins (+/-5secs) contact time 30 ⁇ l samples were transferred into 270 ⁇ l inactivation liquid (as used in examples 1 and 2) using a multipipette and mixed. After 5mins (+/-lmin) 30 ⁇ samples were serially diluted into 270 ⁇ l of Ringers solution using a multipipette and mixed.
  • TVC total viable count
  • the microbes used were S.aureus (Gram positive) and E.coli (Gram negative) .
  • Four formulations were tested on two sequential days in triplicate (6 results per microbe per formulation) . The results are summarized below in Table 6 which gives log reductions in viable count and standard deviations of these results.
  • Antimicrobial 2. .0 2. .0 0. .0 0. .0
  • This product was found to be an effective, storage stable, hard surface cleaning composition. It is believed that the composition gives a reduction in effort both in primary and secondary cleaning, has a strong antimicrobial effect and provides both a persistent, pleasant perfume and persistent insect repellency.

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  • Engineering & Computer Science (AREA)
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Abstract

La présente invention concerne une composition de nettoyage pour des surfaces dures. Cette composition comprend (a) un tensio-actif non ionique, (b) 0,1 à 15 % en poids du produit d'un agent antimicrobien sélectionné dans le groupe comportant des dérivés d'acide benzoïque, des acides dicarboxyliques et des mélanges de ces derniers, et (c) un répulsif pour insectes. Il apparaît que la synergie entre l'agent antimicrobien sélectionné et le tensio-actif non ionique produit une action antimicrobienne efficace sans nécessiter d'autres espèces fortement réactives qui risqueraient de réagir chimiquement avec la matière répulsive pour les insectes.
PCT/EP1997/002495 1996-05-09 1997-04-29 Compositions repulsives pour les insectes comprenant des agents antimicrobiens et des tensio-actifs non ioniques WO1997043369A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU29558/97A AU2955897A (en) 1996-05-09 1997-04-29 Insect-repellent compositions comprising antimicrobial agents and nonionic surfactant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9609668.0A GB9609668D0 (en) 1996-05-09 1996-05-09 Insect-repellant compositions comprising antimicrobial agents and nonionic surfactant
GB9609668.0 1996-05-09

Publications (1)

Publication Number Publication Date
WO1997043369A1 true WO1997043369A1 (fr) 1997-11-20

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Country Link
AU (1) AU2955897A (fr)
GB (1) GB9609668D0 (fr)
IN (1) IN183457B (fr)
WO (1) WO1997043369A1 (fr)
ZA (1) ZA973929B (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19821106A1 (de) * 1998-05-12 1999-11-18 Grewe Helmut F Milbentötendes - Reinigungsmittel für Textilien auf Basis ätherischer Pflanzen- und Baumöle
WO2001057174A1 (fr) * 2000-02-01 2001-08-09 Reckitt Benckiser Inc. Composition de nettoyage de surfaces dures
WO2002097020A3 (fr) * 2001-05-24 2003-03-06 Cussons Int Ltd Composition liquide detergente bactericide
EP1331261A1 (fr) * 2002-01-23 2003-07-30 Chemische Fabrik Dr. Weigert GmbH & Co. KG. Procès de nettoyage et désinfection de la vaiselle
WO2008068488A1 (fr) * 2006-12-08 2008-06-12 Reckitt Benckiser (Uk) Limited Améliorations de compositions de nettoyage acides pour surfaces dures
US9534190B2 (en) 2012-12-20 2017-01-03 Ecolab Usa Inc. Citrate salt bathroom cleaners
US9790456B2 (en) 2012-12-20 2017-10-17 Ecolab Usa Inc. Citrate salt bathroom cleaners
WO2022139745A1 (fr) * 2020-12-24 2022-06-30 Eczacibasi Tuketim Urunleri Sanayi Ve Ticaret Anonim Sirketi Produit de nettoyage antimicrobien efficace contre les insectes
CN114680111A (zh) * 2018-09-19 2022-07-01 大日本除虫菊株式会社 吸收促进剂、含有飞行害虫驱避香料的组合物，及飞行害虫驱避制品

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Publication number Priority date Publication date Assignee Title
JPS6051796A (ja) * 1983-08-31 1985-03-23 ライオン株式会社 清浄剤組成物
JPS6051792A (ja) * 1983-08-31 1985-03-23 ライオン株式会社 洗浄剤組成物
JPS6112798A (ja) * 1984-06-27 1986-01-21 ライオン株式会社 浴室用液体洗浄剤組成物
EP0379256A2 (fr) * 1989-01-17 1990-07-25 Colgate-Palmolive Company Détergents acides, désinfectants et liquides pour tous usages
EP0619363A1 (fr) * 1993-04-08 1994-10-12 Colgate-Palmolive Company Composition de nettoyage domestique liquide repoussant les insectes
WO1996017918A1 (fr) * 1994-12-09 1996-06-13 Unilever Plc Perfectionnements apportes a des compositions de nettoyage antimicrobiennes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051796A (ja) * 1983-08-31 1985-03-23 ライオン株式会社 清浄剤組成物
JPS6051792A (ja) * 1983-08-31 1985-03-23 ライオン株式会社 洗浄剤組成物
JPS6112798A (ja) * 1984-06-27 1986-01-21 ライオン株式会社 浴室用液体洗浄剤組成物
EP0379256A2 (fr) * 1989-01-17 1990-07-25 Colgate-Palmolive Company Détergents acides, désinfectants et liquides pour tous usages
EP0619363A1 (fr) * 1993-04-08 1994-10-12 Colgate-Palmolive Company Composition de nettoyage domestique liquide repoussant les insectes
WO1996017918A1 (fr) * 1994-12-09 1996-06-13 Unilever Plc Perfectionnements apportes a des compositions de nettoyage antimicrobiennes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8518, Derwent World Patents Index; Class A97, AN 85-107786, XP002040329, "Detergent compsn-contg. nonionic surfactant, hydroxy polyvalent carboxylic acid, polypropylene glycol and hydrocarbon e.g. limonene" *
DATABASE WPI Section Ch Week 8518, Derwent World Patents Index; Class A97, AN 85-107790, XP002040331, "Cleaner compsn.-contg. cationic surfactant, polyoxyethylene alkyl ether agent, polymer of maleic acid and terpene alcohol" *
DATABASE WPI Section Ch Week 8609, Derwent World Patents Index; Class D25, AN 86-059770, XP002040330, "Bathroom liq. detergent compsn.-contg. surfactant, hydroxy polyvalent carboxylic acid and terpenic hydrocarbon solvent" *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19821106A1 (de) * 1998-05-12 1999-11-18 Grewe Helmut F Milbentötendes - Reinigungsmittel für Textilien auf Basis ätherischer Pflanzen- und Baumöle
WO2001057174A1 (fr) * 2000-02-01 2001-08-09 Reckitt Benckiser Inc. Composition de nettoyage de surfaces dures
US6936579B2 (en) 2000-02-01 2005-08-30 Reckitt Benckiser Inc. Hard surface cleaning compositions and method of removing stains
WO2002097020A3 (fr) * 2001-05-24 2003-03-06 Cussons Int Ltd Composition liquide detergente bactericide
EP1331261A1 (fr) * 2002-01-23 2003-07-30 Chemische Fabrik Dr. Weigert GmbH & Co. KG. Procès de nettoyage et désinfection de la vaiselle
US8173585B2 (en) 2006-12-08 2012-05-08 Reckitt Benckiser (Uk) Limited Acidic hard surface cleaning compositions
WO2008068488A1 (fr) * 2006-12-08 2008-06-12 Reckitt Benckiser (Uk) Limited Améliorations de compositions de nettoyage acides pour surfaces dures
US9534190B2 (en) 2012-12-20 2017-01-03 Ecolab Usa Inc. Citrate salt bathroom cleaners
US9790456B2 (en) 2012-12-20 2017-10-17 Ecolab Usa Inc. Citrate salt bathroom cleaners
US9834742B2 (en) 2012-12-20 2017-12-05 Ecolab Usa Inc. Citrate salt bathroom cleaners
CN114680111A (zh) * 2018-09-19 2022-07-01 大日本除虫菊株式会社 吸收促进剂、含有飞行害虫驱避香料的组合物，及飞行害虫驱避制品
CN115191431A (zh) * 2018-09-19 2022-10-18 大日本除虫菊株式会社 吸收促进剂、含有飞行害虫驱避香料的组合物，及飞行害虫驱避制品
WO2022139745A1 (fr) * 2020-12-24 2022-06-30 Eczacibasi Tuketim Urunleri Sanayi Ve Ticaret Anonim Sirketi Produit de nettoyage antimicrobien efficace contre les insectes

Also Published As

Publication number Publication date
IN183457B (fr) 2000-01-08
AU2955897A (en) 1997-12-05
ZA973929B (en) 1998-11-09
GB9609668D0 (en) 1996-07-10

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