WO1996039390B1 - Derives de benzimidazole inhibiteurs de la proliferation des cellules musculaires lisses - Google Patents
Derives de benzimidazole inhibiteurs de la proliferation des cellules musculaires lissesInfo
- Publication number
- WO1996039390B1 WO1996039390B1 PCT/US1996/008353 US9608353W WO9639390B1 WO 1996039390 B1 WO1996039390 B1 WO 1996039390B1 US 9608353 W US9608353 W US 9608353W WO 9639390 B1 WO9639390 B1 WO 9639390B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carbon atoms
- alkyl
- phenyl
- hydrogen
- pharmaceutically acceptable
- Prior art date
Links
Abstract
Composés et sels pharmaceutiquement acceptables de composés de formule (I) ou (II), dans lesquelles R est alkyle, phényle ou phényle substitué, R2 est hydrogène, halogène, alcoxy ou alkyle, R1 est hydrogène, alkyle, aryle, arylalkyle ou benzyle substitué. Ces substances sont utiles comme inhibiteurs de la prolifération des cellules musculaires lisses.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9609365A BR9609365A (pt) | 1995-06-06 | 1996-06-03 | Derivados de benzimidazol como inibidores de proliferação de células de músculo liso |
| AU59673/96A AU713043B2 (en) | 1995-06-06 | 1996-06-03 | Benzimidazole derivatives as inhibitors of smooth muscle cell proliferation |
| NZ309490A NZ309490A (en) | 1995-06-06 | 1996-06-03 | Benzimidazole derivatives as inhibitors of smooth muscle cell proliferation |
| EP96916965A EP0830343A1 (fr) | 1995-06-06 | 1996-06-03 | Derives de benzimidazole inhibiteurs de la proliferation des cellules musculaires lisses |
| JP9500980A JPH11506749A (ja) | 1995-06-06 | 1996-06-03 | 平滑筋細胞増殖の阻害薬としてのベンゾイミダゾール誘導体 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/468,482 | 1995-06-06 | ||
| US08/468,482 US6288100B1 (en) | 1995-06-06 | 1995-06-06 | Benzimidazole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996039390A1 WO1996039390A1 (fr) | 1996-12-12 |
| WO1996039390B1 true WO1996039390B1 (fr) | 1997-01-09 |
Family
ID=23859998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1996/008353 WO1996039390A1 (fr) | 1995-06-06 | 1996-06-03 | Derives de benzimidazole inhibiteurs de la proliferation des cellules musculaires lisses |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6288100B1 (fr) |
| EP (1) | EP0830343A1 (fr) |
| JP (1) | JPH11506749A (fr) |
| KR (1) | KR19990022372A (fr) |
| CN (1) | CN1192205A (fr) |
| AR (1) | AR002748A1 (fr) |
| AU (1) | AU713043B2 (fr) |
| BR (1) | BR9609365A (fr) |
| CA (1) | CA2223393A1 (fr) |
| IL (1) | IL118384A0 (fr) |
| NZ (1) | NZ309490A (fr) |
| WO (1) | WO1996039390A1 (fr) |
| ZA (1) | ZA964692B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295432A1 (fr) | 2006-02-10 | 2011-03-16 | TransTech Pharma Inc. | Procédé pour la préparation de dérivés benzimidazoles aminés |
| JP2012507525A (ja) * | 2008-10-30 | 2012-03-29 | オンコセラピー・サイエンス株式会社 | ７−ヒドロキシ−ベンゾイミダゾール−４−イル−メタノン誘導体およびこれを含むｐｂｋ阻害剤 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1062950A (en) * | 1963-12-31 | 1967-03-22 | Gevaert Photo Prod Nv | Trimethine dyes |
| GR78209B (fr) * | 1982-04-15 | 1984-09-26 | May & Baker Ltd | |
| DE3505609A1 (de) | 1985-02-19 | 1986-08-21 | Merck Patent Gmbh, 6100 Darmstadt | Benzimidazolyl-pyridazinone |
| HU193951B (en) | 1985-03-11 | 1987-12-28 | Richter Gedeon Vegyeszet | Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them |
| NZ221729A (en) * | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
| US4859684A (en) * | 1986-09-15 | 1989-08-22 | Janssen Pharmaceutica N.V. | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders |
| US5200422A (en) | 1990-09-24 | 1993-04-06 | Neurosearch A/S | Benzimidazole derivatives, their preparation and use |
| DE4212748A1 (de) | 1992-04-16 | 1993-10-21 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| KR0185225B1 (ko) | 1992-05-21 | 1999-05-15 | 오오쓰까 아끼히꼬 | 포스폰산 디에스테르 유도체 |
| US5387600A (en) | 1992-07-30 | 1995-02-07 | Fuji Photo Film Co., Ltd. | Treating arteriosclerosis using benzimidazole compositions |
-
1995
- 1995-06-06 US US08/468,482 patent/US6288100B1/en not_active Expired - Fee Related
-
1996
- 1996-05-22 IL IL11838496A patent/IL118384A0/xx unknown
- 1996-05-30 AR ARP960102798A patent/AR002748A1/es unknown
- 1996-06-03 EP EP96916965A patent/EP0830343A1/fr not_active Withdrawn
- 1996-06-03 WO PCT/US1996/008353 patent/WO1996039390A1/fr not_active Application Discontinuation
- 1996-06-03 JP JP9500980A patent/JPH11506749A/ja active Pending
- 1996-06-03 NZ NZ309490A patent/NZ309490A/en unknown
- 1996-06-03 AU AU59673/96A patent/AU713043B2/en not_active Ceased
- 1996-06-03 BR BR9609365A patent/BR9609365A/pt not_active Application Discontinuation
- 1996-06-03 KR KR1019970708852A patent/KR19990022372A/ko not_active Withdrawn
- 1996-06-03 CA CA002223393A patent/CA2223393A1/fr not_active Abandoned
- 1996-06-03 CN CN96195888A patent/CN1192205A/zh active Pending
- 1996-06-05 ZA ZA9604692A patent/ZA964692B/xx unknown
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