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WO1996037605A3 - OLIGONUCLEOTIDES ANTISENS POUR BLOQUER LA SYNTHESE DU RECEPTEUR DE L'IgE - Google Patents

OLIGONUCLEOTIDES ANTISENS POUR BLOQUER LA SYNTHESE DU RECEPTEUR DE L'IgE Download PDF

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Publication number
WO1996037605A3
WO1996037605A3 PCT/FR1996/000785 FR9600785W WO9637605A3 WO 1996037605 A3 WO1996037605 A3 WO 1996037605A3 FR 9600785 W FR9600785 W FR 9600785W WO 9637605 A3 WO9637605 A3 WO 9637605A3
Authority
WO
WIPO (PCT)
Prior art keywords
sense oligonucleotides
ige receptor
anti sense
receptor synthesis
blocking ige
Prior art date
Application number
PCT/FR1996/000785
Other languages
English (en)
Other versions
WO1996037605A2 (fr
Inventor
Eduardo Pirotzky
Soudhir Colote
Original Assignee
Scras
Eduardo Pirotzky
Soudhir Colote
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scras, Eduardo Pirotzky, Soudhir Colote filed Critical Scras
Priority to EP96917549A priority Critical patent/EP0828827A2/fr
Priority to AU60082/96A priority patent/AU6008296A/en
Priority to US08/952,597 priority patent/US5892023A/en
Publication of WO1996037605A2 publication Critical patent/WO1996037605A2/fr
Publication of WO1996037605A3 publication Critical patent/WO1996037605A3/fr
Priority to NO975423A priority patent/NO975423D0/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/337—Chemical structure of the base in alpha-anomeric form
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des oligonucléotides antisens qui hybrident sélectivement avec un ou plusieurs gènes nécessaires à bloquer la synthèse du récepteur de l'IgE, des compositions pharmaceutiques les contenant et leur utilisation pour la préparation de médicaments pour le traitement d'allergies.
PCT/FR1996/000785 1995-05-26 1996-05-24 OLIGONUCLEOTIDES ANTISENS POUR BLOQUER LA SYNTHESE DU RECEPTEUR DE L'IgE WO1996037605A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP96917549A EP0828827A2 (fr) 1995-05-26 1996-05-24 OLIGONUCLEOTIDES ANTISENS POUR BLOQUER LA SYNTHESE DU RECEPTEUR DE L'IgE
AU60082/96A AU6008296A (en) 1995-05-26 1996-05-24 Anti sense oligonucleotides for blocking ige receptor synthe sis
US08/952,597 US5892023A (en) 1995-05-26 1996-05-24 Anti sense oligonucleotides for blocking IgE receptor synthesis
NO975423A NO975423D0 (no) 1995-05-26 1997-11-25 Anti-sense oligonukleotider for blokkering av IgE-reseptorsyntese

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9510718.1A GB9510718D0 (en) 1995-05-26 1995-05-26 Antisense oligonucleotides
GB9510718.1 1995-05-26

Publications (2)

Publication Number Publication Date
WO1996037605A2 WO1996037605A2 (fr) 1996-11-28
WO1996037605A3 true WO1996037605A3 (fr) 1996-12-27

Family

ID=10775100

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1996/000785 WO1996037605A2 (fr) 1995-05-26 1996-05-24 OLIGONUCLEOTIDES ANTISENS POUR BLOQUER LA SYNTHESE DU RECEPTEUR DE L'IgE

Country Status (7)

Country Link
US (1) US5892023A (fr)
EP (1) EP0828827A2 (fr)
AU (1) AU6008296A (fr)
CA (1) CA2222197A1 (fr)
GB (1) GB9510718D0 (fr)
NO (1) NO975423D0 (fr)
WO (1) WO1996037605A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2408011A1 (fr) 2000-05-04 2001-11-08 Avi Biopharma, Inc. Composition anti-sens a region d'epissage et methode associee
US8370542B2 (en) * 2002-09-16 2013-02-05 Commvault Systems, Inc. Combined stream auxiliary copy system and method
CA2532795A1 (fr) * 2003-08-07 2005-02-17 Avi Biopharma, Inc. Compose antiviral sens et methode permettant de traiter une infection virale induite par un arnss
US20050222068A1 (en) * 2003-10-23 2005-10-06 Mourich Dan V Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells
US20050171044A1 (en) * 2003-12-24 2005-08-04 Stein David A. Oligonucleotide compound and method for treating nidovirus infections
US20050234002A1 (en) * 2004-01-23 2005-10-20 Mourich Dan V Antisense oligomers and methods for inducing immune tolerance and immunosuppression
WO2005085443A2 (fr) * 2004-03-01 2005-09-15 Massachusetts Institute Of Technology Agents therapeutiques a base d'arni pour le traitement de la rhinite allergique et de l'asthme
ATE498685T1 (de) 2004-06-28 2011-03-15 Univ Western Australia Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon
USRE48960E1 (en) 2004-06-28 2022-03-08 The University Of Western Australia Antisense oligonucleotides for inducing exon skipping and methods of use thereof
CA2875436A1 (fr) * 2004-07-02 2006-08-17 Sarepta Therapeutics, Inc. Technique et compose antibacterien antisens
US8129352B2 (en) * 2004-09-16 2012-03-06 Avi Biopharma, Inc. Antisense antiviral compound and method for treating ssRNA viral infection
US8357664B2 (en) 2004-10-26 2013-01-22 Avi Biopharma, Inc. Antisense antiviral compound and method for treating influenza viral infection
US7524829B2 (en) * 2004-11-01 2009-04-28 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
US20060240032A1 (en) * 2005-03-31 2006-10-26 Hinrichs David J Immunomodulating compositions and methods for use in the treatment of human autoimmune diseases
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
US8329668B2 (en) * 2005-09-08 2012-12-11 Avi Biopharma, Inc. Antisense antiviral compound and method for treating picornavirus infection
WO2007030691A2 (fr) * 2005-09-08 2007-03-15 Avi Biopharma, Inc. Compose antisens antiviral et procede de traitement d'infection picornavirale
US8501704B2 (en) 2005-11-08 2013-08-06 Sarepta Therapeutics, Inc. Immunosuppression compound and treatment method
US8785407B2 (en) * 2006-05-10 2014-07-22 Sarepta Therapeutics, Inc. Antisense antiviral agent and method for treating ssRNA viral infection
SI2024499T1 (en) 2006-05-10 2018-04-30 Sarepta Therapeutics, Inc. Analogues of the oligonucleotide, with cationic links between subunits
US7989608B2 (en) * 2007-12-28 2011-08-02 Avi Biopharma Inc. Immunomodulatory agents and methods of use
EP3404100A1 (fr) 2008-10-24 2018-11-21 Sarepta Therapeutics, Inc. Compositions de saut d'exon multiples pour dmd
US8592386B2 (en) * 2008-12-17 2013-11-26 Sarepta Therapeutics, Inc. Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
EP3431603A1 (fr) 2009-11-12 2019-01-23 The University Of Western Australia Molécules antisens et procédés de traitement de pathologies
EP2499248B1 (fr) 2009-11-13 2017-01-04 Sarepta Therapeutics, Inc. Composé antiviral antisens et méthode de traitement d'une infection par le virus grippal
CN107353317A (zh) 2010-05-28 2017-11-17 萨勒普塔医疗公司 具有修饰的亚基间键和/或端基的寡核苷酸类似物
US8198429B2 (en) 2010-08-09 2012-06-12 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
WO2012031243A2 (fr) 2010-09-03 2012-03-08 Avi Biopharma, Inc. Molécules d'arnds comportant des analogues oligonucléotidiques ayant des liaisons entre sous-unités et/ou des groupes terminaux modifiés
CA2854907C (fr) 2011-11-18 2020-03-10 Sarepta Therapeutics, Inc. Oligonucleotides fonctionnellement modifies et sous-unites associees
IL280443B (en) 2013-03-14 2022-07-01 Sarepta Therapeutics Inc Exon skipping compositions for treating muscular dystrophy
EP2968991A2 (fr) 2013-03-15 2016-01-20 Sarepta Therapeutics, Inc. Compositions améliorées pour le traitement de la dystrophie musculaire
US11020417B2 (en) 2015-06-04 2021-06-01 Sarepta Therapeutics, Inc Methods and compounds for treatment of lymphocyte-related diseases and conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021317A1 (fr) * 1992-04-16 1993-10-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services ISOLATION, CARACTERISATION ET UTILISATION DE LA SOUS-UNITE HUMAINE β DU RECEPTEUR DE HAUTE AFFINITE POUR L'IMMUNOGLOBULINE E
WO1995009002A1 (fr) * 1993-09-30 1995-04-06 University Of Pennsylvania Methode d'inhibition de la phagocytose

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021317A1 (fr) * 1992-04-16 1993-10-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services ISOLATION, CARACTERISATION ET UTILISATION DE LA SOUS-UNITE HUMAINE β DU RECEPTEUR DE HAUTE AFFINITE POUR L'IMMUNOGLOBULINE E
WO1995009002A1 (fr) * 1993-09-30 1995-04-06 University Of Pennsylvania Methode d'inhibition de la phagocytose

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BHATTI, L. ET AL.: "Inhibition of B cell proliferation by antisense DNA to both alpha and beta forms of Fc epsilon R II.", CELL IMMUNOL, (1992 OCT 1) 144 (1) 117-30, XP000561855 *
FOURNIER, S. ET AL.: "Role for low-affinity receptor for IgE (CD23) in normal and leukemic B-cell proliferation.", BLOOD, (1994 SEP 15) 84 (6) 1881-6., XP000609085 *
FU-TONG, LIU ET AL.: "CDNA HETEROGENEITY SUGGESTS STRUCTURAL VARIANTS RELATED TO THE HIGH-AFFINITY IGE RECEPTOR", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 85, no. 15, pages 5639 - 5643, XP000005253 *
ZON, G.: "Oligonucleotide analogues as potential chemotherapeutic agents", PHARMACEUTICAL RESEARCH, VOL. 5 (1988); 539 - 549, XP002008915 *

Also Published As

Publication number Publication date
EP0828827A2 (fr) 1998-03-18
NO975423L (no) 1997-11-25
AU6008296A (en) 1996-12-11
CA2222197A1 (fr) 1996-11-28
US5892023A (en) 1999-04-06
NO975423D0 (no) 1997-11-25
GB9510718D0 (en) 1995-07-19
WO1996037605A2 (fr) 1996-11-28

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