WO1996037183A2 - Compositions capables de masquer les sensations du gout astringent - Google Patents
Compositions capables de masquer les sensations du gout astringent Download PDFInfo
- Publication number
- WO1996037183A2 WO1996037183A2 PCT/US1996/005896 US9605896W WO9637183A2 WO 1996037183 A2 WO1996037183 A2 WO 1996037183A2 US 9605896 W US9605896 W US 9605896W WO 9637183 A2 WO9637183 A2 WO 9637183A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- agents
- oral hygiene
- mouth
- masking
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 137
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- 235000019560 astringent taste sensations Nutrition 0.000 title claims abstract description 22
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- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical class [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 229940098695 palmitic acid Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 235000019809 paraffin wax Nutrition 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000012169 petroleum derived wax Substances 0.000 description 1
- 235000019381 petroleum wax Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 239000001259 polydextrose Substances 0.000 description 1
- 235000013856 polydextrose Nutrition 0.000 description 1
- 229940035035 polydextrose Drugs 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 229940098424 potassium pyrophosphate Drugs 0.000 description 1
- 229940114930 potassium stearate Drugs 0.000 description 1
- ANBFRLKBEIFNQU-UHFFFAOYSA-M potassium;octadecanoate Chemical compound [K+].CCCCCCCCCCCCCCCCCC([O-])=O ANBFRLKBEIFNQU-UHFFFAOYSA-M 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 229940093625 propylene glycol monostearate Drugs 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 150000003378 silver Chemical class 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 229940080350 sodium stearate Drugs 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229910001631 strontium chloride Inorganic materials 0.000 description 1
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 150000003445 sucroses Chemical class 0.000 description 1
- 150000003464 sulfur compounds Chemical class 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/90—Block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- compositions capable of masking astringent taste sensations are directed to compositions capable of masking astringent taste sensations. These composition may be employed in products containing certain materials that impart astringency, which products are intended for introduction into the mouth for purposes such as dietary, nutritional, medicinal, therapeutic, oral hygiene and the like.
- Zinc salts as dicationic ions, are capable of complexing with elements found in compounds which tend to cause the emanation of oral odors, such as sulfur compounds from garlic and onions. Zinc salts are also capable of adhering to the mucus membranes in the mouth. Such adherence prolongs their presence therein, and allows the dicationic zinc salts to be available for complexing with such odor-causing elements.
- manufacturers of oral hygiene products employ zinc salts as a breath freshening agent in certain products, such as mouthwashes and rinses, to assist in controlling bad breath.
- the amount so employed is ordinarily up to about 0.2%. It would be desirable to increase that amount to enhance the activity of the breath freshening agent in the mouth. By so doing, the breath freshening aspect of the oral hygiene product should be more effective and/or last for extended periods of time.
- zinc salts tend to impart an unpleasant and offensive astringent taste sensation that has been described as biting and drying. Hence, at levels greater than that, the astringent taste sensation is even more pronounced and unpleasant.
- anti-microbial agents like quaternary ammonium compounds
- quaternary ammonium compounds are also presently employed by manufacturers of oral hygiene products in certain of such products to assist in retarding dental plaque growth. It would also be desirable to increase the amount of those anti-microbial agents to provide a higher dosage and a more effective hygienic function in the mouth. However, at elevated levels, certain of those anti-microbial agents also tend to impart astringent taste sensations.
- breath freshening agents and/or anti-microbial agents in oral hygiene products to enhance the effectiveness and/or prolong the activity of those agents in the mouth without unpleasant and unwelcome temporal side effects.
- the need exists for a way to mask the unwanted temporal side-effects (e.g.. astringency) imparted by the breath freshening agents and/or anti- microbial agents contained in oral hygiene products, particularly where an increased dosage of those agents is desirably employed.
- the need also exists for a way to mask the unwanted temporal side-effects imparted by products containing certain poly-valent metal cations (like zinc salts) intended for introduction into the mouth and/or ingestion, such as in dietary and nutritional supplements, medicaments, and therapeutic and hygienic products.
- compositions capable of masking unpleasant astringent taste sensations, such as those experienced in the mouth after the introduction of certain materials therein.
- the compositions of this invention are prepared from the combination of a humectant component and a salt component.
- breath freshening agents e.g.. poly-valent metal cations like zinc compounds
- anti-microbial agents e.g.. benzoic acid compounds
- This invention also provides a method of using a composition comprising a humectant component and a salt component to mask astringent taste sensations associated with certain materials which have been introduced into the mouth.
- the masking compositions of this invention comprise a humectant component and a salt component, which, in combination, are capable of masking the astringency of certain breath freshening agents and/or anti-microbial agents when such agents are introduced into the mouth.
- the breath freshening agents are poly-valent metal cations.
- Poly-valent metal cations may also be introduced into the mouth as dietary and nutritional supplements, medicaments, or therapeutic and hygienic products.
- the compositions of this invention are well- suited to mask the astringency of these products when they too are introduced into the mouth.
- the humectant component in the masking compositions of this invention is included to counteract the residual dryness ordinarily experienced in the mouth after use of oral hygiene products containing elevated levels of certain breath freshening agents and/or anti-microbial agents that are astringent.
- Suitable humectants for use in these masking compositions include, for example, glycerin, sorbitol, propylene, mono- and di-glycerides of fatty acids, pectins and combinations thereof.
- Masking compositions prepared with glycerin as a humectant component have been described as leaving a "warming" feeling in the mouth after an oral hygiene product containing such masking compositions has been introduced into the mouth.
- Such masking compositions may, therefore, be suitably employed in products flavored, for instance, with wintergreen flavoring agents.
- Masking compositions prepared with sorbitol as a humectant component have been described as leaving a "cooling" feeling in the mouth after an oral hygiene product containing such masking compositions has been introduced into the mouth.
- Such masking compositions may, therefore, be suitably employed in products flavored, for instance, with mint flavoring agents.
- the salt component in the masking compositions is included therein to counter the residual biting feeling ordinarily experienced in the mouth after use of oral hygiene products containing elevated levels of certain breath freshening agents and/or anti-microbial agents that are astringent.
- Suitable salts for use in these masking compositions include, for example, sodium chloride, potassium chloride, sodium bicarbonate, potassium bicarbonate, sodium carbonate, potassium carbonate and combinations thereof.
- the poly-valent metal cations employed as breath freshening agents whose astringency may be effectively masked by the compositions of the present invention, particularly when employed at elevated levels, include, but are not limited to, zinc salts like zinc chloride, zinc salicylate and zinc gluconate, silver salts like silver nitrate and silver gluconate, and combinations thereof.
- the anti-microbial agents whose astringency may be effectively masked by the compositions of the present invention, particularly when employed at elevated levels, include benzoic acid and derivatives thereof, and other anti-microbial agents possessing similar taste attributes and combinations thereof. Still other anti-microbial agents commonly employed in oral hygiene products, which are said to contribute more of a bitter taste sensation than an astringent taste sensation may also benefit from the use of the masking compositions of this invention.
- Such anti-microbial agents include quaternary ammonium compounds such as alkyl pyridinium halides like cetyl pyridinium chloride, benzethonium chloride and benzalkonium chloride, bisbiguanides like chlorhexidene [1,1' -hexamethylenebis(5- (4- chlorophenyl)biguanide) ] and combinations thereof.
- quaternary ammonium compounds such as alkyl pyridinium halides like cetyl pyridinium chloride, benzethonium chloride and benzalkonium chloride, bisbiguanides like chlorhexidene [1,1' -hexamethylenebis(5- (4- chlorophenyl)biguanide) ] and combinations thereof.
- the humectant should be employed in an amount within the range of about 20% to about 50% by weight of the total weight of the vehicle chosen to deliver the active oral hygiene ingredients.
- the amount of the humectant itself should be within the range of from about 20 to about 40% by weight, with about 35% by weight being preferred, of the total weight of the oral hygiene product in which it is employed.
- the ratio of the humectant component to the salt in the masking composition should be within the range of from about 99.99-99.00% humectant to about 0.01-1.00% salt. Accordingly, the masking compositions of this invention are employed approximately within the ranges referred to above.
- the masking compositions of this invention may be employed in a variety of products, which products may be prepared in a variety of forms -- that is, the vehicle through which the active ingredients and other ingredients are introduced into the mouth. For instance, dietary, nutritional, medicinal, therapeutic and hygienic products may be administered in solid or liquid form. Because of the amount of humectant included in the masking compositions of this invention, it may be preferable to employ the inventive compositions of this application in a liquid delivery form. However, certain products in solid form may also benefit from the capabilities of the masking compositions of this invention, particularly when such solid products are dentifrices like pastes or gels (e.g. toothpastes or dental gels, respectively) , chewing gums, chewable confections or lozenges.
- dentifrices like pastes or gels e.g. toothpastes or dental gels, respectively
- the delivery vehicles may be chosen according to the desired purpose of administering such compounds -- e.g.. supplementing dietary and nutritional requirements, providing medicinal or therapeutic relief or providing oral hygiene treatments. Accordingly, the masking compositions of this invention, which effectively mask the unpleasant oral astringency associated with compounds administered for such purposes, should also be capable of being introduced into the mouth in the recited delivery vehicles.
- Liquid delivery vehicles such as mouthwashes, rinses, sprays and the like, may be used to introduce and deliver breath freshening agents and/or anti-microbial agents into mouth.
- liquid delivery vehicles may be used to deliver compounds, such as poly-valent cations like zinc salts, into the mouth for a variety of intended purposes, such as those described herein.
- the masking composition When a masking composition according to this invention is desirably included in a liquid vehicle for delivery into the mouth, the masking composition (or the individual components thereof) may be mixed with the particular oral hygiene ingredients, together with a liquid base to form a solution, suspension or dispersion.
- the liquid base may comprise water, ethanol, syrups and combinations thereof.
- a masking composition may be prepared by mixing together a humectant component and a salt component. Then sufficient water, ethanol, syrups or combinations thereof, may be added to the liquid mixture with mixing until reaching the desired volume. Other ingredients desirably delivered to the mouth may also be included at this stage of preparation.
- the suspensions may be prepared by conventional methods, such as admixing the thickener with water, and heating the mixture to a temperature within the range of from about 40°C to about 70°C. If the thickener is not water-soluble, a dispersion may form; if the thickener is water-soluble, a solution may form. Other ingredients desirably delivered to the mouth may be admixed with water. The masking composition (or the components thereof) may then be admixed with the thickener-water mixture until substantially uniformity is reached.
- the masking composition when a masking composition according to this invention is desirably included in dentifrice, like a paste or a gel, for delivery into the mouth, the masking composition (or the individual components thereof) may be mixed with a breath freshening agent and/or anti ⁇ microbial agent, or a poly-valent metal cation to be introduced for the herein-described purposes, together with a dentifrice base, such as a paste or gel base.
- the toothpaste or dental gel delivery vehicle generally comprises water typically in an amount within the range of from about 20 to about 40% by weight.
- Polyethylene glycol, polypropylene glycol, glycerin and combinations thereof may also be present in the delivery vehicle to serve as a humectant or a binder in an amount within the range of from about 20 to about 60% by weight.
- the composition may often include a gelling agent or a thickening agent, such as a natural or synthetic gum or gelatin like hydroxyethyl cellulose, cellulose, methyl cellulose, glycerin, carboxypolymethylene, gelatin and the like, and combinations thereof. Gelling agents or thickening agents may be used in an amount within the range from about 0.1 to about 25% by weight.
- Such toothpaste or dental gel compositions containing a masking composition according to this invention may also contain conventional additives such as polishing agents, abrasive agents, desensitizing agents and the like.
- polishing agent in paste form, calcium carbonate or calcium dihydrate may be used as a polishing agent.
- colloidal silica and/or alkali metal aluminosilicate complexes may be employed as a polishing agent since these materials have refractive indices similar to the refractive indices of the gelling systems commonly used in dental gels. These polishing agents may be used in an amount up to about 25% by weight of the toothpaste or dental gel composition.
- the present invention extends to methods for preparing such toothpaste or dental gel compositions.
- the toothpaste or dental gel compositions may be prepared by admixing an effective amount of a masking composition and a toothpaste or dental gel base using conventional methods and apparatus.
- toothpastes or dental gels containing a masking composition according to this invention may be prepared by dispersing a gelling agent in a humectant (either a humectant different from that employed in the masking composition or an additional portion of the humectant so employed in the masking composition) , - 11 -
- a humectant either a humectant different from that employed in the masking composition or an additional portion of the humectant so employed in the masking composition
- This dispersion should be admixed with an aqueous solution of other ingredients, such as sweeteners, fluorine-providing compounds and the like.
- a polishing agent and a flavoring agent may then be admixed therewith.
- the masking composition (or the individual component thereof) may be admixed therewith.
- the prepared toothpaste or dental gel composition may then be tubed or otherwise packaged.
- the liquid components and solid components in such a product should be proportioned to form a creamy or gelled mass which may be extruded from a pressurized container, from a collapsible tube or from other suitable containing dispensers, such as pumps, though limited to those pumps now commercially available.
- compositions of this invention may be used to mask the astringent taste sensations experienced from such breath freshening agents and/or anti-microbial agents, or poly-valent metal cations, that are to be introduced into the mouth in such form.
- acceptable stability and quality, as well as good taste and organoleptic properties are desirable.
- Chewable confection may be prepared by procedures well- known to those skilled in the art. See e.g..
- the masking compositions of this invention may be admixed with the chewable confection base at an appropriate interval during preparation thereof.
- Lozenges are intended to be convenient portable solid dosage forms. Lozenges may be produced in a variety of shapes such as flat, circular, octagonal and biconvex forms. Lozenge bases are generally in two forms: hard boiled candy lozenges and compressed tablet lozenges.
- the lozenge composition may comprise for instance, a breath freshening agent and/or an anti ⁇ microbial agent or an amount of a poly-valent metal cation effective to provide the chosen function of the lozenge and a masking composition according to this invention together with a lozenge base.
- the lozenge composition should comprise an amount of the masking composition, which is effective to mask the astringent sensation experienced from such agents or cations when the lozenge is introduced into the mouth, and as it dissolves therein over time.
- Lozenge formulations generally are well-known, as are their methods of preparation. See e.g.. Remington's.
- the masking composition When a masking composition according to this invention is desirably delivered into the mouth in the form of a chewing gum, the masking composition (or the individual components thereof) may be mixed with a breath freshening agent and/or an anti-microbial agent, or a poly-valent metal cation to be introduced for the herein-described purposes, together with a gum base. - 13 -
- the gum base may be any conventional water-insoluble gum base, which includes those gum bases utilized for chewing gums and bubble gums.
- Illustrative examples include, without limitation, natural and synthetic polymeric materials like elastomers and rubbers.
- polymeric materials suitable as gum bases include substances of vegetable origin such as chicle, crown gum, nispero, rosadinha, jelutong, perillo, niger gutta, tunu, balata, gutta-percha, lechi-capsi, sorva, gutta kay and the like; synthetic elastomers such as butadiene-styrene copolymers, polyisobutylene, isobutylene-isoprene copolymers, polyethylene and the like; and combinations thereof.
- Bulking agents suitable for use in gum bases include monosaccharides, disaccharides, polysaccharides, sugar alcohols, polydextrose, maltodextrins, minerals (such as calcium carbonate, talc, titanium dioxide, dicalcium phosphate and the like) and combinations thereof. Bulking agents may be used in the gum base in an amount up to about 90% by weight of the final chewing gum composition, with an amount within the range of from about 40% to about 70% by weight being desirable and about 50% to about 65% being more desirable.
- the gum base may also contain a variety of traditional ingredients desirable to modify the texture and/or consistency or other properties of the final chewing gum product.
- These ingredients include plasticizers or softeners like lanolin, palmitic acid, oleic acid, stearic acid, sodium stearate, potassium stearate, glyceryl triacetate, glyceryl lecithin, glyceryl monostearate, propylene glycol monostearate, acetylated monoglyceride, glycerine, polyethylene glycol, glycerol, sorbitol, dioctyl-sodium sulfosuccinate, triethyl citrate, tributyl citrate, 1,2- propyleneglycol, mono-, di-, tri-acetates of glycerol and the like, and combinations thereof.
- plasticizers or softeners like lanolin, palmitic acid, oleic acid, stearic acid, sodium
- waxes e.g.. natural and synthetic waxes like petroleum waxes, such as polyurethane waxes, polyethylene waxes, paraffin waxes, microcrystalline waxes and fatty waxes
- vegetable oils e.g.. coconut oil, palm kernel oil and the like
- sorbitan monostearate e.g.. coconut oil, palm kernel oil and the like
- animal fats e.g.. tallow and the like
- propylene glycol and the like may also be desirable to modify the texture and/or consistency or other properties of the final chewing gum product.
- plasticizers may be used in an amount up to about 25%, and preferably in an amount within the range of from about 1% to about 17%, by gum base.
- the present invention extends to methods of making the chewing gum compositions.
- the masking composition may be incorporated into an otherwise conventional chewing gum using standard techniques and equipment known to those skilled in the art.
- Chewing gum bases may be prepared by batch methods. Such methods generally involve mixing and melting the components of the gum base in kettle mixers in numerous stages, placing the resulting homogenous mass on trays to be cooled, dried and thereafter transferred for incorporation into a chewing gum.
- Chewing gum bases may also be prepared by continuous processes, such as with a twin screw extruder. See U.S. Patent Nos. 4,555,407; 5,045,325; and 5,135,760, the disclosures of each of which are hereby incorporated herein by reference.
- an appropriate chewing gum base may be chosen and heated to a temperature sufficiently high to soften the base without adversely affecting the physical and chemical properties and characteristics of the base. While the optimum temperatures may vary depending upon the composition of the chewing gum base, such temperatures may be readily determined by those skilled in the art without undue experimentation.
- the gum base may be heated at a temperature within the range of from about 60°C to about 120°C for a period of time sufficient to soften and render it molten.
- the chewing gum base may be heated under these conditions for a period of time of about thirty minutes just prior to being admixed incrementally with the remaining ingredients of the base.
- the chewing gum base may then be blended with the masking composition according to this invention (or the individual components thereof) and other ingredients desirably delivered to the mouth. Mixing may be continued until a substantially uniform chewing gum composition is obtained. Thereafter, the chewing gum composition may be formed into shapes desirable for chewing gum.
- the chewing gum composition may be prepared with a liquid-filled center, which contains a breath freshening agent and/or an anti-microbial agent together with at least a masking composition according to this invention.
- the liquid-filled center of the chewing gum may contain one of the breath freshening agent and/or the anti-microbial agent or the masking composition, and the other contained in the chewing gum base itself, or vice versa.
- any conventional ingredient for oral hygiene treatments may be employed in the present invention, provided it is stable within the formulation and does not react adversely with any of the components of the formulations.
- active oral hygiene ingredients include plaque-loosening and/or plaque- removing ingredients; ingredients which retard plaque growth; fluoride-releasing ingredients to fight tooth decay; ingredients to prevent or minimize gingivitis; breath freshening ingredients; anti-microbial agents to prevent or minimize microbial infection in the oral cavity; desensitizing agents; tartar-control agents and combinations thereof.
- Plaque-loosening ingredients and/or plaque removing ingredients suitable for use herein as an oral hygiene treatment include abrasives such as dicalcium phosphate, silicon dioxide, calcium carbonate, aluminosilicates, sodium bicarbonate and the like, and combinations thereof.
- Plaque-retarding ingredients suitable for use herein as an oral hygiene treatment include the combination of thymol, menthol, eucalyptol and methyl salicylate (the active essential oil ingredients in LISTERINE ® antiseptic mouth rinses, which mouth rinses are readily available commercially and are manufactured by Warner- Lambert Co., Morris Plains, New Jersey), quaternary ammonium compounds like alkyl pyridinium halides (e.g.. cetyl pyridinium chloride, benzethonium chloride and benzalkonium chloride and the like), triclosan (2,4,4'- trichloro-2-hydroxydiphenyl ether) and combinations thereof.
- alkyl pyridinium halides e.g.. cetyl pyridinium chloride, benzethonium chloride and benzalkonium chloride and the like
- triclosan 2,4,4'- trichloro-2-hydroxydiphenyl ether
- Fluoride-releasing ingredients are compounds characterized by their ability to release fluoride ions or fluoride-containing ions. Due to chemical instability of many fluoride-releasing compounds at acid pH values, these compounds are generally used in alkaline delivery vehicles to provide their intended treatment.
- Suitable fluoride-releasing compounds for use herein as an oral hygiene treatment include inorganic fluoride salts, such as water-soluble alkali metal salts, alkaline earth metal salts and heavy metal salts, such as sodium fluoride, potassium fluoride, stannic fluoride, stannous fluoride, barium fluoride, sodium fluorosilicate, ammonium fluorosilicate, sodium fluorozirconate, sodium monofluorophosphate, aluminum mono- and di-fluorophosphates, fluorinated sodium calcium pyrophosphate and combinations thereof.
- inorganic fluoride salts such as water-soluble alkali metal salts, alkaline earth metal salts and heavy metal salts, such as sodium fluoride, potassium flu
- Anti-gingivitis ingredients suitable for use herein as an oral hygiene treatment include the combination of thymol, menthol, eucalyptol and methyl salicylate (the active essential oil ingredients in LISTERINE ® antiseptic mouth rinses) , and bisbiguanides (like chlorhexidine) .
- Breath fresheners suitable for use herein as an oral hygiene treatment include zinc salts (like zinc chloride, zinc gluconate, zinc salicylate and the like) , copper salts (like copper gluconate and the like) and combinations thereof.
- Anti-microbial agents suitable for use herein as an oral hygiene treatment include the combination of thymol, menthol, eucalyptol and methyl salicylate (the active essential oil ingredients in LISTERINE ® antiseptic mouth rinses) , benzoic acid and derivatives thereof, quaternary ammonium compounds like those noted above, bisbiguanides, triclosan and combinations thereof.
- Desensitizing ingredients suitable for use herein as an oral hygiene treatment include stannous fluoride, citric acid and salts (e.g. , sodium) thereof, potassium nitrate, strontium chloride, calcium phosphate and combinations thereof.
- Tartar-control agents suitable for use herein as an oral hygiene treatment include stannous fluoride, pyrophosphates like tetra-sodium pyrophosphate, sodium pyrophosphate, calcium pyrophosphate and potassium pyrophosphate.
- Hydrogen peroxide and/or sodium bicarbonate may also be included in the oral hygiene products containing the masking composition of this invention to provide an oral hygiene treatment, without the astringency associated with many oral hygiene ingredients.
- additives may also be included.
- additives include orally-acceptable solvents, sweeteners, flavoring agents, anti-foaming agents, humectants, lubricants, dyes or coloring agents, preservatives or shelf-life enhancing agents, organoleptic consistency modifiers or bioadhesives
- Orally-acceptable solvents such as ethyl alcohol, propylene glycol, polyethylene glycol and the like may be used to dissolve the flavoring agents and the active oral hygiene ingredients.
- orally- acceptable solvents may be used in an amount up to about 30% by weight, with about 2% to about 5% being desirable.
- Surfactants may also be used herein to act as solubilizers.
- Surfactants desirably reduce surface tension when dissolved in water or reduce interfacial tension between two liquid components or a liquid component and a solid component.
- the surfactants may be nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants and combinations thereof.
- Suitable surfactants include, but are not limited to, those in the family known as TWEENs and PLURONICs, and may also be found listed and described in McCutcheon's Emulsifiers and Detergents. North American ed. (1988) .
- sweetening agents in any of the forms of delivery vehicles in which the masking composition of this invention may be included. While certain sweeteners may be more desirable when used in one form of delivery vehicle than another, such sweeteners well known in the art, including both natural and alternative sweeteners, may be employed herein with one of ordinary skill in the art making appropriate choices of among those sweeteners.
- the sweeteners suitable for use herein may be selected from water-soluble sweeteners, water- soluble alternative sweeteners, water-soluble sweeteners derived from naturally-occurring water- soluble sweeteners, dipeptide-based sweeteners, protein-based sweeteners, sugar alcohols and combinations thereof.
- sweeteners Without being limited to particular sweeteners, representative classes and examples of such include:
- water-soluble sweeteners such as monosaccharides, disaccharides and polysaccharides [like xylose, ribose, glucose (dextrose) , mannose, galactose, fructose (levulose) , sucrose (sugar) and maltose] , invert sugar (a mixture of fructose and glucose derived from sucrose) , partially hydrolyzed starch, corn syrup solids, dihydrochalcones, monellin, steviosides, glycyrrhizin and combinations thereof;
- water-soluble sweeteners such as monosaccharides, disaccharides and polysaccharides [like xylose, ribose, glucose (dextrose) , mannose, galactose, fructose (levulose) , sucrose (sugar) and maltose] , invert sugar (a mixture of fructose and glucose derived from sucrose) , partially hydrolyze
- water-soluble alternative sweeteners such as saccharin and salts (e.g.. sodium, calcium or potassium) thereof, cyclamate salts (e.g.. sodium or calcium cyclamate salts) , sodium, ammonium or calcium salts of 3,4-dihydro-6-methyl-l-2,3-oxathiazine-4-one- 2,2-dioxide, potassium salt of 3,4-dihydro-6-methyl- l,2,3-oxathiazine-4-one-2,2-dioxide (known under the designation ACESULFAME-K) and combinations thereof;
- saccharin and salts e.g.. sodium, calcium or potassium
- cyclamate salts e.g. sodium or calcium cyclamate salts
- sodium, ammonium or calcium salts sodium, ammonium or calcium salts of 3,4-dihydro-6-methyl-l-2,3-oxathiazine-4-one- 2,2-dioxide
- dipeptide-based sweeteners such as L-aspartic acid derived alternative sweeteners like ot-L-aspartyl- L-phenylalanine methyl ester (commercially available from the Nutrasweet Company under the trademark ASPARTAME ® ) , c_-L-aspartyl-N- (2,2,4,4-tetramethyl-3- thietanyl) -D-alanin-amide hydrate (known under the designation ALITAME) , and methyl esters of C.-L- aspartyl-L-phenylglycine, ⁇ -L-aspartyl-L-2,5- dihydropheny1-glycine, ⁇ -L-asparty1-2,5-dihydro-L- phenylalanine, ⁇ -L-aspartyl-L- (1-cyclohexen) -alanine and combinations thereof;
- L-aspartic acid derived alternative sweeteners like ot-L-aspartyl-
- water-soluble sweeteners derived from naturally occurring water-soluble sweeteners, such as chlorinated sucrose derivatives -- e.g.. chlorodeoxysucrose or chlorodeoxygalactosucrose (known under the designation SUCRALOSE) ;
- protein-based sweeteners such as thaumaoccous danielli (Thaumatin I and II) ;
- sugar alcohols such as sorbitol, xylitol, inositol, maltitol, mannitol and combinations thereof.
- sugar alcohols such as sorbitol, xylitol, inositol, maltitol, mannitol and combinations thereof.
- combinations of sweeteners across these classifications may also be used.
- a sufficient amount of sweetener should be used to provide the level of sweetness desired in the particular composition.
- the amount of sweetener chosen may be within the range from about 0.0025% to about 90% by weight, depending of course on the particular sweetener, its physical properties and characteristics and the level of sweetness desired.
- Flavoring agents may also be used herein, including natural flavors and natural flavor mimetics. Indeed, any flavoring agent generally recognized as safe for food and drug application may be used herein. Suitable flavoring agents include mints (such as peppermint and spearmint) , anethole, citrus flavors (such as orange and lemon) , vanilla, cinnamon, various fruit flavors (such as cherry and apple) and the like. The amount of flavoring agent may vary depending of course on the specific flavoring agent, its physical properties or characteristic and the intensity of the flavor imparted. Flavor enhancers, such as monoammoniumglycyrrhizinate, may also be advantageously employed herein.
- the amount of sweetener and/or flavoring agent employed in the compositions of this invention is a matter of preference subject to such factors as the type of composition and delivery vehicle thereof, the rapidity of delivery of the particular sweetener and/or flavoring agent employed and the intensity desired.
- Anti-foaming agents such as dimethyl polysiloxane, may be advantageously used herein.
- the anti- foaming agent should be employed in an amount up to about 0.2% by weight, with about 0.01% to about 0.1% being desirable.
- Suitable humectants useful herein include glycerin, sorbitol, mono- and di-glycerides of fatty acids, propylene glycol, pectins and the like, and combinations thereof. When used, humectants may be employed in an amount within the range of from about 1% to about 35% by weight.
- Suitable lubricants include lipids (like oils and fats) , euricamide, waxes and phospholipids (like unsaturated and saturated fatty acids and salts thereof, such as aluminum, calcium, magnesium and tin stearates) , silicones and the like may be used in an amount within the range of from about 0.001 to about 10% by weight.
- Suitable dyes or coloring agents may also be advantageously employed herein.
- these dyes or coloring agents include titanium dioxide, silicon dioxide, coloring agents, such as azo-dyes and other dyestuffs and pigments as iron oxides, titanium dioxides, natural dyes and the like may be used in an amount within the range of from about 0.001 to about 10% based upon the weight of the composition.
- Preservatives or shelf-preservation agents such as butylated hydroxyanisole (BHA) , butylated hydroxytoluene (BHT) , parabens like methyl paraben and propyl paraben, tocopherols and the like, and combinations thereof may be employed herein.
- BHA butylated hydroxyanisole
- BHT butylated hydroxytoluene
- parabens like methyl paraben and propyl paraben parabens like methyl paraben and propyl paraben
- tocopherols and the like and combinations thereof
- the preservatives should generally be present in an amount up to about 1% by weight, with about 0.05% to about 0.5% being desirable.
- Suitable organoleptic consistency modifiers or bioadhesives include suspending agents, gelling agents or thickening agents such as cellulosics like methylcellulose, carrageenans like alginic acid and derivatives thereof, xanthan gums, gelatin, acacias and microcrystalline cellulose.
- Such organoleptic consistency modifiers may be used herein in an amount up to about 20% by weight, with about 1% to about 15% being desirable.
- a masking composition prepared according to the present invention, about 1 gram of sodium chloride as a salt was added to about 350 grams of glycerin as a humectant with stirring at room temperature.
- This masking composition may be stored indefinitely, and may also be used as a master batch for oral hygiene products containing the masking compositions.
- three mouth rinse samples were prepared, with each containing a component that is known to impart an astringent sensation to mouth.
- zinc gluconate about 6.7 grams/liter
- benzoic acid about 3 grams/liter
- both zinc gluconate about 6.7 grams/liter
- benzoic acid about 3 grams/liter
- the mouth rinse base for each sample was prepared from the following components: peppermint oil (about 1.5 grams/liter), spearmint oil (about 0.4 grams/liter), anethole (about 0.1 grams/liter), PLURONIC F-127 (about 12 grams/liter) , TWEEN 20 (about 2 grams/liter) and monoammoniumglycyrrhizinate (about 0.7 grams/liter), in addition to the astringency-imparting component. Water was then added to bring these components to a volume of about 1 liter.
- the pH value of each of the samples was adjusted to about 3.8 through the addition of either 1 N NaOH or IN HC1.
- To the first sample about 6.5 mis of IN HC1 was added to bring the pH value from its initial value of about 4.9 to a value of about 3.8. This sample was observed to be cloudy.
- To the second sample about 5 mis of IN NaOH was added to bring the pH value from its initial value of about 3.1 to a value of about 3.8. This sample was also observed to be cloudy.
- the third sample was determined to have a pH value of about 3.88; hence, no adjustment to the pH value was made. This sample was also observed to be cloudy.
- An astringency rating system was established whereby a rating of zero indicates no detectable astringent sensation, and as one proceeds toward the other end of the scale an astringent sensation in an increasingly greater amount was detected.
- Three mouth rinse samples were prepared as above, except that to each was added prior to dilution to 1 liter the masking composition of the present invention -- e.g.. about 1 gram of sodium chloride and about 350 grams of glycerin.
- each of the masking composition- containing samples was adjusted to about 3.8 through the addition of either 1 N NaOH or IN HC1.
- To the first masking composition-containing sample about 7.5 mis of IN HC1 was added to bring the pH value from its initial value of about 5.1 to a value of about 3.9.
- To the second masking composition-containing sample about 3.5 mis of IN NaOH was added to bring the pH value from its initial value of about 3.2 to a value of about 3.8. This sample was observed to be cloudy.
- about 4 mis of IN HC1 was added to bring the pH value from its initial value of about 4 to a value of about 3.8. This sample was also observed to be cloudy.
- mouth rinse samples were prepared based upon known commercial mouth rinses.
- zinc gluconate about 6.7 grams/liter
- the mouth rinse base for the first sample was prepared from the following components: glycerin (about 70 grams/liter), peppermint oil (about 1.5 grams/liter) , spearmint oil (about 0.4 grams/liter), anethole (about 0.1 grams/liter) , PLURONIC F-127 (about 7 grams/liter) and u.s.p alcohol (150 mis), in addition to the breath freshening agent.
- the mouth rinse base for the second sample was prepared from the following components: glycerin (about 160 grams/liter) , peppermint oil (about 1.5 grams/liter), spearmint oil (about 0.4 grams/liter), anethole (about 0.1 grams/liter), PLURONIC F-127 (about 7 grams/liter) and u.s.p alcohol (150 mis), in addition to the breath freshening agent. Water was then added to each sample bring these components to a volume of about 1 liter.
- the pH value of each sample was adjusted to about 3.8 through the addition of IN HCl.
- To the first sample about 7.5 mis of IN HCl was added to bring the pH value from its initial value of about 5.6 to a value of about 3.8.
- To the second sample about 8 mis of IN HCl was added to bring the pH value from its initial value of about 5.7 to a value of about 3.8.
- Two mouth rinse samples were prepared as above, except that to each was added prior to dilution to 1 liter the masking composition of the present invention -- e.g.. about 1 gram of sodium chloride and about 350 grams of glycerin -- from Example 1, supra.
- the masking composition of the present invention e.g.. about 1 gram of sodium chloride and about 350 grams of glycerin -- from Example 1, supra.
- each of these masking composition- containing samples was adjusted to about 3.8 through the addition of about 9 mis of IN HCl.
- the addition of the HCl to the first masking composition-containing sample brought the pH value from its initial value of about 5.8 to a value of about 3.8.
- the addition of the HCl to the second masking composition-containing sample brought the pH value from its initial value of about 5.8 to a value of about 3.8.
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Abstract
Cette invention concerne des compositions qui peuvent masquer les sensations du goût astringent ressenties suite à l'introduction dans la bouche d'agents rafraîchissant l'haleine et/ou d'agents antimicrobiens, ou de certaines matières apportant une assistance dans les domaines de la diététique, de la nutrition, de l'hygiène buccale, ou lors de traitements médicinaux et thérapeutiques et dans d'autres domaines analogues.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU56688/96A AU5668896A (en) | 1995-05-26 | 1996-04-26 | Compositions capable of masking astringent taste sensations |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45184495A | 1995-05-26 | 1995-05-26 | |
US08/451,844 | 1995-05-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1996037183A2 true WO1996037183A2 (fr) | 1996-11-28 |
WO1996037183A3 WO1996037183A3 (fr) | 1997-03-13 |
Family
ID=23793926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/005896 WO1996037183A2 (fr) | 1995-05-26 | 1996-04-26 | Compositions capables de masquer les sensations du gout astringent |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU5668896A (fr) |
WO (1) | WO1996037183A2 (fr) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998037859A1 (fr) * | 1997-02-28 | 1998-09-03 | Fertin A/S | Composition orale indiquee pour l'hygiene bucco-dentaire et les soins dentaires |
WO1999051093A1 (fr) * | 1998-04-06 | 1999-10-14 | Innoscent Ltd. | Compositions orales antimicrobiennes et anti-odeurs |
WO2000057699A1 (fr) * | 1999-03-25 | 2000-10-05 | Innoscent Ltd. | Compositions orales anti-odeurs |
WO2002091846A1 (fr) * | 2001-05-15 | 2002-11-21 | The Procter & Gamble Company | Compositions de confiseries |
EP0920857A3 (fr) * | 1997-11-06 | 2003-01-02 | Dentaid, S.A. | Composition orale pour le traitement de la mauvaise haleine |
EP1043937A4 (fr) * | 1997-12-30 | 2004-05-12 | Wrigley W M Jun Co | Procede permettant de reguler la liberation d'agents antimicrobiens dans une gomme a macher et gomme a macher produite selon ce procede |
US6955827B2 (en) | 1997-12-30 | 2005-10-18 | Wm. Wrigley Jr. Company | Method of controlling release of antimicrobial agents in chewing gum |
WO2007012847A1 (fr) * | 2005-07-27 | 2007-02-01 | Psimedica Ltd | Aliment contenant du silicium |
EP1353653A4 (fr) * | 2000-12-27 | 2008-10-29 | Wrigley W M Jun Co | Chewing-gums et produits relatifs conferant des caracteristiques purificatrices de l'haleine |
WO2012060837A1 (fr) * | 2010-11-04 | 2012-05-10 | Colgate-Palmolive Company | Composition de dentifrice présentant une astringence réduite |
US8778311B2 (en) | 2006-03-22 | 2014-07-15 | The Procter & Gamble Company | Oral zinc compositions |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE393532B (sv) * | 1974-05-02 | 1977-05-16 | Draco Ab | Sett att framstella en farmaceutisk zinkberedning for astadkommande av en smaklig, fordragbar, peroral zinklosning innehallande ett zinkkomplex |
CA1139229A (fr) * | 1979-06-20 | 1983-01-11 | Thomas W. Ritchey | Sel de zinc avec de la glycine pour compositions orales |
JPS63135322A (ja) * | 1986-11-26 | 1988-06-07 | Sunstar Inc | 歯磨組成物 |
US4992259A (en) * | 1990-01-03 | 1991-02-12 | Johnson & Johnson Consumer Products, Inc. | Stable oral composition of zinc |
GB9411747D0 (en) * | 1994-06-11 | 1994-08-03 | Boots Co Plc | Oral hygiene composition |
-
1996
- 1996-04-26 AU AU56688/96A patent/AU5668896A/en not_active Abandoned
- 1996-04-26 WO PCT/US1996/005896 patent/WO1996037183A2/fr active Application Filing
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998037859A1 (fr) * | 1997-02-28 | 1998-09-03 | Fertin A/S | Composition orale indiquee pour l'hygiene bucco-dentaire et les soins dentaires |
EP0920857A3 (fr) * | 1997-11-06 | 2003-01-02 | Dentaid, S.A. | Composition orale pour le traitement de la mauvaise haleine |
EP1043937A4 (fr) * | 1997-12-30 | 2004-05-12 | Wrigley W M Jun Co | Procede permettant de reguler la liberation d'agents antimicrobiens dans une gomme a macher et gomme a macher produite selon ce procede |
US6955827B2 (en) | 1997-12-30 | 2005-10-18 | Wm. Wrigley Jr. Company | Method of controlling release of antimicrobial agents in chewing gum |
WO1999051093A1 (fr) * | 1998-04-06 | 1999-10-14 | Innoscent Ltd. | Compositions orales antimicrobiennes et anti-odeurs |
WO2000057699A1 (fr) * | 1999-03-25 | 2000-10-05 | Innoscent Ltd. | Compositions orales anti-odeurs |
EP1353653A4 (fr) * | 2000-12-27 | 2008-10-29 | Wrigley W M Jun Co | Chewing-gums et produits relatifs conferant des caracteristiques purificatrices de l'haleine |
WO2002091846A1 (fr) * | 2001-05-15 | 2002-11-21 | The Procter & Gamble Company | Compositions de confiseries |
WO2007012847A1 (fr) * | 2005-07-27 | 2007-02-01 | Psimedica Ltd | Aliment contenant du silicium |
US8778311B2 (en) | 2006-03-22 | 2014-07-15 | The Procter & Gamble Company | Oral zinc compositions |
WO2012060837A1 (fr) * | 2010-11-04 | 2012-05-10 | Colgate-Palmolive Company | Composition de dentifrice présentant une astringence réduite |
Also Published As
Publication number | Publication date |
---|---|
WO1996037183A3 (fr) | 1997-03-13 |
AU5668896A (en) | 1996-12-11 |
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