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WO1996032973A1 - Dispositif d'injection de medicament a plusieurs cartouches - Google Patents

Dispositif d'injection de medicament a plusieurs cartouches Download PDF

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Publication number
WO1996032973A1
WO1996032973A1 PCT/US1996/005367 US9605367W WO9632973A1 WO 1996032973 A1 WO1996032973 A1 WO 1996032973A1 US 9605367 W US9605367 W US 9605367W WO 9632973 A1 WO9632973 A1 WO 9632973A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
drive
leadscrew
rotation
injection position
Prior art date
Application number
PCT/US1996/005367
Other languages
English (en)
Inventor
Gerhard E. F. Pawelka
Christopher J. Stringer
Matthew Marsh
David L. Karshmer
Christopher O. Lada
Stephen J. Schoenberg
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Priority to JP8531902A priority Critical patent/JPH10506827A/ja
Priority to AU56648/96A priority patent/AU5664896A/en
Publication of WO1996032973A1 publication Critical patent/WO1996032973A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/31581—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by rotationally moving or pivoting actuator operated by user, e.g. an injection lever or handle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A61M2205/585—Means for facilitating use, e.g. by people with impaired vision by visual feedback having magnification means, e.g. magnifying glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed

Definitions

  • the present invention relates generally to devices for injecting two or more medications simultaneously and, more particularly, to a medication injection device having improved dose setting and injection capabilities.
  • the treatment of diabetes is one such example.
  • an intermediate acting insulin such as isophene insulin
  • ultralente a longer acting type of insulin called ultralente is available.
  • the insulin user injects different ratios or combinations of these insulins several times daily.
  • injection devices in which separate cartridges of a desired medication are housed. It is desirable that both medications be delivered to a patient through a single needle instead of two or more needles.
  • injection devices have a manifold assembly that enables the medications to be mixed together prior to injection.
  • This patent asserts a dispenser for injecting variable mixed proportions of NPH and regular human insulin.
  • the dosages of each medication are set prior to delivery. Dosing is achieved by rotating a dose knob to translate a dosage adjuster to a retracted position. The second dosage knob is adjusted in a similar manner.
  • the dosage adjusters are coupled to a sliding body. After the appropriate dosages are set, the sliding body is forced forwardly, which causes the drive stems to translate forwardly. Since the drive stems are connected to pistons within each medication cartridge, movement of the drive stems drives the pistons forward to expel liquid from the cartridges. The forward stroke of the sliding body is limited by the distance set by the dosage adjusters.
  • Another type of dual medication injection device is proposed in PCT International Application No. PCT/US93/11044.
  • dosage knobs are rotated to translate the dosage adjusters to their retracted positions. Movement of the dosage adjusters compresses springs, which engage flanges on the adjusters. This compression preloads the drive stems so that moving the needle assembly from the predelivery position to the delivery position causes the dosages of pharmaceutical to be automatically driven from the pharmaceutical chambers, past the check valves and through the doubled ended needle cannula.
  • the present invention provides in one embodiment thereof a hand-held liquid medication delivery device capable of simultaneously delivering at least two medication products.
  • the medication products are housed in variable volume containers or cartridges within the mechanism housing of the device.
  • Each cartridge contains a liquid medication between a piston and an exit end.
  • the medication delivery device includes independent bidirectional dosage metering mechanisms for permitting a variable dosage amount of each liquid medication to be set prior to delivery.
  • a delivery mechanism is provided for simultaneously axially advancing piston-engaging stems to engage and axially advance the pistons in the cartridges to effect delivery of the medications into a manifold at the distal end of the device.
  • the medications are mixed within a valved mixing chamber in the manifold, and the mixed product is delivered through a single delivery needle extending from the manifold.
  • a lock and pullback mechanism incorporated into the delivery device automatically prevents the cartridges from being removed from the housing while the injection actuator is in a metering or pre-injection position. The cartridges are replaced after the contents thereof have been exhausted.
  • the present invention provides a medication delivery device having a dosage metering mechanism for setting a dosage of liquid medication to be delivered prior to injection.
  • the dosage metering mechanism includes a knob and indicator dial which function as a single component that is rotatable with respect to the mechanism housing.
  • the mechanism includes an indicator bearing that is locked to the housing.
  • a torsion spring is loaded between the knob and the bearing.
  • the knob/indicator dial is coupled to a movable element on the drive mechanism.
  • the spring is tensed, and a dosage is indicated by a numeral on the indicator dial appearing in a window in the housing.
  • the movable element Upon actuating the delivery mechanism, the movable element is moved out of engagement with knob/indicator dial, thereby enabling the spring to automatically rotate the indicator dial back to a zero dose position.
  • a multi- component medication delivery device having a drive mechanism for simultaneously delivering a set dosage of each injectable product.
  • An elongated tubular element or nut and a drive stem is associated with each liquid medication to be delivered.
  • a driver or carrier is secured to each nut.
  • Each driver is pivotally secured to a hand-operated actuator via side plates.
  • each of the drivers are simultaneously driven forwardly carrying the nut and drive stem therealong.
  • the drive stems engage and axially advance their respective pistons to force the respective set dosages of liquid medications into the manifold and out through the delivery needle.
  • the present invention further provides in one form thereof a liquid medication delivery device having a lock and pullback mechanism which prevents the drive stems or leadscrews from rotating during metering and injection. This mechanism also prevents the cartridges from being changed during metering and injection.
  • the lock and pullback mechanism includes a pullback key having an opening matching the shape of the leadscrew and being rotatable with the leadscrew, a pullback sleeve which is engageable and disengageable with the pullback key, a lock key which is rotatable with respect to the pullback sleeve, and a spring-loaded snap lock.
  • the lock key While the actuator is in its pre-injection or dose-setting position, the lock key is locked in a first rotational position. In this first rotational position, the lock key forces the pullback key and the pullback sleeve into engagement with one another. Since the pullback sleeve is locked against rotation with respect to the housing, the pullback key and leadscrew are prevented from being able to rotate with respect to the housing.
  • the drive nut engages and slightly axially advances the pullback sleeve and the lock key with respect to the housing. This moves the fingers of the lock key out of radial engagement with interfering ribs on the inner surface of the housing to enable the lock key to be rotated between a first rotational position and a second rotational position.
  • a cartridge retainer containing a cartridge of liquid medication is received within the nosepiece of the housing and rotatable within the nosepiece between a locked rotational position, in which the retainer cannot be removed from the nosepiece, and an unlocked rotational position in which the retainer can be removed from the nosepiece.
  • the retainer includes tabs that are keyed for rotation with the lock key.
  • the retainer is locked against rotation in its locked position while the actuator is in its pre-injection position, and the retainer is rotatable with the lock key to its unlocked position while the actuator is in its post-injection position, thereby enabling the retainer and spent cartridge to be removed and replaced with a new variable volume cartridge.
  • the piston of the new cartridge engages and axially spins the leadscrew back to its home position. This is possible since the leadscrew can rotate with respect to the housing while the actuator is in its post-injection position.
  • a multi- component medication delivery device having a drive mechanism for simultaneously delivering a selectively set dosage of each injectable product.
  • the device comprises a mechanism housing and a plurality of variable volume cartridges containing the medication and disposed within the housing, wherein each cartridge defines an axis of delivery of the medication from its respective cartridge.
  • An elongated tubular element or nut and a drive stem is associated with each cartridge.
  • a driver or carrier is secured to each nut.
  • Each driver is pivotally secured to a hand-operated actuator via side plates. During metering, the actuator is in its "up" position, and each leadscrew is advanced a desired distance to set a desired dosage of product to be delivered.
  • the actuator is moved in a direction transverse to the axes of delivery, toward the housing, and into its "down” position.
  • each of the drivers are simultaneously driven forwardly carrying the nut and drive stem therealong.
  • the drive stems engage and axially advance their respective pistons to force the respective set dosages of liquid medications into the manifold and out through the delivery needle.
  • a groove in the actuator receives a tab on the housing resulting in an audible "click” to indicate an end of dose to the user.
  • An advantage of the present invention is that the device enables a user to independently set each dosage of product to be delivered.
  • the device enables bidirectional metering of each dosage to be set.
  • Another advantage of the present invention is that the device is capable of indicating and locking out metering of an insufficient remaining volume of liquid medication in a cartridge.
  • Another advantage of the present invention is that the device provides a tactile, visual, and auditory feedback during metering.
  • Another advantage of the present invention is that the device provides both a visual and auditory indication of an end of dose. Another advantage of the present invention is that the metering mechanism automatically resets upon injection, thereby eliminating the need to manually reset the indicator dial back to zero prior to subsequent metering. Another advantage of the present invention is that metering can be achieved only while the actuator is in the "wing up" or pre-injection position, thereby ensuring proper metering.
  • Another advantage of the present invention is that the device automatically prevents a user from attempting to change cartridges while the device is in its metering or pre-injection position, thereby maintaining dosing accuracy.
  • Another advantage of the present invention is that the leadscrew is automatically unlocked upon a cartridge change, thereby enabling the leadscrew to spin freely back to its home position upon inserting a new cartridge into the housing.
  • FIG. 1 is a perspective view of an embodiment of a medication dispensing device in accordance with the present invention, wherein the wing is shown in its "up" position;
  • Fig. 2 is an exploded view of the device of Fig. 1;
  • Fig. 3 is an enlarged longitudinal sectional view of the medication dispensing device of Fig. 1, wherein the actuating wing is in the "up" position;
  • Fig. 4 is a view of Fig. 3, showing the leadscrews advanced indicating a set dosage has been established;
  • Fig. 5 is a view of Fig. 3, particularly showing the dispensing device immediately after an injection has taken place;
  • Fig. 6 is an enlarged isolated perspective view of the metering mechanism of the device of Fig. 1;
  • Fig. 7 is a sectional view of the engagement between the rotatable clutch member and the elongated nut;
  • Fig. 8 is an isolated elevational end view of the nut and the driver, particularly showing the ratchet teeth of the nut in engagement with the corresponding ratchet teeth of the driver;
  • Fig. 9 is a sectional view showing the externally threaded leadscrew in engagement with the internally threaded portion of the nut;
  • Fig. 10 is a view of Fig. 9, particularly showing the leadscrew fully advanced through the nut;
  • Fig. 11 is an enlarged sectional view of the assembled lock and pullback mechanism of the device of Fig. 1;
  • Fig. 12 is an enlarged sectional view of the lock and pullback mechanism as shown in Fig. 11, taken along line 12-12 in Fig. 11;
  • Fig. 13 is a sectional view of the indicator dial in engagement with the maximum dosage splines in the injection pen housing;
  • Fig. 14 is a sectional view of the wing mechanism of the dispensing device in engagement with the housing in its wing down position;
  • Fig. 15 is an exploded perspective view of the lock and pullback mechanism
  • Fig. 16 is a sectional view of the assembled lock and pullback mechanism particularly showing the lock key within the groove of the pullback sleeve, thereby preventing rotation of the key with respect to the sleeve
  • Fig. 17 is a view of the lock and pullback mechanism of Fig. 16, particularly showing the driver at the end of dose thereby automatically permitting rotation of the lock key with respect to the housing;
  • Fig. 18 is a sectional view of the interference fit between the small flanges of the lock key and the legs of the lock snap;
  • Fig. 19 shows the legs of the lock snap in engagement with the small flanges;
  • Fig. 20 is a view similar to Fig. 19, showing the lock snap out of engagement with the small flanges of the lock key to permit rotation of the lock key with respect to the pullback sleeve;
  • Fig. 21 is a sectional view of the cartridge retainers in the distal housing of the medication dispensing device of Fig. 1, particularly showing the retainers in an unlocked state;
  • Fig. 22 is a view of Fig. 21, except that the cartridge retainers have been rotated to their locked positions;
  • Figs. 23A-23D are a series of elevational views of the medication dispensing device of Fig. 1 showing the manifold being removed (Fig. 23A) , the cartridge retainers being unlocked and removed from the housing (Fig. 23B) , new cartridge retainers being inserted into the housing
  • Fig. 24A is an isolated view, in partial section, of the wing and driver mechanism of the device of Fig. 1, showing the wing in its "up" position.
  • Fig. 24B is a view of Fig. 24, except that the wing is in its "down" position.
  • a medication dispensing device 40 for dispensing two different liquid medications as a mixed product through a single needle 41.
  • the injection device includes a mechanism housing 42 (Fig. 2) and a nosepiece 44.
  • Mechanism housing 42 is contained in housing covers 46 and 48.
  • Both mechanism housing 42 and nosepiece 44 are clear plastic materials made of ABS resins or polycarbonates.
  • mechanism housing 42 and nosepiece 44 are ultrasonically welded to one another.
  • the mechanism housing is placed in a nest supported by the back side of the ribs of the nosepiece, and a far field weld is performed with a horn on the top of the nosepiece.
  • the mechanism housing and nosepiece are spring loaded together, and weld energy is injected orthogonally to the pressure direction at the semicircular ribs of the nosepiece.
  • Mechanism housing 42 comprises two parallel tubular components 50 and 54 for housing the individual components of device 40.
  • Nosepiece 44 is also in the form of two parallel tubular components 52 and 56. Together, tubular components 50 and 52 form a first tubular member and tubular components 54 and 56 form a second tubular member.
  • two parallel tubular members are shown in the drawings, it is possible that additional tubular members may be provided to meter and deliver three or more liquid medications from a single delivery device. Additional features of mechanism housing 42 and nosepiece 44 shall be described infra.
  • dispensing device 40 contains two independent dosage metering mechanisms, a drive mechanism for simultaneously driving the pistons of the cartridges for dual medication injection, and two separate lock and pullback mechanisms.
  • the two metering mechanisms shown in Figs 3-5 are substantially identical except for certain differences illustrated in Fig. 13.
  • the drive mechanism and the lock and pullback mechanisms within each tubular member are substantially identical to one another. Therefore, identical components in each of the two parallel tubular members formed by mechanism housing 42 and nosepiece 44 are given identical reference numerals.
  • Metering mechanism 58 comprises a knob 60, a torsion spring 62, an indicator bearing 64, an indicator dial 66, and a clutch indicator 68.
  • Indicator bearing 64 is a thin, molded plastic annular ring with hook-shaped protrusions 70 extending radially away from its outer circumference. As shown in Fig. 3, protrusions 70 securely fit within openings 71 (Fig. 2) formed at the proximal end of mechanism housing 42.
  • indicator bearing 64 is fixed both rotationally and axially to mechanism housing 42.
  • proximal shall designate a relative axial position toward the knob end of delivery mechanism 40
  • distal shall designate a relative axial position toward the delivery needle end of delivery mechanism 40.
  • indicator dial 66 is an elongate molded plastic cylinder that fits coaxially within tubular region 54 of mechanism housing 42.
  • Knob 60 is a molded plastic cylinder with a closed proximal end and an open distal end. The proximal end of indicator dial 66 snaps into an annular groove (not shown) molded within knob 60 so that indicator dial 66 and knob 60 constitute a single rotatable component.
  • Torsion spring 62 is coupled at one end 72 to indicator dial 66 and at the opposite end 74 to indicator bearing 64.
  • Knob 60 and indicator dial 66 are rotated against the biasing force of torsion spring 62. In the absence of another force to retain knob 60 and indicator dial 66 in a given radial position, torsion spring 62 will return knob 60 and indicator dial 66 to a given initial rotational position, also known as the zero dose position.
  • indicator dial 66 further includes an axially extending spline 76 which rotates within a mating slot 78 on the inside surface of tubular region 54 to confine the rotational travel of indicator dial 66 to less than 360 degrees. This serves to limit the dosage that a user can set for any single injection.
  • an indicator dial 66' which is identical to indicator dial 66 except that spline 76' is of a greater width than spline 76.
  • the maximum dosage that can be set with indicator dial 66' is less than that which can be set with indicator dial 66.
  • the distal portion of indicator dial 66 has a series of numerals 80 printed about the circumference thereof.
  • An opening or window 82 in the wall of tubular region 54 and a corresponding opening 84 in housing cover 48 allows a user to view at least one of numerals 80.
  • a lens 86 (Fig. 2) is provided in opening 84 to magnify the visible numeral 80 as desired.
  • the numerals represent different set dosages of liquid medication to be delivered in international recognized units.
  • the reference numeral "0" is present when knob 60 and indicator dial 66 are in their initial position set by torsion spring 62.
  • the metering mechanism interfaces with the drive mechanism as discussed infra.
  • the drive mechanism includes an elongated molded plastic, hollow cylindrical drive nut 88.
  • Nut 88 includes an internally tapped bore extending therethrough.
  • the distal portion 90 of nut 88 includes internal threads 92. These threads may be any desired helix, such as a 28-45 degree helix.
  • the remaining interior surface of the bore of nut 88 constitutes a relatively smooth surface 94.
  • a shoulder or ledge 96 is formed at the intersection between smooth interior surface 94 and internally threaded surface 92.
  • the outer surface of nut 88 includes a plurality of axially extending splines 98 and 99.
  • splines engage corresponding recesses 103 and 104 in indicator clutch 68, thereby locking nut 88 to indicator clutch 68.
  • the distal end of nut 88 includes an enlarged diameter end 100 including ratchet teeth 102.
  • a drive spring 108 is disposed between the distal end of drive locknut 106 and the distal end 110 formed in the interior of indicator clutch 68.
  • An indicator washer 112 is secured to indicator clutch 68, and an indicator spring 114 is disposed between washer 112 and tubular region 54 of housing 42.
  • An elongated metal externally threaded leadscrew 118 is adapted to threadingly engage the interior threaded surface 92 of drive nut 88.
  • Leadscrew 118 while generally cylindrical, has two diametrically opposite parallel flat surfaces 126 (Fig. 2) extending along its entire length. Leadscrew 118 is longer than drive nut 88, and when assembled, the proximal end of leadscrew 118 extends beyond the threaded portion of drive nut 88.
  • the proximal end of leadscrew 118 includes an enlarged diameter portion 120.
  • a plastic head 122 is slidably snapped onto end piece 124 of leadscrew 118. Head 122 is rotatably attached to end piece 124 and is pivotal with respect thereto.
  • the metering mechanism is coupled to the drive mechanism. Specifically, ratchet teeth 67 of indicator dial 66 are in engagement with ratchet teeth 69 of indicator clutch 68. Thus, rotation of knob 60 results in rotation of indicator clutch 68. Since the splines 98, 99 of drive nut 88 are keyed to grooves 103, 104 in indicator clutch 68, rotation of indicator clutch 68 results in rotation of nut 88. Leadscrew 118 is locked against rotation during metering as shall be discussed infra.
  • knob 60 may be turned either clockwise or counterclockwise to translate leadscrew 118 either forward or backward until the desired dosage is set. This allows a user to change a dosage without wasting the medication to be delivered.
  • a carrier or driver 116 is in constant engagement with distal end 100 of drive nut 88.
  • driver 116 is secured to plates 128 which are pivotally connected to wing 132 by pins 129 being received in pivot bores 133.
  • Wing 132 includes a plastic grip 134 which is received within opening 136 within wing 132, as shown in Fig. 2.
  • Wing 132 includes pivot bores 135, which receive opposite ends of a pivot pin 137 which extends through opening 139 in housing mechanism 42. Bores 127 in drivers 116 receive pins 131 of side plates 128. Referring to Figs.
  • the lock and pullback mechanism comprises a plastic molded, generally cylindrical pullback key 138 which has a proximal portion 140 including an opening 142 that corresponds to the shape of leadscrew 118 and an enlarged distal portion 144 including ratchet teeth 146.
  • the lock and pullback mechanism further comprises a generally cylindrical molded pullback sleeve 148 comprising a proximal hollow cylindrical portion 150 and radially extending flanges 152.
  • the outer surface of pullback sleeve 148 includes a spiral groove or track 154.
  • the interior surface of pullback sleeve 148 including a reduced diameter inner surface 156 and an enlarged inner diameter surface (not shown) .
  • the lock and pullback mechanism further includes a lock key 160, a pullback spring 162, and a snap lock 164.
  • Lock key 160 comprises a generally cylindrical portion 166 having grooved openings 168 formed at the distal end thereof and further having axially extending fingers 170 extending from the opposite end thereof. Fingers 170 include small cylindrical protrusions 172 that fit within spiral groove 154 of pullback sleeve 148.
  • Lock key 160 further includes ledges 174 extending radially inwardly from the inner surface of lock key 160.
  • Snap lock 164 comprises a cylindrical portion 176 and two axially extending legs 178 having outwardly extending tabs 180.
  • Pullback spring 162 is disposed between inner ledge 182 of snap lock 164 and inner radially extending ledges 174 of lock key 160.
  • the lock and pullback mechanism performs several functions.
  • pullback key 138 interfaces with leadscrew 118 to keep the leadscrew 118 from turning during metering and injection.
  • Pullback key 138 is locked from rotation by the engagement of corresponding teeth from pullback sleeve 148 which, in turn, is constantly constrained from rotating by its interface with mechanism housing 42.
  • Lock snap 164 and pullback spring 162 take up the variable position of the end of the glass cartridge.
  • lock snap 164 holds the lock/pullback mechanism within the mechanism housing.
  • Lock key 160 provides a lockout for the cartridge retainers so that the retainers can only be removed and inserted when the wing is in the "down" position.
  • injection device 40 includes cartridges 184, 186 disposed within cartridge retainers
  • Retainers 188, 190 which may be made of a clear plastic material, such as Ektar, include internal ribs
  • Retainers 188, 190 are secured within the tubular regions 52 and 56 of nosepiece 44 as discussed infra. Retainer 188 may be of a different size than retainer 190 so that retainer 188 cannot be inadvertently inserted into cylindrical tube 56, and vice versa.
  • a manifold assembly 192 is secured to the distal end of cartridge retainers 188 and 190 and includes a front housing 194, a rear housing 196, and an elastomeric septum 198 encapsulated therebetween. The manifold assembly is described in greater detail in U.S. Patent Application Serial No.
  • Needle 41 is secured to front manifold housing 194 via threaded coupling member 200.
  • Injection device 40 further includes needle cover 202 and housing cap 204.
  • wing 132 In order to set a dosage, wing 132 must be moved in the direction of arrow 212 to its "up" position, as shown in Fig. 3. This causes heads 122 of leadscrews 118 to be retracted out of engagement with pistons 185, 187 of cartridges 184, as shown in Fig. 3. In addition, movement of wing 132 in the direction of arrow 212 retracts clutch indicator 68 to its proximal position. While in this position, ratchet teeth 67 of indicator dial 66 are in engagement with ratchet teeth 69 of indicator clutch 68 so that rotation of knob 60 and indicator dial 66 results in corresponding rotation of indicator clutch 68.
  • each knob 60 must initially be in the clockwise direction, as indicated by arrows 214 (Fig. 4) to set a desired dosage. Initial rotation in the counterclockwise direction is prevented by the engagement of splines 76, 76' of indicator dials 66, 66' being in engagement with dosage stops 79 formed in tubular regions 50 and 54 (Fig. 13) . Once an initial dosage has been set, that dosage may be increased or decreased as desired by clockwise or counterclockwise rotation of knobs 60.
  • Fig. 4 shows leadscrews 118 being advanced a desired axial distance with respect to their axial positions in Fig. 3, indicating that dosages have been set.
  • Rotation of knob 60 results in corresponding numerals 80 appearing in openings 82 and 84 of housings 42 and 48, respectively, to provide a visual indication of the desired dose.
  • rotation of nut 88 results in teeth 102 of end 100 being moved over teeth 117 of driver 116, resulting in an audible click for each incremental increase or decrease in the set dosage.
  • needle cover 202 is removed from needle 41, and needle 41 is inserted into the user.
  • Wing 132 is then grasped and moved transversely towards the housing as shown by arrow 206 in Fig. 5. This results in drivers 116 moving forward which carry nuts 88 and leadscrews 118 forwardly a predetermined distance resulting in heads 122 engaging and axially advancing associated pistons 185, 187. This forces medication through cannulas 208, 210 and into manifold assembly 192 and subsequently out needle 41.
  • ratchet teeth 69 of clutch indicator 68 move out of engagement with ratchet teeth 67 of indicator dial 66, thereby enabling torsion spring 62 to rotate knob 60 and clutch indicator 66 to its initial rotational position, whereby the numeral zero appears through windows 82 and 84 in housings 42 and 48, respectively.
  • This auto zero feature permits a user to redial another dose without having to first set the metering dial to zero.
  • grip piece 134 of wing 132 includes a downwardly extending boss portion 216 biased in a given axial position with respect to wing 132 by a spring 218.
  • Boss 216 includes a finger 220 that slides over upstanding tab 222 on tubular region 50 and fits into place beneath tab 222 in interfering relationship therewith which holds finger 220 in place. This locks wing 132 in the "down" position at the end of dose.
  • the engagement of finger 220 beneath tab 222 results in an audible click sound, indicating to the user that the complete dosage has been delivered.
  • Spring 218 biases finger 220 beneath tab 222.
  • end 100 of nut 88 engages and axially advances pullback sleeve 148, pullback key 138 and lock key 160, as shown in Figs. 19 and 20.
  • This moves flanges 152 of pullback sleeve 148 out of engagement with groove 149 in tubular housing region 50.
  • This also moves protrusion 224 on lock key 160 out of interfering relationship with extension 226 of tubular region 50.
  • Cartridge retainer 188 and lock key 160 keyed thereto can now be rotated 90 degrees to move protrusions 172 of lock key 160 within helical spline 154 of pullback sleeve 148.
  • Such rotation moves lock key 160 and ledges 174 of lock key 160 axially away from pullback key 138 so that ledges 174 no longer engage pullback key 138.
  • This causes ratchet teeth 146 of pullback key 138 to become disengaged from ratchet teeth 158 of pullback sleeve 148, thereby enabling pullback key 138 and hence leadscrew 118 to rotate with respect to pullback sleeve 148 and mechanism housing 42.
  • the inner surfaces of tubular regions 52 and 56 of nosepiece 44 are specially configured restrict cartridge retainers 188, 190 to a particular radial orientation therewithin.
  • keyed portions 228, 230 of retainers 188, 190 respectively, rotate within grooves 232, 234 formed in the proximal end of nosepiece 44.
  • Each groove 232, 234 extends for 90 degrees about the circumference of the openings in nosepiece 44, thereby limiting rotation of retainers 188, 190 to 90 degrees within nosepiece 44.
  • retainers 188, 190 can be removed from nosepiece 44 only in a particular radial orientation. Referring to Fig. 21, retainers 188, 190 are shown in their unlocked radial positions.
  • retainers 188, 190 have been rotated 90 degrees counterclockwise in the direction of arrows 236 to cause the top edge surfaces of keyed portions 228, 230 to be in engagement with interfering internal threads 238, 240, respectively, thereby preventing the retainers 188, 190 from being axially removed from nosepiece 44.
  • retainers 188, 190 are shown in their locked radial positions in Fig. 22.
  • an insufficient dose remaining feature is shown.
  • a user dials up a dosage greater than that remaining in its cartridge
  • enlarged portion 120 of leadscrew 118 engages ledge 96 of internally threaded nut 88. This provides an interference stop that prevents leadscrew 118 from being translated any further. This indicates to the user that there is an insufficient dosage remaining in the cartridge.
  • the user may choose to inject the dosage already set and then dial up the difference after inserting a new cartridge.
  • Figs. 23A-23D The process for changing a spent cartridge is illustrated in Figs. 23A-23D. It will be appreciated that the process of changing cartridges can occur only while wing 132 is in its "down" position.
  • manifold 192 is removed from cartridge retainers 188, 190 and from the distal end of nosepiece 44, as shown in Fig. 23A.
  • retainers 188, 190 are rotated 90 degrees as indicated by arrow 242, and then removed.
  • the spent cartridges are then removed from the retainers, and new cartridges are inserted therein.
  • Retainers 188, 190 are then inserted back into nosepiece 44, as shown in Fig. 23C.
  • wing 132 In order to make a subsequent injection, wing 132 must be moved to its "up" position (Figs. 1, 24A) in the direction of arrow 212, as shown in Fig. 3. This is necessary in order to cause ratchet teeth 69 of clutch indicator 68 to engage ratchet teeth 67 of indicator dial 66 so that rotation of knob 60 results in rotation of nut 88.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention porte sur un distributeur à plusieurs cartouches (40) permettant d'administrer deux médications liquides au moyen d'une seule aiguille (41). Ce distributeur comporte des mécanismes indépendants de dosage à deux canaux (58), des mécanismes d'entraînement à deux canaux (68, 88, 118, 132) ainsi que des mécanismes de verrouillage et de retrait à deux canaux (138, 148). L'aileron (132) doit se trouver en position 'haute' pour que le dosage puisse s'effectuer. Cet aileron fait exécuter un mouvement de va-et-vient à un dispositif d'entraînement (118) entre une position de pré-injection et une position de post-injection afin de faire aller et venir la vis sans fin (118) lors de la poussée d'injection. L'indicateur de dosage (66) tourne systématiquement vers sa position zéro initiale lors de la poussée d'injection. Le mécanisme de verrouillage et de dégagement, qui empêche systématiquement une rotation de la vis sans fin lors du dosage et de l'injection, verrouille également les dispositifs de retenue de cartouche (188) de façon à ce que ces dispositifs ne puissent sortir du logement (42) que lorsque l'aileron se trouve en position 'basse'. Le manchon de retrait (148) desserre une clé de retrait (138) lors du changement de cartouche (184) de manière à permettre à la vis sans fin de revenir librement en arrière vers sa position de repos.
PCT/US1996/005367 1995-04-19 1996-04-18 Dispositif d'injection de medicament a plusieurs cartouches WO1996032973A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP8531902A JPH10506827A (ja) 1995-04-19 1996-04-18 マルチカートリッジ式薬剤注入装置
AU56648/96A AU5664896A (en) 1995-04-19 1996-04-18 Multi-cartridge medication injection device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/424,660 1995-04-19
US08/424,660 US5584815A (en) 1993-04-02 1995-04-19 Multi-cartridge medication injection device

Publications (1)

Publication Number Publication Date
WO1996032973A1 true WO1996032973A1 (fr) 1996-10-24

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US (1) US5584815A (fr)
JP (1) JPH10506827A (fr)
AU (1) AU5664896A (fr)
CA (1) CA2204504A1 (fr)
WO (1) WO1996032973A1 (fr)

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US10245383B2 (en) 2000-06-16 2019-04-02 Novo Nordisk A/S Injection device
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US9687611B2 (en) 2004-10-21 2017-06-27 Novo Nordisk A/S Injection device with torsion spring and rotatable display
US11446443B2 (en) 2004-10-21 2022-09-20 Novo Nordisk A/S Injection device with torsion spring and rotatable display
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US8357120B2 (en) 2004-10-21 2013-01-22 Novo Nordisk A/S Injection device with torsion spring and rotatable display
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US9662454B2 (en) 2009-06-01 2017-05-30 Sanofi-Aventis Deutschland Gmbh Resetting mechanism for a drug delivery device
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EP2529773A1 (fr) * 2009-06-01 2012-12-05 Sanofi-Aventis Deutschland GmbH Mécanisme de réinitialisation pour dispositif dýapprovisionnement de médicament
AU2014218406B2 (en) * 2009-06-01 2016-06-30 Sanofi-Aventis Deutschland Gmbh A resettable dose setting mechanism for a drug delivery device
EP2529774A1 (fr) * 2009-06-01 2012-12-05 Sanofi-Aventis Deutschland GmbH Mécanisme de réinitialisation pour dispositif dýapprovisionnement de médicament
AU2014218406A1 (en) * 2009-06-01 2014-09-18 Sanofi-Aventis Deutschland Gmbh A resettable dose setting mechanism for a drug delivery device
EP2529775A1 (fr) * 2009-06-01 2012-12-05 Sanofi-Aventis Deutschland GmbH Mécanisme de réinitialisation pour dispositif dýapprovisionnement de médicament
US9517310B2 (en) 2009-06-01 2016-12-13 Sanofi-Aventis Deutschland Gmbh Pen injector with resetting mechanism for receiving new cartridge during driver decoupling and proximal spindle retraction
KR101837926B1 (ko) 2009-06-01 2018-03-13 사노피-아벤티스 도이칠란트 게엠베하 약물 전달 디바이스용 재설정 기구
US9616179B2 (en) 2009-06-01 2017-04-11 Sanofi—Aventis Deutschland GmbH Resetting mechanism for a drug delivery device
US9687613B2 (en) 2009-06-01 2017-06-27 Sanofi-Aventis Deutschland Gmbh Resetting mechanism for a drug delivery device
US8651338B2 (en) 2009-06-02 2014-02-18 Sanofi-Aventis Deutschland Gmbh Delivery of two or more medicaments through a single dose selection and single dispense interface
WO2010139668A1 (fr) * 2009-06-02 2010-12-09 Sanofi-Aventis Deutschland Gmbh Administration d'au moins de deux medicaments par une interface de selection et de distribution a dose unique
US20120125951A1 (en) * 2009-06-02 2012-05-24 Sanofi-Aventis Deutschland Gmbh Delivery of Two or More Medicaments Through a Single Dose Selection and Single Dispense Interface
CN102458513A (zh) * 2009-06-02 2012-05-16 赛诺菲-安万特德国有限公司 两种或更多种药物通过单一剂量选择和单一分配接口的输送
US11819668B2 (en) 2009-10-16 2023-11-21 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
US9415165B2 (en) 2009-10-16 2016-08-16 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
US10806865B2 (en) 2009-10-16 2020-10-20 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
US11033690B2 (en) 2009-10-16 2021-06-15 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
EP2604142A4 (fr) * 2010-08-11 2017-12-06 Kotobuki & Co., Ltd. Récipient distributeur à percussion
EP2460551B1 (fr) * 2010-12-06 2016-04-27 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicaments avec mécanisme de blocage du déclencheur
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
WO2016124430A1 (fr) * 2015-02-02 2016-08-11 Sanofi-Aventis Deutschland Gmbh Unité d'aiguille pour percer une paroi de réservoir de médicament depuis l'intérieur
US11260182B2 (en) 2015-04-16 2022-03-01 Nemoto Kyorindo Co., Ltd. Chemical liquid injector, method for controlling chemical liquid injector, and computer program
EP3284492A4 (fr) * 2015-04-16 2019-01-16 Nemoto Kyorindo Co., Ltd. Dispositif d'injection de médicament liquide, procédé de commande du dispositif d'injection de médicament liquide, et programme informatique

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US5584815A (en) 1996-12-17
CA2204504A1 (fr) 1996-10-24
JPH10506827A (ja) 1998-07-07
AU5664896A (en) 1996-11-07

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