WO1996032944B1 - Method for using ergoline compounds to effect physiological and pathological functions at the 5-ht7 receptor - Google Patents
Method for using ergoline compounds to effect physiological and pathological functions at the 5-ht7 receptorInfo
- Publication number
- WO1996032944B1 WO1996032944B1 PCT/US1996/003807 US9603807W WO9632944B1 WO 1996032944 B1 WO1996032944 B1 WO 1996032944B1 US 9603807 W US9603807 W US 9603807W WO 9632944 B1 WO9632944 B1 WO 9632944B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptor
- blocking
- serotonin
- ameliorated
- compounds
- Prior art date
Links
Abstract
The invention provides a method for treating a mammal affected with a central or peripheral condition which is ameliorated by blocking serotonin activation of the 5-HT7 receptor. The method comprises administering an effective amount of a 5-HT7 receptor blocking dose of a herein disclosed ergoline compound or a pharmaceutically acceptable addition salt thereof. Conditions amenable to treatment according to the method of the invention are those ameliorated by blocking serotonin binding to the 5-HT7 receptor, including cardiovascular shock, septic shock, hypotension, hypovolemia, renal disorders, diarrhea, spastic colon, IBS, IBD, circadian rhythm dysfunction, depression, schizophrenia, migraine headaches and sleep disorders. The compounds of the invention also provide a method to further probe and characterize the role of serotonin throughout the mammalian body.
Claims
AMENDED CLAIMS
[received by the International Bureau on 8 October 1996 (08.10.96); new claim 20 added; remaining claims unchanged (1 page)]
20. Use of a compound I
COMPOUND I
wherein:
R1=NH or O;
R2=H or OR3, wherein R3 is a C^Cg alkyl; n=0 or 1; and pharmaceutically acceptable acid
addition salts thereof,
for preparing a composition for treating a condition
ameliorated by blocking a serotonin mediated effect at a 5-
HT7 receptor in a mammal.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/930,747 US5880134A (en) | 1996-03-20 | 1996-03-20 | Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor |
AU53179/96A AU5317996A (en) | 1995-04-18 | 1996-03-20 | Method for using ergoline compounds to effect physiological and pathological functions at the 5-ht7 receptor |
JP8531733A JPH11503757A (en) | 1995-04-18 | 1996-03-20 | Use of ergoline compounds that produce physiological and pathological functions at 5-HT (7) receptors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42470295A | 1995-04-18 | 1995-04-18 | |
US08/424,702 | 1995-04-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1996032944A1 WO1996032944A1 (en) | 1996-10-24 |
WO1996032944B1 true WO1996032944B1 (en) | 1996-11-28 |
Family
ID=23683559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/003807 WO1996032944A1 (en) | 1995-04-18 | 1996-03-20 | Method for using ergoline compounds to effect physiological and pathological functions at the 5-ht7 receptor |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0738513A1 (en) |
JP (1) | JPH11503757A (en) |
AU (1) | AU5317996A (en) |
CA (1) | CA2218143A1 (en) |
WO (1) | WO1996032944A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
EP0998923A1 (en) * | 1998-10-30 | 2000-05-10 | Basf Aktiengesellschaft | Use of 5-HT7 receptor agonists for the treatment or prophylaxis of ischemias |
WO2000059909A1 (en) * | 1999-03-30 | 2000-10-12 | Shionogi & Co., Ltd. | Heterocyclic compounds having affinities for serotonin receptors |
US20070243240A9 (en) * | 2000-08-24 | 2007-10-18 | Fred Windt-Hanke | Transdermal therapeutic system |
DE10053397A1 (en) | 2000-10-20 | 2002-05-02 | Schering Ag | Use of a dopaminergic active ingredient for the treatment of dopaminerg treatable diseases |
WO2002024641A1 (en) * | 2000-09-22 | 2002-03-28 | Shionogi & Co., Ltd. | Tricyclic indole compounds having affinity for serotonin receptor |
WO2005040169A2 (en) | 2003-09-17 | 2005-05-06 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds as serotonin receptor modulators |
US7598255B2 (en) | 2005-08-04 | 2009-10-06 | Janssen Pharmaceutica Nv | Pyrimidine compounds as serotonin receptor modulators |
JP6440625B2 (en) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | Methods and compositions for treating schizophrenia |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR862466B (en) * | 1985-10-01 | 1987-02-02 | Lilly Co Eli | Esters of dihydrolysergic acid |
US4713384A (en) * | 1985-10-01 | 1987-12-15 | Eli Lilly And Company | Selective method for blocking 5HT2 receptors |
CA1339661C (en) * | 1987-06-15 | 1998-02-10 | Kathlenn Rose Whitten | Cycloalkylamides of (8b)-1alkyl-6 (substituted)ergolines |
EP0489108B1 (en) * | 1989-08-21 | 1996-03-13 | Beth Israel Hospital Association | Use of spiperone derivatives for immunosuppression |
US5043341A (en) * | 1990-04-11 | 1991-08-27 | Eli Lilly And Company | N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides |
US5141944A (en) * | 1990-04-11 | 1992-08-25 | Eli Lilly And Company | N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides |
EP0749313A4 (en) * | 1994-03-11 | 2001-10-24 | Lilly Co Eli | METHOD FOR TREATING STATES RELATED TO THE 5-HT2B RECEPTOR |
-
1996
- 1996-03-20 AU AU53179/96A patent/AU5317996A/en not_active Abandoned
- 1996-03-20 WO PCT/US1996/003807 patent/WO1996032944A1/en active Application Filing
- 1996-03-20 JP JP8531733A patent/JPH11503757A/en active Pending
- 1996-03-20 CA CA002218143A patent/CA2218143A1/en not_active Abandoned
- 1996-03-27 EP EP96610011A patent/EP0738513A1/en not_active Withdrawn
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