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WO1996031208A3 - Verwendung von substituierten piperidin- oder pyrrolidinverbindungen zur behandlung von sigma-rezeptor modulierten krankheiten - Google Patents

Verwendung von substituierten piperidin- oder pyrrolidinverbindungen zur behandlung von sigma-rezeptor modulierten krankheiten Download PDF

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Publication number
WO1996031208A3
WO1996031208A3 PCT/EP1996/001442 EP9601442W WO9631208A3 WO 1996031208 A3 WO1996031208 A3 WO 1996031208A3 EP 9601442 W EP9601442 W EP 9601442W WO 9631208 A3 WO9631208 A3 WO 9631208A3
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WO
WIPO (PCT)
Prior art keywords
substituted piperidine
pyrrolidine compounds
receptor modulated
modulated disorders
sigma
Prior art date
Application number
PCT/EP1996/001442
Other languages
English (en)
French (fr)
Other versions
WO1996031208A2 (de
Inventor
Norbert Kolassa
Johannes Kornhuber
Original Assignee
Byk Gulden Lomberg Chem Fab
Norbert Kolassa
Johannes Kornhuber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab, Norbert Kolassa, Johannes Kornhuber filed Critical Byk Gulden Lomberg Chem Fab
Priority to EP96911993A priority Critical patent/EP0819001A1/de
Priority to JP8529973A priority patent/JPH11503140A/ja
Priority to AU54993/96A priority patent/AU5499396A/en
Priority to US08/930,642 priority patent/US5994369A/en
Publication of WO1996031208A2 publication Critical patent/WO1996031208A2/de
Publication of WO1996031208A3 publication Critical patent/WO1996031208A3/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die Erfindung betrifft die Verwendung von Verbindungen der Formel (I), worin R1, R2, R3, R4, R5, m und n die in der Beschreibung angegebenen Bedeutungen haben, zur Herstellung von Arzneimitteln für die Behandlung von Sigma-Rezeptor modulierten Krankheiten.
PCT/EP1996/001442 1995-04-05 1996-04-02 Verwendung von substituierten piperidin- oder pyrrolidinverbindungen zur behandlung von sigma-rezeptor modulierten krankheiten WO1996031208A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP96911993A EP0819001A1 (de) 1995-04-05 1996-04-02 Verwendung von substituierten piperidin- oder pyrrolidinverbindungen zur behandlung von sigma-rezeptor modulierten krankheiten
JP8529973A JPH11503140A (ja) 1995-04-05 1996-04-02 シグマ−受容体が変調した疾患を治療するための、置換されたピペリジン化合物またはピロリジン化合物の使用
AU54993/96A AU5499396A (en) 1995-04-05 1996-04-02 Use of substituted piperidine or pyrrolidine compounds for t reating sigma-receptor modulated disorders
US08/930,642 US5994369A (en) 1995-04-05 1996-04-02 Substituted piperidine or pyrrolidine compounds for treating sigma-receptor modulated disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH976/95-1 1995-04-05
CH97695 1995-04-05

Publications (2)

Publication Number Publication Date
WO1996031208A2 WO1996031208A2 (de) 1996-10-10
WO1996031208A3 true WO1996031208A3 (de) 1996-11-14

Family

ID=4199588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/001442 WO1996031208A2 (de) 1995-04-05 1996-04-02 Verwendung von substituierten piperidin- oder pyrrolidinverbindungen zur behandlung von sigma-rezeptor modulierten krankheiten

Country Status (5)

Country Link
US (1) US5994369A (de)
EP (1) EP0819001A1 (de)
JP (1) JPH11503140A (de)
AU (1) AU5499396A (de)
WO (1) WO1996031208A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19731521A1 (de) * 1997-07-23 1999-01-28 Byk Gulden Lomberg Chem Fab Budipin bei der Behandlung entzündlicher Erkrankungen des Nervensystems
TW407153B (en) * 1997-10-27 2000-10-01 Nippon Kayaku Kk Imidazole compounds and their use
CA2315840A1 (en) * 1997-12-31 1999-07-08 John R. Mccullough R-procyclidine for treating urinary incontinence
WO1999033454A2 (en) * 1997-12-31 1999-07-08 Sepracor Inc. S-procyclidine for treating urinary incontinence
HN1999000149A (es) * 1998-09-09 2000-01-12 Pfizer Prod Inc Derivados de 4,4-biarilpiperidina
EP1161240B1 (de) * 1998-12-18 2005-08-17 Bristol-Myers Squibb Pharma Company N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
US6897234B2 (en) * 1999-12-17 2005-05-24 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
JP4405811B2 (ja) 2002-03-29 2010-01-27 エーザイ・アール・アンド・ディー・マネジメント株式会社 （１−インダノン）−（１，２，３，６−テトラヒドロピリジン）誘導体
WO2005080396A2 (de) * 2004-02-25 2005-09-01 Basf Aktiengesellschaft Azolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen
WO2009147831A1 (ja) * 2008-06-04 2009-12-10 株式会社Celest 精神障害の治療方法および治療用医薬組成物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000131A1 (en) * 1993-06-23 1995-01-05 Cambridge Neuroscience, Incorporated Sigma receptor ligands and the use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000131A1 (en) * 1993-06-23 1995-01-05 Cambridge Neuroscience, Incorporated Sigma receptor ligands and the use thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BECKMANN, H. ET AL: "The cholinolytic Biperiden in depression", ARCHIVES OF PSYCHIATRY AND NEUROLOGICAL SCIENCES, vol. 231, no. 3, 1982, pages 213 - 220, XP002011683 *
HEATHCOTE, B.V. ET AL: "Pirenzepine selectively inhibits gastric acid secretion: a comparitive pharmacological study between pirenzepine and seven other antiacetylcholine drugs", SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, vol. 15, no. 66, 1980, pages 15 - 26, XP002011684 *
HUDKINS RL ET AL: "M1 muscarinic antagonists interact with sigma recognition sites", LIFE SCI, 1991, 49 (17) P1229-35, ENGLAND, XP002011681 *
JELLINEK, T.: "Mood elevating effect of Trihexyphenidyl and Biperiden in individuals taking antipsychotic medication", DISEASES OF THE NERVOUS SYSTEM, vol. 38, no. 5, May 1977 (1977-05-01), pages 353 - 355, XP002011682 *
VOGELS, O.J.M. ET AL: "Focal dystonia and speech impairment responding to anticholinergic therapy", PAEDIATRIC NEUROLOGY, vol. 11, no. 4, November 1994 (1994-11-01), pages 346 - 348, XP002011685 *

Also Published As

Publication number Publication date
AU5499396A (en) 1996-10-23
WO1996031208A2 (de) 1996-10-10
JPH11503140A (ja) 1999-03-23
EP0819001A1 (de) 1998-01-21
US5994369A (en) 1999-11-30

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