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WO1996030370A3 - Thiazole and thiadiazole derivatives, their preparation and pharmaceutical compositions useful in the treatment of thrombocytopenia - Google Patents

Thiazole and thiadiazole derivatives, their preparation and pharmaceutical compositions useful in the treatment of thrombocytopenia Download PDF

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Publication number
WO1996030370A3
WO1996030370A3 PCT/JP1996/000773 JP9600773W WO9630370A3 WO 1996030370 A3 WO1996030370 A3 WO 1996030370A3 JP 9600773 W JP9600773 W JP 9600773W WO 9630370 A3 WO9630370 A3 WO 9630370A3
Authority
WO
WIPO (PCT)
Prior art keywords
thrombocytopenia
thiazole
preparation
treatment
pharmaceutical compositions
Prior art date
Application number
PCT/JP1996/000773
Other languages
French (fr)
Other versions
WO1996030370A2 (en
Inventor
Masaaki Matsuo
Takashi Ogino
Kiyoshi Tsuji
Original Assignee
Fujisawa Pharmaceutical Co
Masaaki Matsuo
Takashi Ogino
Kiyoshi Tsuji
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9506189.1A external-priority patent/GB9506189D0/en
Priority claimed from GBGB9511226.4A external-priority patent/GB9511226D0/en
Application filed by Fujisawa Pharmaceutical Co, Masaaki Matsuo, Takashi Ogino, Kiyoshi Tsuji filed Critical Fujisawa Pharmaceutical Co
Priority to AU50153/96A priority Critical patent/AU5015396A/en
Publication of WO1996030370A2 publication Critical patent/WO1996030370A2/en
Publication of WO1996030370A3 publication Critical patent/WO1996030370A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A compound of formula (I) wherein R1 is hydrogen, etc., R2 is N- or S-containing unsaturated heterocyclic group, each of which may have suitable substituent(s), X is CH or N and A is (II) or (III) (wherein m is an integer of 0, 1 or 2) and a pharmaceutically acceptable salt thereof, which is useful as a medicament.
PCT/JP1996/000773 1995-03-27 1996-03-26 Thiazole and thiadiazole derivatives, their preparation and pharmaceutical compositions useful in the treatment of thrombocytopenia WO1996030370A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU50153/96A AU5015396A (en) 1995-03-27 1996-03-26 Thiazole and thiadiazole derivatives, their preparation and pharmaceutical compositions useful in the treatment of throm bocytopenia

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9506189.1A GB9506189D0 (en) 1995-03-27 1995-03-27 Thiazole derivatives,process for production thereof and pharmaceutical compositions comprising the same
GB9506189.1 1995-03-27
GB9511226.4 1995-06-02
GBGB9511226.4A GB9511226D0 (en) 1995-06-02 1995-06-02 Heterocyclic compounds processes for production thereof and pharmaceutical compositions comprising the same

Publications (2)

Publication Number Publication Date
WO1996030370A2 WO1996030370A2 (en) 1996-10-03
WO1996030370A3 true WO1996030370A3 (en) 1996-11-28

Family

ID=26306753

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1996/000773 WO1996030370A2 (en) 1995-03-27 1996-03-26 Thiazole and thiadiazole derivatives, their preparation and pharmaceutical compositions useful in the treatment of thrombocytopenia

Country Status (3)

Country Link
AU (1) AU5015396A (en)
IL (1) IL117620A0 (en)
WO (1) WO1996030370A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7173038B1 (en) 1999-11-05 2007-02-06 Astrazeneca Ab Quinazoline derivatives as VEGF inhibitors

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1125817C (en) 1996-02-13 2003-10-29 曾尼卡有限公司 Quinazoline derivatives as VEGF inhibitors
KR100489174B1 (en) 1996-03-05 2005-09-30 제네카-파마 소시에떼아노님 4-anilinoquinazoline derivatives
GB9707800D0 (en) 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
AU733551B2 (en) 1996-09-25 2001-05-17 Astrazeneca Ab Qinoline derivatives inhibiting the effect of growth factors such as VEGF
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
EP1005470B1 (en) 1997-08-22 2007-08-01 AstraZeneca AB Oxindolylquinazoline derivatives as angiogenesis inhibitors
US6262096B1 (en) 1997-11-12 2001-07-17 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
EP1119567B1 (en) 1998-10-08 2005-05-04 AstraZeneca AB Quinazoline derivatives
US6414156B2 (en) 1998-10-21 2002-07-02 Bristol-Myers Squibb Company Process for preparing azacycloalkanoylaminothiazoles
US6214852B1 (en) 1998-10-21 2001-04-10 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US6927214B1 (en) 1999-01-15 2005-08-09 Novo Nordisk A/S Non-peptide GLP-1 agonists
JP2002534512A (en) * 1999-01-15 2002-10-15 ノボ ノルディスク アクティーゼルスカブ Non-peptide GLP-1 agonist
US6392053B2 (en) 1999-12-15 2002-05-21 Bristol-Myers Squibb Company Process for preparing arylacetylaminothiazoles
US6515004B1 (en) 1999-12-15 2003-02-04 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
DE60121931T2 (en) 2000-04-07 2007-03-01 Astrazeneca Ab quinazoline
PL360439A1 (en) * 2000-06-28 2004-09-06 Astrazeneca Ab Substituted quinazoline derivatives and their use as inhibitors
MXPA03000252A (en) 2000-08-09 2003-06-06 Astrazeneca Ab Quinoline derivatives having vegf inhibiting activity.
CN104003956A (en) * 2013-02-27 2014-08-27 中国药科大学 Thiazole compound, preparation method thereof and application in pharmacy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105767A (en) * 1977-03-28 1978-08-08 Merck & Co., Inc. Imidazo [1,2-a] pyridines substituted with a thienyl, thiazolyl, or thiadiazolyl group
EP0412404A2 (en) * 1989-08-07 1991-02-13 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same
EP0422369A2 (en) * 1989-09-07 1991-04-17 Bayer Ag Substituted carbamoyltriazoles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105767A (en) * 1977-03-28 1978-08-08 Merck & Co., Inc. Imidazo [1,2-a] pyridines substituted with a thienyl, thiazolyl, or thiadiazolyl group
EP0412404A2 (en) * 1989-08-07 1991-02-13 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same
EP0422369A2 (en) * 1989-09-07 1991-04-17 Bayer Ag Substituted carbamoyltriazoles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 40, no. 10, 1946, Columbus, Ohio, US; DAHLBOM ET AL.: "Sulfides and sulfones containing ..." page 4061; column 1; XP002005555 *
LAGORCE ET AL.: "Synthesis and Antithyroid activity ...", CHEM. PHARM. BULL., vol. 41, no. 7, 1993, pages 1258 - 1260, XP002005554 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7173038B1 (en) 1999-11-05 2007-02-06 Astrazeneca Ab Quinazoline derivatives as VEGF inhibitors
US9040548B2 (en) 1999-11-05 2015-05-26 Astrazeneca Ab Quinazoline derivatives as VEGF inhibitors

Also Published As

Publication number Publication date
AU5015396A (en) 1996-10-16
WO1996030370A2 (en) 1996-10-03
IL117620A0 (en) 1996-07-23

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