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WO1996024323A1 - Dispositif de transfert - Google Patents

Dispositif de transfert Download PDF

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Publication number
WO1996024323A1
WO1996024323A1 PCT/EP1996/000587 EP9600587W WO9624323A1 WO 1996024323 A1 WO1996024323 A1 WO 1996024323A1 EP 9600587 W EP9600587 W EP 9600587W WO 9624323 A1 WO9624323 A1 WO 9624323A1
Authority
WO
WIPO (PCT)
Prior art keywords
transfer
closure
container
transfer device
containers
Prior art date
Application number
PCT/EP1996/000587
Other languages
German (de)
English (en)
Inventor
Reinhold WOLKENSTÖRFER
Peter Iwatschenko
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Priority to DE59600779T priority Critical patent/DE59600779D1/de
Priority to DK96904064T priority patent/DK0808148T3/da
Priority to EP96904064A priority patent/EP0808148B1/fr
Publication of WO1996024323A1 publication Critical patent/WO1996024323A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration

Definitions

  • the invention relates to a transfer device for the contamination-free transfer of liquids between two containers, each having a closure, with an alignment device which has two receptacles for placement on the closure, one of each container, and a transfer part, which has a transfer has channel.
  • a transfer device of the type mentioned, in which the alignment device and the transfer part from each other are independent components, is described in German utility model G 89 09 304.
  • the alignment device disclosed there has two receptacles which can be formed by free-standing arms or can be designed in the form of a bowl. To mix the liquids, a first piercing mandrel of the transfer part is first pierced through the closure of the first container, and one of the receptacles of the alignment device is placed on the second container.
  • the two containers are aligned axially to one another, and the first container with the transfer part is inserted into the still free receptacle of the alignment device until a second piercing mandrel of the transfer part pierces the closure of the second container so that the liquid of the can pass through the transfer channel into the second container.
  • US-A-3,826,260 describes a syringe with one component of a medicament and a container with another component of the medicament.
  • the syringe and the container are connected to one another by a connecting device, in which a hollow needle, which is sharp on both sides, is arranged and does not penetrate the closures of the syringe or the container.
  • the syringe and container are compressed, thereby pushing one end of the needle through the closure into the syringe and pushes the other end through the closure into the container. It is not intended to separate the needle from the syringe.
  • the needle containing the transfer channel also serves as an injection needle for the medicament mixed in the syringe.
  • DE-A-41 22 476 describes a transfer device.
  • the object of the invention is to provide a transfer device which is simple and safe to use and inexpensive to manufacture and which enables reliable, contamination-free transfer of the liquid.
  • the invention proposes to design a transfer device of the type mentioned at the beginning such that the transfer part can be detachably fastened in the alignment device and that the transfer part can be separated from the container into which the transfer takes place.
  • the transfer device according to the invention constitutes a structural unit. It is therefore more convenient to use than the two individual parts of the known transfer device.
  • the steps preparing the actual transfer process can be carried out more quickly, which not only reduces the workload, but also the risk of contamination of the medical liquids, because the critical phase between the removal of protective covers from the container closures and the piercing spikes and the piercing of the container closures takes less time.
  • the transfer part can be fastened in the alignment device in such a way that it assumes the position most suitable for the transfer process when the receptacles of the alignment device are placed on the container closures. An incorrect placement of the transfer part on the containers is thus avoided.
  • the transfer part is protected by the alignment device from being touched by a careless user. This will Both the risk of contamination of the transfer part and the risk of the user injuring himself with the pointed spikes of the transfer part are reduced.
  • the transfer part is detachably fastened in the alignment device.
  • the alignment device which does not come into contact with the medical fluids, has only low requirements regarding sterility.
  • the alignment device can therefore be manufactured and stored under less critical conditions, and its packaging requires less effort.
  • An alignment device can be used several times in the clinic.
  • much higher sterility requirements are placed on the transfer part.
  • it can be designed as a disposable part made of plastic. In the case of a transfer device according to the invention, only the transfer part consisting of relatively little material then needs to be thrown away, but not the entire transfer device.
  • the design of the transfer part and alignment device according to the invention reduces the manufacturing, packaging, storage, cleaning and disposal costs.
  • the transfer part and the alignment device can also be supplied in a preassembled form, so that they can be used immediately after removal from the packaging.
  • a first piercing mandrel of the transfer part preferably contains both a section of the transfer channel and a section of a ventilation channel. If the first piercing mandrel has a tip, an outlet of the ventilation channel and, further away from the tip, an inlet of the transfer channel, it is avoided that air bubbles flowing out of the ventilation channel get into the transfer channel, where could be compensated for by the negative pressure in the second container even before all of the liquid has been transferred from the first container. This is avoided even more effectively if the outlet of the ventilation channel and the inlet of the transfer channel are separated by an axial wall during the first piercing mandrel.
  • the two piercing mandrels and the inlet and outlet openings arranged thereon are preferably designed such that when a container closure is pierced, no pieces are punched out of the plastic or rubber material of the closure. This risk would exist, for example, in the case of cylindrical, tubular piercing mandrels.
  • the piercing pins are not cylindrical, but are cone-shaped and tapered, the tip being arranged approximately on the central axis of the piercing pin.
  • the transfer part can have an air filter as the inlet of the ventilation duct in order to prevent contamination of the liquids by the inflowing air.
  • a glass fiber filter system with a very low filter resistance is preferably used.
  • the transfer part can also have an automatic valve, preferably a lip valve, so that the ambient air can flow in, but leakage of the liquid is reliably prevented. This is particularly advantageous for collapsible containers, for example bags. If both a filter and an automatic valve are provided, the latter is preferably arranged between the outlet of the ventilation channel on the spike and the filter, so that even if the transfer process is interrupted, no liquid reaches the filter and the latter glued.
  • a manually operable valve for example a flap
  • Means for releasably fastening the transfer part in the aligning device are preferably provided in the transfer device, which ensure an exchange-free arrangement of the transfer part and aligning device. This further increases the user-friendliness of the transfer device and its security against incorrect use.
  • At least one of the receptacles is equipped with latching devices which engage with the closure one of the containers can be brought.
  • At least one of the receptacles is preferably set up to receive the closure of one of the containers in a latching position in which the piercing mandrel associated with this receptacle projects into the closure of the container but does not penetrate it.
  • the inlet or outlet arranged at the tip of the piercing mandrel can be sealed airtight by the container closure surrounding it. This seal prevents unfiltered ambient air from entering the container on the other piercing mandrel (possibly under vacuum) through the transfer duct. This prevents contamination of the medical fluids and / or premature leakage.
  • At least one of the receptacles is set up to receive the closure of one of the containers in two different latching positions.
  • This can be a first latching position in which the piercing mandrel assigned to this receptacle penetrates the closure of the container but does not penetrate it, and a second latching position in which the piercing mandrel penetrates the container closure.
  • a relatively large force is preferably required to move the container closure from the first into the second locking position. tion because this can be the step that immediately initiates the actual transfer operation.
  • the transfer device is preferably designed in such a way that the transfer device can be placed on the container in a manner that is not interchangeable. This is essential for the transfer process, since only the first container may be ventilated.
  • the receptacles of the alignment device and / or the piercing pins of the transfer part and / or protective caps for the piercing pins can have a coding.
  • This coding can be a mechanical one, for example by lugs that engage in suitably arranged recesses.
  • the coding is preferably carried out by color, in particular by the color of the protective caps, because the protective caps are separate components from the preferably one-piece transfer part, which could be produced in two different colors without additional effort.
  • the containers can then have a corresponding color coding.
  • the transfer part is also simultaneously pulled out of the alignment device.
  • the releasable fastening of the transfer part in the alignment device and the shape, size and surface structure of the piercing mandrels are preferably designed in such a way that the force required to release the attachment of the transfer part in the alignment device is greater than that for inserting the second piercing mandrel into the closure of one of the The force required by the container is smaller than the force required to pull the first piercing mandrel out of the closure of the other of the containers.
  • connection between the transfer part and the alignment device is not released when the transfer device is placed on the container to be filled, but when the containers are pulled apart, the first piercing mandrel of the transfer part remains in the closure of the corresponding container. If the alignment device is either held by hand or grips the closure of the other container tightly enough, the transfer part and the alignment device are separated from one another at the same time.
  • the transfer part and the alignment device preferably consist essentially of plastic.
  • metal parts are preferably dispensed with. This avoids mixed waste with metal and plastic components, which can only be disposed of with great effort.
  • the transfer device is preferably designed in such a way that the entire transfer process can be carried out in a constant vertical position of the transfer device without liquid leaking prematurely or being contaminated. This enables a particularly reliable, safe and convenient transfer operation.
  • transfer process refers not only to the actual overflow of liquid, but rather to the entire process, from placing the transfer device on the bottle to be filled to separating the filled bottle from the transfer device.
  • FIG. 2 is a side view of the device of FIG. 1,
  • FIG. 5 shows a longitudinal section through a transfer device plugged onto a container in a representation rotated counterclockwise by 90 °
  • Fig. 6 and Fig. 7 shows a longitudinal section through one on two
  • Transfer device attached to the container rotated 90 ° counterclockwise.
  • FIG. 1 and FIG. 2 show a transfer device, the main components of which are an alignment device 10 and a transfer part 40.
  • the alignment device 10 is approximately dumbbell-shaped and consists of transparent plastic. It has a first receptacle 20 for placement on a closure 92 of a first container 90 and a second receptacle 30 for placement on a closure 102 of a second container 100.
  • the first and the second receptacles 20 and 30 are connected to one another by a drum-shaped connecting section 12 which is set up to receive a transfer part 40 and to hold it in a releasable clamp seat.
  • the connecting section 12 has a narrow guide 14 with a rectangular cross section and a wide guide 16, the latter being provided with a light bead 18 or punctiform elevations running around the inside.
  • the first receptacle 20 has an essentially cylindrical wall 22 with two axially incisions radially opposite one another. The ends of the axial incisions facing the connecting section 12 are widened in a T-shape.
  • a latching device 24 designed as a bead and a stop 26 formed by a region of the wide guide 16 of the connecting section 12 are provided.
  • the second receptacle 30 has a likewise cylindrical wall 32 with a first latching device 34 and a second latching device 36, which are each designed as a bead running around the inside of the wall 32, and a stop 38 connected to the narrow guide 14 of the connecting section 12.
  • the second latching device 36 is arranged close to an edge 37 of the second receptacle 30 facing away from the connecting section 12, and the first latching device 34 is arranged between the stop 38 and the second latching device 36, but not in the middle, but closer to the stop 38.
  • the wall 32 of the second receptacle 30 has two radially opposite axial incisions, which are at their The ends facing the connecting section 12 are each widened in a T-shape and run towards the edge 37 in each case in a recessed area of the wall 32, which at the edge 37 occupies approximately an arc of an initial section of 90 °.
  • An integral transfer part 40 injection-molded from plastic has a first piercing mandrel 50, a second piercing mandrel 70, a central part 44 connecting the mandrels 50 and 70 and a continuous transfer channel 42 running through the mandrels 50 and 70 and the central part 44.
  • the middle part 44 can be detachably fastened in the connecting section 12, an end section 46 located at the first piercing mandrel 50 being received by the wide guide 16 and an end section 48 located at the second piercing mandrel 70 being received by the narrow guide 14.
  • the central part 44 is approximately rectangular in cross section. It is held securely in the alignment device 10 by engagement of the thickened end section 46 with the bead 18.
  • the transfer part 40 is shown in more detail in FIGS. 3 and 4, FIG. 4 showing an embodiment variant with a slightly modified filter 66.
  • the first piercing mandrel 50 is traversed by a section 56 of the transfer channel 42, which opens into an opening forming an inlet 58. Furthermore, the first piercing mandrel 50 is traversed by a section 62 of a ventilation channel 60 which opens into an opening forming an outlet 64.
  • the outlet 64 is closer to a tip 54 of the first piercing mandrel 50 than the inlet 58, with the outlet 64 and the inlet 58 being radially opposite.
  • the first piercing mandrel 50 has a wall 52 which runs parallel to the axis of the first piercing mandrel 50 and forms approximately its diameter in cross section.
  • the wall 52 extends from the tip 54 to just before the inlet 58, where it merges into an inclined, flat end surface 59.
  • the first piercing mandrel 50 initially has a semicircular cross section, the straight side of which is delimited by the wall 52 and the diameter of which widens progressively until a substantially constant area in a region between the outlet 64 and the inlet 58 Cross section is maintained.
  • the cross section of the first piercing mandrel 50 In an adjoining area around the inlet 58, the cross section of the first piercing mandrel 50 increasingly approaches a full circle, in that the straight side, which initially forms the diameter of a semicircle, shifts outward in parallel. This displacement corresponds to the incline of the end face 59 arranged around the inlet 58. With the end of this end face 59 up to the beginning of the middle part 44, the cross section of the first piercing mandrel 50 is essentially circular with a slightly increasing diameter, the transfer duct 42 and the ventilation duct 60 are radially opposite.
  • the ventilation duct 60 has an inlet provided with an air filter 66, which is arranged in the region of the thickened end section 46 in the middle part 44.
  • the transfer duct 42 runs through the middle part 44 and then the second piercing mandrel 70 to an outlet 78 located near a tip 74 of the second piercing mandrel 70.
  • the second piercing mandrel 70 which is traversed by a section 76 of the transfer duct 42 has essentially a circular outer and inner cross section.
  • the second piercing mandrel 70 runs out into the tip 74 at a section 72 that is fluted in the side view.
  • 5 shows the second container 100, here a bottle, with its closure 102 in the second receptacle 30 of the alignment device 10 in a first latching position.
  • a front area 106 of the closure 102 bears against the first latching device 34 and a rear edge 108 of the latch 102 against the second latching device 36.
  • the second piercing mandrel 70 penetrates into a pierceable area made of rubber 104 of the closure 102, but does not penetrate it.
  • the outlet 78 of the piercing mandrel 70 is closed in a gas-tight and liquid-tight manner.
  • the first container 90 here also a bottle, is latched with its closure 92 in the first receptacle 20 of the aligning device 10.
  • a front area 96 of the closure 92 lies against the stop 26 of the first receptacle 20, and a rear edge 98 of the closure 92 against the latching device 2.
  • the first piercing mandrel 50 penetrates a pierceable area 94 of the closure 92 made of rubber.
  • the closure 102 of the second container 100 is accommodated in the second receptacle 30 of the alignment device 10 in a second latching position.
  • the front area 106 of the closure 102 lies against the stop 38 of the second receptacle 30, and the first latching device 34 rests under tension on a side surface 109 of the closure 102.
  • the second piercing mandrel 70 penetrates the pierceable area of the closure 102.
  • the transfer part 40 is first removed from a sterile packaging and inserted into the alignment device 10, in which it engages. It is also possible to use a transfer device which has been preassembled by the manufacturer and in which the transfer part 40 has already been inserted into the alignment device 10.
  • the cover cap 82 is removed from the second piercing mandrel 70, and likewise a protective cover from the pierceable area 104 of the closure 102 of the second container 100. device placed in the first locking position shown in FIG. 5 on the second container 100.
  • the second container 100 stands upright, for example on a table top, and the transfer device is arranged vertically on the closure 102 of the second container 100, so that the central axes of the transfer device and the second container 100 coincide.
  • the second container 100 also remains tightly closed, so that the negative pressure existing in it is maintained.
  • the releasable fastening of the transfer part 40 in the alignment device 10 is designed such that the transfer part 40 remains securely fixed even when the second piercing mandrel 70 is inserted into the closure 102 of the second container 100.
  • the next steps are to remove the cover cap 80 from the first piercing mandrel 50 and a protective cover from the pierceable area 94 of the closure 92 of the first container 90.
  • the closure 92 of the first container 90 is inserted into the in FIG. 6 shown locking position brought in the first receptacle 20, the first piercing mandrel 50 piercing the closure 92.
  • the container 90 which is originally under vacuum, is ventilated via the ventilation channel 60 provided with the filter 66 as soon as the outlet 64 has penetrated the closure 92 of the first container 90.
  • the outlet 78 of the Transfer channel 42 is closed by the pierceable area of the closure 102, so that unfiltered ambient air cannot enter the first container 90 through the transfer channel 42, nor can liquid escape from the first container 90.
  • the unit from the two containers 90 and 100 is still upright.
  • the closure 102 of the second container 100 is now brought into its second latching position in the second receptacle 30, as shown in FIG. 7.
  • a greater force must be applied than is required to lock the closure 102 into the first locking position and to lock the closure 92 into its (only) locking position, because the areas of the wall 32 separated by the T-shaped incisions must be be pushed further apart so that the edge between the front area 106 and the side surface 109 of the closure 102 of the second container 100 can pass the first latching device 34 of the second receptacle 30.
  • the closure 102 of the container 100 In its second latching position, the closure 102 of the container 100 is held on the side surface 109 by the first latching device 34, which is under tension; so it does not engage in the strict sense. Nevertheless, this position is referred to as the (second) rest position.
  • the liquid is drawn from the first container 90 into the second container 100 by the negative pressure in the second container 100.
  • the liquid flows in the direction of the arrow shown in FIG. 7 through the inlet 58, the transfer duct 42 and the outlet 78 into the second container 100, where it mixes with the liquid already contained therein.
  • the vacuum created by the removal of liquid in the first container 90 is compensated for by filtered ambient air which flows through the filter 66, the ventilation duct 60 and the outlet 64 into the first container 90.
  • the first container 90 has been emptied, one is possibly still in the residual vacuum located in the second container 100 through the transfer duct 40, the ventilation duct 60 and the filter 66, which is designed as a glass fiber filter system with a very low filter resistance, reduced to a negligibly small remainder.
  • the now filled second container 100 is separated from the transfer device.
  • the pierceable area 104 of the closure 102 closes again after the second piercing mandrel 70 has been pulled out.
  • the user grips the alignment device 10 with one hand and the second container 100 with the other hand and pulls them apart in the direction of their common axis. As a result, the alignment device 10 is separated from the second container 100. The user then pulls the alignment device 10 off the first container 90.
  • the releasable attachment of the transfer part 40 in the aligning device 10 is designed such that the transfer part 40 is pulled out of the aligning device 10 by the force exerted by the closure 92 of the first container 90 on the first piercing mandrel 50.
  • the transfer part 40 therefore remains stuck in the closure 92 and can be disposed of together with the first container 90 or separately therefrom.
  • the alignment device 10 can be reused for further transfer operations after appropriate cleaning and / or disinfection. Since the alignment device 10 does not come into direct contact with the medical fluids, it does not need to be sterilized.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Massaging Devices (AREA)
  • Seal Device For Vehicle (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

L'invention concerne un dispositif de transfert pour le transfert sans contamination de liquides entre deux récipients pourvus chacun d'une fermeture. Ce dispositif comporte un système d'alignement avec deux adaptateurs dont chacun est placé sur la fermeture d'un récipient, et une partie de transfert qui comporte un conduit de transfert et est montée amovible dans le système d'alignement. Pour perfectionner ce dispositif de transfert, la partie de transfert est séparable du récipient dans lequel le liquide est transféré. Un tel dispositif de transfert est économique à produire, d'une manipulation aisée et sans danger, et permet un transfert de liquides sans contamination en toute fiabilité.
PCT/EP1996/000587 1995-02-10 1996-02-12 Dispositif de transfert WO1996024323A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE59600779T DE59600779D1 (de) 1995-02-10 1996-02-12 Überleitungsgerät
DK96904064T DK0808148T3 (da) 1995-02-10 1996-02-12 Overførselsapparat
EP96904064A EP0808148B1 (fr) 1995-02-10 1996-02-12 Dispositif de transfert

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19504413.4 1995-02-10
DE19504413A DE19504413A1 (de) 1995-02-10 1995-02-10 Überleitungsgerät

Publications (1)

Publication Number Publication Date
WO1996024323A1 true WO1996024323A1 (fr) 1996-08-15

Family

ID=7753629

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/000587 WO1996024323A1 (fr) 1995-02-10 1996-02-12 Dispositif de transfert

Country Status (5)

Country Link
EP (1) EP0808148B1 (fr)
AT (1) ATE172869T1 (fr)
DE (2) DE19504413A1 (fr)
DK (1) DK0808148T3 (fr)
WO (1) WO1996024323A1 (fr)

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US3826260A (en) * 1971-12-27 1974-07-30 Upjohn Co Vial and syringe combination
US3872867A (en) * 1971-06-02 1975-03-25 Upjohn Co Wet-dry additive assembly
FR2293916A1 (fr) * 1974-12-12 1976-07-09 Boisnard Jean Yves Dispositif melangeur d'un produit pulverulent ou lyophilise et de son solvant
DE8909304U1 (de) * 1989-08-01 1989-09-28 Pfrimmer Kabi GmbH & Co KG, 8520 Erlangen Vorrichtung zum Ausrichten einer ersten Flasche in bezug auf eine zweite Flasche
DE3817101A1 (de) * 1988-05-19 1989-11-30 Axel Von Brand Vorrichtung zum ueberleiten von fluessigkeit von einem behaeltnis zu einem anderen behaeltnis
DE4122476A1 (de) * 1991-07-06 1993-01-07 Leopold Pharma Gmbh Verfahren und vorrichtung zum ueberleiten von zwei oder mehr sterilen fluessigkeiten im geschlossenen system

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3872867A (en) * 1971-06-02 1975-03-25 Upjohn Co Wet-dry additive assembly
US3826260A (en) * 1971-12-27 1974-07-30 Upjohn Co Vial and syringe combination
FR2293916A1 (fr) * 1974-12-12 1976-07-09 Boisnard Jean Yves Dispositif melangeur d'un produit pulverulent ou lyophilise et de son solvant
DE3817101A1 (de) * 1988-05-19 1989-11-30 Axel Von Brand Vorrichtung zum ueberleiten von fluessigkeit von einem behaeltnis zu einem anderen behaeltnis
DE8909304U1 (de) * 1989-08-01 1989-09-28 Pfrimmer Kabi GmbH & Co KG, 8520 Erlangen Vorrichtung zum Ausrichten einer ersten Flasche in bezug auf eine zweite Flasche
DE4122476A1 (de) * 1991-07-06 1993-01-07 Leopold Pharma Gmbh Verfahren und vorrichtung zum ueberleiten von zwei oder mehr sterilen fluessigkeiten im geschlossenen system

Also Published As

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EP0808148A1 (fr) 1997-11-26
DE59600779D1 (de) 1998-12-10
ATE172869T1 (de) 1998-11-15
DE19504413A1 (de) 1996-08-22
EP0808148B1 (fr) 1998-11-04
DK0808148T3 (da) 1999-07-19

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