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WO1996022305A3 - Modified peptides - Google Patents

Modified peptides Download PDF

Info

Publication number
WO1996022305A3
WO1996022305A3 PCT/GB1996/000057 GB9600057W WO9622305A3 WO 1996022305 A3 WO1996022305 A3 WO 1996022305A3 GB 9600057 W GB9600057 W GB 9600057W WO 9622305 A3 WO9622305 A3 WO 9622305A3
Authority
WO
WIPO (PCT)
Prior art keywords
modified peptides
compounds
prophylaxis
formula
treatment
Prior art date
Application number
PCT/GB1996/000057
Other languages
French (fr)
Other versions
WO1996022305A2 (en
Inventor
Alejandro Jose Daniels
Dennis Heyer
Johann Jakob Leban
Original Assignee
Wellcome Found
Alejandro Jose Daniels
Dennis Heyer
Johann Jakob Leban
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found, Alejandro Jose Daniels, Dennis Heyer, Johann Jakob Leban filed Critical Wellcome Found
Priority to AU43943/96A priority Critical patent/AU4394396A/en
Publication of WO1996022305A2 publication Critical patent/WO1996022305A2/en
Publication of WO1996022305A3 publication Critical patent/WO1996022305A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to compounds of formula (I), to the use of such compounds in medicine especially in the treatment or prophylaxis of conditions associated with eating disorders and to pharmaceutical compositions containing such compounds.
PCT/GB1996/000057 1995-01-12 1996-01-12 Modified peptides WO1996022305A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU43943/96A AU4394396A (en) 1995-01-12 1996-01-12 Modified peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9500601.1A GB9500601D0 (en) 1995-01-12 1995-01-12 Modified peptides
GB9500601.1 1995-01-12

Publications (2)

Publication Number Publication Date
WO1996022305A2 WO1996022305A2 (en) 1996-07-25
WO1996022305A3 true WO1996022305A3 (en) 1996-09-06

Family

ID=10767945

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/000057 WO1996022305A2 (en) 1995-01-12 1996-01-12 Modified peptides

Country Status (3)

Country Link
AU (1) AU4394396A (en)
GB (1) GB9500601D0 (en)
WO (1) WO1996022305A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2814367B1 (en) * 2000-09-25 2008-12-26 Inst Nat Sante Rech Med NPFF RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN AND HYPERALGIA
SE0103476D0 (en) * 2001-10-18 2001-10-18 Markus Heilig New use
ZA200508439B (en) 2003-05-05 2007-03-28 Probiodrug Ag Medical use of inhibitors of glutaminyl and glutamate cyclases
US20050137142A1 (en) 2003-11-03 2005-06-23 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
US7304086B2 (en) 2004-02-05 2007-12-04 Probiodrug Ag Inhibitors of glutaminyl cyclase
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN101668525A (en) 2007-03-01 2010-03-10 前体生物药物股份公司 New use of glutaminyl cyclase inhibitors
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
BR112012008346B1 (en) 2009-09-11 2021-12-21 Vivoryon Therapeutics N.V. HETEROCYCLIC DERIVATIVES, THEIR PREPARATION PROCESS, AND PHARMACEUTICAL COMPOSITION
EP2542549B1 (en) 2010-03-03 2016-05-11 Probiodrug AG Inhibitors of glutaminyl cyclase
KR101790806B1 (en) 2010-03-10 2017-11-20 프로비오드룩 아게 Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
ES2570167T3 (en) 2011-03-16 2016-05-17 Probiodrug Ag Benzimidazole derivatives as glutaminyl cyclase inhibitors
EP3461819B1 (en) 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017035A1 (en) * 1993-01-20 1994-08-04 Dr. Karl Thomae Gmbh Aminoacid derivates, medicaments containing these compounds and process for preparing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017035A1 (en) * 1993-01-20 1994-08-04 Dr. Karl Thomae Gmbh Aminoacid derivates, medicaments containing these compounds and process for preparing the same

Also Published As

Publication number Publication date
WO1996022305A2 (en) 1996-07-25
AU4394396A (en) 1996-08-07
GB9500601D0 (en) 1995-03-01

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