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WO1996021422A1 - Compositions cosmetiques anhydres contenant des agents actifs sur le plan dermatologique - Google Patents

Compositions cosmetiques anhydres contenant des agents actifs sur le plan dermatologique Download PDF

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Publication number
WO1996021422A1
WO1996021422A1 PCT/US1996/001560 US9601560W WO9621422A1 WO 1996021422 A1 WO1996021422 A1 WO 1996021422A1 US 9601560 W US9601560 W US 9601560W WO 9621422 A1 WO9621422 A1 WO 9621422A1
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WIPO (PCT)
Prior art keywords
cosmetic
cosmetic composition
agent
carrier
composition according
Prior art date
Application number
PCT/US1996/001560
Other languages
English (en)
Inventor
Yolanda Laboy
James Michael Wilmott
Anna Szczepanowski
Original Assignee
Mary Kay Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mary Kay Inc. filed Critical Mary Kay Inc.
Priority to AU48643/96A priority Critical patent/AU4864396A/en
Priority to EP96904572A priority patent/EP0802785A1/fr
Priority to PL96321293A priority patent/PL185239B1/pl
Priority to BR9607560A priority patent/BR9607560A/pt
Publication of WO1996021422A1 publication Critical patent/WO1996021422A1/fr
Priority to UA97073757A priority patent/UA56991C2/uk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0279—Porous; Hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/31—Anhydrous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • compositions of the invention relate to cosmetic compositions including delivery systems that provide new ways of delivering dermatologically active agents to cosmetically significant areas of the stratum corneum.
  • Compositions of the invention are particularly, but not exclusively, useful as eye enhancers to provide cosmetic benefits to eye areas such as the eyelids, under eye areas and to the canthus or outer eye corner and are also useful for cosmetic treatment of the lips and other topical areas.
  • the invention includes novel film-forming systems to assist delivery of the active agent. These film-forming systems yield supplementary enhancements and are useful independently of the delivery system.
  • BACKGROUND The eyes themselves are the focus of any person's identity and personality as well as a focal point of attention for others. In any face-to-face encounter, the eyes provide a powerful medium of unspoken communication. The appearance of the eyelids and facial areas around the eyes is critical to the appearance of the eyes, and hence to the impression one person receives of another. Accordingly, eye-treatment compositions comprise an important segment of the cosmetics industry.
  • the eyes are cosmetically a sensitive and sometimes difficult area to treat. They are subject to congenital defects, deficiencies and disorders and the appearance of the eye areas can quickly deteriorate owing to aging, the effects of weather, diet and so on. Quality cosmetic treatment of eye areas can bring great visual and psychological benefits to an individual by making striking improvements in their appearance.
  • Some common eye area problems include wrinkling, cracking, formation of fine lines, blotching and discoloration. These problems may blemish the upper and lower eyelids, particularly the under eye area and also the corners of the eye, especially the outer corner known as “the canthus” that are prone to form cracks and lines, often inelegantly referenced as “crow's feet”.
  • the cosmetics industry has offered a wide range of remedies to conceal, fill, color or otherwise modulate the appearance of unattractive eye areas.
  • Mascaras, eyeliners and other eyelash treatments are used to enhance and define the appearance of the eyelashes, eyebrows and the edges of the eyelids and can have a beneficial and sometimes theatrical impact on the eyes as a whole.
  • More significant to the purposes of the present invention are cosmetics used for treating the major dermal areas in the vicinity of the eye, notably the eyelids, the under-eye area and the outer eye corner areas.
  • Such cosmetics are eye shadows, eye creams, and eyeliners.
  • general use cosmetics such as foundations and makeups can be used in the eye area, caution is needed because of the risk of contaminating the eye with stinging or irritating allergenic ingredients or of inducing swelling or bacterial infection.
  • Eye cosmetics can be difficult to apply smoothly or evenly, or may have an unpleasant or tacky feel, or poor film-forming capabilities (being hard to spread) , or have high drag or may be difficult to remove. Few eye cosmetics provide long term structural dermatological improvements, except for special-purpose eye creams and moisturizers, containing skin revitalizing ingredients. Generally, such eye creams are intended for use at night and will not hold eye shadow satisfactorily so that they cannot be used for normal daytime wear because they do not provide significant enhancement of appearance.
  • M dermatologically active is used herein to describe materials that act on the skin to provide a long term improvement of one kind or another, being an improvement that endures or begins after the cosmetic makeup is removed.
  • dermatological activity is to be distinguished from cosmetic properties that are only effective while the cosmetic is present on the skin.
  • alpha hydroxy carbolic acids of relatively low molecular weight, for example with 10 carbon or less.
  • alpha hydroxy acids these acids are known to have a number of useful effects on the skin.
  • Referenced “AH ⁇ 's” herein which is a common abbreviation in both the popular press and the technical literature, alpha hydroxy acids can moisturize dry skin and improve various disorders including acne and psoriasis and other skin anomalies.
  • AH ⁇ 's are also effective in revitalizing the skin. Depending upon the concentration and length of application they can cause, or stimulate, exfoliation which is the removal of outer keratinous or horny tissue layers, and stimulate renewal of new skin layers to provide a significant improvement in the appearance of the skin.
  • Some AHA's that have been, used to provide these benefits are the simplest alpha hydroxy acid, namely glycolic acid, as well as lactic acid, citric acid and malic acid. These acids are also known as “fruit acids” because they are found in fruits and in the case of glycolic acid, in sugar cane. There are many other AHA's, or equivalent alpha keto acids and the like, that are known, or have been suggested for use in revitalizing skin or otherwise providing useful dermatological skin functions. Some beta hydroxy acids, for example salicylic acid, also have useful dermatological properties. Some such "skin acids” are disclosed in Yu et al . U.S. Patent No. 5,091,171 the disclosure of which is hereby incorporated herein by reference thereto.
  • AHA's of interest are usually quite hydrophilic, dissolve readily in water and, in the case of lactic acid become liquid around room temperature (about 16.8 °C) .
  • Such hydrophilicity is usually incompatible with common hydrophobic eye cosmetics such as eye shadows, or eye primers.
  • the anhydrous nature of such eye cosmetics means that small quantities of active hydrophilic agents for example ⁇ H ⁇ 's may either lose their activity due to chemical or physico-chemical combination, or fail to be delivered to the skin surface in an adequately hydrophilic or aqueous environment to be effective.
  • preferred environments for such agents are significantly acidic, a condition which is difficult to provide at skin surfaces treated with anhydrous, or substantially hydrophobic, cosmetics.
  • a critical problem with any eye cosmetic is to avoid irritation of, or stimulation of allergic or pathogenic reactions in the eye.
  • AHA's can be very acidic and are known to be significantly irritating, even when applied to durable areas of the skin. Avoiding irritation is of special significance to products intended for daily use, in the eye or other sensitive skin areas.
  • One way of delivering dermatologically or cosmetically active agents in a cosmetic vehicle is by containing the active agents in or on a suitable particulate carrier.
  • a suitable particulate carrier Of particular interest for use as a carrier are small porous polymeric particles or microspheres.
  • a problem with this approach is that having employed an affinity between a medium containing the active agent and the microsphere to O 96/21422 PO7US96/01560
  • the active agent loaded into the microsphere, it is then necessary to overcome that affinity to release the active agent. It is also important that the delivery vehicle not possess a greater affinity for the dermatologically active agent than does the carrier, otherwise the active agent may discharge prematurely from the porous carrier into the vehicle and be dissipated.
  • U.S. Patent 5,292,512 discloses a cosmetic composition for topical application in which dermatologically active agents such as acne treatments, for example retinoids and benzoyl peroxide, hormones, antifungal, antibiotics and so on are absorbed on carrier particles for delivery to the skin.
  • dermatologically active agents such as acne treatments, for example retinoids and benzoyl peroxide, hormones, antifungal, antibiotics and so on are absorbed on carrier particles for delivery to the skin.
  • Typical carrier particles are organic polymeric microspheres. Active products are introduced into the microspheres by dissolving them in a suitable solvent such as water, glycerol or the like (column 4 lines 47-54) .
  • Schaefer et al The objective of Schaefer et al . is to deliver the active products into the sebaceous follicles for release beneath the epidermis. To this end Schaefer et al . employs rather small microspheres of which 80% have a diameter of between 3 ⁇ m and 10 ⁇ m which is apparently of an appropriate size to travel into the follicles past the epidermus. (See column 1 line 45 to column 2 line 40.) Schaefer et al . provides no 96/21422 PCIYUS96/01560
  • Schaefer et al . 's loaded microspheres are formulated in various hydrophilic or hydrophobic gel compositions and are reported to provide excellent antiacne properties, presumably due to the penetration of the active ingredient loaded carrier particles into sebaceous follicles.
  • Schaefer et al . 's compositions are clearly intended as single purpose preparations providing improved delivery of a specified active agent and lack independent cosmetic benefits. If the user wants to obtain cosmetic benefits additional to acne or other therapeutic treatments, a cosmetic preparation will need to be applied separately which cosmetic may be incompatible with the acne treatment.
  • Schaefer et al . do not attempt to incorporate active-agent-loaded microspheres into a cosmetic base or to address the problems that may arise in doing so.
  • the invention as claimed, is intended to provide a remedy. It solves the problem of how to deliver a dermatologically active hydrophilic agent to eye and other sensitive skin surface areas in an essentially hydrophobic cosmetic composition.
  • the invention provides a cosmetic composition in which a dermatologically active hydrophilic agent constituted in a liquid hydrophilic medium is either adsorbed or absorbed into or onto a suitable particulate carrier.
  • This carrier-active-agent system can be incorporated into a substantially anhydrous cosmetic base, for example cream suspension.
  • the anhydrous base preferably comprises one or more film-forming agents to provide a novel cosmetic composition which can be topically applied to deliver the hydrophilic agent to the skin.
  • Preferred embodiments of the invention provide solutions to the problem of providing a useful cosmetic composition containing an effective concentration of a dermatologically active agent which can provide controlled release of the dermatologically active agent to the skin.
  • Cosmetic compositions according to the invention can be formulated into a wide range of cosmetics products, for example, pigmented eye shadows, non-pigmented eye shadow primers, lipsticks, moisturizers, lip treatments, foundations, and the like. These new cosmetics products in addition to having valuable cosmetic properties, have dermatological activity and provide lasting benefits.
  • an eye shadow can be formulated with a skin revitalizing agent, for example an alpha hydroxy acid, to provide both immediate and long-term improvements to the eye lids.
  • the hydrophobicity of the vehicle should tend to inhibit the hydrophilic active medium from egressing from the microsphere. While not being bound by any particular theory, it is a concept of the invention that the spreading and massaging actions that normally accompany topical application of the product act to bring AHA-loaded microspheres into contact with the skin where skin moisture draws the AHA-containing hydrophilic medium out of the microspheres.
  • the cosmetic compositions of the invention are applied to particular skin areas, such as around the eyes and on the lips, they are subject to a constant kneading action as the eyelids are blinked and the lips are moved or wiped, providing continual turnover of the microspheres contacting the skin surface, and replenishment of the AHA-containing hydrophilic medium supplied to that surface.
  • the film- forming nature of the anhydrous base produces a water-loss barrier on the skin's surface inhibiting transpiration of water from the skin.
  • This control of water loss enables the upper cutaneous level of the skin to increase its water content thereby promoting the egress of the dermatologically active agent from the carrier into the skin.
  • any water or other suitable solvent for the dermatologically active agent that is introduced by subsequent application of a secondary cosmetic product using the inventive composition as a primer can also assist the egress of the active agent from the carrier to the s.kin.
  • Organic polymeric microsphere tend to be slippery and do not adhere to the skin. Strong adhesive properties can be provided to the microspheres by incorporating them into anhydrous cosmetic compositions containing suitable film- forming agents, including novel film-forming systems pursuant to the invention. When such a film system is used in cosmetic compositions containing microspheres, a good anhydrous film can be obtained with excellent spreadability and no tackiness or drag.
  • Fine lines in the skin can be both cosmetically masked or concealed by a filling and light-diffusing action of the microspheres while also being dermatologically reduced by a skin revitalization action of the AHA's.
  • Preferred formulations can also diffuse light to reduce the appearance of dark circles beneath the eyes and provide a soft focus effect.
  • Preferred embodiments of the invention can also enhance the water barrier properties of skin surfaces to which they are applied, potentially promoting the action of dermatologically active hydrophilic agents delivered through the cosmetic and increasing the durability of cosmetics applied over- the inventive product.
  • Preferred embodiments of the invention relate to novel cosmetic compositions containing an effective quantity of a polar dermatologically active agent, a sufficient quantity of suitable adsorbing or absorbing carrier to support the dermatologically active agent and one or more film-forming agents in a substantially anhydrous vehicle or base formulated to deliver the dermatologically active agent to the surface of the stratum corneum.
  • This composition provides properties which enables a wearer or user to enjoy their usual, cosmetically assisted, attractive appearance while, at the same time, gaining one or more dermatological benefits which will endure after removal of the cosmetic.
  • the essentially or substantionally anhydrous base provides a medium or vehicle for dispersal of the active-agent loaded carrier particles which medium can be liquid or semi-solid, for example, a dispersant or solvent for other cosmetic ingredients bringing desired cosmetic properties to the composition.
  • the anhydrous base can thus comprise a more or less volatile hydrophobic cosmetic solvent in which a gelling agent is optionally dispersed to provide a desired consistency.
  • Suitable carrier materials include but are not limited to polymeric organic microspheres and inorganic particulates.
  • Some commercially available microspherical powders useful in the preparation of the cosmetic materials of this invention include organic polymeric materials for example polyethylene, polypropylene and copolymers thereof, polyurethane, polyesters, polya ides, poly ethylmethacrylate, nylon, ethylene acrylates copolymers and polyvinylidene copolymers.
  • Substantially any non-toxic, non-irritating, cosmetically compatible organic polymeric material that can be provided in a satisfactorily adsorbent or absorbent form for the purposes of this invention, and which is compatible with the anhydrous vehicle, can be used.
  • inorganic particulates include talc, clays, organic modified clays, kaolin, mica, calcium salicylate and various carbonates of various metals, for example calcium and magnesium.
  • the carrier particles should not be too large or their presence as a component of the composition will be apparent to the user and may give a particulate coarse or sandy, rather than, smooth feel to the cosmetic.
  • at least eighty percent of the particles should not exceed 50 and preferably not exceed 20 microns.
  • the particles should be too small, or they may be absorbed in the sebaceous follicles, which is not desired, and will provide too small a storage volume for the passenger dermatologically active agent.
  • the carrier particles should be relatively large to be able to release passenger active from either the surface or through surface openings from interior volumes of the particles.
  • at least eighty percent of the carrier particles are in excess of 10 microns in diameter.
  • a particularly preferred range for at least eighty percent of the particles is from 10 to 20 microns, more preferably from 10 to 15 microns.
  • a useful average particle size is from 12 to 20 microns.
  • a porous carrier particle is particularly preferred whereby a liquid phase can be absorbed within the particle to occupy, for example, from 10 to 90 percent of the particle's volume, rather than simply being retained on the particle's surface.
  • An absorbent matrix powder serving as a carrier for topical delivery of the dermatologically active agent or dermatologically active solution can comprise porous synthetic organic polymeric microspheres, for example a cosmetically acceptable polyamide such as nylon 12, in a proportion of from about 0.1 to about 40.0 percent, preferably from about 5.0 to about 20.0 percent, and more preferably from about 6.5 to about 10.0 percent by weight of the cosmetic composition.
  • the organic polymeric microspheres impart desirable feel properties for example creamy, powdery and silky qualities to consumer formulations, and enhance the light-scattering qualities of the formulation.
  • the organic polymeric microspheres When discharged of AHA or other dermatologically active agents the organic polymeric microspheres are available to absorb skin oils, helping control oil breakthrough.
  • Dermatologically Active Agents examples include, but are not limited to, the following: anesthetics, for example, benzyl alcohol, lidocaine and menthol; astringents, for example, witch hazel, benzoic acid and aluminum or aluminum/zirconium salts; keratolytics, for example resorcinol, salicylic acid, ascorbic acid and acetic acid; exfoliants, for example, lactic acid, glycolic acid and other alpha or beta hydroxy acids; vasoconstrictors, for example, phenylepinephine hydrochloride; external analgesics, for example, tripelenna ine hydrochloride and camphor; anti-inflammatory agents, for example, salts of glycyrrhizic acid, alpha bisabolol; salicylate derivatives and ibuprofen; anti-irritants, for example, allantoin, proteins
  • anesthetics for example, benzyl alcohol, lidocaine
  • the active material is to be absorbed onto or absorbed into a particulate carrier which in turn is dispersed in an essentially anhydrous cosmetic base or vehicle, it is preferred that the dermatologically active agent or ingredient be polar and have little or no affinity for the components of the essentially anhydrous base.
  • One or more dermatologically active agents in a range of from about 0.01 to about 10.0 percent by weight of the composition can be incorporated into preferred embodiments of the current composition. More preferably these agents can be added from about 0.5 to about 8.0 percent and still more preferably from about 1.0 to about 5.0 percent. Other active agents can be used in equivalent proportions depending upon their activity however proportions are preferred in the sensitive eye area.
  • Preferred dermatologically active agents are classes of exfoliants known as alpha and beta hydroxy acids respectively. These materials can be used to both moisturize and revitalize the skin resulting in better structural and visual qualities. These benefits may begin to be apparent only after long-term use of the cosmetic composition of the invention on a regular, for example daily, basis for a period of from days to weeks, for example, beginning at fourteen or twenty-one days and continuing until from three to six months of daily or twice daily applications or even continuing indefinitely.
  • the novel, substantially anhydrous eye or lip cosmetic composition of this embodiment of the invention contains, as dermatologically active hydrophilic agent, at least one alpha hydroxy acid (“AHA” herein) , for example lactic acid, citric, malic, mixed fruit acids, or mixtures thereof, supported on a matrix, or in a porous particulate carrier.
  • AHA alpha hydroxy acid
  • the AHA is preferably supported on the carrier particles so as to be present in surface pores of the carrier particles and also in interior pores communicating with those surface pores, whereby the AHA bearing hydrophilic medium can be released at the particle surface and withdrawn from the carrier particle by skin moisture, possibly by capillary action.
  • alpha hydroxy acids which can be used in practicing this invention include a straight or branched chain aliphatic acid with not more than three substituents in the aliphatic backbone, said substituents being non-basic and being selected from the group consisting of hydroxy, aldehyde, keto, carboxyl, chloro and nitro. Acidity and water or hydroalcoholic solubility are desirable characteristics of the alpha hydroxy acids used in the present invention.
  • Some preferred alpha hydroxy acids contain at least one hydrophobic moiety being a carbon atom having four substantially non-polar bonds for example carbon-carbon or carbon-hydrogen bonds. Such hydrophobicity is believed useful to balance the electronegative hydroxy and carboxyl radicals for improved biological compatibility and efficiency.
  • alpha hydroxy aliphatic acids are preferably nonocarboxylic acids selected from the group consisting of 2-hydroxy-n-butanoic acid, 2-hydroxy-isobutanoic, 2-hydroxy- n-pentanoic, 2-hydroxy-isopentanoic, 2-hydroxy-n-hexanoic acid, 2-hydroxy-isohexanoic acid.
  • Di- or polyhydric analogs thereof can also be used, for example, 2,X-dihydroxy analogs thereof where "X" is an integer from 3 to 6, as appropriate for the respective monohydroxy acid, indicating the carbon atom location of a second hydroxyl substituent in a carbon atom other than the number one or two carbon atoms.
  • such dihydroxy acids balance the additional electronegativity attributable to the second hydroxyl with a further hydrophobic moiety as described above.
  • the solvent system should have little or no affinity for the essentially anhydrous base. This is important to retaining both the solvent and its dermatologically active solute in or on the carrier and to preserving the intended functionality of the dermatologically active agent.
  • the solvent should be suitably vicous to further help retard the migration of the dermatologically active agent from the carrier.
  • the solvent should be inert or inactive with respect to, or at least not negatively impact the functionality of the dermatologically active agent.
  • Hydrophilic Solvents Some classes of liquid hydrophilic solvents or disperse phase media that can be used alone or in combinations as adjuvants to assist the loading of the dermatologically active agent or agents onto or into the particular carrier include but are not limited to water, alcohols and ethers.
  • a suitable class of alcohols comprises mono-, di-, tri- or polyhydroxy alcohols having the formula: (OH) I R - (CH) ⁇ - (C) v - (CH 2 ). - R 1
  • R 1 H , CH 3 , O-CH j , 0 -CH 2 -CH 3
  • Suitable examples of such compounds include glycerin, propylene glycol, dipropylene glycol, propanol, isopropanol, butanol, isobutanol, pentanol, isopentanol, neopentanol, diglycerol, polyglycerol, sorbitol, polyethylene glycerol, and polyol.
  • Suitable ethers include unsubstituted and substituted ethers for example UCON (trademark) fluid, Union Carbide Corp. or DOWANOL (trademark) fluids, Dow Chemical Company or CARBITOL (trademark) and CELLOSOLVE (trademark) solvents from Union Carbide.
  • suitable viscous, hydrophilic solvents or blends of solvents can be used with the dermatologically active agent in a proportion of from about 99 parts: 1 part to about 1 part: 99 parts.
  • preferred proportions are chosen to exploit the physical or physico-chemical characteristics of the solvent to deliver the dermatologically active agent an active form in a liquid phase for uptake by absorbent carrier particles.
  • major properties of solvent are preferred, for example a proportion of from about 1:1 to about 1:20 parts agent to solvent, on a weight basis.
  • a preferred solvent for a dermatologically active agent for example an alpha hydroxy acid (AHA) is glycerin.
  • AHA alpha hydroxy acid
  • the solvent's viscosity helps retain the AHA within or on the particulate carrier while the hydrophilicity permits skin moisture to draw dissolved AHA out of or off of the microparticle.
  • the invention provides for a film-forming agent to assist with the adhesion of the loaded particulate carrier onto the skin and to help form an occlusive barrier to enhance the buildup of water on or near the surface of the skin.
  • film-forming is meant that an essentially continuous layer of product is formed on the surface of the skin.
  • occlusive is meant that a barrier is placed on the surface of the skin which barrier substantially blocks or retards the loss of volatile materials from the skin's surface and enables them to build up in the upper layers of the skin.
  • the barrier film is preferably hydrophobic.
  • Suitable cosmetic film-forming agents that can be used alone or in combination include but are not limited to metallic soaps, waxes and film-forming emollients. Some non-limiting examples of each of these classes of cosmetic film-forming agents will now be described. Others will be known to those skilled in the art.
  • Metallic soaps are useful materials which function to aid adhesion and to promote the formation of a hydrophobic film.
  • the metallic soap gelling agent or agents can be an alkaline earth or aluminum alkanoate of from six to twenty carbon atoms, for example, the laurate, oleate, or stearate salts of calcium, magnesium, zinc, aluminum or lithium or mixtures thereof.
  • a cosmetic metal soap, for example zinc laurate can be used in a proportion of from about 1.0 to about 5.0 percent, preferably about 3.0 percent by weight of the composition.
  • Metallic soap functions as an ionic gelling agent, aids adhesion and adds to hydrophobic film formation.
  • R-X a long chain saturated, unsaturated, cyclic or branched chain alkyl radical of from C 8 to C, 000000
  • X is -H, -OR 1 or -C-OR 11 , where R 1 is H, or a saturated, unsaturated, cyclic or branched chain alkyl radical of from C,, to C ⁇ t ⁇ ; R 11 is H or residue of a mono-, di-, tri- or polyhydroxy compound capable of forming a mono-, di-, tri or polyester.
  • Preferred waxes have melting points which exceed 100 °F.
  • Materials such as glyceryl wax esters, beeswax, ceresin wax, carnauba wax, candelilla wax and other cosmetically acceptable waxes can be used.
  • a total wax content of from 0 to 10.0 percent is adequate for formulating satisfactory cosmetics, pursuant to the invention.
  • total wax content does not exceed 5.0 percent and more preferably not 3.0 percent.
  • Suitable waxes are, for example, glyceryl tribehenate, ceresin wax and microcrystalline wax used in proportions of from about 0.00 to about 5.00 percent, preferably about 0.1 to 1.5 percent. More preferably from about 0.25 to 0.5 percent of waxes such as glyceryl tribehenate and a somewhat higher proportion of about 1 to 2 percent of a ceresin was are used.
  • the low wax content attainable with cosmetic compositions according to the invention has the advantage of providing low drag and enhanced removability.
  • Useful wax functions are adhesion, imparting a creamy feel to the product, film forming and increasing viscosity.
  • Emollients useful in the present invention include those with the following formula c n H (2n + 2 . ⁇ ) , where n is an integer from 6 to greater than 1 million and x is 0 or an even integer no greater than n and may include saturated, unsaturated, branched and cyclic hydrocarbon chains. Examples include: mineral oil, petrolatum, PERMETHYL (trademark) fluids, and polybutylenes.
  • Further useful film-forming emollients include the mono-, di-, tri- or poly-branched, -cyclic, -saturated or - unsaturated alkyl esters or ethers of di, tri or polyhydroxy compounds for example ethylene glycol, propylene glycol, glycerin, sorbitol or polyol.
  • emollients include but are not limited to vegetable oils for example soybean oil, babassu oil, castor oil, cottonseed oil, Chinese tallow oil, crambe oil, perilla oil, Danish rapeseed oil, rice bran oil, palm oil, palm kernel oil, olive oil, linseed oil, coconut oil, sunflower oil, safflower oil, peanut oil, and corn oil.
  • Preferred saturated and unsaturated vegetable oils are those having fatty acid components with 6 to 24 carbon atoms.
  • Suitable emollient film-forming agents include esters of the formula:
  • R.-C-OR or R.-O-C- (CH,) -C-O-R, 0 II 0 i " 0 i '
  • R, and R z are saturated, unsaturated, branched or cyclic alkyl radicals of 2 to 24 carbon atoms and n is an integer from 0 to about 20.
  • Silicone-based auxiliary film-forming agents may also contain a silicone material to provide some measure of auxiliary film-forming ability.
  • Suitable silicone materials are preferably insoluble in water and cyclo ethicone, polyalkylsiloxanes, polyarylsiloxanes, polyalkylarylsiloxanes, polysiloxane gums, amino functional polysiloxanes and polyethersiloxane copolymers. Teachings directed to additional suitable silicone materials can be found in U.S 4,788,006; U.S. 4,341,799; 4,152,416; 3,964,500; 3,208,911; 4,364,837 and U.S. 4,465,619, the disclosures of all of which are hereby incorporated herein by reference there to.
  • auxiliary film-forming agents comprises substances formed by the polymerization of alkylene oxide monomers of the formula 0 / ⁇ H(CH 2 ) n - HC - CH 2
  • n is an integer from 0 to about 3.
  • These materials can be either a homogeneous polymer or a copolymer of two or more monomers.
  • homogeneous polymers include polypropylene oxide and polybutylene oxide. Typically, the molecular weights of these materials is between 100 and 10,000 daltons. Additionally, these materials can be condensed with a mono or polyhydroxyalkyl alcohol as exemplified by the UCON (trademark) fluids from Union Carbide Corp.
  • the film-forming agent can be used alone or in combination with other film-forming agents to achieve desired aesthetic properties in the final preparation.
  • a preferred range of film-forming agents is from 1 to 99%, more preferably from about 1 to 50% by weight of the composition.
  • Suitable non-hardening film formers for example dimethicone, can be used in proportions of from about 0.5 to about 5.0 percent, preferably about 0.6 to 1.5 percent, and more preferably about 1.0 percent.
  • Preferred functions include film forming, skin protectant or water-barrier forming agent, lubricious and silky emollient.
  • Film enhancing agents for example aluminum-myristate- treated mica, in a proportion of from about 4.0 to about 20.0 percent by weight of the composition, preferably about 5.0 to 8.0 percent, and more preferably 6.5 percent can be used.
  • Preferred film enhancer functions include adhesion to skin, imparting of a creamy and silky feel to the composition and enhancing hydrophobic film formation.
  • the invention also provides a novel film-forming system which comprises relatively high proportions of a particulate mineral gelling agent, for example a bentonite-clay based gelling agent, and of a metallic soap gelling agent, such for example as zinc laurate, while using only a small proportion of wax, if any.
  • a particulate mineral gelling agent for example a bentonite-clay based gelling agent
  • a metallic soap gelling agent such for example as zinc laurate
  • carrier loading of our AHA is achieved by dissolving the AHA in glycerine and absorbing the glycerine-dissolved AHA on porous microspheres or fine polymer particles.
  • This system is intended for use in a hydrophobic environment where the AHAs remain in storage contained in the porous microspheres.
  • microspheres When applied to the skin, as the cosmetic is rubbed or massage ⁇ into cne skin, microspheres are brushed across the skin surface, bringing them into contact with moisture which releases the hydrophilic AHA-glycerine system from the microporous polymer particles.
  • the AH ⁇ is preferably loaded on the carrier particles, for example, porous nylon particles in a liquid medium which should be sufficiently viscous to be held in the particles' pores during formulation.
  • Lactic acid melts at 16.8 °C and can be absorbed into porous carrier particles, without the need for any adjuvant, at temperatures above this melting point, by blending in appropriate proportions, for example, near 1:1 by weight, until the lactic acid is absorbed.
  • Other acids such as a mixture of fruit acids, can be similarly loaded on to carrier particles by agitating ie. blending, by using fine powders with a sufficiently small particle size to be contained in the carrier's pores.
  • the novel, substantially anhydrous eye or lip cosmetic composition of this embodiment of the invention contains, as dermatologically active hydrophilic agent, at least one AHA, for example lactic acid or mixed fruit acids, supported on a matrix, or porous particulate carrier in powder form, of a synthetic organic polymer, for example nylon.
  • AHA is preferably present in surface pores of the carrier particles and also in interior pores communicating with those surface pores, so that the AHA can be released at the particle surface and withdrawn from the carrier particle by skin moisture.
  • the invention also provides a low-wax, or zero-wax, cream- to-powder film-forming vehicle for the foregoing AHA-loaded system.
  • This low-wax vehicle is made possible by a unique combination of a relatively high proportion of a gelling agent such as a bentonite and a high proportion of a metal soap, preferably in a volatile solvent system such as a cyclomethicone, for example dimethicone or a non-polar solvent, for example a volatile hydrocarbon.
  • novel eye enhancers according to the invention are surprisingly long lasting, as shown by comparative data. Whereas traditional eye makeups may need refreshing after a few hours and are usually fading noticeably in about six hours, eye cosmetics produced according to the invention can endure satisfactorily for over 12 hours without unacceptable fading.
  • Cream-to-powder products according to the invention are quick drying.
  • the solvent evaporates off in a matter of a few seconds to provide a silky smooth powder film.
  • Inclusion of a light- diffusing agent scatters light in the shadows between wrinkles cracks or other skin defects and helps give the product a soft focus appearance.
  • Such eye enhancers pursuant to the invention work synergistically the film-forming system and AH ⁇ loaded porous microspheres to provide an enhanced appearance on application, giving the skin an illusion of improved skin quality while the alpha hydroxy acid released on contact with the skin actively conditions or revitalizes the skin, so that after a period of regular use, which may be as low as four weeks, the appearance of the skin without cosmetics is improved.
  • a preferred hydrophobic vehicle for the active-agent-loaded microsphere particles is a silicone gel, which is preferably formulated using a volatile silicone solvent such as a dimethicone.
  • a preferred gelling agent is a bentonite powder.
  • the invention preferably employs a low wax, cosmetic film-forming system comprising, in weight percent based on the weight of the composition, from 5.0 to 13.0 percent of a particulate mineral gelling agent, for example a bentonite, and at least 1.0 percent of a metallic soap gelling agent, with no more than 5.0 percent of a cosmetic wax material, if present, dispersed in a volatile cosmetic solvent, preferably a cyclomethicone in a proportion of from about 30.0 to 70.0 percent.
  • a particulate mineral gelling agent for example a bentonite
  • metallic soap gelling agent preferably a metallic soap gelling agent
  • a volatile solvent for example a cyclomethicone, preferably the penta er form
  • a hydrophobic vehicle for example for a cream-to-powder composition.
  • Suitable proportions are from about 20.0 to about 70.0 percent by weight of the composition, preferably about 30 to 40 percent, and more preferably about, 33.0 percent. Functions as a wetting agent while quickly evaporating upon application.
  • a gelling agent suitable for a volatile solvent for example quaternium-18 bentonite, from about 1.0 to about 15.0 percent, more preferably from about 3 to 10 percent, and more preferably about 5.0 to 6.0 percent. Physically stabilizes the composition and functions as a pigment- suspension vehicle and to absorb oil and reduce shine.
  • a wetting agent for example sorbitan isostearate, from about 1.0 to about 10.0 percent by weight of the composition, preferably about 3.5 to 4.5 percent, and more preferably about 4.0 percent can be used.
  • Preferred wetting agents allow for increased capacity of solid material, and impart a hydrophobic film.
  • Additional polymeric microspheres Synthetic polymeric microspheres additional to the AHA carrier powder, for example poly ethylmethacrylate, can be used in a proportion of from about 8.0 to about 20.0 percent by weight of the composition, preferably about 10.0 to 15.0 percent, and more preferably 12.0 percent. Such additional polymeric microspheres act as feel enhancers, providing a "ball bearing" feel on application, and a velvety, dry feel after application and evaporation of the solvent. Additional functions include light scattering and impartation of a powdery feel to the product.
  • Oily esters An oily, low-volatility solvent ester, for example isononyl isononanoate, is useful for volatility and molecular weight control of the solvent system in a proportion of from about 1.0 to about 10.0 percent by weight, preferably from about 4.0 to 6.0 percent, and more preferably about 5.0 percent of a solvent.
  • Preferred solvents also function as lipophilic emollients, aid in the solubilization of the ingredients and are miscible with the volatile carrier solvent (for example dimethicone) .
  • One or more oil soluble moisturizers for example lauryl PC ⁇ , in a proportion of from about 0.4 to about 2.5 percent, preferably about 0.5 percent, or cetyl dimethicone, in a proportion of from about 1.0 to about 5.0 percent by weight of the composition, can be used to enhance moisturization. Cetyl dimethicone provides a light, dry feel and aids film formation.
  • Oil absorbents Kaolin or other oil absorbents in a proportion of from about 0.50 to about 3.0 percent by weight of the composition, preferably about 0.7 to 1.5 percent, and more preferably 1.00 percent can be used. Preferred oil absorbent functions include absorption of excess skin oils, skin adhesion, light diffusion, and opacification. Opacifiers. An opacifier, for example titanium dioxide, can be used in a proportion of from about 0.10 to about 5.0 percent by weight of the composition, preferably about 0.3 to 1.0 percent, and more preferably 0.50 percent to provide coverage and help mask skin defects.
  • a volatile polar activator solvent for the gellant for example hexylene glycol
  • hexylene glycol can be used in a proportion of from about 0.75 to about 1.75 percent by weight of the composition, preferably about 0.85 percent. This will act as a binder plasticizing agent, solvent and softener while providing resistance to moisture and oxidation.
  • Preservatives such as, for example, methyl or propyl paraben, can be used in proportions of, for example, 0.1 to 0.3 percent by weight, as is known to those skilled in the art.
  • vitamin E linoleate in a percentage of about 0.10 percent as a supplemental moisturizer
  • vitamin E acetate at about 0.10 percent functions as a free radical scavenger and an antioxidant
  • retinyl pal itate at about 0.1 percent functions as a derivative of retinoic acid to reduce fine lines
  • ceramides at a percentage below about 0.3 percent function as a skin firmer
  • sphingolipids serve the function of skin firming at a percentage below about 0.3 percent, function to improve the skin's barrier thereby increasing moisturization and decreasing penetration of irritant substances.
  • a class of cyclomethicone compounds that is preferred for use in the cosmetic compositions of this invention is illustrated by compounds of the formula -[R.R 2 SiO] n -, in which R and R is each lower alkyl having from one to four carbon atoms with or without innocuous substitutes selected from the group consisting of halo, hydroxyl, carboxyl or methoxy and n is from 3 to 6; which compounds are cyclized.
  • the volatile cyclomethicone solvent used can be a single one of the foregoing compounds or a mixture thereof and the compound or compounds can be a homopolymer in which all n monomeric units are similar, or a heteropolymer in which they are different.
  • cyclomethicones are dimethicones especially homopolymers in which n is 4 or 5; and R and R is each methyl such as octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane.
  • ingredients can be used, as known to those skilled in the art, in proportions known to those skilled in the art.
  • Such ingredients include, but are not limited to, fragrance, color, pigments, preservatives, wetting agents, oil absorbents, opacifiers, and antioxidants.
  • Table I sets forth the ingredients used in Examples 1 and 2.
  • a Glycerin 20 20 is provided.
  • Example 1 porous Nylon-12 microspheres are loaded with lactic acid using a glycerin solvent. Glycerin is mixed in a blender with an equal amount of lactic acid to form phase A using the proportions set forth in Table II. Nylon-12 powder is then added to phase A in a ratio of two parts phase A to three parts Nylon-12. The glycerin lactic acid phase is substantially completely absorbed by the Nylon-12 microspheres, increasing their density, to produce a free flowing powder. This combination is blended for one hour to produce a physically stable, mildly tacky, lactic acid powder blend which is subsequently used in Example 9.
  • Example 1 is repeated using mixed fruit acids in place of lactic acid in the proportions indicated in Table I. A physically stable, mildly tacky powder is obtained and used in Example 10.
  • a dry mix for use in eye enhancer compositions is prepared in a single phase using the ingredients referred to in Table II. Powdered zinc laurate is combined with aluminum [ yristate] coated mica, kaolin, and titanium dioxide and blended until a smooth homogenous powder is obtained.
  • Table III sets forth the ingredients used in Examples 4-5.
  • porous Nylon-12 microspheres are loaded with lactic acid without the use of solvents.
  • the phase A ingredient is slowly added to the phase B ingredient while mixing on a blender at room temperature.
  • the preparation yields a 4:1 Nylon-12/lactic acid blend utilized in Example 7.
  • Example 4 is repeated, substituting mixed fruit acids for lactic acid and reducing the proportion nylon-12 utilized, to yield a product with a 1:1 ratio of nylon-12 to mixed fruit acids. This preparation is utilized in Example 6. Table IV sets forth the ingredients used in Examples 6-8.
  • Example 6 incorporates the composition prepared as in Example 5 in an anhydrous base according to the percentages listed in Table III.
  • the phase B ingredients are dispersed by mixing for at least three minutes at high speed. Once -4b- dispersed, phase B is added to phase C and blended at low speed for one minute. Phase A ingredients are mixed and heated to 65 degrees Celsius until clear. When phase A is clear, the blended phase B and C mixture is added, in a propeller type mixer until uniform and free of lumps. Once this mix is uniform, phase D ingredients are added and the mix is again blended to uniformity.
  • Example 6 is repeated with the addition of Nylon-12 at phase B, to further enhance the feel of the composition, and the substitution of solventless nylon-12 carrier lactic acid blend, as prepared in Example 4, for solventless nylon-12 carrier mixed fruit acid blend as prepared in Example 5.
  • the acid blend substitution yields a composition with a higher percentage of alpha hydroxy acid.
  • Example 8 Solventless Nylon-12/Mixed Fruit Acid Blend in an Anhydrous Base as a Color Primer
  • Example 8 utilizes the procedure designated in Example 6 with the inclusion of a phase E comprising additives and colorants.
  • This final phase involves the mixture being brought to 45 degrees Celsius at which point the phase E ingredients are added and blended until uniform.
  • the cetyl dimethicone and dimethicone are substantially replaced with cyclomethicone.
  • the less volatile cetyl dimethicone and dimethicone lead to the production of a creamy composition whereas the more volatile cyclomethicone produces a composition that will rub out into a cream to powder vehicle.
  • Various coloring agents can be used as is evidenced by the inclusion of several coloring agents as phase B ingredients.
  • Table V sets forth the ingredients used in Examples 9-10.
  • Example 9 blends the compositions prepared in Examples 1 and 5 and adds to them the ingredients listed in Table III.
  • the procedure for preparing Example 9 is that used in example 8.
  • Example 9 makes use of hydrophobic sphingolipids complex to promote skin firming.
  • Example 9 is repeated with the substitution of Example 2, mixed fruit acid powder blend, in place of Example 1, lactic acid powder blend.
  • Physiological Benefits Controlled biophysical studies, employing the eye cosmetic composition of Examples 9 (lactic acid) and 10 (mixed fruit acids) , demonstrated valuable structural dermatological improvements. Some controlled tests showed significant increases in the moisture content of the canthus (outer eye corner) and under eye, accompanied by an increase in firmness and a reduction in fine lines and wrinkles. Twenty female subjects per product were treated in a half- face design with the products of Examples 9 and 10. The Example 9 or 10 product alone was applied around one eye and a moisturizing eye cream concentrate was applied, prior to the product, around the other eye. Treatments were applied to the face twice daily, but not on the morning on which measurements were taken. Skin moisturization, firmness and the textural characteristics of the canthus were determined, as described below.
  • Example 9 the lactic acid formulation of Example 9 was more effective than the mixed fruit acid (MFA) formulation of Example 10, and the eye cream moisturizer provided a useful additional motorization benefit, at four or more weeks. Comparable, albeit slightly lower, results were obtained on the under eye, as shown in Table VII, below.
  • Table IX show a significant, 16 percent increase in firmness obtained with the lactic acid formulation of Example 9, after only four weeks of use.
  • the mixed fruit acid (MFA) formulation of Example 10 was somewhat less effective, but still produced a significant increase in skin firmness. Better results are obtained after six weeks and by using a moisturizer.
  • compositions of the invention can be used as an eyeshadow primer to reduce eyeshadow creasing and color loss and to impart water resistance.
  • Eyeshadow creasing is a well-known phenomenon frequently exhibited by people with oily skin, which displays itself as an unevenness in color, or displacement of eye shadow into ridges and furrows, that may develop within a few hours of application of eyeshadow.
  • the inventive eyeshadow primer composition was applied to one eyelid only of each panelist and allowed to dry for one minute, following which a rose-colored eyeshadow was applied to both eyelids.
  • the eyelids were videotaped immediately following application of eyeshadow and a picture of the center of each eyelid was frozen for image analysis. The procedure was repeated three and six hours after the first application. Image analysis showed that primer-treated eyelids exhibited insignificant increases in unevenness of the eye shadow, even after six hours. In contrast, unevenness of eyeshadow coverage increased significantly at both three and six hours on eyelids lacking primer. Eyeshadow color.
  • Other tests showed that the eyeshadow primer composition of Example 9 was effective in controlling eyeshadow color loss. Neither formula changed the color of a superimposed eyeshadow, as measured with a chromameter.
  • the forehead was chosen as a target site for color control tests because of difficulties in safely measuring eyelid color and because of physiological similarities between the forehead and eyelids with regard to the presence of sebum and the like.
  • Eyeshadow and primer were applied to one side of the forehead of each of twelve subjects. Eyeshadow alone was applied to the other. Immediately after each application, color measurements were made with a chromameter and repeated three and six hours later.
  • the color of the eyeshadow was not changed by applying it over the primer composition of the invention.
  • the present invention is particularly suitable for application to modern industrial processes.
  • it is useful in the cosmetics industry where it can provide new products offering new benefits to consumers, as described herein.

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Abstract

L'invention a pour objet de nouvelles compositions cosmétiques contenant des systèmes d'administration topiques pour des agents polaires actifs sur le plan dermatologique. Des agents actifs, par exemple, des acides alpha hydroxy revitalisant la peau sont absorbés ou adsorbés sur des particules de support, de préférence poreuses, à l'aide d'un solvant polaire visqueux tel que de la glycérine, si nécessaire, et dispersés dans une base cosmétique anhydre avec un système filmogène. Ces compositions peuvent être formulées en une variété de produits cosmétiques différents, par exemple, des ombres à paupière, des produits de traitement de base des yeux et des produits de traitement des lèvres, qui offrent tous des avantages cosmétiques immédiats appréciables et dont l'action dermatologique s'exerce à plus long terme.
PCT/US1996/001560 1995-01-11 1996-01-11 Compositions cosmetiques anhydres contenant des agents actifs sur le plan dermatologique WO1996021422A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU48643/96A AU4864396A (en) 1995-01-11 1996-01-11 Anhydrous cosmetic compositions with dermatologically active agents
EP96904572A EP0802785A1 (fr) 1995-01-11 1996-01-11 Compositions cosmetiques anhydres contenant des agents actifs sur le plan dermatologique
PL96321293A PL185239B1 (pl) 1995-01-11 1996-01-11 Zasadniczo bezwodna kompozycja kosmetyczna do miejscowego stosowania oraz sposób jej wytwarzania
BR9607560A BR9607560A (pt) 1995-01-11 1996-01-11 Composições cométicas anidras contendo agentes dermatologicamente ativo
UA97073757A UA56991C2 (uk) 1995-01-11 1996-11-01 Практично безводна косметична композиція для місцевого застосування (варіанти), спосіб її виготовлення, олівець для очей та косметична плівкоутворювальна система

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US08/371,222 1995-01-11

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WO1999058104A1 (fr) * 1998-05-12 1999-11-18 Interhealth Ab Compositions therapeutiques
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KR100348826B1 (ko) * 1999-11-12 2002-08-17 주식회사 태평양 수용성 활성성분의 피부 흡수도가 향상된 수중유형 화장료 조성물의 제조방법
WO2004039348A1 (fr) * 2002-10-25 2004-05-13 Australian Importers, Ltd. Formulations pour administration topique de substances bioactives et leurs procedes d'utilisation
FR2892019A1 (fr) * 2005-10-14 2007-04-20 Oreal Procede de traitement des rides et kit de mise en oeuvre
WO2007020536A3 (fr) * 2005-07-12 2007-07-19 Oreal Procede cosmetique pour le ciblage de rides
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WO2015150694A1 (fr) 2014-03-31 2015-10-08 Arkema France Composition cosmetique pour l'eclaircissement de la peau
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WO1998058628A1 (fr) * 1997-06-20 1998-12-30 Mary Kay Inc. Composition cosmetique renfermant un agent de blanchiment et un desquamant
WO1999058104A1 (fr) * 1998-05-12 1999-11-18 Interhealth Ab Compositions therapeutiques
US6406708B1 (en) 1998-05-12 2002-06-18 Interhealth Ab Therapeutic compositions
FR2788692A1 (fr) * 1999-01-26 2000-07-28 Oreal Composition anhydre comprenant une phase particulaire et une phase huileuse comprenant de l'isononanoate d'isononyle, utilisation en cosmetique, pharmacie ou hygiene
EP1023890A1 (fr) * 1999-01-26 2000-08-02 L'oreal Composition anhydre, utilisation en cosmétique, pharmacie ou hygiéne
US6344205B1 (en) 1999-01-26 2002-02-05 L'oreal S.A. Anhydrous composition, cosmetic, pharmaceutical or hygiene use
US7393548B2 (en) * 1999-03-22 2008-07-01 J.P. M.E.D. Ltd. Nano oil in glycerin emulsion
KR100348826B1 (ko) * 1999-11-12 2002-08-17 주식회사 태평양 수용성 활성성분의 피부 흡수도가 향상된 수중유형 화장료 조성물의 제조방법
WO2004039348A1 (fr) * 2002-10-25 2004-05-13 Australian Importers, Ltd. Formulations pour administration topique de substances bioactives et leurs procedes d'utilisation
US9162084B2 (en) 2002-10-25 2015-10-20 Cellmedics, Inc. Formulations for topical delivery of bioactive substances and methods for their use
US7241456B2 (en) 2002-10-25 2007-07-10 Australian Importers Ltd. Formulations for topical delivery of bioactive substances and methods for their use
WO2007020536A3 (fr) * 2005-07-12 2007-07-19 Oreal Procede cosmetique pour le ciblage de rides
FR2892019A1 (fr) * 2005-10-14 2007-04-20 Oreal Procede de traitement des rides et kit de mise en oeuvre
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US8920821B2 (en) 2006-04-14 2014-12-30 Perrigo Israel Pharmaceuticals Ltd. Pharmaceutical compositions comprising silica microspheres
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BR9607560A (pt) 1998-12-15
AR003918A1 (es) 1998-09-30
CA2209657A1 (fr) 1996-07-18
EP0802785A1 (fr) 1997-10-29
PL321293A1 (en) 1997-12-08
MX9705234A (es) 1998-06-28
AU4864396A (en) 1996-07-31
PL185239B1 (pl) 2003-04-30
UA56991C2 (uk) 2003-06-16
CN1172426A (zh) 1998-02-04

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