WO1996018735A3 - Tgf-beta superfamily type ii receptor having binding affinity for bone morphogenic protein (bmp) - Google Patents
Tgf-beta superfamily type ii receptor having binding affinity for bone morphogenic protein (bmp) Download PDFInfo
- Publication number
- WO1996018735A3 WO1996018735A3 PCT/US1995/016412 US9516412W WO9618735A3 WO 1996018735 A3 WO1996018735 A3 WO 1996018735A3 US 9516412 W US9516412 W US 9516412W WO 9618735 A3 WO9618735 A3 WO 9618735A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptor
- tgf
- binding affinity
- type
- bone morphogenic
- Prior art date
Links
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title abstract 3
- 210000000988 bone and bone Anatomy 0.000 title abstract 2
- 230000000921 morphogenic effect Effects 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 abstract 2
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 abstract 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The present invention relates to a novel TGF-β superfamily type II receptor having binding affinity for a bone morphogenic protein, osteogenic protein 1 (OP-1). The novel type II receptor has a serine/threonine kinase domain followed by a long serine and threonine rich region in the C-terminal end. The invention further provides nucleic acids encoding the novel type II receptor as well as vectors and host cells expressing the nucleic acids and recombinant production methods using the nucleic acids. Complexes of the novel type II receptor with an appropriate TGF-β superfamily type I receptor are also provided.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU44249/96A AU4424996A (en) | 1994-12-14 | 1995-12-14 | A tgf-beta superfamily type ii receptor having binding affinity |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35600594A | 1994-12-14 | 1994-12-14 | |
| US08/356,005 | 1994-12-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996018735A2 WO1996018735A2 (en) | 1996-06-20 |
| WO1996018735A3 true WO1996018735A3 (en) | 1996-08-29 |
Family
ID=23399692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/016412 WO1996018735A2 (en) | 1994-12-14 | 1995-12-14 | Tgf-beta superfamily type ii receptor having binding affinity for bone morphogenic protein (bmp) |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU4424996A (en) |
| WO (1) | WO1996018735A2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000514777A (en) * | 1995-08-14 | 2000-11-07 | クリエイティブ バイオモレキュールズ，インコーポレイテッド | Binding of osteogenic protein (OP-1) and its analogs to the cell surface receptor ALK-1 and its analogs |
| US6936582B1 (en) | 1997-09-09 | 2005-08-30 | Curis, Inc. | Synergistic effects of OP/BMP morphogens and GDNF/NGF neurotrophic factors |
| AU749454B2 (en) * | 1997-09-09 | 2002-06-27 | Stryker Corporation | Synergistic effects of OP/BMP morphogens and GDNF/NGF neurotrophic factors |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014412A2 (en) * | 1994-11-04 | 1996-05-17 | The Procter & Gamble Company | cDNA ENCODING A BMP TYPE II RECEPTOR |
| WO1996014579A1 (en) * | 1994-11-04 | 1996-05-17 | The Procter & Gamble Company | The use of a bmp protein receptor complex for screening bone metabolism actives and cells co-transfected with a type ii bmp receptor and a type i bmp receptor |
-
1995
- 1995-12-14 WO PCT/US1995/016412 patent/WO1996018735A2/en active Application Filing
- 1995-12-14 AU AU44249/96A patent/AU4424996A/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014412A2 (en) * | 1994-11-04 | 1996-05-17 | The Procter & Gamble Company | cDNA ENCODING A BMP TYPE II RECEPTOR |
| WO1996014579A1 (en) * | 1994-11-04 | 1996-05-17 | The Procter & Gamble Company | The use of a bmp protein receptor complex for screening bone metabolism actives and cells co-transfected with a type ii bmp receptor and a type i bmp receptor |
Non-Patent Citations (2)
| Title |
|---|
| B. ROSENZWEIG ET AL.: "Cloning and characterisation of a human type II receptor for bone morphogenetic proteins", PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 7632 - 7636, XP002007953 * |
| P. TEN DIJKE ET AL.: "Identification of type 1 receptors for osteogenic protein 1 and bone morphogenetic protein 4", J. BIOL. CHEM., vol. 269, no. 25, 1994, pages 16985 - 16988, XP002007952 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU4424996A (en) | 1996-07-03 |
| WO1996018735A2 (en) | 1996-06-20 |
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