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WO1996016647B1 - Utilisation d'agents bloquant les canaux de chlorure pour abaisser la pression intraoculaire - Google Patents

Utilisation d'agents bloquant les canaux de chlorure pour abaisser la pression intraoculaire

Info

Publication number
WO1996016647B1
WO1996016647B1 PCT/US1995/015283 US9515283W WO9616647B1 WO 1996016647 B1 WO1996016647 B1 WO 1996016647B1 US 9515283 W US9515283 W US 9515283W WO 9616647 B1 WO9616647 B1 WO 9616647B1
Authority
WO
WIPO (PCT)
Prior art keywords
chloride channel
channel blocking
blocking activity
compound
amended
Prior art date
Application number
PCT/US1995/015283
Other languages
English (en)
Other versions
WO1996016647A2 (fr
WO1996016647A3 (fr
Filing date
Publication date
Priority claimed from US08/346,660 external-priority patent/US5559151A/en
Application filed filed Critical
Priority to EP95943595A priority Critical patent/EP0786994B1/fr
Priority to AU45027/96A priority patent/AU709322B2/en
Priority to JP8518938A priority patent/JPH10510289A/ja
Priority to DE69533723T priority patent/DE69533723T2/de
Publication of WO1996016647A2 publication Critical patent/WO1996016647A2/fr
Publication of WO1996016647A3 publication Critical patent/WO1996016647A3/fr
Publication of WO1996016647B1 publication Critical patent/WO1996016647B1/fr

Links

Abstract

L'invention présente des compositions pharmaceutiques, ainsi que le procédé correspondant, visant à traiter le glaucome et/ou l'hypertension oculaire dans l'oeil d'un mammifère en lui administrant une préparation pharmaceutique, relevant de cette invention, qui comporte un ou plusieurs composés témoignant d'une activité de blocage des canaux de chlorure, comme constituant actif. La formule ci-après donne des exemples de ces agents bloquants employés pour la préparation pharmaceutique et la thérapie (I). Dans cette formule, R est hydrogène ou un cation acceptable du point de vue pharmaceutique, un alcali ou un métal alcalino-terreux, par exemple, ou bien une amine quaternaire; R peut également représenter une fraction formatrice d'ester, un radical alkyle à faible poids moléculaire, par exemple, ayant jusqu'à six atomes de carbone, pouvant être dérivé d'un alcanol à faible poids moléculaire.
PCT/US1995/015283 1994-11-30 1995-11-22 Utilisation d'agents bloquant les canaux de chlorure pour abaisser la pression intraoculaire WO1996016647A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP95943595A EP0786994B1 (fr) 1994-11-30 1995-11-22 Utilisation d'agents bloquant les canaux de chlorure pour abaisser la pression intraoculaire
AU45027/96A AU709322B2 (en) 1994-11-30 1995-11-22 Use of chloride channel blockers for reducing intraocular pressure
JP8518938A JPH10510289A (ja) 1994-11-30 1995-11-22 眼圧を降下するためのクロリドチャンネル遮断剤の使用
DE69533723T DE69533723T2 (de) 1994-11-30 1995-11-22 Verwendung von chloridekanalblockern zur senkung des intraokulären druckes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/346,660 1994-11-30
US08/346,660 US5559151A (en) 1994-11-30 1994-11-30 Method for reducing intraocular pressure in the mammalian eye by administration of chloride channel blockers

Publications (3)

Publication Number Publication Date
WO1996016647A2 WO1996016647A2 (fr) 1996-06-06
WO1996016647A3 WO1996016647A3 (fr) 1996-09-06
WO1996016647B1 true WO1996016647B1 (fr) 1996-10-10

Family

ID=23360457

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/015283 WO1996016647A2 (fr) 1994-11-30 1995-11-22 Utilisation d'agents bloquant les canaux de chlorure pour abaisser la pression intraoculaire

Country Status (8)

Country Link
US (3) US5559151A (fr)
EP (1) EP0786994B1 (fr)
JP (1) JPH10510289A (fr)
AU (1) AU709322B2 (fr)
CA (1) CA2206123A1 (fr)
DE (1) DE69533723T2 (fr)
ES (1) ES2230552T3 (fr)
WO (1) WO1996016647A2 (fr)

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Publication number Priority date Publication date Assignee Title
US5763491A (en) * 1994-12-09 1998-06-09 The Regents Of The University Of California Method for enhancing outflow of aqueous humor in treatment of glaucoma
US6228873B1 (en) 1994-12-09 2001-05-08 The Regents Of The University Of California Method for enhancing outflow of aqueous humor in treatment of glaucoma
US6696475B2 (en) 1997-04-22 2004-02-24 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
WO2000024707A1 (fr) 1998-10-22 2000-05-04 Neurosearch A/S Derives de phenyle substitue, leur preparation et leur application
PT977741E (pt) 1997-04-22 2004-01-30 Neurosearch As Derivados de fenilo substituido, sua preparacao e utilizacao
US6245814B1 (en) 1998-05-08 2001-06-12 Calyx Therapeutics, Inc. Diphenylethylene compounds
US6331633B1 (en) 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
US6624197B1 (en) 1998-05-08 2003-09-23 Calyx Therapeutics, Inc. Diphenylethylene compounds
US7105552B2 (en) * 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
ATE224358T1 (de) * 1998-10-02 2002-10-15 Neurosearch As Diaminocyclobuten-3,4-dionderivate, deren herstellung und deren verwendung
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US20080108825A1 (en) * 1999-11-08 2008-05-08 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20020002200A1 (en) * 2000-02-04 2002-01-03 Bishwagit Nag Novel diphenylethylene compounds
US7323496B2 (en) * 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US6525093B1 (en) * 1999-11-08 2003-02-25 Calyx Therapeutics Inc. Compounds to treat diabetes and associated conditions
US20080103302A1 (en) * 2000-02-04 2008-05-01 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US7119112B2 (en) * 2002-02-28 2006-10-10 Icagen, Inc. Sulfonamides as potassium channel blockers
US20100035239A1 (en) * 2003-09-11 2010-02-11 Isis Pharmaceuticals, Inc. Compositions for use in identification of bacteria
US20060065627A1 (en) * 2004-09-29 2006-03-30 James Clarke Processing electronic devices using a combination of supercritical fluid and sonic energy
US10280060B2 (en) 2006-03-06 2019-05-07 The Coca-Cola Company Dispenser for beverages having an ingredient mixing module

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE68785T1 (de) * 1985-07-31 1991-11-15 Hoechst Ag N-substituierte 5-nitroanthranilsaeuren, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen.
US4981871A (en) * 1987-05-15 1991-01-01 Abelson Mark B Treatment of ocular hypertension with class I calcium channel blocking agents
JPH0650489B2 (ja) * 1988-02-05 1994-06-29 日本電気株式会社 Asn.1情報データ化方式
FR2685917A1 (fr) * 1992-01-06 1993-07-09 Adir Nouveau derive de la pyridylsulfonyluree des procedes de preparation et les compositions pharmaceutiques le contenant.
US5435998A (en) * 1994-08-03 1995-07-25 Abelson; Mark B. Treatment of low-tension glaucoma by topical administration of calcium channel blocking agents

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