WO1996016647B1 - Utilisation d'agents bloquant les canaux de chlorure pour abaisser la pression intraoculaire - Google Patents
Utilisation d'agents bloquant les canaux de chlorure pour abaisser la pression intraoculaireInfo
- Publication number
- WO1996016647B1 WO1996016647B1 PCT/US1995/015283 US9515283W WO9616647B1 WO 1996016647 B1 WO1996016647 B1 WO 1996016647B1 US 9515283 W US9515283 W US 9515283W WO 9616647 B1 WO9616647 B1 WO 9616647B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chloride channel
- channel blocking
- blocking activity
- compound
- amended
- Prior art date
Links
- 108010062745 Chloride Channels Proteins 0.000 title claims abstract 20
- 102000011045 Chloride Channels Human genes 0.000 title claims abstract 20
- 230000004410 intraocular pressure Effects 0.000 title claims 4
- 150000001875 compounds Chemical class 0.000 claims abstract 23
- 230000000903 blocking effect Effects 0.000 claims abstract 18
- 238000000034 method Methods 0.000 claims abstract 13
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 13
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 7
- 239000001257 hydrogen Substances 0.000 claims abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 7
- 239000004480 active ingredient Substances 0.000 claims abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 5
- 150000001768 cations Chemical class 0.000 claims abstract 4
- 150000001412 amines Chemical group 0.000 claims abstract 3
- ZWJINEZUASEZBH-UHFFFAOYSA-N fenamic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC=C1 ZWJINEZUASEZBH-UHFFFAOYSA-N 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 10
- WBSMIPAMAXNXFS-UHFFFAOYSA-N 5-Nitro-2-(3-phenylpropylamino)benzoic acid Chemical compound OC(=O)C1=CC([N+]([O-])=O)=CC=C1NCCCC1=CC=CC=C1 WBSMIPAMAXNXFS-UHFFFAOYSA-N 0.000 claims 8
- RNOJGTHBMJBOSP-KRWDZBQOSA-N IAA-94 Chemical compound C1([C@]2(C(C3=C(Cl)C(Cl)=C(OCC(O)=O)C=C3C2)=O)C)CCCC1 RNOJGTHBMJBOSP-KRWDZBQOSA-N 0.000 claims 5
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 4
- RNOJGTHBMJBOSP-UHFFFAOYSA-N 2-[(6,7-dichloro-2-cyclopentyl-2-methyl-1-oxo-3h-inden-5-yl)oxy]acetic acid Chemical compound C1C2=CC(OCC(O)=O)=C(Cl)C(Cl)=C2C(=O)C1(C)C1CCCC1 RNOJGTHBMJBOSP-UHFFFAOYSA-N 0.000 claims 4
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 4
- KPRZOPQOBJRYSW-UHFFFAOYSA-N 2-(aminomethyl)phenol Chemical class NCC1=CC=CC=C1O KPRZOPQOBJRYSW-UHFFFAOYSA-N 0.000 claims 3
- 229940054534 ophthalmic solution Drugs 0.000 claims 3
- 239000002997 ophthalmic solution Substances 0.000 claims 3
- YSCNMFDFYJUPEF-OWOJBTEDSA-N 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid Chemical compound OS(=O)(=O)C1=CC(N=C=S)=CC=C1\C=C\C1=CC=C(N=C=S)C=C1S(O)(=O)=O YSCNMFDFYJUPEF-OWOJBTEDSA-N 0.000 claims 2
- -1 DIDS (4 Chemical class 0.000 claims 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 229910001413 alkali metal ion Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229960001948 caffeine Drugs 0.000 claims 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 2
- 229940031098 ethanolamine Drugs 0.000 claims 2
- 230000000324 neuroprotective effect Effects 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 150000001629 stilbenes Chemical class 0.000 claims 2
- 235000021286 stilbenes Nutrition 0.000 claims 2
- 125000005270 trialkylamine group Chemical group 0.000 claims 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 2
- 229960000281 trometamol Drugs 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 150000002989 phenols Chemical class 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010030043 Ocular hypertension Diseases 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
Abstract
L'invention présente des compositions pharmaceutiques, ainsi que le procédé correspondant, visant à traiter le glaucome et/ou l'hypertension oculaire dans l'oeil d'un mammifère en lui administrant une préparation pharmaceutique, relevant de cette invention, qui comporte un ou plusieurs composés témoignant d'une activité de blocage des canaux de chlorure, comme constituant actif. La formule ci-après donne des exemples de ces agents bloquants employés pour la préparation pharmaceutique et la thérapie (I). Dans cette formule, R est hydrogène ou un cation acceptable du point de vue pharmaceutique, un alcali ou un métal alcalino-terreux, par exemple, ou bien une amine quaternaire; R peut également représenter une fraction formatrice d'ester, un radical alkyle à faible poids moléculaire, par exemple, ayant jusqu'à six atomes de carbone, pouvant être dérivé d'un alcanol à faible poids moléculaire.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95943595A EP0786994B1 (fr) | 1994-11-30 | 1995-11-22 | Utilisation d'agents bloquant les canaux de chlorure pour abaisser la pression intraoculaire |
| AU45027/96A AU709322B2 (en) | 1994-11-30 | 1995-11-22 | Use of chloride channel blockers for reducing intraocular pressure |
| JP8518938A JPH10510289A (ja) | 1994-11-30 | 1995-11-22 | 眼圧を降下するためのクロリドチャンネル遮断剤の使用 |
| DE69533723T DE69533723T2 (de) | 1994-11-30 | 1995-11-22 | Verwendung von chloridekanalblockern zur senkung des intraokulären druckes |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/346,660 | 1994-11-30 | ||
| US08/346,660 US5559151A (en) | 1994-11-30 | 1994-11-30 | Method for reducing intraocular pressure in the mammalian eye by administration of chloride channel blockers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1996016647A2 WO1996016647A2 (fr) | 1996-06-06 |
| WO1996016647A3 WO1996016647A3 (fr) | 1996-09-06 |
| WO1996016647B1 true WO1996016647B1 (fr) | 1996-10-10 |
Family
ID=23360457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/015283 WO1996016647A2 (fr) | 1994-11-30 | 1995-11-22 | Utilisation d'agents bloquant les canaux de chlorure pour abaisser la pression intraoculaire |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US5559151A (fr) |
| EP (1) | EP0786994B1 (fr) |
| JP (1) | JPH10510289A (fr) |
| AU (1) | AU709322B2 (fr) |
| CA (1) | CA2206123A1 (fr) |
| DE (1) | DE69533723T2 (fr) |
| ES (1) | ES2230552T3 (fr) |
| WO (1) | WO1996016647A2 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763491A (en) * | 1994-12-09 | 1998-06-09 | The Regents Of The University Of California | Method for enhancing outflow of aqueous humor in treatment of glaucoma |
| US6228873B1 (en) | 1994-12-09 | 2001-05-08 | The Regents Of The University Of California | Method for enhancing outflow of aqueous humor in treatment of glaucoma |
| US6696475B2 (en) | 1997-04-22 | 2004-02-24 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
| WO2000024707A1 (fr) | 1998-10-22 | 2000-05-04 | Neurosearch A/S | Derives de phenyle substitue, leur preparation et leur application |
| PT977741E (pt) | 1997-04-22 | 2004-01-30 | Neurosearch As | Derivados de fenilo substituido, sua preparacao e utilizacao |
| US6245814B1 (en) | 1998-05-08 | 2001-06-12 | Calyx Therapeutics, Inc. | Diphenylethylene compounds |
| US6331633B1 (en) | 1998-05-08 | 2001-12-18 | Calyx Therapeutics Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US6624197B1 (en) | 1998-05-08 | 2003-09-23 | Calyx Therapeutics, Inc. | Diphenylethylene compounds |
| US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| ATE224358T1 (de) * | 1998-10-02 | 2002-10-15 | Neurosearch As | Diaminocyclobuten-3,4-dionderivate, deren herstellung und deren verwendung |
| US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US20080108825A1 (en) * | 1999-11-08 | 2008-05-08 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| US20020002200A1 (en) * | 2000-02-04 | 2002-01-03 | Bishwagit Nag | Novel diphenylethylene compounds |
| US7323496B2 (en) * | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| US6525093B1 (en) * | 1999-11-08 | 2003-02-25 | Calyx Therapeutics Inc. | Compounds to treat diabetes and associated conditions |
| US20080103302A1 (en) * | 2000-02-04 | 2008-05-01 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| US7119112B2 (en) * | 2002-02-28 | 2006-10-10 | Icagen, Inc. | Sulfonamides as potassium channel blockers |
| US20100035239A1 (en) * | 2003-09-11 | 2010-02-11 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of bacteria |
| US20060065627A1 (en) * | 2004-09-29 | 2006-03-30 | James Clarke | Processing electronic devices using a combination of supercritical fluid and sonic energy |
| US10280060B2 (en) | 2006-03-06 | 2019-05-07 | The Coca-Cola Company | Dispenser for beverages having an ingredient mixing module |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE68785T1 (de) * | 1985-07-31 | 1991-11-15 | Hoechst Ag | N-substituierte 5-nitroanthranilsaeuren, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen. |
| US4981871A (en) * | 1987-05-15 | 1991-01-01 | Abelson Mark B | Treatment of ocular hypertension with class I calcium channel blocking agents |
| JPH0650489B2 (ja) * | 1988-02-05 | 1994-06-29 | 日本電気株式会社 | Ａｓｎ．１情報データ化方式 |
| FR2685917A1 (fr) * | 1992-01-06 | 1993-07-09 | Adir | Nouveau derive de la pyridylsulfonyluree des procedes de preparation et les compositions pharmaceutiques le contenant. |
| US5435998A (en) * | 1994-08-03 | 1995-07-25 | Abelson; Mark B. | Treatment of low-tension glaucoma by topical administration of calcium channel blocking agents |
-
1994
- 1994-11-30 US US08/346,660 patent/US5559151A/en not_active Expired - Fee Related
-
1995
- 1995-11-22 DE DE69533723T patent/DE69533723T2/de not_active Expired - Fee Related
- 1995-11-22 CA CA002206123A patent/CA2206123A1/fr not_active Abandoned
- 1995-11-22 AU AU45027/96A patent/AU709322B2/en not_active Ceased
- 1995-11-22 ES ES95943595T patent/ES2230552T3/es not_active Expired - Lifetime
- 1995-11-22 EP EP95943595A patent/EP0786994B1/fr not_active Expired - Lifetime
- 1995-11-22 WO PCT/US1995/015283 patent/WO1996016647A2/fr active IP Right Grant
- 1995-11-22 JP JP8518938A patent/JPH10510289A/ja not_active Ceased
-
1996
- 1996-09-23 US US08/716,756 patent/US5705530A/en not_active Expired - Lifetime
-
1997
- 1997-12-29 US US08/998,912 patent/US5866605A/en not_active Expired - Lifetime
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