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WO1996013284A1 - Composition de traitement de lesions - Google Patents

Composition de traitement de lesions Download PDF

Info

Publication number
WO1996013284A1
WO1996013284A1 PCT/GB1995/002542 GB9502542W WO9613284A1 WO 1996013284 A1 WO1996013284 A1 WO 1996013284A1 GB 9502542 W GB9502542 W GB 9502542W WO 9613284 A1 WO9613284 A1 WO 9613284A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
nocc
occ
plasticiser
weight
Prior art date
Application number
PCT/GB1995/002542
Other languages
English (en)
Inventor
Yimin Qin
Keith Dennis Gilding
Original Assignee
Innovative Technologies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovative Technologies Limited filed Critical Innovative Technologies Limited
Priority to AU37503/95A priority Critical patent/AU3750395A/en
Publication of WO1996013284A1 publication Critical patent/WO1996013284A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides

Definitions

  • the present invention relates to compositions which are useful in the treatment
  • the invention relates more particularly to such compositions which
  • OCC O-carboxymethyl chitosan
  • NOCC is a known material and its preparation is disclosed for example in US-
  • NOCC may be prepared by a solid phase reaction between
  • OCC may be produced by a similar
  • composition for use in treating a wound comprising a hydrogel containing OCC or
  • compositions in accordance with the invention are useful in the treatment of
  • a film having a high MVTR typically 3,000 to 12.000 g m “2 24hr " ' (e.g.
  • compositions may also be used in the treatment of sinuses.
  • compositions in accordance with the invention have a viscosity in the
  • compositions in accordance with the invention will generally contain a
  • OCC OCC
  • NOCC NOCC
  • the plasticiser will generally be present in a maximum amount of 20% by
  • plasticiser examples include polyhydroxy compounds, e.g. glycerol, sorbitol,
  • propylene glycol and polyethylene glycol (a preferred example of which is PEG 400).
  • the most preferred plasticiser glycerol glycerol.
  • the aqueous phase of the gel will for preference comprise isotonic buffered saline, e.g. phosphate buffered saline.
  • Additional components may be included in the composition to enhance their functionality
  • antimicrobial agents which may be used at a level
  • a preferred anti-microbial agent is chlorhexidine
  • Antimicrobial properties may also be achieved by use of enzymes, e.g. glucose
  • a further possibility is to include a component, e.g. pectin, which facilitates
  • This component may for example be used in an amount up to
  • compositions for use in accordance with the invention may be produced in
  • compositions may be produced by dissolving the required amounts of OCC or NOCC (e.g. 3-5%), plasticiser and any other components in
  • composition may be sterilised by
  • the gels obtained may be incorporated into a convenient delivery system, e.g. a
  • the invention is illustrated by the following non-limiting Example.
  • a gel was produced by dissolving 3-4% NOCC and 1 -2% high methoxy pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette composition, utile dans le traitement d'une lésion, par exemple des lésions creuses, comprend un hydrogel contenant du O-carboxyméthyle chitosane ou du N,O-carboxyméthyle chitosane ainsi qu'un composé plastifiant.
PCT/GB1995/002542 1994-10-28 1995-10-30 Composition de traitement de lesions WO1996013284A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37503/95A AU3750395A (en) 1994-10-28 1995-10-30 Wound treatment composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9421969A GB9421969D0 (en) 1994-10-28 1994-10-28 Wound treatment composition
GB9421969.8 1994-10-28

Publications (1)

Publication Number Publication Date
WO1996013284A1 true WO1996013284A1 (fr) 1996-05-09

Family

ID=10763689

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1995/002542 WO1996013284A1 (fr) 1994-10-28 1995-10-30 Composition de traitement de lesions

Country Status (3)

Country Link
AU (1) AU3750395A (fr)
GB (1) GB9421969D0 (fr)
WO (1) WO1996013284A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997003710A1 (fr) * 1995-07-19 1997-02-06 Innovative Technologies Limited Composition cicatrisante
WO1998050050A1 (fr) * 1997-05-06 1998-11-12 Chitogenics, Inc. N, o-carboxymethyl-chitosane a liaison covalente et ses applications
US6124273A (en) * 1995-06-09 2000-09-26 Chitogenics, Inc. Chitin hydrogels, methods of their production and use
US6645947B1 (en) 1999-05-20 2003-11-11 Chitogenics, Inc. Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins
WO2006034688A1 (fr) * 2004-09-27 2006-04-06 Universität Hamburg Procede de production d'un pansement
US7265097B2 (en) 2002-08-20 2007-09-04 Chitogenics, Inc. Methods of drug delivery using sulphated chitinous polymers
WO2015061606A1 (fr) * 2013-10-24 2015-04-30 Medtronic Xomed, Inc. Pâte d'occlusion au chitosane
US9192692B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan stenting paste
US9970303B2 (en) 2014-05-13 2018-05-15 Entrotech, Inc. Erosion protection sleeve
CN111135338A (zh) * 2019-12-31 2020-05-12 瑞希(重庆)生物科技有限公司 一种止血凝胶及其制备方法
US10926000B2 (en) 2016-05-13 2021-02-23 Colorado School Of Mines Deposition-conversion method for tunable calcium phosphate coatings on substrates and apparatus prepared thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903268A (en) * 1968-02-12 1975-09-02 Lescarden Ltd Chitin and chitin derivatives for promoting wound healing
US4659700A (en) * 1984-03-02 1987-04-21 Johnson & Johnson Products, Inc. Chitosan-glycerol-water gel
EP0356060A2 (fr) * 1988-08-18 1990-02-28 Minnesota Mining And Manufacturing Company Composition pour remplir des blessures
EP0426368A2 (fr) * 1989-10-31 1991-05-08 Howmedica Inc. Compositions contenant des dérivés de chitine pour empêcher l'adhésion

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903268A (en) * 1968-02-12 1975-09-02 Lescarden Ltd Chitin and chitin derivatives for promoting wound healing
US4659700A (en) * 1984-03-02 1987-04-21 Johnson & Johnson Products, Inc. Chitosan-glycerol-water gel
EP0356060A2 (fr) * 1988-08-18 1990-02-28 Minnesota Mining And Manufacturing Company Composition pour remplir des blessures
EP0426368A2 (fr) * 1989-10-31 1991-05-08 Howmedica Inc. Compositions contenant des dérivés de chitine pour empêcher l'adhésion

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
R.A.A.MUZZARELLI ET AL.: "N-CARBOXYBUTYL CHITOSAN AND FIBRIN GLUE IN CUTANEOUS REPAIR PROCESSES", JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, vol. 5, no. 4, US, pages 396 - 410, XP000213548 *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6124273A (en) * 1995-06-09 2000-09-26 Chitogenics, Inc. Chitin hydrogels, methods of their production and use
WO1997003710A1 (fr) * 1995-07-19 1997-02-06 Innovative Technologies Limited Composition cicatrisante
WO1998050050A1 (fr) * 1997-05-06 1998-11-12 Chitogenics, Inc. N, o-carboxymethyl-chitosane a liaison covalente et ses applications
US7238678B2 (en) * 1999-05-20 2007-07-03 Chitogenics, Inc. Adhesive N,O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins
US6645947B1 (en) 1999-05-20 2003-11-11 Chitogenics, Inc. Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins
US6809085B1 (en) 1999-05-20 2004-10-26 Chitogenics, Inc. Adherent N,O-Carboxymethylchitosan drug delivery devices for moist tissue and methods of their use
US6894035B2 (en) * 1999-05-20 2005-05-17 Chitogenics, Inc. Adhesive N,O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins
US7265097B2 (en) 2002-08-20 2007-09-04 Chitogenics, Inc. Methods of drug delivery using sulphated chitinous polymers
WO2006034688A1 (fr) * 2004-09-27 2006-04-06 Universität Hamburg Procede de production d'un pansement
WO2015061606A1 (fr) * 2013-10-24 2015-04-30 Medtronic Xomed, Inc. Pâte d'occlusion au chitosane
US9192574B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan paste wound dressing
US9192692B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan stenting paste
JP2016533775A (ja) * 2013-10-24 2016-11-04 メドトロニック・ゾーメド・インコーポレーテッド キトサンペースト創傷手当て材
AU2014340006B2 (en) * 2013-10-24 2018-06-28 Medtronic Xomed, Inc. Chitosan stenting paste
US9970303B2 (en) 2014-05-13 2018-05-15 Entrotech, Inc. Erosion protection sleeve
US10926000B2 (en) 2016-05-13 2021-02-23 Colorado School Of Mines Deposition-conversion method for tunable calcium phosphate coatings on substrates and apparatus prepared thereof
CN111135338A (zh) * 2019-12-31 2020-05-12 瑞希(重庆)生物科技有限公司 一种止血凝胶及其制备方法

Also Published As

Publication number Publication date
AU3750395A (en) 1996-05-23
GB9421969D0 (en) 1994-12-21

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