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WO1996012804A3 - Recombinant dna - Google Patents

Recombinant dna Download PDF

Info

Publication number
WO1996012804A3
WO1996012804A3 PCT/GB1995/002520 GB9502520W WO9612804A3 WO 1996012804 A3 WO1996012804 A3 WO 1996012804A3 GB 9502520 W GB9502520 W GB 9502520W WO 9612804 A3 WO9612804 A3 WO 9612804A3
Authority
WO
WIPO (PCT)
Prior art keywords
recombinant dna
gene
preparation
spermine
spermidine
Prior art date
Application number
PCT/GB1995/002520
Other languages
French (fr)
Other versions
WO1996012804A2 (en
Inventor
Nicholas Yannoutsos
Original Assignee
Imutran Ltd
Nicholas Yannoutsos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imutran Ltd, Nicholas Yannoutsos filed Critical Imutran Ltd
Priority to EP95934745A priority Critical patent/EP0788544A2/en
Priority to NZ294293A priority patent/NZ294293A/en
Priority to AU37054/95A priority patent/AU3705495A/en
Priority to JP8513741A priority patent/JPH10508196A/en
Publication of WO1996012804A2 publication Critical patent/WO1996012804A2/en
Publication of WO1996012804A3 publication Critical patent/WO1996012804A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The complete human CD59 gene has been cloned. The gene is useful in the preparation of transgenic xenograft donor animals. As part of the cloning procedure, concentration and purification of a crude DNA preparation including high concentrations of spermine and spermidine was carried out by dialysis.
PCT/GB1995/002520 1994-10-25 1995-10-25 Recombinant dna WO1996012804A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP95934745A EP0788544A2 (en) 1994-10-25 1995-10-25 Recombinant dna
NZ294293A NZ294293A (en) 1994-10-25 1995-10-25 Recombinant cd59 (complement inhibitory protein)
AU37054/95A AU3705495A (en) 1994-10-25 1995-10-25 Recombinant dna
JP8513741A JPH10508196A (en) 1994-10-25 1995-10-25 Recombinant DNA

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9421464A GB9421464D0 (en) 1994-10-25 1994-10-25 Recombinant DNA
GB9421464.0 1994-10-25

Publications (2)

Publication Number Publication Date
WO1996012804A2 WO1996012804A2 (en) 1996-05-02
WO1996012804A3 true WO1996012804A3 (en) 1996-09-06

Family

ID=10763344

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1995/002520 WO1996012804A2 (en) 1994-10-25 1995-10-25 Recombinant dna

Country Status (9)

Country Link
EP (1) EP0788544A2 (en)
JP (1) JPH10508196A (en)
AU (1) AU3705495A (en)
CA (1) CA2202130A1 (en)
GB (1) GB9421464D0 (en)
IL (1) IL115727A0 (en)
NZ (1) NZ294293A (en)
WO (1) WO1996012804A2 (en)
ZA (1) ZA959051B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166288A (en) * 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
B. HECKL-OSTREICHER ET AL.: "Localisation of the human CD59 gene by fluorescence in situ hybridization and pulse-field gel electrophoresis", CYTOGENET. CELL GENET., vol. 63, 1993, pages 144 - 146, XP002005585 *
G. ERIC PLUM ET AL.: "Structural and electrostatic effects on binding of trivalent cations to double-stranded and single-stranded poly (d(AT))", BIOPLOYMERS, vol. 29, no. 1, 1990, pages 13 - 27, XP002005587 *
J. GRIFFITH ET AL.: "RecA protein rapidly crystallizes in the presence of spermidine: a valuable step in its purification and physical characterization", BIOCHEMISTRY, vol. 24, 1985, pages 158 - 162, XP002005586 *
J.G. PETRANKA ET AL.: "Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIECNES USA, vol. 89, 1992, pages 7876 - 7879, XP002005583 *
J.G. PETRANKA ET AL.: "The structure of the CD59 gene", COMPLEMENT INFLAMMATION, vol. 8, no. 3-4, 1991, pages 209 - 210, XP002005584 *
M. TONE ET AL.: "Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation", JOURNAL OF MOLECULAR BIOLOGY, vol. 227, 1992, pages 971 - 976, XP002005582 *

Also Published As

Publication number Publication date
NZ294293A (en) 1999-08-30
WO1996012804A2 (en) 1996-05-02
EP0788544A2 (en) 1997-08-13
GB9421464D0 (en) 1994-12-07
IL115727A0 (en) 1996-01-19
ZA959051B (en) 1997-04-25
AU3705495A (en) 1996-05-15
CA2202130A1 (en) 1996-05-02
JPH10508196A (en) 1998-08-18

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