WO1996012190B1 - Presentation d'antigenes hydrophobes a des lymphocytes t par des molecules cd1 - Google Patents
Presentation d'antigenes hydrophobes a des lymphocytes t par des molecules cd1Info
- Publication number
- WO1996012190B1 WO1996012190B1 PCT/US1995/013274 US9513274W WO9612190B1 WO 1996012190 B1 WO1996012190 B1 WO 1996012190B1 US 9513274 W US9513274 W US 9513274W WO 9612190 B1 WO9612190 B1 WO 9612190B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cdl
- presented
- antigen
- lipoarabinomannan
- lipoarabinomannan antigen
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title claims abstract 55
- 102000036639 antigens Human genes 0.000 title claims abstract 55
- 108091007433 antigens Proteins 0.000 title claims abstract 55
- 210000001744 T-lymphocyte Anatomy 0.000 title claims abstract 13
- 230000002209 hydrophobic effect Effects 0.000 title claims 2
- 210000004027 cell Anatomy 0.000 claims abstract 20
- 238000000034 method Methods 0.000 claims abstract 19
- 229960005486 vaccine Drugs 0.000 claims abstract 15
- 230000001939 inductive effect Effects 0.000 claims abstract 6
- 230000030741 antigen processing and presentation Effects 0.000 claims abstract 5
- 239000002981 blocking agent Substances 0.000 claims abstract 4
- 238000002255 vaccination Methods 0.000 claims abstract 3
- 239000003112 inhibitor Substances 0.000 claims abstract 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 6
- 230000005867 T cell response Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 3
- 230000036039 immunity Effects 0.000 claims 3
- 230000004044 response Effects 0.000 claims 3
- 241000186367 Mycobacterium avium Species 0.000 claims 2
- 241000186366 Mycobacterium bovis Species 0.000 claims 2
- 241000186365 Mycobacterium fortuitum Species 0.000 claims 2
- 241000186362 Mycobacterium leprae Species 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000009696 proliferative response Effects 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 201000008827 tuberculosis Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 241000186359 Mycobacterium Species 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 230000001461 cytolytic effect Effects 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 102100024219 T-cell surface glycoprotein CD1a Human genes 0.000 abstract 6
- 230000000903 blocking effect Effects 0.000 abstract 1
- -1 cells Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Abstract
L'invention concerne des antigènes présentés par CD1, des compositions, des cellules, des inhibiteurs et des procédés relatifs à l'utilisation de la présentation de l'antigène lipoarabinomannane (LAM) par des molécules CD1, y compris des procédés de détection de la présence d'un antigène LAM présenté par CD1 dans un échantillon; des procédés d'isolement desdits antigènes LAM présentés par CD1 ainsi que les antigènes isolés; des vaccins contenant des antigènes LAM présentés par CD1 ainsi que des méthodes de vaccination, des procédés de blocage de la présentation de l'antigène LAM par CD1, des procédés d'identification et/ou d'isolement d'agents bloquant la CD1 ainsi que les agents bloquant la CD1 isolée, des procédés d'induction de l'expression de CD1 ainsi que les lymphocytes T destinés à être utilisés dans les procédés énoncés.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95941326A EP0786088B1 (fr) | 1994-10-13 | 1995-10-13 | Presentation d'antigenes de lipoarabinomannane a des lymphocytes t par des molecules cd1 |
| AT95941326T ATE212129T1 (de) | 1994-10-13 | 1995-10-13 | Präsentation von aus lipoarabinomannan bestehenden antigenen an t-zellen durch cd1 moleküle |
| DE69525058T DE69525058D1 (de) | 1994-10-13 | 1995-10-13 | Präsentation von aus lipoarabinomannan bestehenden antigenen an t-zellen durch cd1 moleküle |
| JP8513411A JPH10510142A (ja) | 1994-10-13 | 1995-10-13 | Ｃｄ１分子によるｔ細胞に対する疎水性抗原の提示 |
| AU42779/96A AU694299B2 (en) | 1994-10-13 | 1995-10-13 | Presentation of hydrophobic antigens to T-cells by CD1 molecules |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/322,979 | 1994-10-13 | ||
| US08/322,980 | 1994-10-13 | ||
| US08/322,979 US5853737A (en) | 1992-12-10 | 1994-10-13 | Method for inducing a CD1-restricted immune response |
| US08/322,980 US5679347A (en) | 1992-12-10 | 1994-10-13 | Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods |
| US50149195A | 1995-07-12 | 1995-07-12 | |
| US08/501,600 | 1995-07-12 | ||
| US08/501,491 | 1995-07-12 | ||
| US08/501,600 US6238676B1 (en) | 1992-12-10 | 1995-07-12 | Presentation of hydrophobic antigens to T-cells by CD1 molecules |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| WO1996012190A2 WO1996012190A2 (fr) | 1996-04-25 |
| WO1996012190A3 WO1996012190A3 (fr) | 1996-06-27 |
| WO1996012190A9 WO1996012190A9 (fr) | 1996-08-01 |
| WO1996012190B1 true WO1996012190B1 (fr) | 1996-09-06 |
Family
ID=27502254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/013274 WO1996012190A2 (fr) | 1994-10-13 | 1995-10-13 | Presentation d'antigenes hydrophobes a des lymphocytes t par des molecules cd1 |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP1170592A1 (fr) |
| JP (1) | JPH10510142A (fr) |
| AT (1) | ATE212129T1 (fr) |
| AU (1) | AU694299B2 (fr) |
| CA (1) | CA2202680A1 (fr) |
| DE (1) | DE69525058D1 (fr) |
| WO (1) | WO1996012190A2 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6238676B1 (en) | 1992-12-10 | 2001-05-29 | Brigham And Women's Hospital | Presentation of hydrophobic antigens to T-cells by CD1 molecules |
| US7063844B2 (en) | 1992-12-10 | 2006-06-20 | The Brigham And Women's Hospital, Inc. | Presentation of hydrophobic antigens to T-cells by CD1 molecules |
| BR9507389A (pt) * | 1994-04-14 | 1997-09-16 | Adcock Ingram Ltd | Método para detectar a presença de uma espécie mycobacterium e um kit e anticorpos para uso no mesmo |
| JP2001515868A (ja) * | 1997-09-12 | 2001-09-25 | ブライハム アンド ウイメンズ ホスピタル | Ｃｄ１制限免疫応答のための合成抗原 |
| EP1071452A1 (fr) * | 1998-04-13 | 2001-01-31 | Brigham Women's Hospital, Inc. | Compositions vaccinales comprenant des antigenes cd-1 et un compose de stimulation des cellules t, et procedes d'utilisation desdites compositions |
| WO2001094949A2 (fr) * | 2000-06-05 | 2001-12-13 | The Brigham And Women's Hospital, Inc. | Compositions solubles a base de cd1 et leurs utilisations |
| FR2819724B1 (fr) * | 2001-01-22 | 2005-05-13 | Inst Necker | Moyens pour induire une reponse immune aux antigenes bacteriens polysccharidiques et aux structures proteiques des capsides de virus |
| WO2004093903A2 (fr) | 2003-04-18 | 2004-11-04 | The Brigham And Women's Hospital, Inc. | Procedes et compositions d'immunomodulation mettant en oeuvre des antigenes cd1 |
| GB0708874D0 (en) * | 2007-05-08 | 2007-06-13 | Univ The Of Birmingham | Assay for detecting mycrobacterial infection |
| WO2020033366A1 (fr) | 2018-08-08 | 2020-02-13 | Nantbio, Inc. | Lymphocytes t restreints à cd1 recombinés et méthodes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1564592A (en) * | 1991-02-12 | 1992-09-07 | Dynagen, Inc. | Agglutination test for mycobacterial antigens in biological samples |
| AU1423892A (en) * | 1991-02-12 | 1992-09-07 | Colorado State University Research Foundation | Monoclonal antibodies directed towards mycobacterial antigens |
| DE69433115T2 (de) * | 1993-06-21 | 2004-04-01 | Brigham And Women's Hospital, Boston | Verfahren zur isolierung von cda-präsentierten antigenen, cd1-präsentierte antigeneenthaltende impfstoffe und in besagten verfahren verwendbare zelllinien |
-
1995
- 1995-10-13 AT AT95941326T patent/ATE212129T1/de not_active IP Right Cessation
- 1995-10-13 DE DE69525058T patent/DE69525058D1/de not_active Expired - Lifetime
- 1995-10-13 AU AU42779/96A patent/AU694299B2/en not_active Ceased
- 1995-10-13 WO PCT/US1995/013274 patent/WO1996012190A2/fr active IP Right Grant
- 1995-10-13 EP EP01202176A patent/EP1170592A1/fr not_active Withdrawn
- 1995-10-13 JP JP8513411A patent/JPH10510142A/ja not_active Ceased
- 1995-10-13 CA CA002202680A patent/CA2202680A1/fr not_active Abandoned
- 1995-10-13 EP EP95941326A patent/EP0786088B1/fr not_active Expired - Lifetime
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