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WO1996012018A3 - Nouvelles immunophillines et acides nucleiques correspondants - Google Patents

Nouvelles immunophillines et acides nucleiques correspondants Download PDF

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Publication number
WO1996012018A3
WO1996012018A3 PCT/US1995/012632 US9512632W WO9612018A3 WO 1996012018 A3 WO1996012018 A3 WO 1996012018A3 US 9512632 W US9512632 W US 9512632W WO 9612018 A3 WO9612018 A3 WO 9612018A3
Authority
WO
WIPO (PCT)
Prior art keywords
immunophilins
novel
nucleic acids
corresponding nucleic
proteins
Prior art date
Application number
PCT/US1995/012632
Other languages
English (en)
Other versions
WO1996012018A2 (fr
Inventor
Cohn Suzanne H Bourgeois
Gail A Baughman
Original Assignee
Salk Inst For Biological Studi
Cohn Suzanne H Bourgeois
Gail A Baughman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi, Cohn Suzanne H Bourgeois, Gail A Baughman filed Critical Salk Inst For Biological Studi
Priority to AU37616/95A priority Critical patent/AU3761695A/en
Publication of WO1996012018A2 publication Critical patent/WO1996012018A2/fr
Publication of WO1996012018A3 publication Critical patent/WO1996012018A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne de nouvelles protéines d'immunophillines exprimées en prépondérance par des lymphocytes T. Ces protéines appartiennent à la classe des protéines de liaison de FK-506 (FKBP), et sont capables de se lier à la FK-506 (ou à ses analogues) et à la rapamycine. Ces protéines inhibent l'activité calcineurine phosphatase lorsqu'elles sont liées à un ligand, et leur ARNm est induit par des glucocorticoïdes (la dexaméthazone par exemple). Ces protéines ont une activité peptidyle-prolyle cis/trans isomérase. L'invention concerne également le codage des acides nucléiques pour ces immunophilines, des anticorps contre ces immunophilines et leur utilisation dans cette perspective, par exemple pour identifier ou détecter des composés utiles en tant qu'agents immunodépresseurs.
PCT/US1995/012632 1994-10-14 1995-09-28 Nouvelles immunophillines et acides nucleiques correspondants WO1996012018A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37616/95A AU3761695A (en) 1994-10-14 1995-09-28 Novel immunophilins and corresponding nucleic acids

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32336794A 1994-10-14 1994-10-14
US08/323,367 1994-10-14
US44128595A 1995-05-15 1995-05-15
US08/441,285 1995-05-15

Publications (2)

Publication Number Publication Date
WO1996012018A2 WO1996012018A2 (fr) 1996-04-25
WO1996012018A3 true WO1996012018A3 (fr) 1996-06-20

Family

ID=26983919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/012632 WO1996012018A2 (fr) 1994-10-14 1995-09-28 Nouvelles immunophillines et acides nucleiques correspondants

Country Status (2)

Country Link
AU (1) AU3761695A (fr)
WO (1) WO1996012018A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426411B1 (en) 1997-05-30 2002-07-30 Dana-Farber Cancer Institute PGC-1, a novel brown fat pparγ coactivator
US7883855B2 (en) 2006-07-21 2011-02-08 Abbott Laboratories Immunosuppressant drug extraction reagent for immunoassays
JP5450092B2 (ja) 2006-12-29 2014-03-26 アボット・ラボラトリーズ 全血中の分子または薬物の検出のための診断検査
CA2673314C (fr) 2006-12-29 2014-03-11 Abbott Laboratories Reactif de lyse non denaturante destine a etre utilise en immunoessai de capture en solution
US7914999B2 (en) 2006-12-29 2011-03-29 Abbott Laboratories Non-denaturing lysis reagent
WO2008082982A1 (fr) 2006-12-29 2008-07-10 Abbott Laboratories Dosage amélioré de médicaments immunosuppresseurs
BRPI0721236A2 (pt) * 2007-01-29 2015-09-08 Wyeth Corp complexo purificado; célula hospedeira recombinante; método para identificar um composto teste que aumenta a formação de um complexo que inclui o composto teste; método de aumentar a formação de um complexo que inclui um ligante de imunofilina; método de diminuir a atividade do canal de cálcio da abertura dependente da tensão da membrana, e/ou atividade fkbp52, em uma célula; método de estimular o crescimento de neurite e/ou sobrevivência de uma célula neuronal; método de tratar um distúbio associado com disfunção de canal de cálcio tipo l; método de estimular o crescimento de neurite de uma célula neuronal; uso de um ligante de imunofilina; uso de um ligante de imunofilina em combinação com um antagonista do canal de cálcio tipo l; ligante de imunofilina; e composição.

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018527A1 (fr) * 1991-04-09 1992-10-29 Children's Research Institute Analyse de detection de la rapamycine
FR2688227A1 (fr) * 1992-03-04 1993-09-10 Inst Nat Sante Rech Med Proteines formant des complexes avec des chaperones et leurs ligands, leurs fragments, leur obtention et leurs applications biologiques.
WO1993023548A2 (fr) * 1992-05-20 1993-11-25 Vertex Pharmaceuticals Incorporated Procede de detection d'arn messagers codant la proteine de liaison fk506 a specificite tissulaire et ses utilisations
WO1993025533A1 (fr) * 1992-06-05 1993-12-23 Abbott Laboratories Procedes et reactifs pour le dosage d'immnosuppresseurs
WO1994015964A1 (fr) * 1993-01-15 1994-07-21 Dana-Farber Cancer Institute, Inc. PROTEINE DE LIAISON D'ADN DE LYMPHOCYTE T ACTIVE, NF-AT¿p?

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018527A1 (fr) * 1991-04-09 1992-10-29 Children's Research Institute Analyse de detection de la rapamycine
FR2688227A1 (fr) * 1992-03-04 1993-09-10 Inst Nat Sante Rech Med Proteines formant des complexes avec des chaperones et leurs ligands, leurs fragments, leur obtention et leurs applications biologiques.
WO1993023548A2 (fr) * 1992-05-20 1993-11-25 Vertex Pharmaceuticals Incorporated Procede de detection d'arn messagers codant la proteine de liaison fk506 a specificite tissulaire et ses utilisations
WO1993025533A1 (fr) * 1992-06-05 1993-12-23 Abbott Laboratories Procedes et reactifs pour le dosage d'immnosuppresseurs
WO1994015964A1 (fr) * 1993-01-15 1994-07-21 Dana-Farber Cancer Institute, Inc. PROTEINE DE LIAISON D'ADN DE LYMPHOCYTE T ACTIVE, NF-AT¿p?

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
ASAMI ET AL.: "Detection of the FK-506-FKBP-calcineurin complex by a simple binding assay", BIOCHEM.- BIOPHYS. RES. COMMUN., vol. 192, no. 3, pages 1388 - 1394, XP024767691, DOI: doi:10.1006/bbrc.1993.1570 *
BAUGHMAN ET AL.: "FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition", MOL. CELL. BIOL., vol. 15, no. 8, pages 4395 - 4402, XP000606991 *
DUMONT ET AL.: "The immunosuppressive and toxic effects of FK-506 are mechanistically related : pharmacology of a novel antagonist of FK-506 and rapamycin", J. EXP. MED., vol. 176, no. 3, pages 751 - 760, XP000606993, DOI: doi:10.1084/jem.176.3.751 *
DUTZ ET AL.: "A role for calcineurin in degranulation of murine cytotoxic T lymphocytes", J. IMMUNOLOGY, vol. 150, no. 7, 1 April 1993 (1993-04-01), pages 2591 - 2598 *
HARDING ET AL.: "A receptor for the immunosuppressant FK506 is a cis/trans peptidyl-prolyl isomerase", NATURE, vol. 341, 26 October 1989 (1989-10-26), pages 758 - 760, XP001153476, DOI: doi:10.1038/341758a0 *
LIU ET AL.: "Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes", CELL, vol. 66, 23 August 1991 (1991-08-23), pages 807 - 815, XP027461712, DOI: doi:10.1016/0092-8674(91)90124-H *
LIU ET AL.: "Inhibition of T cells signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity", BIOCHEMISTRY, vol. 31, no. 16, pages 3896 - 3901, XP000310587, DOI: doi:10.1021/bi00131a002 *
MURTHY ET AL.: "Identification of a 14 KDa immunophilin from calf thymus which binds to both rapamycin and FK506 (distinct from 10-12 KDa FK-506 binding protein.", CLIN. CHEM., vol. 39, no. 6, pages 1230, XP000606992 *
PARSONS ET AL.: "Regulation of calcineurin phosphatase activity and interaction with FK-506/FK-506 binding protein complex", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 30, 29 July 1994 (1994-07-29), pages 196109 - 19616 *
SEWELL ET AL.: "Inhibition of calcineurin by a novel FK-506-binding protein", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 33, 19 August 1994 (1994-08-19), pages 21094 - 21102, XP002116178 *
STANDAERT ET AL.: "Molecular cloning and overexpression of the human FK506-binding protein FKBP", NATURE, vol. 346, 16 August 1990 (1990-08-16), pages 671 - 674, XP055276695 *
TAI ET AL.: "Potentiation of progesterone receptor-mediated transcription by the immunosupressant FK 506", BIOCHEMISTRY, vol. 33, no. 35, 6 September 1994 (1994-09-06), pages 10666 - 10671 *
WIEDERRECHT ET AL.: "Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 30, pages 21753 - 21760, XP002950110 *

Also Published As

Publication number Publication date
AU3761695A (en) 1996-05-06
WO1996012018A2 (fr) 1996-04-25

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