WO1996008198A1 - Apparatus and method for analyzing body composition based on bioelectrical impedance analysis - Google Patents
Apparatus and method for analyzing body composition based on bioelectrical impedance analysis Download PDFInfo
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- WO1996008198A1 WO1996008198A1 PCT/KR1995/000119 KR9500119W WO9608198A1 WO 1996008198 A1 WO1996008198 A1 WO 1996008198A1 KR 9500119 W KR9500119 W KR 9500119W WO 9608198 A1 WO9608198 A1 WO 9608198A1
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- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 238000000034 method Methods 0.000 title claims description 41
- 238000011871 bio-impedance analysis Methods 0.000 title description 7
- 239000002184 metal Substances 0.000 claims abstract description 6
- 210000000577 adipose tissue Anatomy 0.000 claims description 12
- 235000013861 fat-free Nutrition 0.000 claims description 9
- 210000000476 body water Anatomy 0.000 claims description 8
- 238000005259 measurement Methods 0.000 abstract description 21
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000007796 conventional method Methods 0.000 description 8
- 210000003423 ankle Anatomy 0.000 description 6
- 210000000707 wrist Anatomy 0.000 description 6
- 230000037396 body weight Effects 0.000 description 4
- 210000004247 hand Anatomy 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
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- 239000000243 solution Substances 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
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- 201000011510 cancer Diseases 0.000 description 1
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- 230000003247 decreasing effect Effects 0.000 description 1
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- 238000003113 dilution method Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4869—Determining body composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0537—Measuring body composition by impedance, e.g. tissue hydration or fat content
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4869—Determining body composition
- A61B5/4872—Body fat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
- G06F3/01—Input arrangements or combined input and output arrangements for interaction between user and computer
- G06F3/02—Input arrangements using manually operated switches, e.g. using keyboards or dials
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
- G06F3/14—Digital output to display device ; Cooperation and interconnection of the display device with other functional units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/04—Constructional details of apparatus
- A61B2560/0487—Special user inputs or interfaces
Definitions
- the present invention relates to an apparatus for analyzing body composition based on bioelectrical impedance analysis, and a method therefore.
- the present invention relates to an apparatus for quantitatively analyzing body composition such as body fluid and body fat and the like by measuring the impedance of body segments such as arm, leg and trunk, by contacting the palm of hand and the sole of foot to metal plate electrodes, and by analyzing the measured values.
- a human body is composed of water, protein, bone and fat, in addition to the small amount of elements. The total of these elements constitutes the body weight.
- the quantitative measurement for the respective element is called body composition analysis.
- the percentage occupied by fat is called fatness, and the fatness is used as the criterium for assessing the nutritional status, and also is used in diagnosing various adult diseases.
- fat free mass FFM
- Patients associated with the nutrition deficit such as cancer are subjected to a periodically measuring FFM to know the curing state or the progress of the illness. In the case where a fatty man performs exercise to reduce the body weight, it frequently happens that the body weight shows little variation within a relatively short period of several months.
- the body composition is measured, it may be found that the amount of muscle has increased and the amount of fat has decreased. In this way, the effects of the exercise can be measured in a scientific manner. Further, based on the analysis of body composition, the growth in children and the nutrition status in old men can be diagnosed. Particularly, for various patients, the water distribution can be measured, thereby obtaining a clue for the patient's fluid balance.
- Another conventional method is to measure the thickness of the subcutaneous fat layer by using a caliper, ultrasound or near infrared light. These methods has the disadvantage that the accuracy is low. Further, there are imaging methods based on nuclear magnetic resonance (NMR), dual energy X-ray absorptiometry (DEXA). However, these methods are too expensive to carry out frequently. Further, there are dilution methods such as heavy water (D2O) dilution or bromide solution dilution. However, these methods are difficult to use.
- NMR nuclear magnetic resonance
- DEXA dual energy X-ray absorptiometry
- BIA bioelectrical impedance analysis
- a small amount of alternating current is passed through the body and the body resistance is measured, then total body water, water distribution between intracelluar and extracellular water, fat free mass can be determined.
- Total fat is the weight minus FFM and thus percent body fat can be calculated.
- the conventional method In the conventional method, an examinee should lie on a bed and sticky electrodes are applied on the skin. A calculation process is often required to obtain body composition following the impedance measurement. Because of these cumbersome measurement processes, it is difficult to use it. In addition, the conventional method measures the whole body impedance only and thus individual variations in segmental distribution of lean mass produces measurement errors. In the conventional method, electrodes should be applied on the designated location precisely and the measurement errors are often induced in the electrode application process. It is of further inconvenience that hairs should be removed for the electrode application. The above conventional method requires a long period time for the measurement.
- the weight is automatically measured by stepping on the machine, the examinee or patient data can be easily typed in using a key pad.
- the body composition results are displayed on a display unit and are printed out immediately following the measurement. It is a further object of the present invention that impedance is measured for the body segments as well as the whole body.
- An apparatus for analyzing body composition comprises: metal plate electrodes 1, 2, 3 and 4 contacting the palms and the soles; an impedance measuring instrument 5 for measuring impedance of the body using the current voltage ratio, which includes a terminal Ti consisting of a pair of current Ci and voltage Vi terminals and a terminal T2 consisting of a pair of current C2 and voltage V2 terminals, thereby an alternating current in the magnitude of 0.1-2.0 mA between 1 KHz and 1 MHz passes between said terminals Ti and T2 and a voltage difference is measured between said terminals Ti and T2; electronic s itches 6 connecting said plate electrodes to said impedance measuring terminals Ti and T2; a load cell 10 for measuring the weight; a key pad 11 for inputting the patient data such as height, age, and sex; a microprocessor 18 for calculating the body composition results using measured data; amplifier 15 and filter 16 and A/D converter 17 for interfacing said impedance meter 5 and weight measurement systems 10 to said microprocessor 18; and
- a body composition analyzer In a body composition analyzer according to the present invention, the results analyzed by a microprocessor 18 are displayed on a display unit 12 and can be printed out with a printer 14.
- a method for analyzing body composition comprises: connecting a pair of current Ci and voltage Vi electrodes to one plate electrode; connecting the other pair of current C2 and voltage V2 electrodes to the other plate electrode; controlling the on/off of the switch 6 with a microprocessor 18; measuring segmental body impedances; measuring the weight of a body with a load cell 10; inputting patient data such as the height, age, sex on a key pad 11; calculating body compositions such as total body water, fat free mass and percent body fat with a microprocessor 18; and displaying the analyzed results on a display unit 12; and/or printing the analyzed results out with a printer 14.
- Fig. 1 schematically illustrates electrical connections between four plate electrode analyzer and impedance measuring terminals
- Fig. 2 schematically illustrates electrical connections between two plate electrode analyzer and impedance measuring terminals
- Fig. 3 is a schematic view of the invented analyzer using four plate electrodes
- Fig. 4 is a schematic view of the invented analyzer using two plate electrodes
- Fig. 5 illustrates components of the analyzer and their electrical connections
- Fig. 6 illustrates the conventional measurement of the body impedance in which electrodes are attached on the skin of the right hand and foot;
- Fig. 7 is an electrical model of the body; and Fig. 8 illustrates electrical connections for measuring segmental impedance of the body.
- Fig. 1 schematically illustrates electrical connections between four plate electrode analyzer and impedance measuring terminals.
- Fig. 3 is a schematic view of the invented analyzer using four plate electrodes, and
- Fig. 5 illustrates components of the analyzer and their electrical connections.
- An apparatus for analyzing body composition according to the present invention comprises metal plate electrodes 1, 2, 3 and 4 contacting the palms and the soles; an impedance measuring instrument 5 for measuring impedance of the body using the current voltage ratio, which includes a terminal Ti consisting of a pair of current Ci and voltage Vi terminals and a terminal T2 consisting of a pair of current C2 and voltage V2 terminals, thereby an alternating current in the magnitude of 0.1-2.0 mA between 1 KHz and 1 MHz passes between said terminals Ti and T2 and a voltage difference is measured between said terminals Ti and T2; electronic switches 6 connecting said plate electrodes to said impedance measuring terminals Ti and T2; a load cell 10 for measuring the weight; a key pad 11 for inputting the patient
- the results are displayed on the display unit 12, and when needed, a printer(14) can be added for printing the results.
- a conventional impedance method four surface electrodes 19, 20, 21 and 22 are attached on the wrist, the back of hand, the ankle and the back of foot as shown in Fig. 6, electrically connecting the human body to an impedance measuring instrument. Then an electrical current is injected between the hand and the foot and voltage measured between the wrist and the ankle by 4-electrode method.
- the 4-electrode method utilizes a pair of current electrodes and a pair of voltage electrodes.
- electrodes are attached on the skin of the body.
- the device passes a sine wave current in the magnitude of 0.1-2.0mA at the frequency of about 1-1000 KHz between electrode Cl and C2, measures a voltage difference between electrodes VI and V2, and then calculate the body impedance using the voltage- current ratio.
- Resistance(R) is a function of the length(L), the cross -sectional area(A), and the resistivity( p ) of the conductor,
- the volume of the conductor is a function of the length L and the cross- sectional area A.
- Total body water (TBW) and fat free mass (FFM) are conductive mass in the body. Assuming that the length of the conductive mass is replaced by the height(Ht) and the resistivity( p ) is constant between individuals. TBW and FFM can be expressed by equation E4.
- Equation E4 constants Cl and C2 are determined by the regression between Ht 2 /R and TBW or FFM. Once the prediction equation is completed, TBW and FFM can be found by inserting body resistance and height into equation E4. Total body fat(FAT) is found by the body 'weight minus FFM, and the percent body fat is defined by equation E5.
- percent body fat 100 (Wt - FFM)/ Wt (E5)
- 2-electrode method is used, where impedance is measured between terminals TI and T2.
- a pair of current Cl and voltage VI terminals are connected to terminal TI and the other pair of current C2 and voltage V2 terminals are connected to terminal T2.
- terminal TI is connected to one or two plate electrodes and terminal T2 is connected to one or two plate electrodes which are not connected to terminal TI.
- the impedance of the body is measured between terminals TI and T2.
- the 2-electrode method can reduce the number of electrodes.
- this method has a contact resistance problem between the skin of the body and the electrodes. Therefore the body composition analyzer according to the present invention utilizes a large contact surface area which reduces the contact resistance.
- electrolytes-rich cream or solution applied on the palm and the sole can reduce the contact resistance further.
- a method for analyzing body composition comprises connecting a pair of current Ci and voltage Vi electrodes to one plate electrode; connecting the other pair of current C2 and voltage V2 electrodes to other plate electrodes; controlling the on/off of the switch 6 with a microprocessor 18; measuring segmental body impedances; measuring the weight of a body with a load cell 10; inputting patient data such as the height, age, sex on a key pad 11; calculating body compositions such as total body water, fat free mass and percent body fat with a microprocessor 18; and displaying the analyzed results on a display unit 12; and/or printing the analyzed results out with a printer 14.
- Fig. 2 is a schematic view of a body composition analyzer using two plate electrodes. As shown in Fig.
- an apparatus includes a hand electrode 7 for contacting the palms, a foot electrode 8 for contacting the soles, an impedance measuring instrument 5, a weight scale 10, an automatic ruler 13, a microprocessor 9, and interfacing electronics 15, 16 and 17 and a printer 14.
- a key pad for inserting the patient data such as age and sex, and a display unit can be included.
- a body composition analyzer Using a body composition analyzer according to the present invention, impedance of a body segment such as a right arm, a left arm, a right leg, and a whole body can be measured.
- Fig. 7 illustrates electrical model of body segments. As shown in Fig. 7, Ri, R2, R3, R4, and R5 are the resistances of the right arm, the left arm, the trunk, the right leg and the left leg, respectively. The whole body resistance (Rw) is measured between the palms and soles as shown in Fig. 8 and is expressed as equation E6.
- Rw (Ri • R 2 )/(R ⁇ + R2) + R3 + (R 4 • R S )/(R4 + Rs) (E6)
- the resistance of the right arm (Ri) plus the resistance of the left arm (R2) is measured by a connection shown in Fig. 8(D) and is expressed as equation E7.
- Resistance(Rw-2) of the both legs and the left arm can be measured as shown in Fig. 8(F) and resistance (Rw-i) of the both legs and the right arm can be measured as show in Fig. 8(E). These are expressed as equations E8 and E9.
- Rw-2 Ri + R3 + (R4 • Rs)/(R4 + Rs) (E8)
- arm resistance RI and R2 can be calculated.
- R 2 (Ra +Rw-2 -Rw- ⁇ )/2 (E12)
- Resistance of the right leg (R4) plus the resistance of the left leg(R5) can be measured as shown in Fig. 8(C) and can be expressed as equation E13.
- Rw-s (R ⁇ - R2)/(R ⁇ - ( -R2)+R3- , -R (E14)
- Rw-4 (Ri - R 2 )/(Ri+R2)+R3+Rs (E15)
- leg resistances R4 and R5 can be calculated.
- Resistance(Rt) of the trunk is found by subtracting parallel resistance of arms and legs from the resistance of the whole body.
- Rt Rw - (Ri • R 2 )/(R ⁇ + R2) - (R4 • R 5 )/(R4 + Rs) (E19)
- Body composition such as total body water(TBW) and fat free mass(FFM ) can be calculated by using Ht 2 /Rw, where Ht is the height and Rw is the whole body resistance. Segmental resistance ratios such as Ra/Rt can be used as an additional predictor.
- constants Cl, C2 and C3 are determined by the regression technique between impedance independent variables and TBW or FFM determined by a standard method.
- Ra can be replaced by RI or Ra+Rl.
- Segmental composition is a function of segmental impedance.
- FFM of the right arm is expressed as equation E21.
- the amount of body fat can be calculated by subtracting FFM from the weight.
- Percent body fat (%BF) is expressed as E23.
- %BF 100 x (Wt - FFM )/Wt (E23)
- An apparatus for measuring the impedance the body utilizes an alternating current in the magnitude of 0.1-2.0 mA at the frequency between 1 and 1000 KHz is frequently employed for a body composition analyzer.
- ECW to TBW ratio can be expressed by the following equation.
- the technique for calculation water distribution can be applied to the body composition analyzer according to the present invention as well as a conventional technique.
- a current and a voltage electrode are separately connected to the surface electrode.
- a current and a voltage electrode are connected to a metal plate electrode according to two electrode method, and then the body contacts this surface electrode.
- an examinee steps on the foot electrodes 3 and 4 with bare feet and touches the hand electrodes 1 and 2 with the palms. The measurement can be done much like measurement of the weight on the electronic scale.
- a person with a light cloth inputs his height, age, sex, and then touches his palms on right hand electrode 1, left hand electrode 2 and steps on right foot electrode 3 and left foot electrode 4.
- Terminal Ti consisting Ci and voltage Vi terminals, is connected to one or two electrodes and terminal T2. consisting of current C2 and voltage V2 terminal, is connected to one or two electrodes which are not connected to terminal Ti.
- Impedance measuring instrument 5 measures the impedance of the body between terminals Ti and T 2 .
- Electronic switches 6 change electrical connections between four electrodes 1, 2, 3 and 4 and terminals, Ti and T2. and measure segmental impedance of the body.
- a microprocessor 18 controls on/off of electronic switches 6 and measures segmental resistance as shown in Fig. 8(A)-(H).
- Fig. 8(A) shows the measurement of the whole body between the hands and the feet
- Fig. 8(B) shows the measurement between the right hand and the right foot
- Fig. 8(C) shows the measurement between the left foot and the right foot
- Fig. 8(D) shows the measurement between the left hand and the right hand
- Fig. 8(E) shows the measurement between the right hand the left foot
- Fig. 8(F) shows the measurement between the left hand and the both feet
- Fig. 8(G) shows the measurement between the right foot and the both hands
- Fig. 8(H) shows the measurement between the both hands and the both feet.
- the body weight is measured by a load cell located under the foot plate electrodes.
- a signal of the load cell is sent to the microprocessor 18 though a amplifier 15 and a filter 16 and A/D converter 17.
- the height is input on a key pad 11.
- the age and sex are also input on the key pad 11.
- the microprocessor 18 calculates total body water (TBW), fat free mass (FFM ) and percent body fat (%BF) using the measured values and the typed values.
- TW total body water
- FAM fat free mass
- %BF percent body fat
- the present invention makes it possible for a person to measure his body composition by himself much like a electronic weight measurement.
- the plate electrode method according to the present invention provides a highly reproducible electrical contacts between the body and the electrode without any special cautions. Further more a large contact area between the body and the electrodes reduces contact resistance effectively and measure impedance of the body reliably.
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Abstract
The present invention relates to an apparatus for analyzing body composition, which comprises metal plate electrodes (1, 2, 3 and 4) contacting the palms and the soles; an impedance measuring instrument (5) for measuring impedance of the body using the current voltage ratio, which includes a terminal T1 consisting of a pair of current C1 and voltage V1 terminals and a terminal T2 consisting of a pair of current C2 and voltage V2 terminals, thereby an alternating current in the magnitude of 0.1-2.0 mA between 1 KHz and 1 MHz passes between said terminals T1 and T2 and a voltage difference is measured between said terminals T1 and T2; electronic switches (6) connecting said plate electrodes to said impedance measuring terminals T1 and T2; a load cell (10) for measuring the weight; a key pad (11) for inputting the patient data such as height, age, and sex; a microprocessor (18) for calculating the body composition results using measured data; amplifier (15) and filter (16) and A/D converter (17) for interfacing said impedance meter (5) and weight measurement systems (10) to said microprocessor (18); and a display unit (12) for displaying the results.
Description
APPARATUS AND METHOD FOR ANALYZING BODY COMPOSITION BASED ON BIOELECTRICAL IMPEDANCE ANALYSIS
FIELD OF THE INVENTION
The present invention relates to an apparatus for analyzing body composition based on bioelectrical impedance analysis, and a method therefore. Particularly, the present invention relates to an apparatus for quantitatively analyzing body composition such as body fluid and body fat and the like by measuring the impedance of body segments such as arm, leg and trunk, by contacting the palm of hand and the sole of foot to metal plate electrodes, and by analyzing the measured values.
DESCRIPTION OF THE PRIOR ART
A human body is composed of water, protein, bone and fat, in addition to the small amount of elements. The total of these elements constitutes the body weight. The quantitative measurement for the respective element is called body composition analysis. The percentage occupied by fat is called fatness, and the fatness is used as the criterium for assessing the nutritional status, and also is used in diagnosing various adult diseases. In the medical terms, of the body composition, fat free mass (FFM) is the main components for supporting the human body. Patients associated with the nutrition deficit such as cancer are subjected to a periodically measuring FFM to know the curing state or the progress of the illness. In the case where a fatty man performs exercise to reduce the body
weight, it frequently happens that the body weight shows little variation within a relatively short period of several months. In this case, if the body composition is measured, it may be found that the amount of muscle has increased and the amount of fat has decreased. In this way, the effects of the exercise can be measured in a scientific manner. Further, based on the analysis of body composition, the growth in children and the nutrition status in old men can be diagnosed. Particularly, for various patients, the water distribution can be measured, thereby obtaining a clue for the patient's fluid balance.
There are various conventional methods for measuring body composition. One of them is hydrodensitometry, and this method is carried out in the following manner. The body density is found by measuring the weight under water. Then the amount of fat is calculated, using the body density. This method is based on the principle that fat is lighter than FFM. This method is highly accurate, and therefore, it is used as a standard method. However, it has the disadvantages that it is a troublesome task to carry it out and that it can not be applied to an old man or to a sick person.
Another conventional method is to measure the thickness of the subcutaneous fat layer by using a caliper, ultrasound or near infrared light. These methods has the disadvantage that the accuracy is low. Further, there are imaging methods based on nuclear magnetic resonance (NMR), dual energy X-ray absorptiometry (DEXA). However, these methods are too expensive to carry out frequently.
Further, there are dilution methods such as heavy water (D2O) dilution or bromide solution dilution. However, these methods are difficult to use.
As another method for measuring body composition, there is a bioelectrical impedance analysis (BIA). BIA method is safe, inexpensive, and quick.
In the conventional BIA method, a small amount of alternating current is passed through the body and the body resistance is measured, then total body water, water distribution between intracelluar and extracellular water, fat free mass can be determined. Total fat is the weight minus FFM and thus percent body fat can be calculated.
In the conventional method, four surface EKG electrodes or similar electrodes are attached on the wrist , the hand, the ankle, and the foot of an examinee with the supine posture. Then the impedance between the wrist and the ankle is measured. The surface electrodes are often sticky in order to be applied on the skin easily. When terminals of impedance instrument are connected to the electrodes, an alternating current in the magnitude of 0.1 - 2.0 mA at the frequency of about 1-1000 KHz is passed between the distal pair of hand and foot electrodes. Between the inner pair of the wrist and ankle electrodes, the resistance of the body is measured.
In the conventional BIA method, four electrodes are applied on the skin of the wrist, the hand, the ankle, and the foot. Then a current is injected into the body and a voltage difference is measured. This is 4-electrode method in which a pair of electrodes are used for the current injection and the other pair
are used for the voltage detection.
In the conventional method, an examinee should lie on a bed and sticky electrodes are applied on the skin. A calculation process is often required to obtain body composition following the impedance measurement. Because of these cumbersome measurement processes, it is difficult to use it. In addition, the conventional method measures the whole body impedance only and thus individual variations in segmental distribution of lean mass produces measurement errors. In the conventional method, electrodes should be applied on the designated location precisely and the measurement errors are often induced in the electrode application process. It is of further inconvenience that hairs should be removed for the electrode application. The above conventional method requires a long period time for the measurement.
OBTECTS OF THE INVENTION
It is an object of the present invention to provide an apparatus for analyzing body composition by measuring the electrical impedance, in which body composition is measured in a simple and convenient manner without a specially trained examiner, like when measuring the weight on a scale.
It is another object of the present invention to provide an apparatus for measuring the body impedance quickly and conveniently, in which a person contacts the surface of the plate electrodes with his palms and soles instead of appling sticky electrodes on the skin.
It is a further object of the present invention that the contact
resistance is reduced effectively by using a large contact area between the body and the electrodes.
It is a further object of the present invention that the weight is automatically measured by stepping on the machine, the examinee or patient data can be easily typed in using a key pad.
It is a further object of the present invention that the body composition results are displayed on a display unit and are printed out immediately following the measurement. It is a further object of the present invention that impedance is measured for the body segments as well as the whole body.
It is a further object of the present invention that body composition results are provided for the body segments as well as the whole body.
SUMMARY OF THE INVENTION
An apparatus for analyzing body composition according to the present invention comprises: metal plate electrodes 1, 2, 3 and 4 contacting the palms and the soles; an impedance measuring instrument 5 for measuring impedance of the body using the current voltage ratio, which includes a terminal Ti consisting of a pair of current Ci and voltage Vi terminals and a terminal T2 consisting of a pair of current C2 and voltage V2 terminals, thereby an alternating current in the magnitude of 0.1-2.0 mA between 1 KHz and 1 MHz passes between said terminals Ti and T2 and a voltage
difference is measured between said terminals Ti and T2; electronic s itches 6 connecting said plate electrodes to said impedance measuring terminals Ti and T2; a load cell 10 for measuring the weight; a key pad 11 for inputting the patient data such as height, age, and sex; a microprocessor 18 for calculating the body composition results using measured data; amplifier 15 and filter 16 and A/D converter 17 for interfacing said impedance meter 5 and weight measurement systems 10 to said microprocessor 18; and a display unit 12 for displaying the results.
In a body composition analyzer according to the present invention, the results analyzed by a microprocessor 18 are displayed on a display unit 12 and can be printed out with a printer 14.
A method for analyzing body composition according to the present invention comprises: connecting a pair of current Ci and voltage Vi electrodes to one plate electrode; connecting the other pair of current C2 and voltage V2 electrodes to the other plate electrode; controlling the on/off of the switch 6 with a microprocessor 18; measuring segmental body impedances; measuring the weight of a body with a load cell 10; inputting patient data such as the height, age, sex on a key pad 11;
calculating body compositions such as total body water, fat free mass and percent body fat with a microprocessor 18; and displaying the analyzed results on a display unit 12; and/or printing the analyzed results out with a printer 14.
BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1 schematically illustrates electrical connections between four plate electrode analyzer and impedance measuring terminals; Fig. 2 schematically illustrates electrical connections between two plate electrode analyzer and impedance measuring terminals;
Fig. 3 is a schematic view of the invented analyzer using four plate electrodes; Fig. 4 is a schematic view of the invented analyzer using two plate electrodes;
Fig. 5 illustrates components of the analyzer and their electrical connections;
Fig. 6 illustrates the conventional measurement of the body impedance in which electrodes are attached on the skin of the right hand and foot;
Fig. 7 is an electrical model of the body; and Fig. 8 illustrates electrical connections for measuring segmental impedance of the body.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
Reference "will now be made to the drawings wherein like structures will be provided with like reference designations.
Fig. 1 schematically illustrates electrical connections between four plate electrode analyzer and impedance measuring terminals. Fig. 3 is a schematic view of the invented analyzer using four plate electrodes, and Fig. 5 illustrates components of the analyzer and their electrical connections. An apparatus for analyzing body composition according to the present invention comprises metal plate electrodes 1, 2, 3 and 4 contacting the palms and the soles; an impedance measuring instrument 5 for measuring impedance of the body using the current voltage ratio, which includes a terminal Ti consisting of a pair of current Ci and voltage Vi terminals and a terminal T2 consisting of a pair of current C2 and voltage V2 terminals, thereby an alternating current in the magnitude of 0.1-2.0 mA between 1 KHz and 1 MHz passes between said terminals Ti and T2 and a voltage difference is measured between said terminals Ti and T2; electronic switches 6 connecting said plate electrodes to said impedance measuring terminals Ti and T2; a load cell 10 for measuring the weight; a key pad 11 for inputting the patient data such as height, age, and sex; a microprocessor 18 for calculating the body composition results using measured data; amplifier 15 and filter 16 and A/D converter 17 for interfacing said impedance meter 5 and weight measurement systems 10 to said microprocessor 18; and a display unit 12 for displaying the results.
In the body composition analyzing apparatus of the present
invention, the results are displayed on the display unit 12, and when needed, a printer(14) can be added for printing the results.
In a conventional impedance method, four surface electrodes 19, 20, 21 and 22 are attached on the wrist, the back of hand, the ankle and the back of foot as shown in Fig. 6, electrically connecting the human body to an impedance measuring instrument. Then an electrical current is injected between the hand and the foot and voltage measured between the wrist and the ankle by 4-electrode method.
The 4-electrode method utilizes a pair of current electrodes and a pair of voltage electrodes. In a state of supine posture, electrodes are attached on the skin of the body. When an impedance measuring device is connected to these attached electrodes, the device passes a sine wave current in the magnitude of 0.1-2.0mA at the frequency of about 1-1000 KHz between electrode Cl and C2, measures a voltage difference between electrodes VI and V2, and then calculate the body impedance using the voltage- current ratio. Resistance(R) is a function of the length(L), the cross -sectional area(A), and the resistivity( p ) of the conductor,
R = L/A (El)
Equation E2 is found by multiplying L to the numerator and denominator of the right side of equation El,
R = L2/(AL) (E2)
The volume of the conductor is a function of the length L and the cross- sectional area A. Thus
R = p L2/R (E3)
Total body water (TBW) and fat free mass (FFM) are conductive mass in the body. Assuming that the length of the conductive mass is replaced by the height(Ht) and the resistivity( p ) is constant between individuals. TBW and FFM can be expressed by equation E4.
TBW or FFM =Cι • Ht2 /R + C2 (E4)
In equation E4, constants Cl and C2 are determined by the regression between Ht2/R and TBW or FFM. Once the prediction equation is completed, TBW and FFM can be found by inserting body resistance and height into equation E4. Total body fat(FAT) is found by the body 'weight minus FFM, and the percent body fat is defined by equation E5.
percent body fat (%BF) = 100 (Wt - FFM)/ Wt (E5)
In the present invention, 2-electrode method is used, where impedance is measured between terminals TI and T2. A pair of current Cl and voltage VI terminals are connected to terminal
TI and the other pair of current C2 and voltage V2 terminals are connected to terminal T2. On the other hand, terminal TI is connected to one or two plate electrodes and terminal T2 is connected to one or two plate electrodes which are not connected to terminal TI. When the body is touched to the plate electrodes, the impedance of the body is measured between terminals TI and T2.
The 2-electrode method can reduce the number of electrodes. However, this method has a contact resistance problem between the skin of the body and the electrodes. Therefore the body composition analyzer according to the present invention utilizes a large contact surface area which reduces the contact resistance. In addition, electrolytes-rich cream or solution applied on the palm and the sole can reduce the contact resistance further. A method for analyzing body composition according to the present invention comprises connecting a pair of current Ci and voltage Vi electrodes to one plate electrode; connecting the other pair of current C2 and voltage V2 electrodes to other plate electrodes; controlling the on/off of the switch 6 with a microprocessor 18; measuring segmental body impedances; measuring the weight of a body with a load cell 10; inputting patient data such as the height, age, sex on a key pad 11; calculating body compositions such as total body water, fat free mass and percent body fat with a microprocessor 18; and displaying the analyzed results on a display unit 12; and/or printing the analyzed results out with a printer 14.
According to the present impedance method, four plate electrodes are used when a person steps on foot electrodes 3
and 4 with the bare feet and touches hand electrodes 1 and 2 with the palm, the impedance of segmental body is measured. The impedance of a body segment can be used to determine segmental composition as well as whole body composition. In another method, two electrodes are used, where palms contact one electrode and soles contact the other electrode. The electrical circuit of the two electrode analyzer is shown in Fig. 2. Fig. 4 is a schematic view of a body composition analyzer using two plate electrodes. As shown in Fig. 4, an apparatus according to the present invention includes a hand electrode 7 for contacting the palms, a foot electrode 8 for contacting the soles, an impedance measuring instrument 5, a weight scale 10, an automatic ruler 13, a microprocessor 9, and interfacing electronics 15, 16 and 17 and a printer 14.
As shown in Fig. 4, a key pad for inserting the patient data such as age and sex, and a display unit can be included.
Using a body composition analyzer according to the present invention, impedance of a body segment such as a right arm, a left arm, a right leg, and a whole body can be measured. Fig. 7 illustrates electrical model of body segments. As shown in Fig. 7, Ri, R2, R3, R4, and R5 are the resistances of the right arm, the left arm, the trunk, the right leg and the left leg, respectively. The whole body resistance (Rw) is measured between the palms and soles as shown in Fig. 8 and is expressed as equation E6.
Rw = (Ri • R2)/(Rι + R2) + R3 + (R4 • RS)/(R4 + Rs) (E6)
The resistance of the right arm (Ri) plus the resistance of the left arm (R2) is measured by a connection shown in Fig. 8(D) and is expressed as equation E7.
Resistance(Rw-2) of the both legs and the left arm can be measured as shown in Fig. 8(F) and resistance (Rw-i) of the both legs and the right arm can be measured as show in Fig. 8(E). These are expressed as equations E8 and E9.
Rw-2 = Ri + R3 + (R4 • Rs)/(R4 + Rs) (E8)
Rw-i = R2 + R3 + (R4 • Rδ)/(R4 + Rs) (E9)
Subtracting E9 from E8, Equation E10 is found.
From Equation E7 and E10, arm resistance RI and R2 can be calculated.
Ri = (Ra +Rw-2 -Rw-ι)/2 (Ell)
R2 = (Ra +Rw-2 -Rw-ι)/2 (E12)
Resistance of the right leg (R4) plus the resistance of the left leg(R5) can be measured as shown in Fig. 8(C) and can be
expressed as equation E13.
R ϋ = R + Rs (E13)
Resistance(Rw-5) of the both arms and the right leg is measured as shown in Fig. 8(H) and resistance(Rw-4) of the both arms and the left leg is measured as shown in Fig. 8(G). These are expressed as equations E13 and E14.
Rw-s =(Rι - R2)/(Rι-(-R2)+R3-,-R (E14)
Rw-4 = (Ri - R2)/(Ri+R2)+R3+Rs (E15)
Subtracting E15 from E14, equation E16 is found.
From equation E13 and E16, leg resistances R4 and R5 can be calculated.
R =( R I + Rw-s - Rw- )/2 (E17)
Rs = ( R Z + Rw-s - Rw-4)/2 (E18)
Resistance(Rt) of the trunk is found by subtracting parallel resistance of arms and legs from the resistance of the whole body.
Rt = Rw - (Ri • R2)/(Rι + R2) - (R4 • R5)/(R4 + Rs) (E19)
Body composition such as total body water(TBW) and fat free mass(FFM ) can be calculated by using Ht2/Rw, where Ht is the height and Rw is the whole body resistance. Segmental resistance ratios such as Ra/Rt can be used as an additional predictor.
TBW or FFM = Cι - Ht2/Rw + C2- (Ra/Rt)Ht2/Rw + C3 (E20)
In the above equation, constants Cl, C2 and C3 are determined by the regression technique between impedance independent variables and TBW or FFM determined by a standard method. In the above equation, Ra can be replaced by RI or Ra+Rl. Segmental composition is a function of segmental impedance. For example, FFM of the right arm is expressed as equation E21.
FFM left arm = Ci • Ht2 /Rw +C2 (E21)
The amount of body fat can be calculated by subtracting FFM from the weight.
Fat =Wt -FFM (E22)
Percent body fat (%BF) is expressed as E23.
%BF = 100 x (Wt - FFM )/Wt (E23)
An apparatus for measuring the impedance the body utilizes an alternating current in the magnitude of 0.1-2.0 mA at the frequency between 1 and 1000 KHz is frequently employed for a body composition analyzer.
In order to measure intracellular water (ICW) and extracellular water(ECW) separately, multifrequency technique measure the body impedance at a low frequency near 1 KHz and high frequency near 1 MHz. The impedance ratio measured at a high and low frequency, Rhigh/Rlow, can be used to calculate water distribution. For example, ECW to TBW ratio can be expressed by the following equation.
ECW/TBW = Ci - (Rhigh/Rlow) + C2 (E24)
The technique for calculation water distribution can be applied to the body composition analyzer according to the present invention as well as a conventional technique.
In the conventional body composition analyzer, current and voltage electrodes are separately connected to the surface electrode. In the analyzer according to the present invention, a current and a voltage electrode are connected to a metal plate electrode according to two electrode method, and then the body contacts this surface electrode. Using an body composition analyzer according to the present invention, an examinee steps on the foot electrodes 3 and 4 with bare feet and touches the hand electrodes 1 and 2 with the palms. The measurement can be done much like measurement
of the weight on the electronic scale. When using this body composition analyzer, a person with a light cloth inputs his height, age, sex, and then touches his palms on right hand electrode 1, left hand electrode 2 and steps on right foot electrode 3 and left foot electrode 4. Terminal Ti, consisting Ci and voltage Vi terminals, is connected to one or two electrodes and terminal T2. consisting of current C2 and voltage V2 terminal, is connected to one or two electrodes which are not connected to terminal Ti. Impedance measuring instrument 5 measures the impedance of the body between terminals Ti and T2.
Electronic switches 6 change electrical connections between four electrodes 1, 2, 3 and 4 and terminals, Ti and T2. and measure segmental impedance of the body.
As show in Fig. 2 and Fig. 4, using a two electrode body composition analyzer, two palms touch hand electrode 7 and two soles touch foot electrode 8. Terminal Ti is connected to the hand electrode 7, terminal T2 is connected to the foot electrode 8, and then whole body impedance between the palms and the soles is measured.
A microprocessor 18 controls on/off of electronic switches 6 and measures segmental resistance as shown in Fig. 8(A)-(H).
Fig. 8(A) shows the measurement of the whole body between the hands and the feet, Fig. 8(B) shows the measurement between the right hand and the right foot, Fig. 8(C) shows the measurement between the left foot and the right foot, Fig. 8(D) shows the measurement between the left hand and the right
hand, Fig. 8(E) shows the measurement between the right hand the left foot, Fig. 8(F) shows the measurement between the left hand and the both feet, Fig. 8(G) shows the measurement between the right foot and the both hands, and Fig. 8(H) shows the measurement between the both hands and the both feet. The body weight is measured by a load cell located under the foot plate electrodes. A signal of the load cell is sent to the microprocessor 18 though a amplifier 15 and a filter 16 and A/D converter 17. The height is input on a key pad 11. In addition to the height, the age and sex are also input on the key pad 11. The microprocessor 18 calculates total body water (TBW), fat free mass (FFM ) and percent body fat (%BF) using the measured values and the typed values. The results are displayed on a display unit 12 and/or are printed out with a printer 14.
The present invention makes it possible for a person to measure his body composition by himself much like a electronic weight measurement. The plate electrode method according to the present invention provides a highly reproducible electrical contacts between the body and the electrode without any special cautions. Further more a large contact area between the body and the electrodes reduces contact resistance effectively and measure impedance of the body reliably.
It should be apparent to those skilled in the art that variations and modifications can be added to the present invention which is limited only by the appended claims.
Claims
1. An apparatus for analyzing body composition comprising: metal plate electrodes 1, 2, 3 and 4 contacting the palms and the soles; an impedance measuring instrument 5 for measuring impedance of the body using the current voltage ratio, which includes a terminal T. consisting of a pair of current Ci and voltage Vi terminals and a terminal T2 consisting of a pair of current C2 and voltage V2 terminals, thereby an alternating current in the magnitude of 0.1-2.0 mA between 1 KHz and 1 MHz passes between said terminals Ti and T2 and a voltage difference is measured between said terminals Ti and T2; electronic switches 6 connecting said plate electrodes to said
impedance measuring terminals Ti and T2; a load cell 10 for measuring the weight; a key pad 11 for inputting the patient data such as height, age, and sex; a microprocessor 18 for calculating the body composition results using measured data; amplifier 15 and filter 16 and A/D converter 17 for interfacing said impedance measuring instrument 5 and a load cell 10 to said microprocessor 18; and a display unit 12 for displaying the results.
2. An apparatus for analyzing body composition according to claim 1 further including a printer 14 which prints said results out.
3. An apparatus for analyzing body composition according to claim 1 further including an automatic ruler 13 which measures the height of an examinee.
4. An apparatus for analyzing body composition comprising: a hand electrode 7 for contacting the palms; a foot electrode 8 for contacting the soles; an impedance measuring instrument 5 for measuring segmental impedances between said palms and soles; a weight scale 10 for measuring the weight of an examinee; an automatic ruler 13 for measuring the height of an examinee; a microprocessor 9 for calculating the body composition results using measured data; interfacing electronics 15, 16 and 17 for interfacing said impedance measuring instrument 5 and said weight scale 10 to said microprocessor 9; and a printer 14 for printing out said results.
5. An apparatus for analyzing body composition according to claim 4 further including a key pad 11 for inputting the patient data such as height, age, and sex.
6. An apparatus for analyzing body composition according to claim 4 further including a display 12 for displaying said results.
7. A method for determining bioelectrical impedance using a two electrode method, which comprises: connecting a pair of current Cl and voltage VI terminals to terminal TI: 5 connecting the other pair of current C2 and voltage V2 terminals to terminal T2; connecting terminal TI to one or two plate electrodes which are not connected to terminal TI; and connecting terminal T2 to one or two plate electrodes which 10 are not connected to terminal TI.
8. A method for determining bioelectrical impedance using a two electrode method, which comprises: connecting a hand electrode 7 to a terminal Ti consisting of 15 a pair of current Ci and voltage Vi terminals; and connecting a foot electrode 8 to a terminal T2 consisting of a pair of current C2 and voltage V2 terminals.
9. A method for analyzing body composition, which comprises: 20 connecting a pair of current Ci and voltage Vi electrodes to one plate electrode; connecting the other pair of current C2 and voltage V2 electrodes to the other plate electrode; controlling the on/off of the switch 6 'with a microprocessor 25 18; measuring segmental body impedances; measuring the weight of a body with a load cell 10; inputting patient data such as the height, age, sex on a key pad 11; calculating body compositions such as total body water, fat free mass and percent body fat with a microprocessor 18; and displaying the analyzed results on a display unit 12.
10. A method according to claim 9 wherein said step of measuring segmental body impedances comprises: connecting a pair of current Cl and voltage VI terminals to terminal TI: connecting the other pair of current C2 and voltage V2 terminals to terminal T2; connecting terminal TI to one or two plate electrodes which are not connected to terminal TI; and connecting terminal T2 to one or two plate electrodes -which are not connected to terminal TI.
11. A method according to claim 9 or 10 further including a step of printing out said results with a printer 14.
12. A method for analyzing body composition, 'which comprises: connecting a hand electrode 7 to a terminal Ti consisting of a pair of current Ci and voltage Vi terminals,' connecting a foot electrode 8 to a terminal T2 consisting of a pair of current C2 and voltage V2 terminals; measuring segmental body impedances; measuring the weight of a body with a load cell 10; measuring the height of a body with an automatic ruler 13; calculating body compositions such as total body water, fat free mass and percent body fat with a microprocessor 9; and printing the analyzed results out with a printer 14.
13. A method according to claim 12 wherein said step of measuring segmental body impedances comprises: connecting a hand electrode 7 to a terminal Ti consisting of a pair of current Ci and voltage Vi terminals; and connecting a foot electrode 8 to a terminal T2 consisting of a pair of current C2 and voltage V2 terminals.
Applications Claiming Priority (2)
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KR1994/23440 | 1994-09-15 | ||
KR1019940023440A KR0123408B1 (en) | 1994-09-15 | 1994-09-15 | Method and apparatus for determining body composition using bioelectrical impedance analysis |
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PCT/KR1995/000119 WO1996008198A1 (en) | 1994-09-15 | 1995-09-15 | Apparatus and method for analyzing body composition based on bioelectrical impedance analysis |
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WO1998051216A1 (en) * | 1997-05-16 | 1998-11-19 | St. Luke's-Roosevelt Hospital | Method of predicting body composition in prepubertal children infected with human immunodeficiency virus |
EP0940120A1 (en) * | 1998-03-03 | 1999-09-08 | Seb S.A. | Apparatus and method for measuring the composition of a body |
WO1999052425A3 (en) * | 1998-04-15 | 1999-12-02 | Braun Gmbh | Body composition analyzer with trend display |
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WO1998051216A1 (en) * | 1997-05-16 | 1998-11-19 | St. Luke's-Roosevelt Hospital | Method of predicting body composition in prepubertal children infected with human immunodeficiency virus |
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US6735468B2 (en) | 2000-02-02 | 2004-05-11 | Massachusetts Institute Of Technology | Arthroscopic impedance probe to detect cartilage degeneration |
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US6766272B2 (en) | 2000-10-27 | 2004-07-20 | Tanita Corporation | Method and apparatus for deriving body fat area |
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FR2830740A1 (en) * | 2001-10-12 | 2003-04-18 | Seb Sa | Subject body composition measuring apparatus, has electronic module for measuring bioelectric impedance, and voltage generator for square wave excitation voltage generation |
WO2003030735A1 (en) * | 2001-10-12 | 2003-04-17 | Seb S.A. | Apparatus for measuring body composition |
US7233823B2 (en) | 2001-10-12 | 2007-06-19 | Seb S.A. | Apparatus for measuring body composition |
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KR960009972A (en) | 1996-04-20 |
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