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WO1996005770A1 - Dispositif de prelevement sanguin, de separation du plasma et de distribution haute precision du plasma - Google Patents

Dispositif de prelevement sanguin, de separation du plasma et de distribution haute precision du plasma Download PDF

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Publication number
WO1996005770A1
WO1996005770A1 PCT/SE1995/000952 SE9500952W WO9605770A1 WO 1996005770 A1 WO1996005770 A1 WO 1996005770A1 SE 9500952 W SE9500952 W SE 9500952W WO 9605770 A1 WO9605770 A1 WO 9605770A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
plunger
plasma
fluid
blood
Prior art date
Application number
PCT/SE1995/000952
Other languages
English (en)
Inventor
Karl Erik Sundstrom
Lars Eric Sundstrom
Hans Olof Sundstrom
Original Assignee
Karl Erik Sundstrom
Lars Eric Sundstrom
Hans Olof Sundstrom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karl Erik Sundstrom, Lars Eric Sundstrom, Hans Olof Sundstrom filed Critical Karl Erik Sundstrom
Publication of WO1996005770A1 publication Critical patent/WO1996005770A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B01L3/50215—Test tubes specially adapted for centrifugation purposes using a float to separate phases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components

Definitions

  • Plasma separation Blood collection, plasma separation, and high precision plasma dispensing device.
  • This invention relates to an apparattis and a method for collecting a multiphase fluid such as blood and for separating and partitioning said fluid into a lighter phase and more partic ularly to blood collection in milliliter quantities , to plasma separation by centrifugation and to high precision plasma dispensings in microliter quantities, BACKGROUND
  • Specimen collection and specimen handling is an area of verv high cost, becautse it is very labour intensive. It is also prone to error. It subjects workers to biohazards from infectiuous agents which contami nate blood and is the area which at present is considered to be in greatest need of technological innovation and improvement.
  • the integral specimen collection, plasma separation and high precision plasma dispensing devise consists of a syringe with a p l unger designed as a cup and beeng provided with a ring shaped part with a self tapping screw working in the syringe when rotated, said cup is large enough to contain a plasma separating thixotropic gel and all the parts of the blood hea v i er then the plasma.
  • the ring shaped part on its bad side may have spoakes for engagement to turning devises.
  • the syringe is evacuated, and it is filled lite any other known evacuated specimen col l ect i on tube through a rubber stopper.
  • the plasma separation is performed by centrif ug n t ion or the syringe.
  • the heavier parts of the blood is trapped in the plunger behind the gel plug, which by force created by centrifugation has moved from the bottom of the cup towards its top, thus leaving the p l asma in front of the plunger free to be dispensed from the syringe when the plunger is advanced.
  • Flasma dispensing is done through dispensing device after penetrating the rubber stopper.
  • the size and the high precision of the volume dispensed may be controlled by the angu l ar movement of the plunger, which worts as an internal micrometer screw inside the syringe.
  • Fig 1 shows a cross section of the evacuated blood collection device empty except for a volume of thi xotropic gel at the bottom.
  • Fig 2 shows a cross section of the device equiped with a need l e and filled with blood.
  • Fig 3 shows a cross section of the device after centrifugation.
  • Fig 4 shows a cross section of the devise equipped with a delivery tip.
  • Fi g 5 shows the device of Fig 1 providec with a linearyl movable plungerrod 19.
  • the device consists of a plastic syringe 1 equi pped with a plunger 2 that is shaped lite a deep cup. This cup is pressfitted into an other plunger 3, which is equi pped with a self tapping scew thread 4 threading the syringe 1.
  • the plunger-cup 2 is partly filled with a gel-l i ke thi xothropic agent 5 of the type in common practise to separ ate the plasma from the rest of the blood.
  • the syringe is provided with a rubber stopper 6.
  • the plunger 3 is equipped with blade-life radially oriented spoakes 7 for eng agement to turning devices.
  • FIG. 1 shows the blood-collection device equipped with a hypodermic needle 8 fitted onto a valve containing adaptor 9 (eqiped with a needle 10) for multiple prelevment of a type used in common prax is by the profession.
  • the needle 10 is shown penetrating the rubberstooper 6.
  • the syringe is filled with blood 11.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Ce dispositif se compose d'une seringue (1) et d'un piston ayant une forme en U (2), suffisamment large pour contenir un gel thixotropique (5) séparant le plasma et tous les composants sanguins plus lourds. Par centrifugation, le bouchon de gel, qui s'est déplacé pour recouvrir les composants sanguins plus lourds, est emprisonné dans le piston (2), libérant ainsi le plasma à l'avant où il sera distribué à partir de la seringue au fur et à mesure que l'on pousse le piston (2) vers l'avant.
PCT/SE1995/000952 1994-08-19 1995-08-18 Dispositif de prelevement sanguin, de separation du plasma et de distribution haute precision du plasma WO1996005770A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9402812-3 1994-08-19
SE9402812A SE9402812D0 (sv) 1994-08-19 1994-08-19 Bloodcollection, plasmaseparation and high precision plasma dispensing device

Publications (1)

Publication Number Publication Date
WO1996005770A1 true WO1996005770A1 (fr) 1996-02-29

Family

ID=20394999

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1995/000952 WO1996005770A1 (fr) 1994-08-19 1995-08-18 Dispositif de prelevement sanguin, de separation du plasma et de distribution haute precision du plasma

Country Status (2)

Country Link
SE (1) SE9402812D0 (fr)
WO (1) WO1996005770A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT404317B (de) * 1996-08-02 1998-10-27 Greiner & Soehne C A Verschlussvorrichtung, trennvorrichtung sowie aufnahmebehälter für eine aufnahmeeinrichtung
AT409725B (de) * 1997-05-12 2002-10-25 Greiner & Soehne C A Trennvorrichtung
EP1056490A4 (fr) * 1998-02-27 2003-01-08 Cohesion Tech Inc Dispositif de separation de cellule et seringue de dosage
US7188734B2 (en) 2001-03-30 2007-03-13 Greiner Bio-One Gmbh Holding device, particularly for bodily fluids, comprising a separating device, and a separating device therefor
EP2277625A1 (fr) 2004-01-23 2011-01-26 Greiner Bio-One GmbH Dispositif de retenue pour le sang, les liquides organiques, des échantillons de tissus ou de cultures de tissus
US7927563B1 (en) 2009-10-13 2011-04-19 Cytomedix, Inc. Kit for separation of biological fluids
US8394342B2 (en) 2008-07-21 2013-03-12 Becton, Dickinson And Company Density phase separation device
US8747781B2 (en) 2008-07-21 2014-06-10 Becton, Dickinson And Company Density phase separation device
US8794452B2 (en) 2009-05-15 2014-08-05 Becton, Dickinson And Company Density phase separation device
JP2014533142A (ja) * 2012-03-05 2014-12-11 ドンクー バイオ アンド ファルマシーオー．， エルティーディー．Ｄｏｎｇｋｏｏ Ｂｉｏ ＆ Ｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． 成分分離器
US9333445B2 (en) 2008-07-21 2016-05-10 Becton, Dickinson And Company Density phase separation device
US9682373B2 (en) 1999-12-03 2017-06-20 Becton, Dickinson And Company Device for separating components of a fluid sample
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886928A (en) * 1970-03-07 1975-06-03 Sarstedt W Device for the extraction of blood
EP0265876A2 (fr) * 1986-10-27 1988-05-04 Habley Medical Technology Corporation Seringue du type vernier avec dispositif de dosage encliquetable
WO1990002516A1 (fr) * 1988-09-13 1990-03-22 Safe-Tec Clinical Products, Inc. Dispositif d'acheminement et de collecte d'un fluide a fermeture hermetique device
EP0363485A1 (fr) * 1987-06-18 1990-04-18 Terumo Kabushiki Kaisha Procede et appareil de prelevement d'echantillons sanguins
WO1991000114A1 (fr) * 1989-06-23 1991-01-10 Ultradent Products, Inc. Seringue a plongeur ameliore

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886928A (en) * 1970-03-07 1975-06-03 Sarstedt W Device for the extraction of blood
EP0265876A2 (fr) * 1986-10-27 1988-05-04 Habley Medical Technology Corporation Seringue du type vernier avec dispositif de dosage encliquetable
EP0363485A1 (fr) * 1987-06-18 1990-04-18 Terumo Kabushiki Kaisha Procede et appareil de prelevement d'echantillons sanguins
WO1990002516A1 (fr) * 1988-09-13 1990-03-22 Safe-Tec Clinical Products, Inc. Dispositif d'acheminement et de collecte d'un fluide a fermeture hermetique device
WO1991000114A1 (fr) * 1989-06-23 1991-01-10 Ultradent Products, Inc. Seringue a plongeur ameliore

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277331B1 (en) 1996-08-02 2001-08-21 C. A. Greiner & Söhne Gesellschaft mbH Holding device for body fluids and tissues
AT404317B (de) * 1996-08-02 1998-10-27 Greiner & Soehne C A Verschlussvorrichtung, trennvorrichtung sowie aufnahmebehälter für eine aufnahmeeinrichtung
AT409725B (de) * 1997-05-12 2002-10-25 Greiner & Soehne C A Trennvorrichtung
EP1056490A4 (fr) * 1998-02-27 2003-01-08 Cohesion Tech Inc Dispositif de separation de cellule et seringue de dosage
US9682373B2 (en) 1999-12-03 2017-06-20 Becton, Dickinson And Company Device for separating components of a fluid sample
US7188734B2 (en) 2001-03-30 2007-03-13 Greiner Bio-One Gmbh Holding device, particularly for bodily fluids, comprising a separating device, and a separating device therefor
US8448800B2 (en) 2004-01-23 2013-05-28 Greiner Bio-One Gmbh Method for the assembly of a cap with a receptacle
EP2277625A1 (fr) 2004-01-23 2011-01-26 Greiner Bio-One GmbH Dispositif de retenue pour le sang, les liquides organiques, des échantillons de tissus ou de cultures de tissus
US8747781B2 (en) 2008-07-21 2014-06-10 Becton, Dickinson And Company Density phase separation device
US9452427B2 (en) 2008-07-21 2016-09-27 Becton, Dickinson And Company Density phase separation device
US10350591B2 (en) 2008-07-21 2019-07-16 Becton, Dickinson And Company Density phase separation device
US9933344B2 (en) 2008-07-21 2018-04-03 Becton, Dickinson And Company Density phase separation device
US8394342B2 (en) 2008-07-21 2013-03-12 Becton, Dickinson And Company Density phase separation device
US9714890B2 (en) 2008-07-21 2017-07-25 Becton, Dickinson And Company Density phase separation device
US9333445B2 (en) 2008-07-21 2016-05-10 Becton, Dickinson And Company Density phase separation device
US9339741B2 (en) 2008-07-21 2016-05-17 Becton, Dickinson And Company Density phase separation device
US9700886B2 (en) 2008-07-21 2017-07-11 Becton, Dickinson And Company Density phase separation device
US9802189B2 (en) 2009-05-15 2017-10-31 Becton, Dickinson And Company Density phase separation device
US9919309B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US12090476B2 (en) 2009-05-15 2024-09-17 Becton, Dickinson And Company Density phase separation device
US9364828B2 (en) 2009-05-15 2016-06-14 Becton, Dickinson And Company Density phase separation device
US9079123B2 (en) 2009-05-15 2015-07-14 Becton, Dickinson And Company Density phase separation device
US9731290B2 (en) 2009-05-15 2017-08-15 Becton, Dickinson And Company Density phase separation device
US8998000B2 (en) 2009-05-15 2015-04-07 Becton, Dickinson And Company Density phase separation device
US9919308B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US9919307B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US11786895B2 (en) 2009-05-15 2023-10-17 Becton, Dickinson And Company Density phase separation device
US11351535B2 (en) 2009-05-15 2022-06-07 Becton, Dickinson And Company Density phase separation device
US10343157B2 (en) 2009-05-15 2019-07-09 Becton, Dickinson And Company Density phase separation device
US8794452B2 (en) 2009-05-15 2014-08-05 Becton, Dickinson And Company Density phase separation device
US10376879B2 (en) 2009-05-15 2019-08-13 Becton, Dickinson And Company Density phase separation device
US10413898B2 (en) 2009-05-15 2019-09-17 Becton, Dickinson And Company Density phase separation device
US10456782B2 (en) 2009-05-15 2019-10-29 Becton, Dickinson And Company Density phase separation device
US10807088B2 (en) 2009-05-15 2020-10-20 Becton, Dickinson And Company Density phase separation device
US7927563B1 (en) 2009-10-13 2011-04-19 Cytomedix, Inc. Kit for separation of biological fluids
JP2014533142A (ja) * 2012-03-05 2014-12-11 ドンクー バイオ アンド ファルマシーオー．， エルティーディー．Ｄｏｎｇｋｏｏ Ｂｉｏ ＆ Ｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． 成分分離器
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid

Also Published As

Publication number Publication date
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