+

WO1996003527A3 - Procede et sonde diagnostiques - Google Patents

Procede et sonde diagnostiques Download PDF

Info

Publication number
WO1996003527A3
WO1996003527A3 PCT/GB1995/001721 GB9501721W WO9603527A3 WO 1996003527 A3 WO1996003527 A3 WO 1996003527A3 GB 9501721 W GB9501721 W GB 9501721W WO 9603527 A3 WO9603527 A3 WO 9603527A3
Authority
WO
WIPO (PCT)
Prior art keywords
exon
diagnostic method
introns
sequence
probe
Prior art date
Application number
PCT/GB1995/001721
Other languages
English (en)
Other versions
WO1996003527A2 (fr
Inventor
David Tarin
Yasuhiro Matsumura
Original Assignee
Isis Innovation
David Tarin
Yasuhiro Matsumura
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9414704A external-priority patent/GB9414704D0/en
Priority claimed from GB9420878A external-priority patent/GB9420878D0/en
Priority claimed from GBGB9509881.0A external-priority patent/GB9509881D0/en
Application filed by Isis Innovation, David Tarin, Yasuhiro Matsumura filed Critical Isis Innovation
Priority to JP8505569A priority Critical patent/JPH10504188A/ja
Priority to EP95925936A priority patent/EP0771361A2/fr
Publication of WO1996003527A2 publication Critical patent/WO1996003527A2/fr
Publication of WO1996003527A3 publication Critical patent/WO1996003527A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Des introns et un nouvel exon, l'exon 9a, sont formés comme produits de transcription pendant l'expression non régulée du gène CD44 dans des cellules tumorales. De nouvelles sondes comprennent des oligonucléotides marqués qui s'hybrident avec des brins complémentaires produits par synthèse sur des introns. Un procédé diagnostique consiste à hybrider ces sondes avec des acides nucléiques provenant de cellules de mammifères. On décrit l'intron In-9 doté d'une séquence 474 bp et l'exon 9a doté d'une séquence 436 bp.
PCT/GB1995/001721 1994-07-21 1995-07-21 Procede et sonde diagnostiques WO1996003527A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP8505569A JPH10504188A (ja) 1994-07-21 1995-07-21 診断方法およびプローブ
EP95925936A EP0771361A2 (fr) 1994-07-21 1995-07-21 Procede et sonde diagnostiques

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9414704.8 1994-07-21
GB9414704A GB9414704D0 (en) 1994-07-21 1994-07-21 Diagnostic method and probe
GB9420878.2 1994-10-17
GB9420878A GB9420878D0 (en) 1994-10-17 1994-10-17 Diagnostic method and probe
GB9509881.0 1995-05-16
GBGB9509881.0A GB9509881D0 (en) 1994-07-21 1995-05-16 Diagnostic method & probe

Publications (2)

Publication Number Publication Date
WO1996003527A2 WO1996003527A2 (fr) 1996-02-08
WO1996003527A3 true WO1996003527A3 (fr) 1996-03-28

Family

ID=27267290

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1995/001721 WO1996003527A2 (fr) 1994-07-21 1995-07-21 Procede et sonde diagnostiques

Country Status (4)

Country Link
EP (1) EP0771361A2 (fr)
JP (1) JPH10504188A (fr)
CA (1) CA2195404A1 (fr)
WO (1) WO1996003527A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999004036A1 (fr) * 1997-07-14 1999-01-28 Isis Innovation Limited Detection de cancer a base de cd44
WO2005001126A1 (fr) * 2003-06-12 2005-01-06 Korea Research Institute Of Bioscience And Biotechnology Necessaire de detection du cancer gastrique et cancer gastrique metastatique

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988002783A1 (fr) * 1986-10-16 1988-04-21 Nordisk Insulinlaboratorium Procede et agent de detection des structures genetiques de patients ayant une grande tendance a developper un iddm
JPH02109982A (ja) * 1988-10-18 1990-04-23 Teijin Ltd 遺伝子断片，プローブ及びそれを用いる染色体異常検出方法
WO1991010734A1 (fr) * 1990-01-12 1991-07-25 Hsc Research Development Corporation Introns et exons du gene de la fibrose cystique et mutations a differentes positions du gene
EP0558257A1 (fr) * 1992-02-24 1993-09-01 The Scripps Research Institute Maladie de Gaucher: détection d'une nouvelle mutation dans l'intron 2 du gène de la glucocerebrosidase
WO1993022458A1 (fr) * 1992-04-24 1993-11-11 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Methode predictive pour un comportement suicidaire
WO1994002633A1 (fr) * 1992-07-21 1994-02-03 Isis Innovation Limited Methode de diagnostic

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988002783A1 (fr) * 1986-10-16 1988-04-21 Nordisk Insulinlaboratorium Procede et agent de detection des structures genetiques de patients ayant une grande tendance a developper un iddm
JPH02109982A (ja) * 1988-10-18 1990-04-23 Teijin Ltd 遺伝子断片，プローブ及びそれを用いる染色体異常検出方法
WO1991010734A1 (fr) * 1990-01-12 1991-07-25 Hsc Research Development Corporation Introns et exons du gene de la fibrose cystique et mutations a differentes positions du gene
EP0558257A1 (fr) * 1992-02-24 1993-09-01 The Scripps Research Institute Maladie de Gaucher: détection d'une nouvelle mutation dans l'intron 2 du gène de la glucocerebrosidase
WO1993022458A1 (fr) * 1992-04-24 1993-11-11 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Methode predictive pour un comportement suicidaire
WO1994002633A1 (fr) * 1992-07-21 1994-02-03 Isis Innovation Limited Methode de diagnostic

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 014, no. 318 *
TARIN D ET AL: "derranged activity of the CD44 gene and other loci as biomarkers for progression to metastatic stability", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 17g, pages 173 - 185 *

Also Published As

Publication number Publication date
JPH10504188A (ja) 1998-04-28
CA2195404A1 (fr) 1996-02-08
EP0771361A2 (fr) 1997-05-07
WO1996003527A2 (fr) 1996-02-08

Similar Documents

Publication Publication Date Title
Kay et al. Association of an unusual form of a Pax7-like gene with increased efficiency of skeletal muscle regeneration
CA2172722A1 (fr) Procedes et compositions pour le sequencage efficace d'acide nucleique
Cifarelli et al. Random amplified hybridization microsatellites (RAHM): isolation of a new class of microsatellite-containing DNA clones
EP1375676A3 (fr) Synthétisation de polynucléotides par ligature d'oligomères multiples
EP0832290A1 (fr) Sequence d'amorce universelle pour une amplification multiplex de l'adn
EP0644889A4 (fr) COMPOSITIONS ET PROCEDES DE MODULATION DE LA -g(b)-AMYLOIDE.
WO1998020165A3 (fr) Marqueurs bialleliques
DE3779175D1 (de) Bestimmte, von einem papillomavirus-genom abgeleitete dns-sequenzen, deren anwendungen fuer in vitro-diagnostische zwecke und die herstellung von antigenzusammensetzungen.
WO1999010358A3 (fr) Procede de production de polymeres d'acide nucleique
DE3575731D1 (de) Herstellung von dna in grossem umfang.
MXPA05009140A (es) Metodo para la deteccion de trastornos geneticos.
CA2133956A1 (fr) Methode de sequencage de l'adn
EP1734134A3 (fr) Nouveau gène spécifique à la prostate servant au diagnostic, au prognostic et au traitment du cancer de la prostate
Terkelsen et al. Repeated primed in situ labeling: formation and labeling of specific DNA sequences in chromosomes and nuclei
WO1996003527A3 (fr) Procede et sonde diagnostiques
Prochazka Microsatellite hybrid capture technique for simultaneous isolation of various STR markers.
WO1996023880A3 (fr) Nouvel allele de recepteur h2 a l'histamine humain et procedes de detection de variantes du recepteur h¿2?
DE60044203D1 (de) Gen das in schizophrenie defekt ist
Cosenza et al. A MvaI PCR-RFLP detecting a silent allele at the goat α-lactalbumin locus
Schreiber et al. Frameshift mutations in exons 9 and 10 of the porphobilinogen deaminase gene produce a crossreacting immunological material (CRIM)-negative form of acute intermittent porphyria
Lumsden et al. Characterization and linkage mapping often sheep microsatellite markers derived from a sheep x hamster cell hybrid
EP1106695A3 (fr) Procédé de production d'acides L-aminés par fermentation de bactéries corynéformes dont le gène glyA a une activité réduite
Hermans et al. Absence of alternative splicing in bcr-abl mRNA in chronic myeloid leukemia cell lines
IL134729A (en) Methods of synthesizing polynucleotides by ligation of multiple oligomers
EP1055725A3 (fr) Procédé de production de L-aminoacides par fermentation de bactéries et séquences nucléotides codantes pour le gene accDA

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1995925936

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 1996 750854

Country of ref document: US

Date of ref document: 19961223

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2195404

Country of ref document: CA

WWP Wipo information: published in national office

Ref document number: 1995925936

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1995925936

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载