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WO1996003502A3 - Muc1 derived proteins for the diagnosis, imaging and therapy of human cancer - Google Patents

Muc1 derived proteins for the diagnosis, imaging and therapy of human cancer Download PDF

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Publication number
WO1996003502A3
WO1996003502A3 PCT/IB1995/000627 IB9500627W WO9603502A3 WO 1996003502 A3 WO1996003502 A3 WO 1996003502A3 IB 9500627 W IB9500627 W IB 9500627W WO 9603502 A3 WO9603502 A3 WO 9603502A3
Authority
WO
WIPO (PCT)
Prior art keywords
muc1
human cancer
alt
diagnosis
therapy
Prior art date
Application number
PCT/IB1995/000627
Other languages
French (fr)
Other versions
WO1996003502A2 (en
Inventor
Daniel H Wreschner
Original Assignee
Univ Ramot
Daniel H Wreschner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ramot, Daniel H Wreschner filed Critical Univ Ramot
Priority to AU29906/95A priority Critical patent/AU2990695A/en
Publication of WO1996003502A2 publication Critical patent/WO1996003502A2/en
Publication of WO1996003502A3 publication Critical patent/WO1996003502A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a biochemically pure MUC1 protein, selected from the group consisting of MUC1/X, MUC1/X/alt, MUC1/Y, MUC1/Y/alt, MUC1/V, MUC1/V/alt, MUC1/W, MUC1/W/alt, MUC1/Z and MUC1/Z/alt or a functional derivative thereof devoid of a tamdem repeat array. The invention also provides a diagnostic agent for the detection of human cancer cells and a pharmaceutical composition for the treatment of human cancer, and a method for detecting the presence of cancer in a patient.
PCT/IB1995/000627 1994-07-26 1995-07-21 Muc1 derived proteins for the diagnosis, imaging and therapy of human cancer WO1996003502A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU29906/95A AU2990695A (en) 1994-07-26 1995-07-21 Mucin-derived proteins for the diagnosis, imaging, and therapy of human cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11046494A IL110464A0 (en) 1994-07-26 1994-07-26 Novel proteins for the diagnosis, imaging, and therapy of human cancer
IL110464 1994-07-26

Publications (2)

Publication Number Publication Date
WO1996003502A2 WO1996003502A2 (en) 1996-02-08
WO1996003502A3 true WO1996003502A3 (en) 1996-09-12

Family

ID=11066387

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1995/000627 WO1996003502A2 (en) 1994-07-26 1995-07-21 Muc1 derived proteins for the diagnosis, imaging and therapy of human cancer

Country Status (3)

Country Link
AU (1) AU2990695A (en)
IL (1) IL110464A0 (en)
WO (1) WO1996003502A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548643B1 (en) 1994-11-16 2003-04-15 Austin Research Institute Antigen carbohydrate compounds and their use in immunotherapy
GB9810040D0 (en) 1998-05-11 1998-07-08 Univ Nottingham Blood borne tumour markers
GB9827228D0 (en) 1998-12-10 1999-02-03 Univ Nottingham Cancer detection method and reagents
DE19917195B4 (en) * 1999-04-16 2006-09-28 Immatics Biotechnologies Gmbh Peptide for triggering an immune reaction against tumor cells, pharmaceutical compositions containing them, their uses, nucleic acid coding therefor and expression vector containing said nucleic acid
WO2001018035A2 (en) 1999-09-08 2001-03-15 Transgene S.A. Muc-1 derived peptides
EP1257565A4 (en) * 2000-02-01 2005-04-06 Austin Research Inst Mucin-1 derived antigens and their use in immunotherapy
CA2430060C (en) 2000-11-27 2015-11-24 Minerva Biotechnologies Corporation Identification and use of cell surface receptor-binding ligands for the diagnosis and treatment of cancer
US20020110841A1 (en) 2000-12-22 2002-08-15 KUFE Donald W. Regulation of cell growth by MUC1
CA2442531A1 (en) 2001-03-29 2002-10-10 Ramot University Authority For Applied Research & Industrial Development Ltd. Peptides and antibodies to muc 1 proteins
JP2004536578A (en) * 2001-03-30 2004-12-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Anti-MUC-1 single chain antibodies for tumor targeting
US7183388B2 (en) 2001-03-30 2007-02-27 The Regents Of The University Of California Anti-MUC-1 single chain antibodies for tumor targeting
WO2003046188A1 (en) * 2001-11-27 2003-06-05 Nexyte Ab Production of eukaryotic proteins and nucleic acid molecules in c. elegans
US20030235868A1 (en) * 2002-04-22 2003-12-25 Dyax Corporation Antibodies specific for mucin polypeptide
JP2006502110A (en) * 2002-07-03 2006-01-19 イミュノジェン・インコーポレーテッド Antibodies against non-released Muc1 and Muc16 and uses thereof
GB2424273B (en) 2002-11-14 2007-06-27 Univ Nottingham Method for preparing tumour marker protein
JP2007531505A (en) * 2002-11-27 2007-11-08 ミネルバ バイオオテクノロジーズ コーポレーション Techniques and compositions for diagnosis and treatment of cancer (MUC1)
US8129506B2 (en) 2003-10-24 2012-03-06 Genzyme Corporation Modulation of the interaction of MUC1 with MUC1 ligands
ATE527285T1 (en) 2005-01-28 2011-10-15 Univ Ramot ANTI-MUC1 ALPHA BETA ANTIBODIES
AU2006249801A1 (en) * 2005-05-26 2006-11-30 Dana-Farber Cancer Institute, Inc. Modulation of MUC1-dependent anti-estrogen resistance
RU2636532C2 (en) 2005-05-27 2017-11-23 Онкиммьюн Лимитед Improved immunoassay methods
GB2426581A (en) 2005-05-27 2006-11-29 Univ Nottingham Immunoassay methods
CN101632020B (en) 2006-09-13 2013-11-27 昂西免疫有限公司 Improved immunoassay methods
WO2008097840A2 (en) 2007-02-02 2008-08-14 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of muc1 by hsf1 and stat3
US7871784B2 (en) 2007-02-02 2011-01-18 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of apoptosis by MUC1 and BH3-containing proapoptotic proteins
CA2976089A1 (en) 2015-02-10 2016-08-18 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009867A1 (en) * 1989-12-22 1991-07-11 Imperial Cancer Research Technology Limited Mucin nucleotides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009867A1 (en) * 1989-12-22 1991-07-11 Imperial Cancer Research Technology Limited Mucin nucleotides

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
LIGTENBERG, M. ET AL.: "Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, 5 April 1990 (1990-04-05), MD US, pages 5573 - 5578, XP002008226 *
MAGARIAN-BLANDER, J. ET AL.: "Specific and effective T-cell recognition of cells transfected with a truncated human mucin cDNA.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, (1993 AUG 12) 690, 231-43., XP000575939 *
OZZELLO, L. ET AL.: "The use of natural interferon alpha conjugated to a monoclonal antibody anti mammary epithelial mucin (Mc5) for the treatment of human breast cancer xenografts.", BREAST CANCER RESEARCH AND TREATMENT, (1993) 25 (3) 265-76., XP000575935 *
WRESCHNER, D. ET AL.: "Does a novel form of the breast cancer marker protein, MUC1, act as a receptor molecule that modulates signal transduction?.", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, (1994) 353, 17-26., XP000575964 *
WRESCHNER, D. ET AL.: "Human epithelial tumor antigen cDNA sequences. Differential splicing may generate multiple protein forms", EUR. J. BIOCHEM. (1990), 189(3), 463-73, XP000575962 *
ZRIHAN-LICHT, S. ET AL.: "Characterization and molecular cloning of a novel MUC1 protein, devoid of tandem repeats, expressed in human breast cancer tissue.", EUROPEAN JOURNAL OF BIOCHEMISTRY, (1994 SEP 1) 224 (2) 787-95., XP000575936 *

Also Published As

Publication number Publication date
IL110464A0 (en) 1994-10-21
AU2990695A (en) 1996-02-22
WO1996003502A2 (en) 1996-02-08

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