WO1996003165A1 - Prothese de paroi abdominale - Google Patents
Prothese de paroi abdominale Download PDFInfo
- Publication number
- WO1996003165A1 WO1996003165A1 PCT/GB1995/001715 GB9501715W WO9603165A1 WO 1996003165 A1 WO1996003165 A1 WO 1996003165A1 GB 9501715 W GB9501715 W GB 9501715W WO 9603165 A1 WO9603165 A1 WO 9603165A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- prosthesis
- antimicrobial agent
- retaining
- resorbable
- gel
- Prior art date
Links
- 210000003815 abdominal wall Anatomy 0.000 title claims abstract description 21
- 239000004599 antimicrobial Substances 0.000 claims abstract description 33
- 239000004744 fabric Substances 0.000 claims abstract description 14
- 239000000758 substrate Substances 0.000 claims abstract description 14
- 108010010803 Gelatin Proteins 0.000 claims abstract description 13
- 239000008273 gelatin Substances 0.000 claims abstract description 13
- 229920000159 gelatin Polymers 0.000 claims abstract description 13
- 235000019322 gelatine Nutrition 0.000 claims abstract description 13
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 13
- 239000011148 porous material Substances 0.000 claims abstract description 13
- 239000012528 membrane Substances 0.000 claims abstract description 7
- 229920000728 polyester Polymers 0.000 claims abstract description 5
- 239000000499 gel Substances 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 8
- -1 polypropylene Polymers 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 4
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 2
- 239000011888 foil Substances 0.000 claims description 2
- 238000005470 impregnation Methods 0.000 claims description 2
- 239000012982 microporous membrane Substances 0.000 claims description 2
- 230000035515 penetration Effects 0.000 claims description 2
- 239000012620 biological material Substances 0.000 claims 1
- 239000005445 natural material Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 abstract description 6
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 230000000845 anti-microbial effect Effects 0.000 abstract description 3
- 208000014674 injury Diseases 0.000 abstract description 3
- 238000002791 soaking Methods 0.000 abstract description 3
- 206010019909 Hernia Diseases 0.000 abstract description 2
- 208000027418 Wounds and injury Diseases 0.000 abstract description 2
- 230000006378 damage Effects 0.000 abstract description 2
- 239000002131 composite material Substances 0.000 description 15
- 239000000463 material Substances 0.000 description 10
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 10
- 229960001225 rifampicin Drugs 0.000 description 10
- 230000003115 biocidal effect Effects 0.000 description 9
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 5
- 239000004810 polytetrafluoroethylene Substances 0.000 description 5
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 229920000339 Marlex Polymers 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000010276 construction Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 108010025899 gelatin film Proteins 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 229920000544 Gore-Tex Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000000842 anti-protozoal effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003904 antiprotozoal agent Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Definitions
- This invention relates to prosthetic material for the repair of the abdominal wall in the case of injury or lesion caused, for example, by hernia, invasive infection or trauma.
- the invention also encompasses prostheses made from such material.
- the invention addresses the general problem of providing prosthetic material for abdominal wall reconstruction.
- PTFE polytetrafluoroethylene
- GORE-TEX soft tissue patch and macroporous polypropylene mesh (particularly as sold as MARLEX ) have been used as prosthetic materials for abdominal wall reconstruction.
- Brown et al . (Ann. Surgery 201(6) 705-711 (1985)) experimentally compared PTFE and polypropylene mesh abdominal wall prostheses and found a slight preference for the PTFE material.
- Antibiotics were administered systemically in these experiments. In spite of the prior work that has been carried out in this area, there remains a low but significant rate of infection associated with synthetic tissue patches for abdominal wall reconstruction.
- an abdominal wall prosthesis which is capable of retaining and delivering, an antimicrobial agent.
- the prosthesis may comprise a composite structure of a resorbable porous material which absorbs and retains the microbiological agent.
- the composite may further comprise a non-resorbable mesh capable for use in abdominal wall reconstruction.
- Goeau-Brissonniere et al. (Ann. Vaac. Surgery 5(5) 408- 412 (1991) ) used protein-impregnated porous materials containing rifampin as a vascular graft. In that case, the purpose of the protein-impregnation was to completely seal the graft, rather than specifically to provide a matrix for the rifampin. Graft sealing is not a requirement of abdominal wall prostheses, so the prior publication of Goeau-Brissonniere et al. does little to address the problem addressed by the present invention.
- the porous material of this invention preferably comprises a substrate which is impregnated or otherwise associated with a suitable substance capable of retaining the antimicrobial agent.
- the substance capable of retaining an antimicrobial agent will not be a separate foil or film. Instead, the substance capable of retaining an antimicrobial agent impregnates the interstices of the substrate to form a composite prosthetic structure.
- the substance capable of retaining an antimicrobial agent will be completely resorbable in nature and the substrate will be either of synthetic or natural origin and will be non- resorbable once implanted into the patient.
- the substrate itself may be macroporous or microporous membrane, mesh or fabric. If a fabric, the fabric may be non-woven, woven, or preferably knitted.
- the fibre from which the fabric is prepared may be polymeric, for example PTFE, polypropylene or polyester, particularly polyethyleneterephthalate (PET) .
- the substance capable of retaining the antimicrobial agent may be a gel or have a gel-like or sponge-like open structure.
- the substance is proteinaceous.
- the protein may be any suitable material having the desired properties for its intended use.
- the protein is gelatin (which is within the meaning of the term "protein” as it is used in this specification) , ideally partially cross-linked as described in EP-A- 0183365.
- the protein may also be a polyglycollic acid gel or other synthetic absorbable gel.
- a suitable and highly desirable protein-impregnated porous material is available from Vascutek Limited under the trade mark GELSEAL.
- the resorbable gelatin and the membrane mesh or fabric substrate be of a composite construction.
- Figures 1 and 2 the advantage of using a composite construction is clearly demonstrated. Specifically, in Figure 1, a non-composite, non-impregnated abdominal wall prothesis is shown. As demonstrated the antibiotic is forced to diffuse a great distance in order to surround and protect the mesh. During this diffusion process, antibiotic is lost and therefore lower concentrations of the antimicrobial agents is present at the site of prosthesis insertion. In the composite structure as shown in Figure 2, the antibiotic completely surrounds, the membrane, mesh or fabric due to the interlocking (impregnated) nature of the resorbable gelatin and the non-resorbable membrane, mesh or fabric. This allows the gelatin to completely envelope the substrate and dispense a high antimicrobial concentration around and into the mesh.
- the antimicrobial agent of this invention may be an antiviral, an antibacterial, an antifungal or an antiprotozoal.
- Antibacterials include natural and semi- synthetic antibiotics as well as wholly synthetic antibacterials.
- Rifampin is an antibacterial which may be used to advantage in the present invention. Mixtures of different antimicrobial agents may be used. Sufficient antimicrobial agent will be present to provide an antimicrobial-effective dose of the agent in the conditions of use.
- the porous material contains the antimicrobial agent.
- the antimicrobial agent may be absorbed in or adsorbed on the substrate, or even chemically bound to it in some convenient way, providing that its efficacy is not impaired.
- Prostheses in accordance with the invention may be prepared by the following process, which itself forms part of the invention.
- a process for the preparation of a prosthesis as described above comprising loading the porous material with antimicrobial agent.
- the anti ⁇ microbial agent may be supplied in liquid form; if a solid at room temperature, it may be provided in the form of a solution, for example in water or normal saline. In such a case, loading will conveniently be achieved by contacting the porous material with the antimicrobial agent in liquid form, for example by spraying or, preferably, immersion.
- the gelatin-sealed knitted polyester graft available under the trade mark GE SOFT from Vascutek Limited may be soaked just before use in a lmg/ml normal saline solution of rifampin at 37°C for 15 minutes. This is not to suggest that these conditions are limiting, but rather they are illustrative of the concentration and conditions that may be used to achieve a suitable loading.
- the porous material itself may be prepared in any suitable way, for example as indicated in EP-A-0183365.
- prostheses in accordance with the invention is to reconstruct the abdominal wall of humans or, if required, other animals.
- the invention is therefore expected to be useful in a method of reconstructing the abdominal wall, the method comprising suturing or otherwise connecting a prostheses as described above to the abdominal wall margin.
- an antimicrobial agent in the preparation of a prosthesis for the abdominal wall.
- Prosthesis material which may be porous, will generally also be used in the preparation.
- Gelatin-sealed knitted polyester graft patches were prepared in accordance with EP-A-0183365 and were soaked in a lmg/ml normal saline solution of rifampin (RIFADINE ) at 37°C for 15 minutes.
- RFADINE rifampin
- Circular patches 2 cm in diameter containing Rifampicin are implanted subcutaneously in rabbits.
- the patches were either gelatin impregnated mesh (Gel+) or mesh only
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Afin de réduire le risque d'infection dans la reconstruction de la paroi abdominale endommagée à la suite d'une hernie ou d'une autre blessure, une prothèse comprend un matériau poreux contenant un agent antibactérien et/ou un autre agent antimicrobien. De préférence, le matériau poreux comprend un substrat sous forme d'une membrane, d'un maillage ou d'une étoffe, en polyester tricoté non résorbable, imprégné d'une gélatine partiellement réticulée (résorbable) ou recouvert de celle-ci, auquel on peut incorporer par mouillage un agent antimicrobien avant de suturer ledit matériau avec le bord de la paroi abdominale.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU29872/95A AU2987295A (en) | 1994-07-21 | 1995-07-20 | Prostheses for the abdominal wall |
| JP8505567A JPH10503099A (ja) | 1994-07-21 | 1995-07-20 | 腹壁のための人工器官 |
| EP95925930A EP0772468A1 (fr) | 1994-07-21 | 1995-07-20 | Prothese de paroi abdominale |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9414746.9 | 1994-07-21 | ||
| GB9414746A GB9414746D0 (en) | 1994-07-21 | 1994-07-21 | Prosthetic material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1996003165A1 true WO1996003165A1 (fr) | 1996-02-08 |
Family
ID=10758690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB1995/001715 WO1996003165A1 (fr) | 1994-07-21 | 1995-07-20 | Prothese de paroi abdominale |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0772468A1 (fr) |
| JP (1) | JPH10503099A (fr) |
| AU (1) | AU2987295A (fr) |
| GB (1) | GB9414746D0 (fr) |
| WO (1) | WO1996003165A1 (fr) |
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19613730A1 (de) * | 1996-03-26 | 1997-10-02 | Ethicon Gmbh | Flächiges Implantat |
| US6113641A (en) * | 1997-08-27 | 2000-09-05 | Ethicon, Inc. | Prosthesis for the obturation of a hernial canal |
| US6180848B1 (en) | 1997-08-27 | 2001-01-30 | Ethicon, Inc. | Prosthesis obturating device for the obturation of a hernial canal |
| US6241768B1 (en) | 1997-08-27 | 2001-06-05 | Ethicon, Inc. | Prosthetic device for the repair of a hernia |
| FR2840801A1 (fr) * | 2002-06-18 | 2003-12-19 | Cie De Rech En Composants Impl | Implant prothetique composite |
| WO2005051448A1 (fr) * | 2003-11-26 | 2005-06-09 | Ethicon Gmbh | Implant chirurgical |
| FR2865379A1 (fr) * | 2005-03-02 | 2005-07-29 | Cie De Rech En Composants Impl | Implant prothetique composite |
| WO2006032497A1 (fr) | 2004-09-24 | 2006-03-30 | Aesculap Ag & Co. Kg | Implant antimicrobien comprenant une structure poreuse souple |
| US7025063B2 (en) | 2000-09-07 | 2006-04-11 | Ams Research Corporation | Coated sling material |
| RU2465654C1 (ru) * | 2011-07-27 | 2012-10-27 | Николай Александрович Пострелов | Способ моделирования условий протезирующей герниопластики брюшной стенки |
| US8317808B2 (en) | 2008-02-18 | 2012-11-27 | Covidien Lp | Device and method for rolling and inserting a prosthetic patch into a body cavity |
| US8753359B2 (en) | 2008-02-18 | 2014-06-17 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
| US8758373B2 (en) | 2008-02-18 | 2014-06-24 | Covidien Lp | Means and method for reversibly connecting a patch to a patch deployment device |
| US8808314B2 (en) | 2008-02-18 | 2014-08-19 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
| US8888811B2 (en) | 2008-10-20 | 2014-11-18 | Covidien Lp | Device and method for attaching an implant to biological tissue |
| US8906045B2 (en) | 2009-08-17 | 2014-12-09 | Covidien Lp | Articulating patch deployment device and method of use |
| US9034002B2 (en) | 2008-02-18 | 2015-05-19 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9044235B2 (en) | 2008-02-18 | 2015-06-02 | Covidien Lp | Magnetic clip for implant deployment device |
| US9301826B2 (en) | 2008-02-18 | 2016-04-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9393002B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
| US9393093B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
| US9398944B2 (en) | 2008-02-18 | 2016-07-26 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9833240B2 (en) | 2008-02-18 | 2017-12-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9999424B2 (en) | 2009-08-17 | 2018-06-19 | Covidien Lp | Means and method for reversibly connecting an implant to a deployment device |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2846549B1 (fr) * | 2002-11-04 | 2005-08-05 | Sofradim Production | Prothese de renfort de structures tissulaires |
| DE102004051487A1 (de) * | 2004-10-21 | 2006-04-27 | Ethicon Gmbh | Chirurgisches Implantat |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0183365A2 (fr) * | 1984-11-30 | 1986-06-04 | Vascutek Limited | Greffe vasculaire |
-
1994
- 1994-07-21 GB GB9414746A patent/GB9414746D0/en active Pending
-
1995
- 1995-07-20 AU AU29872/95A patent/AU2987295A/en not_active Abandoned
- 1995-07-20 JP JP8505567A patent/JPH10503099A/ja active Pending
- 1995-07-20 EP EP95925930A patent/EP0772468A1/fr not_active Withdrawn
- 1995-07-20 WO PCT/GB1995/001715 patent/WO1996003165A1/fr not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0183365A2 (fr) * | 1984-11-30 | 1986-06-04 | Vascutek Limited | Greffe vasculaire |
Non-Patent Citations (3)
| Title |
|---|
| A. FREYRIE ET AL.: "INTERACTION BETWEEN VASCULAR PROSTHESES AND RIFAMPICIN IN THE PREVENTION OF THE GRAFTS INFECTION. AN EXPERIMENTAL STUDY.", INTERNATIONAL ANGIOLOGY, vol. 11, no. 2, pages 113 - 116 * |
| M. D'ADDATO ET AL.: "PREVENTION OF EARLY GRAFT INFECTION WITH RIFAMPICIN BONDED GELSEAL GRAFTS: A MULTICENTRE EXPERIMENTAL STUDY.", CARDIOVASCULAR SURGERY, vol. 2, no. 2, pages 254 - 258 * |
| SCOTT D. JENKINS ET AL.: "A COMPARISON OF PROSTHETIC MATERIALS USED TO REPAIR ABDOMINAL WALL DEFECTS.", SURGERY, vol. 94, no. 2, pages 392 - 398 * |
Cited By (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6162962A (en) * | 1996-03-26 | 2000-12-19 | Ethicon Gmbh & Co., Kg | Areal implant |
| DE19613730C2 (de) * | 1996-03-26 | 2002-08-14 | Ethicon Gmbh | Flächiges Implantat zum Verstärken oder Verschließen von Körpergewebe |
| DE19613730A1 (de) * | 1996-03-26 | 1997-10-02 | Ethicon Gmbh | Flächiges Implantat |
| US6113641A (en) * | 1997-08-27 | 2000-09-05 | Ethicon, Inc. | Prosthesis for the obturation of a hernial canal |
| US6180848B1 (en) | 1997-08-27 | 2001-01-30 | Ethicon, Inc. | Prosthesis obturating device for the obturation of a hernial canal |
| US6241768B1 (en) | 1997-08-27 | 2001-06-05 | Ethicon, Inc. | Prosthetic device for the repair of a hernia |
| US7025063B2 (en) | 2000-09-07 | 2006-04-11 | Ams Research Corporation | Coated sling material |
| US8147478B2 (en) | 2000-09-07 | 2012-04-03 | Ams Research Corporation | Coated sling material |
| FR2840801A1 (fr) * | 2002-06-18 | 2003-12-19 | Cie De Rech En Composants Impl | Implant prothetique composite |
| WO2003105726A1 (fr) * | 2002-06-18 | 2003-12-24 | Compagnie De Recherche En Composants, Implants Et Materiels Pour L'application Clinique | Implant prothetique composite |
| WO2005051448A1 (fr) * | 2003-11-26 | 2005-06-09 | Ethicon Gmbh | Implant chirurgical |
| DE10355189B4 (de) * | 2003-11-26 | 2015-04-30 | Johnson & Johnson Medical Gmbh | Verfahren zum Herstellen eines chirurgischen Implantats sowie chirurgisches Implantat |
| WO2006032497A1 (fr) | 2004-09-24 | 2006-03-30 | Aesculap Ag & Co. Kg | Implant antimicrobien comprenant une structure poreuse souple |
| JP2008514248A (ja) * | 2004-09-24 | 2008-05-08 | アエスクラップ アーゲー ウント コー カーゲー | 可撓性で多孔性の構造をもつ抗菌性埋入物 |
| FR2865379A1 (fr) * | 2005-03-02 | 2005-07-29 | Cie De Rech En Composants Impl | Implant prothetique composite |
| US8753359B2 (en) | 2008-02-18 | 2014-06-17 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
| US9393093B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
| US8758373B2 (en) | 2008-02-18 | 2014-06-24 | Covidien Lp | Means and method for reversibly connecting a patch to a patch deployment device |
| US8808314B2 (en) | 2008-02-18 | 2014-08-19 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
| US10695155B2 (en) | 2008-02-18 | 2020-06-30 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
| US10182898B2 (en) | 2008-02-18 | 2019-01-22 | Covidien Lp | Clip for implant deployment device |
| US9005241B2 (en) | 2008-02-18 | 2015-04-14 | Covidien Lp | Means and method for reversibly connecting a patch to a patch deployment device |
| US10159554B2 (en) | 2008-02-18 | 2018-12-25 | Covidien Lp | Clip for implant deployment device |
| US9034002B2 (en) | 2008-02-18 | 2015-05-19 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9044235B2 (en) | 2008-02-18 | 2015-06-02 | Covidien Lp | Magnetic clip for implant deployment device |
| US9107726B2 (en) | 2008-02-18 | 2015-08-18 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
| US9301826B2 (en) | 2008-02-18 | 2016-04-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9393002B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
| US8317808B2 (en) | 2008-02-18 | 2012-11-27 | Covidien Lp | Device and method for rolling and inserting a prosthetic patch into a body cavity |
| US9398944B2 (en) | 2008-02-18 | 2016-07-26 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9833240B2 (en) | 2008-02-18 | 2017-12-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US8888811B2 (en) | 2008-10-20 | 2014-11-18 | Covidien Lp | Device and method for attaching an implant to biological tissue |
| US9999424B2 (en) | 2009-08-17 | 2018-06-19 | Covidien Lp | Means and method for reversibly connecting an implant to a deployment device |
| US8906045B2 (en) | 2009-08-17 | 2014-12-09 | Covidien Lp | Articulating patch deployment device and method of use |
| RU2465654C1 (ru) * | 2011-07-27 | 2012-10-27 | Николай Александрович Пострелов | Способ моделирования условий протезирующей герниопластики брюшной стенки |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9414746D0 (en) | 1994-09-07 |
| JPH10503099A (ja) | 1998-03-24 |
| AU2987295A (en) | 1996-02-22 |
| EP0772468A1 (fr) | 1997-05-14 |
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