WO1996003150B1 - Compositions containing hemicelluloses and polyphenols for treating gastrointestinal disorders - Google Patents
Compositions containing hemicelluloses and polyphenols for treating gastrointestinal disordersInfo
- Publication number
- WO1996003150B1 WO1996003150B1 PCT/US1995/009230 US9509230W WO9603150B1 WO 1996003150 B1 WO1996003150 B1 WO 1996003150B1 US 9509230 W US9509230 W US 9509230W WO 9603150 B1 WO9603150 B1 WO 9603150B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- dietary fiber
- food
- polyphenol
- group
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 31
- 150000008442 polyphenolic compounds Chemical class 0.000 title claims abstract 14
- 235000013824 polyphenols Nutrition 0.000 title claims abstract 14
- 229920002488 Hemicellulose Polymers 0.000 title claims abstract 12
- 208000018522 Gastrointestinal disease Diseases 0.000 title claims abstract 3
- 241001465754 Metazoa Species 0.000 claims abstract 14
- 102000004190 Enzymes Human genes 0.000 claims abstract 4
- 108090000790 Enzymes Proteins 0.000 claims abstract 4
- 244000052616 bacterial pathogen Species 0.000 claims abstract 3
- 230000003247 decreasing effect Effects 0.000 claims abstract 2
- 235000013325 dietary fiber Nutrition 0.000 claims 15
- 235000013305 food Nutrition 0.000 claims 13
- SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 claims 7
- 229920000189 Arabinogalactan Polymers 0.000 claims 7
- 239000001904 Arabinogalactan Substances 0.000 claims 7
- 235000019312 arabinogalactan Nutrition 0.000 claims 7
- 229930003935 flavonoid Natural products 0.000 claims 6
- 150000002215 flavonoids Chemical class 0.000 claims 6
- 235000017173 flavonoids Nutrition 0.000 claims 6
- 229920001542 oligosaccharide Polymers 0.000 claims 6
- 239000000419 plant extract Substances 0.000 claims 5
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 claims 3
- 229930091371 Fructose Natural products 0.000 claims 3
- 239000005715 Fructose Substances 0.000 claims 3
- 229920000926 Galactomannan Polymers 0.000 claims 3
- 229920001202 Inulin Polymers 0.000 claims 3
- UGXQOOQUZRUVSS-ZZXKWVIFSA-N [5-[3,5-dihydroxy-2-(1,3,4-trihydroxy-5-oxopentan-2-yl)oxyoxan-4-yl]oxy-3,4-dihydroxyoxolan-2-yl]methyl (e)-3-(4-hydroxyphenyl)prop-2-enoate Chemical compound OC1C(OC(CO)C(O)C(O)C=O)OCC(O)C1OC1C(O)C(O)C(COC(=O)\C=C\C=2C=CC(O)=CC=2)O1 UGXQOOQUZRUVSS-ZZXKWVIFSA-N 0.000 claims 3
- 229930002877 anthocyanin Natural products 0.000 claims 3
- 235000010208 anthocyanin Nutrition 0.000 claims 3
- 239000004410 anthocyanin Substances 0.000 claims 3
- 150000004636 anthocyanins Chemical class 0.000 claims 3
- 229920000617 arabinoxylan Polymers 0.000 claims 3
- 230000029087 digestion Effects 0.000 claims 3
- -1 fructose oligosaccharides Chemical class 0.000 claims 3
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical group O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims 3
- 229940029339 inulin Drugs 0.000 claims 3
- 150000002482 oligosaccharides Chemical class 0.000 claims 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 3
- 235000018553 tannin Nutrition 0.000 claims 3
- 239000001648 tannin Substances 0.000 claims 3
- 229920001864 tannin Polymers 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 235000015099 wheat brans Nutrition 0.000 claims 3
- 241000282472 Canis lupus familiaris Species 0.000 claims 2
- 241001112696 Clostridia Species 0.000 claims 2
- 241000283086 Equidae Species 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- 241000218652 Larix Species 0.000 claims 2
- 241000282898 Sus scrofa Species 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 244000309466 calf Species 0.000 claims 2
- 235000005487 catechin Nutrition 0.000 claims 2
- 150000001765 catechin Chemical class 0.000 claims 2
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 244000144977 poultry Species 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract 3
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 3
- 241000186000 Bifidobacterium Species 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 208000010643 digestive system disease Diseases 0.000 abstract 1
- 208000018685 gastrointestinal system disease Diseases 0.000 abstract 1
Abstract
Compositions containing hemicelluloses in combination with polyphenols, methods of preparing the compositions, and methods of treating humans or animals with the composition are provided. Also provided is a method for increasing growth rate, improving feed efficiency and decreasing scour after weaning in an animal by administering an effective amount of the composition to the animal. The hemicelluloses preferably are not consumed by human alimentary enzymes or harmful bacteria, such as putrefactive or pathogenic bacteria, in the gastrointestinal tract, and are consumed by beneficial bacteria, such as bifidobacteria, in the gastrointestinal tract. The polyphenols preferably decrease the amount of harmful bacteria in the gastrointestinal tract. The compositions can optionally contain a carrier or be used as a feed addition and are administered to humans or other animals in an amount sufficient to treat the gastrointestinal disorder.
Claims
1. A composition comprising a dietary fiber which is water soluble, resists digestion by alimentary enzymes and is selectively digested by Bifidobactena and a polyphenol in an amount effective to alleviate gastrointestinal diseases caused by putrefactive or pathogenic bacteria in a human or other animal.
2. The composition of claim 1 wherein the dietary fiber is a hemicellulose and wherein the polyphenol contains at least three phenol moieties and has a molecular weight of between 280 and 6,000.
3. The composition of claim 2 wherein the hemicellulose is selected from the group consisting of arabinoxylan, galactomannan, arabinogalactan and wheat bran hemicellulose.
4. The composition of claim 1 wherein the dietary fiber is selected from the group consisting of inulin, fructose oligosaccharides, and transglycosylated oligosaccharides.
5. The composition of claim 1 wherein the polyphenol is a flavonoid.
6. The composition of claim 5 wherein the flavonoid is selected from the group consisting of tannins, taxifolins, catecholines, anthocyanins, and catechins.
7. The composition of claim 1 further comprising a pharmaceutically acceptable carrier for oral consumption.
8. The composition of claim 7 wherein the carrier is food.
9. A method for treating diseases in animals caused by putrefactive or pathogenic bacteria, the method comprising administering an effective amount of a composition comprising a dietary fiber which is water soluble, resists digestion by alimentary enzymes and is selectively digested by Bifidobactena, and a polyphenol to alleviate the disease in a human or other animal in need of treatment thereof.
10. The method of claim 9 wherein the dietary fiber is a hemicellulose and wherein the polyphenol contains at least three phenol moieties and has a molecular weight of between 280 and 6,000.
11. The method of claim 10 wherein the hemicellulose is selected from the group consisting of arabinoxylan, galactomannan, arabinogalactan and wheat bran hemicellulose.
12. The method of claim 9 wherein the dietary fiber is selected from the group consisting of inulin, fructose oligosaccharides and transglycosylated oligosaccharides.
13. The method of claim 9 wherein the polyphenol is a flavonoid.
14. The method of claim 13 wherein the flavonoid is selected from the group consisting of tannins, taxifolins, catecholines, anthocyanins and catechii-s.
15. The method of claim 9 wherein the composition is administered in a dosage of between 10 and 300 mg/kg body weight.
16. The method of claim 9 further comprising adding a carrier to the composition.
17. The method of claim 16 wherein the carrier is food.
18. The method of claim 17 wherein the composition is added to food in a concentration effective to increase the relative ratio of Bifidobactena to Clostridia.
19. The method of claim 17 wherein the composition is added to food in a concentration of between 0.1 and 5% by weight of the food.
20. The method of claim 17 wherein the composition is added to food in a concentration of between 0.1 and 2% by weight of the food.
21. The method of claim 9 wherein the animal is human.
22. The method of claim 21 wherein the animal is selected from the group consisting of poultry, swine, horses, calves, dogs and cats.
23. A method for increasing growth rate, improving feed efficiency and decreasing scour after weaning in an animal, the method comprising administering an effective amount of a composition comprising a dietary fiber, which is water soluble, resists digestion by animal alimentary enzymes, and is selectively digested by Bifidobactena, and a polyphenol to the animal.
24. The method of claim 23 wherein the dietary fiber is a hemicellulose and wherein the polyphenol contains at least three phenol moieties and has a molecular weight of between 280 and 6,000.
25. The method of claim 24 wherein the hemicellulose is selected from the group consisting of arabinoxylan, galactomannan, arabinogalactan and wheat bran hemicellulose.
26. The method of claim 23 wherein the dietary fiber is selected from the group consisting of inulin, fructose oligosaccharides and transglycosy lated oligosaccharides .
27. The method of claim 23 wherein the polyphenol is a flavonoid.
28. The method of claim 27 wherein the flavonoid is selected from the group consisting of tannins, taxifolins, catecholines, anthocyanins and catechins.
29. The method of claim 23 wherein the composition is administered in a dosage of between 10 and 300 mg/kg body weight.
30. The method of claim 23 further comprising adding a carrier to the composition.
31. The method of claim 30 wherein the carrier is food.
32. The method of claim 31 wherein the composition is added to food in a concentration effective to increase the relative ratio of bifidobactena to Clostridia.
33. The method of claim 32 wherein the composition is added to food in a concentration of between 0.1 and 5% by weight of the food.
34. The method of claim 32 wherein the composition is added to food in a concentration of between 0.1 and 2% by weight of the food.
35. The method of claim 35 wherein the animal is selected from the group consisting of poultry, swine, horses, calves, dogs and cats.
36. The composition of claim 3 wherein the dietary fiber is arabinogalactan.
37. The composition of claim 1 wherein the composition comprises a plant extract comprising the dietary fiber and the polyphenol.
38. The composition of claim 37 wherein the plant extract is derived from a tree of the genus Larix.
39. The composition of claim 38 wherein the dietary fiber is arabinogalactan.
40. The method of claim 9 or 23 wherein the dietary fiber is arabinogalactan.
41. The method of claim 9 or 23 wherein the method comprises administering to the animal a plant extract, wherein the plant extract comprises the dietary fiber and the polyphenol.
42. The method of claim 41 wherein the plant extract is derived from a tree of the genus Larix.
43. The method of claim 42 wherein the dietary fiber is arabinogalactan.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE69533593T DE69533593T2 (en) | 1994-07-21 | 1995-07-21 | PREPARATIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDER CONTAINING ARABINOGALACTAN AND POLYPHENOLS OF LARIX. |
| EP95927341A EP0797451B1 (en) | 1994-07-21 | 1995-07-21 | Compositions containing arabinogalactan and polyphenols from larix for treating gastrointestinal disorders |
| AT95927341T ATE277638T1 (en) | 1994-07-21 | 1995-07-21 | PREPARATIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS CONTAINING ARABINOGALACTAN AND POLYPHENOLS FROM LARIX. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27841494A | 1994-07-21 | 1994-07-21 | |
| US278,414 | 1994-07-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996003150A1 WO1996003150A1 (en) | 1996-02-08 |
| WO1996003150B1 true WO1996003150B1 (en) | 1996-05-02 |
Family
ID=23064883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/009230 WO1996003150A1 (en) | 1994-07-21 | 1995-07-21 | Compositions containing hemicelluloses and polyphenols for treating gastrointestinal disorders |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US5614501A (en) |
| EP (1) | EP0797451B1 (en) |
| AT (1) | ATE277638T1 (en) |
| DE (1) | DE69533593T2 (en) |
| WO (1) | WO1996003150A1 (en) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5614501A (en) * | 1994-07-21 | 1997-03-25 | The University Of Montana | Compositions and methods for animal husbandry and for treating gastrointestinal disorders |
| AUPM835394A0 (en) * | 1994-09-23 | 1994-10-13 | King, Michael G. Dr. | Method for controlling or eliminating the need to smoke tobacco, and for treating ailments which may lead to the said need |
| US6071480A (en) * | 1994-12-22 | 2000-06-06 | Abbott Laboratories | Method for generating a standing sonic wave, methods of sonication with a standing sonic wave, and a standing sonic wave sonicator |
| EP2179726A3 (en) * | 1995-12-26 | 2012-09-26 | Block Drug Company, Inc. | Dietary fiber inulin delivery system |
| US6297273B1 (en) | 1996-04-02 | 2001-10-02 | Mars, Inc. | Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions |
| US5965175A (en) * | 1997-03-27 | 1999-10-12 | The Iams Company | Composition and method for repartitioning nitrogen and increasing colonic blood flow in dogs to promote intestinal health |
| FI107014B (en) * | 1997-07-25 | 2001-05-31 | Oriola Oy | herbal remedies |
| AU9578898A (en) | 1997-09-24 | 1999-04-12 | Geoffrey N Richards | Composition and method for reducing pathogenic bacteria in food products |
| US6039952A (en) * | 1997-10-22 | 2000-03-21 | The Iams Company | Composition and method for improving clinical signs in animals with renal disease |
| DK172775B1 (en) * | 1998-03-12 | 1999-07-12 | Diarex V G Andresen | Animal feed additives containing a flavanoid-containing mimosa extract and animal feed containing the same and method t |
| EP1076547A4 (en) | 1998-04-27 | 2001-09-26 | Larex Inc | Derivatives of arabinogalactan and compositions including the same |
| EP1094722A1 (en) * | 1999-04-27 | 2001-05-02 | Diomeda Antonio Tortora | Nutraceuticals and ingredients for functional foods |
| FR2801791B1 (en) * | 1999-12-03 | 2003-05-30 | Elpronat | COMPOSITION FOR ANIMALS CONTAINING METHYL SALICYLATE |
| US6703056B2 (en) | 2000-09-29 | 2004-03-09 | The Procter + Gamble Co. | Beverage compositions comprising arabinogalactan and defined minerals |
| US6706295B2 (en) | 2000-09-29 | 2004-03-16 | The Procter & Gamble Co. | Compositions comprising arabinogalactan and a defined protein component |
| US20020110632A1 (en) * | 2000-09-29 | 2002-08-15 | The Procter & Gamble Co. | Beverage compositions comprising arabinogalactan and defined vitamins |
| MXPA03008145A (en) * | 2001-03-09 | 2003-12-12 | Land O Lakes Farmland Feed Llc | Method of feeding a ruminant. |
| US6365152B1 (en) | 2001-03-15 | 2002-04-02 | Bovine Health Products, Inc. | Scours treatment and method of making same |
| ES2253555T5 (en) * | 2001-08-20 | 2019-04-02 | Cargill Inc | Non-starch polysaccharides |
| WO2004017979A2 (en) * | 2002-08-16 | 2004-03-04 | Finzelberg Gmbh & Co. Kg | Medicament, food supplement, and fodder additive |
| US7252836B2 (en) * | 2003-01-13 | 2007-08-07 | Penwest, Ltd. | Food and feed compositions including resistant starch |
| US6936598B2 (en) * | 2003-11-21 | 2005-08-30 | Hill's Pet Nutrition, Inc. | Composition and method |
| EP1695713A4 (en) * | 2003-12-12 | 2009-06-24 | Taiyo Kagaku Kk | Enteropathy ameliorating composition |
| DE602004027120D1 (en) * | 2004-05-25 | 2010-06-24 | Cognis Ip Man Gmbh | Oral and / or topical preparations |
| BRPI0418986A (en) * | 2004-08-05 | 2007-12-11 | Anidral Srl | folic acid producing bifidobacterium bacterial strains, formulations and their uses |
| EP1869161B1 (en) * | 2005-10-11 | 2010-01-06 | Probiotical S.p.a. | Method for the preparation of anallergic probiotic bacterial cultures and related use |
| KR100710657B1 (en) | 2005-11-24 | 2007-04-24 | 코스맥스 주식회사 | Whitening cosmetic composition containing dihydroquecetin |
| EP2012596A1 (en) * | 2006-05-03 | 2009-01-14 | Anidral S.R.L. | Symbiotic composition comprising non-digestible polysaccharides and bifidobacteria which metabolize them and its uses |
| US9420807B2 (en) * | 2007-04-02 | 2016-08-23 | Purina Animal Nutrition Llc | Method of feeding young monogastric mammals and composition fed to young monogastric mammals |
| GB0718974D0 (en) | 2007-09-28 | 2007-11-07 | Univ Leuven Kath | oligosaccharides derived from arabinoxylan for prevention of gastrointestinal infection |
| CA2747569A1 (en) * | 2007-12-21 | 2009-07-02 | University Of Graz | Use larch wood material for treating inflammation |
| US8734867B2 (en) * | 2007-12-28 | 2014-05-27 | Liveleaf, Inc. | Antibacterial having an extract of pomegranate combined with hydrogen peroxide |
| JP5490020B2 (en) * | 2008-01-24 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| GB0805360D0 (en) * | 2008-03-25 | 2008-04-30 | Univ Leuven Kath | Arabinoxylan oligosaccharide preparation |
| BRPI0913441A8 (en) | 2008-06-09 | 2017-10-03 | Temple Inland | PREBIOTICS COMPOSITION AND METHODS OF PRODUCTION AND USE OF THE SAME |
| CN102421891B (en) | 2009-03-04 | 2015-11-25 | 生命之叶公司 | For method and the material of the site activation complexing of biomolecules |
| US8784844B2 (en) | 2009-09-30 | 2014-07-22 | Lonza Ltd. | Arabinogalactan for enhancing the adaptive immune response |
| FI20096137A0 (en) * | 2009-11-04 | 2009-11-04 | Upm Kymmene Corp | METHOD OF INFLUENCING THE MICROBIOTAN IN THE ANIMAL DIGESTION CHANNEL, FEED COMPOSITION CONTAINING THE MICROBIC MODULATOR AND THE USE OF THE MICROBIC MODULATOR |
| US9585920B2 (en) | 2011-02-04 | 2017-03-07 | Katherine Rose Kovarik | Method and system for treating cancer cachexia |
| US9408880B2 (en) | 2013-12-20 | 2016-08-09 | Katherine Rose Kovarik | Method and system for prevention and treatment of allergic and inflammatory diseases |
| US9457077B2 (en) | 2009-11-18 | 2016-10-04 | Katherine Rose Kovarik | Method and system for targeting the microbiome to promote health and treat allergic and inflammatory diseases |
| EP2509453A4 (en) * | 2009-12-08 | 2013-11-20 | Tin Inc D B A Temple Inland | Nutritional composition and methods of making and using same |
| US20110214318A1 (en) * | 2010-03-05 | 2011-09-08 | Sony Ericsson Mobile Communications Ab | Paper Stock Card with Wireless Communication Capability |
| US11357722B2 (en) | 2011-02-04 | 2022-06-14 | Seed Health, Inc. | Method and system for preventing sore throat in humans |
| US12279989B2 (en) | 2011-02-04 | 2025-04-22 | Seed Health, Inc. | Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity |
| US10085938B2 (en) | 2011-02-04 | 2018-10-02 | Joseph E. Kovarik | Method and system for preventing sore throat in humans |
| US11273187B2 (en) | 2015-11-30 | 2022-03-15 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing depression in an individual |
| US11523934B2 (en) | 2011-02-04 | 2022-12-13 | Seed Health, Inc. | Method and system to facilitate the growth of desired bacteria in a human's mouth |
| US10842834B2 (en) | 2016-01-06 | 2020-11-24 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease |
| US10111913B2 (en) | 2011-02-04 | 2018-10-30 | Joseph E. Kovarik | Method of reducing the likelihood of skin cancer in an individual human being |
| US10548761B2 (en) | 2011-02-04 | 2020-02-04 | Joseph E. Kovarik | Method and system for reducing the likelihood of colorectal cancer in a human being |
| US11419903B2 (en) | 2015-11-30 | 2022-08-23 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US10086018B2 (en) | 2011-02-04 | 2018-10-02 | Joseph E. Kovarik | Method and system for reducing the likelihood of colorectal cancer in a human being |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US9987224B2 (en) | 2011-02-04 | 2018-06-05 | Joseph E. Kovarik | Method and system for preventing migraine headaches, cluster headaches and dizziness |
| US10583033B2 (en) | 2011-02-04 | 2020-03-10 | Katherine Rose Kovarik | Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being |
| US11191665B2 (en) | 2011-02-04 | 2021-12-07 | Joseph E. Kovarik | Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being |
| US10687975B2 (en) | 2011-02-04 | 2020-06-23 | Joseph E. Kovarik | Method and system to facilitate the growth of desired bacteria in a human's mouth |
| US10835560B2 (en) | 2013-12-20 | 2020-11-17 | Joseph E. Kovarik | Reducing the likelihood of skin cancer in an individual human being |
| US10010568B2 (en) | 2011-02-04 | 2018-07-03 | Katherine Rose Kovarik | Method and system for reducing the likelihood of a spirochetes infection in a human being |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US9730967B2 (en) | 2011-02-04 | 2017-08-15 | Katherine Rose Kovarik | Method and system for treating cancer cachexia |
| US12257272B2 (en) | 2015-12-24 | 2025-03-25 | Seed Health, Inc. | Method and system for reducing the likelihood of developing depression in an individual |
| US10314865B2 (en) | 2011-02-04 | 2019-06-11 | Katherine Rose Kovarik | Method and system for treating cancer and other age-related diseases by extending the healthspan of a human |
| US10512661B2 (en) | 2011-02-04 | 2019-12-24 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US10245288B2 (en) | 2011-02-04 | 2019-04-02 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing NASH in an individual diagnosed with non-alcoholic fatty liver disease |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| US9192635B2 (en) | 2011-06-24 | 2015-11-24 | Liveleaf, Inc. | Method of treating damaged mucosal or gastrointestinal tissue by administering a composition comprising a mixture of pomegranate and green tea extracts and releasably bound hydrogen peroxide |
| US8722040B2 (en) | 2011-06-24 | 2014-05-13 | Liveleaf, Inc. | Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites |
| US20130236529A1 (en) * | 2012-03-09 | 2013-09-12 | Flavitpure, Inc. | Composition and methods to enhance anti-oxidation, gut flora and immunity in pets |
| EP2638914A1 (en) * | 2012-03-16 | 2013-09-18 | Lonza Ltd | Composition comprising arabinogalactan and polyphenols from larch trees |
| US8710027B2 (en) * | 2012-04-10 | 2014-04-29 | Flavitpure, Inc. | Method of using nutritional compounds dihydroquercetin (taxifolin) and arabinogalactan in combination with dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors associated with metabolic syndrome and hypercholesterolemia |
| US20130287919A1 (en) * | 2012-04-26 | 2013-10-31 | Flavitpure, Inc. | Method of using dietary ingredients dihydroquercetin (taxifolin), arabinogalactan and arabinogalactan in combination with dihydroquercetin (taxifolin) for applications in food products |
| US20130331354A1 (en) * | 2012-06-07 | 2013-12-12 | Flavitpure, Inc. | Method and composition utilizing larch wood extracts in animal feed |
| RU2504386C1 (en) * | 2012-12-18 | 2014-01-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | Preparation for prevention of diarrhoea in newborn calves |
| US8716351B1 (en) | 2012-12-23 | 2014-05-06 | Liveleaf, Inc. | Methods of treating gastrointestinal spasms |
| US9393259B2 (en) * | 2013-03-21 | 2016-07-19 | Lonza Ltd. | Composition comprising arabinogalactan and polyphenols from larch trees |
| US10994013B2 (en) | 2013-04-24 | 2021-05-04 | Temple University—Of the Commonwealth System of Higher Education | Solid dosage form containing arabinogalactan |
| US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
| US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
| US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
| US12246043B2 (en) | 2013-12-20 | 2025-03-11 | Seed Health, Inc. | Topical application to treat acne vulgaris |
| US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
| US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
| CN107404902A (en) | 2015-02-13 | 2017-11-28 | 马斯公司 | Pet food feeds system |
| US20210038664A1 (en) * | 2018-02-09 | 2021-02-11 | Atp Institute Pty Ltd | Formulation and method of use |
| WO2021173814A1 (en) * | 2020-02-26 | 2021-09-02 | Ralco Nutrition, Inc. | Compositions based on dietary fibers and essential oils |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3337526A (en) * | 1965-10-15 | 1967-08-22 | St Regis Paper Co | Process for preparing arabinogalactan |
| SE446940B (en) * | 1983-02-16 | 1986-10-20 | Carl Axel Virdalm | MEASURES FOR FIGHTING DISEASE CONDITIONS IN THE FOOD MELTER CONTAINING SHALL OR OUTSIDE OF BEERS OR FRUITS |
| SE8304821L (en) * | 1983-09-08 | 1985-03-09 | Bio Carb Ab | ARABINOGALACTANTS, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM |
| DK454683D0 (en) * | 1983-10-03 | 1983-10-03 | Mogens Gjerloev | GAS ADMINISTRATIVE FOR TREATMENT OF ANIMALS AND USE OF ANIMALS |
| DE3564370D1 (en) * | 1985-08-30 | 1988-09-22 | Nestle Sa | Dietetic product with depurating and antidiarrheal activity and process for its preparation |
| DE3622896A1 (en) * | 1986-07-08 | 1988-01-21 | Klaus Dr Laemmerhirt | Compound of tannin and crosslinked polyvinylpyrrolidone for the treatment of diarrhoeal disorders and wounds |
| US4927811A (en) * | 1988-11-15 | 1990-05-22 | Coors Biotech, Inc. | Method and composition for improved animal husbandry |
| GB8923890D0 (en) * | 1989-10-24 | 1989-12-13 | Rowett Research Services Limit | Dietary material |
| US5294458A (en) * | 1992-04-03 | 1994-03-15 | Maruha Corporation | Pet food |
| JPH06219953A (en) * | 1993-01-27 | 1994-08-09 | Ajinomoto Co Inc | Medicine for preventing and improving diarrhea, food for preventing and improving diarrhea and feed for preventing and improving scours |
| US5439893A (en) * | 1993-05-26 | 1995-08-08 | University Of Montana | Methods for the treatment and prevention of diarrhea |
| US5614501A (en) * | 1994-07-21 | 1997-03-25 | The University Of Montana | Compositions and methods for animal husbandry and for treating gastrointestinal disorders |
| US5882520A (en) * | 1995-10-26 | 1999-03-16 | The University Of Montana | Use of arabinogalactan in aqueous two phase extractions |
-
1995
- 1995-05-04 US US08/434,492 patent/US5614501A/en not_active Expired - Lifetime
- 1995-07-21 AT AT95927341T patent/ATE277638T1/en not_active IP Right Cessation
- 1995-07-21 WO PCT/US1995/009230 patent/WO1996003150A1/en active IP Right Grant
- 1995-07-21 DE DE69533593T patent/DE69533593T2/en not_active Expired - Lifetime
- 1995-07-21 EP EP95927341A patent/EP0797451B1/en not_active Expired - Lifetime
-
1999
- 1999-07-19 US US09/356,759 patent/US6087092A/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO1996003150B1 (en) | Compositions containing hemicelluloses and polyphenols for treating gastrointestinal disorders | |
| US6087092A (en) | Compositions and methods for animal husbandry and for treating gastrointestinal disorders | |
| US10780137B2 (en) | Composition to improve gut health and animal performance and methods of making the same | |
| JPH0256062B2 (en) | ||
| Wallace et al. | Microbial feed additives for ruminants | |
| EA017656B1 (en) | Composition for prevention and treatment of pig dysentery | |
| US5112624A (en) | Prevention of digestive disturbances in herbivores | |
| JP2015521052A (en) | Methods and compositions utilizing larch wood extract in animal feed | |
| WO1995017103A1 (en) | The use of mannan-rich materials in feedstuffs | |
| KR20000052237A (en) | A method of manufacturing a feed composite ,which contains yellow earth and chitosan, for livestock and cultured fish | |
| IE53057B1 (en) | Lactation improvement method | |
| Tabeling et al. | Studies on nutrient digestibilities (pre‐caecal and total) in pancreatic duct‐ligated pigs and the effects of enzyme substitution | |
| AU732890B2 (en) | Method for improving the efficacy of a probiotic, preparation of nutritional additives, and animal feed containing it | |
| EP1083800A1 (en) | Piglet feeding method | |
| CN114831248B (en) | Biological mildew removing agent and preparation method and application thereof | |
| AU2003204441A1 (en) | Animal Food Supplement Compositions and Methods of Use | |
| KR20010068226A (en) | composition containing chitosan oligo saccharide and aminoethyl sulfonic acid for use as fodder and drinking water additives | |
| Hampson et al. | Pre-weaning supplementary feed and porcine post-weaning diarrhoea | |
| JPH06256180A (en) | Enteric environment-improving composition | |
| EP1605776B1 (en) | Method and composition for preventing or reducing diarrhea | |
| JP3257690B2 (en) | Feed for livestock with dietary fiber | |
| CN105454695A (en) | Feed additive for preventing and curing porcine diarrhea | |
| US20170014443A1 (en) | Compositions and methods for treating gastrointestinal disorders for humans and animal husbandry | |
| KR100892050B1 (en) | Weaned pig feed additive composition containing beta glucan and yeast organic iron | |
| JPH1189512A (en) | Health hood |