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WO1996000592A3 - Biodegradable fracture fixation plates and uses thereof - Google Patents

Biodegradable fracture fixation plates and uses thereof Download PDF

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Publication number
WO1996000592A3
WO1996000592A3 PCT/US1995/008171 US9508171W WO9600592A3 WO 1996000592 A3 WO1996000592 A3 WO 1996000592A3 US 9508171 W US9508171 W US 9508171W WO 9600592 A3 WO9600592 A3 WO 9600592A3
Authority
WO
WIPO (PCT)
Prior art keywords
prosthetic devices
biodegradable
fixation plates
pharmacologically active
reinforced
Prior art date
Application number
PCT/US1995/008171
Other languages
French (fr)
Other versions
WO1996000592A2 (en
Inventor
C Mauli Agrawal
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Priority to AU29521/95A priority Critical patent/AU2952195A/en
Publication of WO1996000592A2 publication Critical patent/WO1996000592A2/en
Publication of WO1996000592A3 publication Critical patent/WO1996000592A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/121—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/121—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L31/123—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention provides materials for use in biodegradable structural prosthetic devices with enhanced load-bearing strength and reinforced flexibility. Prosthetic devices are also provided, which comprise a biodegradable polymer layer, reinforced by a biodegradable material, and optionally, the inclusion of pharmacologically active substances, such as growth factors and anti-microbial agents. The prosthetic devices provide for gradually decreasing structural support that lessens as the implant degrades and is compensated by new bone growth. The degradation also provides for the controlled release of the pharmacologically active agents. The prosthetic devices are exemplified by bone fixation plates.
PCT/US1995/008171 1994-06-28 1995-06-28 Biodegradable fracture fixation plates and uses thereof WO1996000592A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU29521/95A AU2952195A (en) 1994-06-28 1995-06-28 Biodegradable fracture fixation plates and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26731994A 1994-06-28 1994-06-28
US08/267,319 1994-06-28

Publications (2)

Publication Number Publication Date
WO1996000592A2 WO1996000592A2 (en) 1996-01-11
WO1996000592A3 true WO1996000592A3 (en) 1996-02-22

Family

ID=23018279

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/008171 WO1996000592A2 (en) 1994-06-28 1995-06-28 Biodegradable fracture fixation plates and uses thereof

Country Status (2)

Country Link
AU (1) AU2952195A (en)
WO (1) WO1996000592A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001519818A (en) * 1997-04-16 2001-10-23 ホワイト、スポット、アクチェンゲゼルシャフト Biodegradable osteosynthesis graft
US7541049B1 (en) 1997-09-02 2009-06-02 Linvatec Biomaterials Oy Bioactive and biodegradable composites of polymers and ceramics or glasses and method to manufacture such composites
SI1112095T1 (en) 1998-09-11 2003-04-30 Gerhard Dr. Schmidmaier Biologically active implants
US6398814B1 (en) 1998-09-14 2002-06-04 Bionx Implants Oy Bioabsorbable two-dimensional multi-layer composite device and a method of manufacturing same
US6350284B1 (en) 1998-09-14 2002-02-26 Bionx Implants, Oy Bioabsorbable, layered composite material for guided bone tissue regeneration
WO2000054821A1 (en) * 1999-03-16 2000-09-21 Regeneration Technologies, Inc. Molded implants for orthopedic applications
RU2227037C2 (en) * 2001-11-16 2004-04-20 Малахов Олег Алексеевич Material for osteoplasty
US8016865B2 (en) 2003-09-29 2011-09-13 Depuy Mitek, Inc. Method of performing anterior cruciate ligament reconstruction using biodegradable interference screw
US8641738B1 (en) 2004-10-28 2014-02-04 James W. Ogilvie Method of treating scoliosis using a biological implant
US8123787B2 (en) 2004-10-28 2012-02-28 Ogilvie James W Method of treating scoliosis using a biological implant
MD2856G2 (en) * 2005-03-29 2006-04-30 Валериу ФАЛА Material for osteoplasty (variants)
MD2877G2 (en) * 2005-04-05 2006-05-31 Валериу ФАЛА Material for osteoplasty (variants)
FI20055194L (en) * 2005-04-27 2006-10-28 Bioretec Oy Bioabsorbable and bioactive composite material and method for preparing the composite
WO2017041109A1 (en) * 2015-09-03 2017-03-09 Case Western Reserve University Polymer fiber scaffolds and uses thereof
US20210146016A1 (en) 2019-11-15 2021-05-20 Evonik Operations Gmbh Fiber reinforced compositions and methods of manufacture for medical device applications

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4279249A (en) * 1978-10-20 1981-07-21 Agence Nationale De Valorisation De La Recherche (Anvar) New prosthesis parts, their preparation and their application
EP0194192A1 (en) * 1985-02-22 1986-09-10 Ethnor Absorbable composite chirurgical material, method of preparation, resorbable prosthesis based on this material and use of this prosthesis
WO1990004982A1 (en) * 1988-11-10 1990-05-17 Biocon Oy Biodegradable surgical implants and devices
WO1990013302A1 (en) * 1989-04-28 1990-11-15 Brigham And Women's Hospital Novel materials and methods for guided tissue regeneration
EP0550875A1 (en) * 1991-12-31 1993-07-14 Schierholz, Jörg, Dr.Dr. Implantable polymeric device containing pharmaceutical agents and process for its production
US5281419A (en) * 1992-09-28 1994-01-25 Thomas Jefferson University Biodegradable drug delivery system for the prevention and treatment of osteomyelitis
EP0636377A1 (en) * 1993-07-28 1995-02-01 JOHNSON & JOHNSON MEDICAL, INC. Composite surgical material

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4279249A (en) * 1978-10-20 1981-07-21 Agence Nationale De Valorisation De La Recherche (Anvar) New prosthesis parts, their preparation and their application
EP0194192A1 (en) * 1985-02-22 1986-09-10 Ethnor Absorbable composite chirurgical material, method of preparation, resorbable prosthesis based on this material and use of this prosthesis
WO1990004982A1 (en) * 1988-11-10 1990-05-17 Biocon Oy Biodegradable surgical implants and devices
WO1990013302A1 (en) * 1989-04-28 1990-11-15 Brigham And Women's Hospital Novel materials and methods for guided tissue regeneration
EP0550875A1 (en) * 1991-12-31 1993-07-14 Schierholz, Jörg, Dr.Dr. Implantable polymeric device containing pharmaceutical agents and process for its production
US5281419A (en) * 1992-09-28 1994-01-25 Thomas Jefferson University Biodegradable drug delivery system for the prevention and treatment of osteomyelitis
EP0636377A1 (en) * 1993-07-28 1995-02-01 JOHNSON & JOHNSON MEDICAL, INC. Composite surgical material

Also Published As

Publication number Publication date
WO1996000592A2 (en) 1996-01-11
AU2952195A (en) 1996-01-25

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