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WO1996000095A1 - Pompe de perfusion de medicaments a siege de soupape en fluoropolymere - Google Patents

Pompe de perfusion de medicaments a siege de soupape en fluoropolymere Download PDF

Info

Publication number
WO1996000095A1
WO1996000095A1 PCT/US1994/007112 US9407112W WO9600095A1 WO 1996000095 A1 WO1996000095 A1 WO 1996000095A1 US 9407112 W US9407112 W US 9407112W WO 9600095 A1 WO9600095 A1 WO 9600095A1
Authority
WO
WIPO (PCT)
Prior art keywords
medication
valve seat
valve
infusion pump
valve member
Prior art date
Application number
PCT/US1994/007112
Other languages
English (en)
Inventor
William P. Van Antwerp
Virote Indravuhd
Original Assignee
Minimed Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minimed Inc. filed Critical Minimed Inc.
Priority to PCT/US1994/007112 priority Critical patent/WO1996000095A1/fr
Publication of WO1996000095A1 publication Critical patent/WO1996000095A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14216—Reciprocating piston type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/24—Check- or non-return valves

Definitions

  • the present invention relates generally to medication infusion pumps, particularly of the type adapted for implantation directly into the body of a patient and for programmed operation to deliver medication to the patient, and more particularly to a medication infusion pump having an improved valve seat designed to minimize or prevent accumulation of medication deposits thereon.
  • Medication infusion pumps are generally known in the art for use in delivering a selected medication to a patient in a scheduled or preprogrammed manner.
  • infusion pumps have been developed in compact form and adapted for direct implantation into the body of a patient, to deliver a specific medication such as insulin to the patient in discrete doses over an extended time period.
  • An implantable infusion pump of this general type includes an internal medication chamber for receiving and storing a supply of the selected medication in liquid form, in combination with a miniature pump mechanism and associated programmable control means for operating the pump mechanism to deliver discrete doses of the medication from the internal storage chamber and through a catheter to the patient.
  • an implantable medication infusion pump of this general type see U.S. Patent 4,573,994.
  • the internal pump mechanism typically comprises an electro agnetically driven pulsatile pump having a solenoid operated piston mounted for reciprocation within a cylinder to draw medication from the internal storage chamber, and to deliver such medication through the catheter to the patient.
  • the pulsatile piston operates in conjunction with an inlet check valve having a spring-loaded valve member movable between open and closed positions with respect to an annular valve seat.
  • the valve member and valve seat are normally constructed from biocompatable and relatively inert materials, such as a movable valve disk of a silicone elastomer material and a rigid annular valve seat defined at the end of a ferrule formed of a titanium or titanium alloy.
  • medication deposits having a particle-like structure are known to accumulate over a period of time in the vicinity of the valve seat.
  • the formation of such medication deposits is believed to be attributable to shear denaturation and/or precipitation of pharmaceutical components in response to relatively high mechanical stresses applied to the medication in the immediate vicinity of the valve seat, as the valve member moves between the open and closed positions.
  • Such deposits are especially likely when relatively complex medications having a relatively large molecular structure are used, such as protein based pharmaceuticals including insulin and others.
  • protein and other organic constituents present in such pharmaceuticals exhibit a tendency to adhere to the surface of titanium metal components, resulting in an accumulation of proteinaceous deposits at the valve seat. This presence of medication deposits is undesirable and may over time result in valve leakage, typically in the form of undesirable back-flow of body fluids into the interior of the implanted infusion pump.
  • a medication infusion pump for programmable delivery of a selected medication to a patient, wherein the infusion pump includes an internal pump mechanism having a check valve defining substantially inert and nonadherent surfaces to prevent accumulation of medication deposits thereon.
  • the check valve comprises a valve member and an associated valve seat which define nonmetallic and substantially nonadherent surfaces to prevent sticking and accumulation of medication deposits in the vicinity of the valve seat.
  • the valve member comprises a movable disk of a silicone elastomer material or the like for opening and closure movement relative to an annular valve seat.
  • the valve seat is defined by a fluoropolymer material to provide a substantially inert and highly nonadherent surface.
  • the valve seat consists of a one-piece annular element made of fluoropolymer material.
  • the fluoropolymer valve seat is formed by a fluoropolymer cap mounted onto a ferrule base of titanium or titanium alloy.
  • a ferrule base includes a fluoropolymer coating applied thereto to define the valve seat surface.
  • a ferrule base includes an annular groove for seated reception of a fluoropolymer ring in a position defining the valve seat for closure engagement with the valve member.
  • Fig. 1 is a perspective view depicting a typical implantable medication infusion pump
  • Fig. 2 is an enlarged and somewhat schematic vertical sectional view of the pump of FIG. l, and illustrating an internal pump mechanism for delivering medication from a storage reservoir to a patient;
  • Fig. 3 is an enlarged and somewhat schematic sectional view illustrating portions of an internal pump mechanism, constructed to include a one-piece fluoropolymer valve seat in accordance with the preferred embodiment and illustrating the novel features of the invention;
  • Fig. 4 is an enlarged fragmented sectional view corresponding with a portion of the valve seat depicted in Fig. 3, and illustrating another alternative preferred form of the invention
  • Fig. 5 is a enlarged fragmented sectional view similar to Fig. 4, and illustrating still another alternative preferred form of the invention.
  • Fig. 6 is an enlarged fragmented sectional view similar to Figs. 4 and 5, and illustrating still another alternative preferred embodiment of the invention.
  • an implantable medication infusion pump referred to generally in Figs. 1 and 2 by the reference numeral 10 is provided for use in administering a selected medication to a patient in a controlled, preprogrammed manner.
  • the infusion pump 10 receives and stores a quantity of the selected medication 11 within an internal medication chamber 12 (Fig. 2) .
  • the internal medication chamber 12 may be of the type shown in Fig. 2, or it may also be a flexible metal bellows reservoir as shown in U.S . Patent No. 4,573,994, to Fischell et al.
  • a miniature pump mechanism 14 is provided for delivering the medication from the chamber 12 through a catheter 16 to the patient.
  • the pump mechanism 14 includes a check valve (not shown in Figs. 1 and 2) having substantially inert and highly nonadherent valve surfaces to prevent accumulation of medication deposits and resultant potential for valve leakage.
  • the illustrative medication infusion pump 10 comprises a small substantially self-contained unit adapted for direct implantation into the body of patient.
  • the pump 10 comprises an hermetically sealed pump housing or case 18 formed from a biocompatible material, such as titanium or titanium alloy.
  • the pump housing 18 defines the internal medication chamber 12 for receiving and storing the supply of the selected medication 11 in liquid form, such as insulin for a diabetic patient.
  • the pump housing 18 encases the internal pump mechanism 14 in combination with electronic control circuitry 20 and a battery 22 for periodically operating the pump 14 to deliver medication doses via the catheter 16 to the patient.
  • the control circuitry 20 is suitably preprogrammed to deliver the medication in accordance with individual patient need.
  • An inlet or refill fitting 24 on the pump housing 18 is adapted to receive a hypodermic needle (not shown) to permit percutaneous refilling of the medication chamber 12 without requiring surgical access to the infusion pump 10.
  • the internal pump mechanism 14 comprises a positive displacement, solenoid operated pulsatile pump device having a piston 26 adapted for reciprocal displacement within a pump cylinder 28.
  • the piston 26 is drawn electromagnetically by a coil 29 in a first direction followed by a return stroke in an opposite, second direction under the influence of a return spring 30.
  • the piston 26 functions to draw the medication into the pump cylinder 28 via an inflow port 31, past an inlet check valve 32 into the cylinder 28, followed by delivery of the medication from the pump cylinder and through an outflow port 34 and via the catheter 16 to the patient.
  • the check valve 32 comprises a valve member 36 shown in the form of a resilient valve disk movably carried at one end of the piston 26 for engaging a one-piece annular valve seat 38 which circumscribes the inflow port 31.
  • a biasing spring 40 is interposed between the piston 26 and the valve disk 36 for spring-loading the valve disk toward a closed position seated upon the annular valve seat 38, as the piston 26 strokes toward the annular valve seat 38.
  • FIG. 4 illustrates one preferred configuration for the interengaging surfaces of the valve disk 36 and the annular valve seat 38 in accordance with the present invention.
  • the annular valve seat 38 comprises a one-piece, rigid annular structure defining a relatively narrow or discrete circular edge 39 presented axially in a direction toward the adjacent valve disk 36.
  • the valve disk 36 is formed from a resilient elastomer material, such as silicone rubber, for resilient and conforming engagement with the valve seat. Over a period of time, a portion of the valve disk 36 may assume a recessed geometric set in approximate conformance with the shape of the circular edge 39 of the annular valve seat 38.
  • valve disk 36 As the piston 26 is driven reciprocally within the pump cylinder 28, the valve disk 36 is displaced back and forth with respect to the annular valve seat 38, between open and closed positions.
  • the biasing force applied by the spring 40 is concentrated upon the narrow area of the valve seat edge 39, to result in a substantial mechanical compression force applied to a film of the medication then-present within the space between the valve disk 36 and the annular valve seat 38.
  • the surface of the annular valve seat 38, including the region of engagement with the valve member 36 is defined by a substantially inert, and substantially nonadherent material formed preferably from a selected fluoropolymer such as polytetrafluoroethylene, such as the material marketed by DuPont under the trademark Teflon.
  • Alternative materials could also be used for the annular valve seat 38.
  • Alternative materials include copolymers such as tetrafluoroethylene (such as the material marketed by DuPont under the trademark TE FZ EL or by Dow under the trademark HALAR) , chloropolymers such as polytetrachloroethylene (such as the material marketed by 3M under the trademark KEL-F) , fluorosilicone acrylate, ultra-high molecular weight polyethylene or polypropylene, or fluoroepoxies.
  • the desired characteristics of the material of the annular valve seat 38 are low surface energy plus a high degree of a chin ability. It will be understood that both the preferred embodiment and any of the alternate embodiments can utilize any of these materials.
  • An annular valve seat 138 comprises an annular cap 144 of polytetrafluoroethylene-based material which can be formed to close tolerance requirements to define the valve seat edge 139 with precision geometry.
  • the preferred construction for the polytetrafluoroethylene cap 144 includes an underside surface shaped for substantially mated press-fit mounting onto a conforming surface on a ferrule base 148 of titanium or a titanium alloy.
  • a step 150 may be formed in the periphery of the cylinder 28 to assist in retaining the polytetrafluoroethylene cap 144 seated firmly upon the ferrule base 148.
  • the annular outwardly presented surface of the cap 144 defines the valve seat edge 139, having a substantially inert, low surface energy to avoid significant chemical interaction with the medication 11, and further to prevent and eliminate adherence of any particle-deposits which might be produced upon flow of the medication between the inlet valve disk and valve seat.
  • FIG. 5 illustrates additional alternative preferred forms of the invention. More specifically, with reference to Fig. 5, a ferrule base 248 of titanium or titanium alloy may be treated to include a surface coating 244 in the vicinity of an annular valve seat 238, thereby providing the desired valve seat surface of substantially inert and nonadherent material.
  • FIG. 6 illustrates a ferrule base 348 having an annular groove 352 formed therein for seated, press-fit reception of a polytetrafluoroethylene ring 344. While a ring 344 of circular cross-section is shown, it will be understood that alternative ring configurations adapted for sealing engagement with the adjacent valve disk 36 may be used.
  • the present invention thus provides an improved valve device for a pump mechanism employed within a
  • valve device is constructed with nonmetallic and substantially nonadherent valve surfaces to minimize and/or eliminate accumulation of medication deposits at the valve seat.
  • the preferred valve construction includes a fluoropolymer valve seat surface in combination with a nonmetallic valve member of a silicone elastomer or the like.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne une pompe (10) de perfusion de médicaments destinée à être utilisée dans l'apport programmable d'un médicament sélectionné à un patient, ladite pompe (10) comporte un siège (38) de soupape en fluoropolymère au contact duquel peut venir un élément de soupape non métallique (36). Ledit siège (38) de soupape en fluoropolymère définit une surface sensiblement inerte et non adhérente afin d'empêcher l'accumulation sur celle-ci de dépôts de médicaments. Lesdits dépôts sont supposés se produire du fait de la dénaturation et/ou précipitation par cisaillement à proximité du siège (38) de soupape, en réponse à des forces de compression relativement élevées appliquées sur le médicamant lorsque l'élément de soupape (36) s'ouvre et se ferme. Ledit siège (38) de soupape en fluoropolymère assure une surface particulièrement non adhérente à des médicaments à base de protéines tels que l'insuline.
PCT/US1994/007112 1994-06-23 1994-06-23 Pompe de perfusion de medicaments a siege de soupape en fluoropolymere WO1996000095A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US1994/007112 WO1996000095A1 (fr) 1994-06-23 1994-06-23 Pompe de perfusion de medicaments a siege de soupape en fluoropolymere

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/007112 WO1996000095A1 (fr) 1994-06-23 1994-06-23 Pompe de perfusion de medicaments a siege de soupape en fluoropolymere

Publications (1)

Publication Number Publication Date
WO1996000095A1 true WO1996000095A1 (fr) 1996-01-04

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Family Applications (1)

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PCT/US1994/007112 WO1996000095A1 (fr) 1994-06-23 1994-06-23 Pompe de perfusion de medicaments a siege de soupape en fluoropolymere

Country Status (1)

Country Link
WO (1) WO1996000095A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2779705A1 (fr) * 1997-09-03 1999-12-17 Bespak Plc Perfectionnement a ou lies a des valves de dosage pour conteneurs distributeurs pressurises
WO2009069045A1 (fr) * 2007-11-27 2009-06-04 Koninklijke Philips Electronics N.V. Dispositif implantable de délivrance d'une substance thérapeutique
WO2012071395A1 (fr) * 2010-11-22 2012-05-31 Aria Cv, Inc. Système et méthode permettant de réduire la pression pulsatile
US8876850B1 (en) 2014-06-19 2014-11-04 Aria Cv, Inc. Systems and methods for treating pulmonary hypertension
US9987153B2 (en) 2010-06-08 2018-06-05 The Regents Of The University Of Minnesota Vascular elastance
US11141581B2 (en) 2019-09-06 2021-10-12 Aria Cv, Inc. Diffusion and infusion resistant implantable devices for reducing pulsatile pressure
US11331105B2 (en) 2016-10-19 2022-05-17 Aria Cv, Inc. Diffusion resistant implantable devices for reducing pulsatile pressure

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560375A (en) * 1983-06-30 1985-12-24 Pudenz-Schulte Medical Research Corp. Flow control valve
US4568250A (en) * 1982-09-07 1986-02-04 Greatbatch Enterprises, Inc. Low power electromagnetic pump
US4573994A (en) * 1979-04-27 1986-03-04 The Johns Hopkins University Refillable medication infusion apparatus
US4958661A (en) * 1989-08-08 1990-09-25 The Lee Company Check valve
US5178366A (en) * 1991-02-20 1993-01-12 Masako Kiyohara Valve seal

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4573994A (en) * 1979-04-27 1986-03-04 The Johns Hopkins University Refillable medication infusion apparatus
US4568250A (en) * 1982-09-07 1986-02-04 Greatbatch Enterprises, Inc. Low power electromagnetic pump
US4560375A (en) * 1983-06-30 1985-12-24 Pudenz-Schulte Medical Research Corp. Flow control valve
US4958661A (en) * 1989-08-08 1990-09-25 The Lee Company Check valve
US5178366A (en) * 1991-02-20 1993-01-12 Masako Kiyohara Valve seal

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2779705A1 (fr) * 1997-09-03 1999-12-17 Bespak Plc Perfectionnement a ou lies a des valves de dosage pour conteneurs distributeurs pressurises
WO2009069045A1 (fr) * 2007-11-27 2009-06-04 Koninklijke Philips Electronics N.V. Dispositif implantable de délivrance d'une substance thérapeutique
US10617538B2 (en) 2010-06-08 2020-04-14 Regents Of The University Of Minnesota Vascular elastance
US9987153B2 (en) 2010-06-08 2018-06-05 The Regents Of The University Of Minnesota Vascular elastance
US11583420B2 (en) 2010-06-08 2023-02-21 Regents Of The University Of Minnesota Vascular elastance
CN103260547A (zh) * 2010-11-22 2013-08-21 阿里阿Cv公司 用于降低脉动压力的系统和方法
US9017359B2 (en) 2010-11-22 2015-04-28 Aria Cv, Inc. System and method for reducing pulsatile pressure
US11938291B2 (en) 2010-11-22 2024-03-26 Aria Cv, Inc. System and method for reducing pulsatile pressure
US9333328B2 (en) 2010-11-22 2016-05-10 Aria Cv, Inc. System and method for reducing pulsatile pressure
CN103260547B (zh) * 2010-11-22 2016-08-10 阿里阿Cv公司 用于降低脉动压力的系统和方法
US11406803B2 (en) 2010-11-22 2022-08-09 Aria Cv, Inc. System and method for reducing pulsatile pressure
US10751519B2 (en) 2010-11-22 2020-08-25 Aria Cv, Inc. System and method for reducing pulsatile pressure
US10702682B2 (en) 2010-11-22 2020-07-07 Aria Cv, Inc. System and method for reducing pulsatile pressure
US10350397B2 (en) 2010-11-22 2019-07-16 Aria Cv, Inc. System and method for reducing pulsatile pressure
WO2012071395A1 (fr) * 2010-11-22 2012-05-31 Aria Cv, Inc. Système et méthode permettant de réduire la pression pulsatile
US9039725B1 (en) 2014-06-19 2015-05-26 Aria Cv, Inc. Systems and methods for treating pulmonary hypertension
US10682448B2 (en) 2014-06-19 2020-06-16 Aria Cv, Inc. Systems and methods for treating pulmonary hypertension
US9801989B2 (en) 2014-06-19 2017-10-31 Aria Cv, Inc. Systems and methods for treating pulmonary hypertension
US9610391B2 (en) 2014-06-19 2017-04-04 Aria Cv, Inc. Systems comprising an implantable component for treating pulmonary hypertension
US11511089B2 (en) 2014-06-19 2022-11-29 Aria Cv, Inc. Systems and methods for treating pulmonary hypertension
US9242082B2 (en) 2014-06-19 2016-01-26 Aria Cv, Inc. Systems and methods for treating pulmonary hypertension
US8876850B1 (en) 2014-06-19 2014-11-04 Aria Cv, Inc. Systems and methods for treating pulmonary hypertension
US11992636B2 (en) 2014-06-19 2024-05-28 Aria Cv, Inc. Systems and methods for treating pulmonary hypertension
US11331105B2 (en) 2016-10-19 2022-05-17 Aria Cv, Inc. Diffusion resistant implantable devices for reducing pulsatile pressure
US11141581B2 (en) 2019-09-06 2021-10-12 Aria Cv, Inc. Diffusion and infusion resistant implantable devices for reducing pulsatile pressure
US11833343B2 (en) 2019-09-06 2023-12-05 Aria Cv, Inc. Diffusion and infusion resistant implantable devices for reducing pulsatile pressure

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