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WO1996041634A3 - Utilisation d'un inhibiteur de transcriptase inverse non-nucleosidique en association avec des inhibiteurs de nucleosides pour le traitement d'infections a vih - Google Patents

Utilisation d'un inhibiteur de transcriptase inverse non-nucleosidique en association avec des inhibiteurs de nucleosides pour le traitement d'infections a vih Download PDF

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Publication number
WO1996041634A3
WO1996041634A3 PCT/EP1996/002540 EP9602540W WO9641634A3 WO 1996041634 A3 WO1996041634 A3 WO 1996041634A3 EP 9602540 W EP9602540 W EP 9602540W WO 9641634 A3 WO9641634 A3 WO 9641634A3
Authority
WO
WIPO (PCT)
Prior art keywords
association
treatment
nucleoside
hiv infection
reverse transcriptase
Prior art date
Application number
PCT/EP1996/002540
Other languages
English (en)
Other versions
WO1996041634A2 (fr
Inventor
Colla Paolo La
Maria Elena Marongiu
Giovanna Piras
Original Assignee
Sardinian Antiviral Research C
Colla Paolo
Maria Elena Marongiu
Giovanna Piras
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sardinian Antiviral Research C, Colla Paolo, Maria Elena Marongiu, Giovanna Piras filed Critical Sardinian Antiviral Research C
Priority to AU63552/96A priority Critical patent/AU6355296A/en
Publication of WO1996041634A2 publication Critical patent/WO1996041634A2/fr
Publication of WO1996041634A3 publication Critical patent/WO1996041634A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne l'utilisation, pour le traitement d'infections à VIH, d'un inhibiteur de transcriptase inverse no n-nucléosidique, notamment des dérivés de 6-benzyl-4-oxopyrimidine de formule générale (I), dans laquelle X est choisi dans le groupe constitué de O, S; R est choisi dans le groupe comprenant alkyle de C1 à C4, cycloalkyle C5 et C6; R', R' et Z sont identiques ou différents et représentent H, alkyle de C1 à C4, sous réserve que lorsque X vaut 0, R et R' ne peuvent être tous les deux égaux à H, leurs sels pharmaceutiquement acceptables et leurs dérivés solubles, en association avec des inhibiteurs de nucléoside choisis dans le groupe constitué de AZT, d4T et leurs dérivés phosphodiesters ou phosphotriesters. L'invention concerne également des compositions pharmaceutiques destinées au traitement d'infections à VIH comprenant une association de différents composants.
PCT/EP1996/002540 1995-06-13 1996-06-12 Utilisation d'un inhibiteur de transcriptase inverse non-nucleosidique en association avec des inhibiteurs de nucleosides pour le traitement d'infections a vih WO1996041634A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU63552/96A AU6355296A (en) 1995-06-13 1996-06-12 Use of a non-nucleoside reverse transcriptase inhibitor in a ssociation with nucleoside inhibitors for the treatment of h iv infection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95CA000009A IT1281502B1 (it) 1995-06-13 1995-06-13 Impiego di un inibitore non nucleosidico della trascrittasi inversa in associazione con inibitori nucleosidici per il trattamento della
ITCA95A000009 1995-06-13

Publications (2)

Publication Number Publication Date
WO1996041634A2 WO1996041634A2 (fr) 1996-12-27
WO1996041634A3 true WO1996041634A3 (fr) 1997-01-23

Family

ID=11347060

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/002540 WO1996041634A2 (fr) 1995-06-13 1996-06-12 Utilisation d'un inhibiteur de transcriptase inverse non-nucleosidique en association avec des inhibiteurs de nucleosides pour le traitement d'infections a vih

Country Status (3)

Country Link
AU (1) AU6355296A (fr)
IT (1) IT1281502B1 (fr)
WO (1) WO1996041634A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72207C2 (uk) 1998-04-07 2005-02-15 Брістол- Майєрс Сквібб Фарма Компані Фармацевтична композиція ефавіренцу з добавкою дезінтегруючих агентів у вигляді швидкорозчинних капсул або таблеток та спосіб її виготовлення
WO2001007027A2 (fr) * 1999-07-22 2001-02-01 Vertex Pharmaceuticals Incorporated Inhibiteurs d'helicase virale
MY169670A (en) * 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
AU2010275526A1 (en) 2009-07-24 2012-03-15 Vanderbilt University Isoform selective Phospholipase D inhibitors
CA2850597A1 (fr) 2011-09-30 2013-04-04 Vanderbilt University Therapies antivirales avec des inhibiteurs de phospholipase d
AU2013359311A1 (en) * 2012-12-11 2015-07-23 Vanderbilt University Methods and compositions of treating HIV infection

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TRAMONTANO E ET AL: "Characterization of the anti-HIV-1 activity of 3,4-dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs), new non-nucleoside reverse transcriptase inhibitors", MICROBIOLOGICA (PAVIA), 17 (4). 1994. 269-279., XP000609825 *

Also Published As

Publication number Publication date
AU6355296A (en) 1997-01-09
IT1281502B1 (it) 1998-02-18
ITCA950009A0 (it) 1995-06-13
ITCA950009A1 (it) 1996-12-13
WO1996041634A2 (fr) 1996-12-27

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