+

WO1996040307A1 - Piece pour la reparation de tissus - Google Patents

Piece pour la reparation de tissus Download PDF

Info

Publication number
WO1996040307A1
WO1996040307A1 PCT/US1996/008916 US9608916W WO9640307A1 WO 1996040307 A1 WO1996040307 A1 WO 1996040307A1 US 9608916 W US9608916 W US 9608916W WO 9640307 A1 WO9640307 A1 WO 9640307A1
Authority
WO
WIPO (PCT)
Prior art keywords
patch
tissue
flanges
tissue repair
repair
Prior art date
Application number
PCT/US1996/008916
Other languages
English (en)
Inventor
Pete L. Villalpando
John R. Daugherty
Original Assignee
W.L. Gore & Associates, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by W.L. Gore & Associates, Inc. filed Critical W.L. Gore & Associates, Inc.
Priority to AU62540/96A priority Critical patent/AU6254096A/en
Publication of WO1996040307A1 publication Critical patent/WO1996040307A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/10—Homopolymers or copolymers of propene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L27/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
    • C08L27/02—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L27/12—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment containing fluorine atoms
    • C08L27/18—Homopolymers or copolymers or tetrafluoroethene

Definitions

  • This invention relates to the field of implantable tissue repair patches intended for the repair of living tissue.
  • Implantable patch materials for repair of living tissue defects have been known for some time.
  • These patch materials are typically made from a single sheet of a flexible, strong, biocompatible polymeric material. Sheets of polypropylene mesh have been used extensively, as have sheets of microporous polytetrafluoroethylene (hereinafter PTFE).
  • PTFE microporous polytetrafluoroethylene
  • GORE-TEX ® Soft Tissue Patch is a sheet of porous PTFE having a microstructure of nodes and fibrils with an average fibril length of about 22 microns. The porous microstructure allows adjacent living tissue to grow into the void spaces of the material, forming an attachment to the patch and thereby increasing the strength of the repair.
  • These conventional patch materials are all in the form of a single sheet of flexible biocompatible material. They are typically attached to only one side of a tissue defect by suturing or by staples.
  • the present invention is a tissue repair patch comprising a flexible, biocompatible sheet of material having a perimeter and having two or more flanges around at least a portion of the perimeter. A space is disposed between the flanges whereby the flanges of the patch are placed on either side of the tissue to be repaired.
  • the flanges are secured to the tissue by conventional means such as by suturing or by stapling.
  • tissue repair patch of the present invention is anticipated to be particularly useful for the repair of structural diaphragms such as in the case of inguinal hernia repairs, it is also anticipated to be useful for repairs of other tissues such as, for example, vascular system repair, repair of heart muscle tissue or for various other soft tissue closures.
  • the flanged patch of the present invention is also anticipated to be useful as the synthetic patch material intended to close the open end of the skeletal muscle ventricle (SMV) portion of a left ventricular assist device.
  • An LVAD typically comprises a booster pump in series with the arterial output of the heart intended to aid the heart of an individual suffering from chronic congestive heart failure.
  • This booster pump is a skeletal muscle ventricle typically created from a strip of latissimus dorsi muscle rolled up and sewn together to form an open-ended muscle pouch.
  • Two vascular grafts form the inlet and outlet of the pump and connect it to the aorta which is usually ligated between the grafts to force aortic flow through the skeletal muscle ventricle.
  • a circular sheet of synthetic patch material is used to connect the two vascular grafts to the open end of the muscle pouch.
  • LVAD's and the use of the patch material are described by Thomas GA et al . in an article entitled "Pericardium- Lined Skeletal Muscle Ventricles in Circulation up to 589 Days” (Society of Thoracic Surgeons 1994; 58:1-11).
  • the patch can be made to have any desired planar shape including circular, ovoid, square and rectangular.
  • the flanges can extend around the entire perimeter of the patch or alternatively may be incorporated into only one or more portions of the perimeter. There may be two flanges or more than two. For example, if the tissue to be repaired included two different layers, then three flanges may be desirable whereby a middle flange is placed between the two layers of tissue with the two outer flanges on either side of the two layers of tissue.
  • the patch may be made from any biocompatible material with adequate strength and flexibility for the intended repair. While porous PTFE is believed to be most preferred, other suitable materials include polyethylene terephthalate fabrics and polypropylene meshes.
  • Figure 1 describes a combined cross sectional and perspective view of a tissue repair patch having two flanges around the perimeter of the patch.
  • Figure 2 describes a combined cross sectional and perspective view of a tissue repair patch having three flanges around the perimeter of the patch.
  • Figure 3 describes a cross sectional view of an apparatus for laminating porous PTFE films to make the inventive patch.
  • Figures 4A and 4B describe a flanged patch used to connect two vascular grafts to a skeletal muscle ventricle.
  • FIG. 1 describes a combined cross sectional and perspective view of a tissue repair patch 10 having two flanges and 3 disposed around the perimeter 17 of the patch 10. While the patch illustrated is of circular shape, the patch may be made to have any desired shape including ovoid, square and rectangular. Further, although this illustrated patch includes flanges around the entire perimeter, the flanges may extend around only one or more portions of the perimeter. Flanges H and 13_ are located on either side of tissue 15. The central portion of the patch exclusive of the flanges is located within tissue defect 1_9 intended to be repaired by the patch K). Attachment of the patch K) to the tissue 1_5 is by conventional means such as by sutures or staples placed through the overlapping surfaces of the tissue 15 and patch flanges H and 13.
  • Figure 2 describes a tissue repair patch 10 having three flanges 21, 22 and 23 disposed around the perimeter 17 of the patch 10.
  • Middle flange 22 separates adjacent tissue layers 25 and 26 while outer flanges £1 and 23 are located on the outer surfaces of tissue layers 25 and 26.
  • the preferred material for the tissue repair patch is porous PTFE.
  • Porous PTFE having a microstructure of nodes interconnected by fibrils is generally made as described by U.S. Patents 3,953,566 and 4,187,390 to Gore.
  • Porous PTFE of this type for use as implantable patches is preferably expanded by stretching simultaneously in multiple directions within the plane of the material, typically in directions separated by 45 degrees.
  • the inventive patch is preferably made from two or more layers of porous PTFE sheet material laminated together over the central region of the patch and kept separated over the flanged region to prevent adhesion.
  • laminated is meant any method of adhesion that accomplishes bonding whereby the laminated surfaces remain laminated together during normal use of the article.
  • Lamination can be accomplished by various means including the use of adhesives such as silicone adhesives and thermoplastic adhesives such as FEP which accomplish lamination by melting of the thermoplastic by the application of heat and pressure to the areas intended to be laminated.
  • adhesives such as silicone adhesives and thermoplastic adhesives such as FEP which accomplish lamination by melting of the thermoplastic by the application of heat and pressure to the areas intended to be laminated.
  • a more preferred method involves thermal bonding by applying heat and pressure sufficient to melt-bond the materials comprising the surfaces to be bonded, that is heat and pressure sufficient to melt bond the porous PTFE.
  • one method involves the use of a separation material to prevent lamination from occurring in the flange region while the central region of the patch is being laminated.
  • a separation material is Kapton® (DuPont de Nemours, Circleview, OH), a thin, flexible polyimide film that is capable of withstanding the temperatures necessary to melt bond the porous PTFE. This material does not adhere to the porous PTFE during the lamination process.
  • a preferred method of making the flanged patch is to make it from multiple layers of thin, porous PTFE film.
  • Films of this type made as taught by U.S. Patents 3,953,566 and 4,187,390 are particularly strong in their longitudinal direction (the direction they were stretched during manufacture). By stacking these films with their longitudinal directions oriented in various different directions, a patch with high strength in all directions within the plane of the patch is achieved.
  • One or more suitably shaped sheets of Kapton are used within the stack of film as a separation material to create two or more flanges.
  • the laminating apparatus is described by Figure 3.
  • a vacuum of about 76 cm of water was applied to fixture 43 via port 45.
  • Fixture 43 supports porous metal plate 41 sealed by a gasket 44-
  • the porous metal plate (316L stainless steel, approximately 5 micron pore size, Mott Metallurgical Corp., Farmington CT, part no. 10005-6.5-.5), had a 15 cm diameter circular surface and was of about 1 cm thickness.
  • a sheet of porous, PTFE film 4_7 having a uniaxial fibrillar orientation was placed over the surface of the porous metal plate 41 so that there were essentially no wrinkles in the film 47, with the vacuum below the porous metal plate 41 holding the film 47 in place.
  • the film used was of about 0.01 mm thickness, about 16.5 cm width and 20 cm length, and had a density of about 0.3 g/cc and a fibril length of about 50 microns. This fibril length is an estimated mean value determined by examining scanning electron photomicrographs of the film surface.
  • the density of solid, non-porous PTFE is generally considered to be about 2.2 g/cc, consequently the film used was about 86% porous by bulk volume.
  • a second layer 48 of the same film was placed over the first layer 42, with the fibrillar orientation of the second layer 48 rotated ten degrees with respect to the fibrillar orientation of the first layer 4_7.
  • a third layer was then placed over the second, rotated an additional ten degrees.
  • a ring-shaped sheet 61 of Kapton polyimide film was included in the stack of porous PTFE film layers as a separation material to prevent lamination of the adjacent layers of porous PTFE film in the region of the flanges. These adjacent layers of porous PTFE are laminated together in the central region of the patch where the ring- shaped sheet 61 of Kapton polyimide film is open in its respective center region.
  • a sheet of Kapton polyimide film 49 of about 0.05 mm thickness and of larger length and width than the porous PTFE film sheets was placed over the stack of film sheets.
  • a circular steel restraining ring _0 was placed over the edges of the polyimide film-covered stack of porous PTFE film.
  • the inside diameter of the retaining ring 50 was of larger diameter than the diameter of the porous metal plate 41 so that only a slight amount of interference existed when even 72 layers of porous PTFE film were used in the stack.
  • a compressive force 5J5 of about 450 kg was applied to the ring by a Carver laboratory press (model M, Fred Carver Inc., Menomonee Falls, WI).
  • the force 55 was applied via heavy metal plates 5J . and 53 heated by electrical cartridge heaters.
  • the temperature of the surface of the polyimide film 49 was monitored by a thermocouple 57 connected to an electronic temperature controller; thirty minutes after reaching an indicated temperature of 365°C, the heated press with metal plates 5_1 and 53 was removed and the stack of film layers was allowed to cool.
  • the covering sheet of polyimide film 49 was then removed from the laminated stack of porous PTFE film layers along with all ring- shaped sheets 61 of separation material.
  • the porous PTFE may be made to have pore sizes appropriate for the intended tissue repair depending on whether or not tissue ingrowth is desired.
  • fibril lengths greater than ten microns and more preferably greater than twenty microns are desired to allow tissue ingrowth while fibril lengths of less than fifty microns are generally preferred for suitable material strength.
  • average fibril lengths are preferably less than 10 microns and more preferably less than 5 microns.
  • the fibril length of porous expanded PTFE that has been expanded in a single direction is defined herein as the average of ten measurements between nodes connected by fibrils in the direction of expansion. Ten measurements are made in the following manner.
  • a photomicrograph is made of a representative portion of the sample surface, of adequate magnification to show at least five sequential fibrils within the length of the photomicrograph.
  • Two parallel lines are drawn across the length of the photomicrograph so as to divide the photograph into three equal areas, with the lines being drawn in the direction of expansion and parallel to the direction of orientation of the fibrils.
  • Measuring from left to right five measurements of fibril length are made along the top line in the photograph beginning with the first node to intersect the line near the left edge of the photograph and continuing with consecutive nodes intersecting the line.
  • Five more measurements are made along the other line from right to left beginning with the first node to intersect the line on the right hand side of the photograph.
  • the ten measurements obtained by this method are averaged to obtain the fibril length of the material.
  • the fibril length is estimated by examining a representative photomicrograph of the material surface and comparing fibril lengths as described above in a manner that represents the various directional orientations of the fibrils.
  • FIG. 4A and the cross sectional view of Figure 4B describe the use of the flanged patch JjO of the present invention to close the open end of the SMV portion 73 of an LVAD 7_1.
  • the patch is used primarily as a means to connect a pair of vascular grafts 75 and 77 to the SMV 73 via suture lines 81..
  • the two flanges ⁇ and 13 of the patch _0 are used respectively to attach via suture lines 83 to the pericardium inner lining 85 and the outer skeletal muscle 87 that form the SMV 73.
  • pericardium 85 is not used to line the SMV 73
  • the two flanges H and 13 may be attached to either side of the edge of the skeletal muscle 87 used to form the SMV 73.
  • a tissue repair patch comprising a flexible, biocompatible sheet of material having a perimeter, and having at least two flanges around at least a portion of the perimeter with a space disposed between the flanges.
  • tissue repair patch according to claim 1 wherein the tissue repair patch is comprised of porous polytetrafluoroethylene.
  • tissue repair patch according to claim 2 wherein the tissue repair patch is a hernia repair patch. 4. A tissue repair patch according to claim 2 wherein the tissue repair patch is a vascular repair patch.
  • tissue repair patch according to claim 2 wherein the tissue repair patch is a soft tissue closure patch.
  • tissue repair patch according to claim 2 wherein the tissue repair patch connects a pair of vascular grafts to a left ventricle assist device.
  • a tissue repair patch according to claim 2 wherein the porous polytetrafluoroethylene has a microstructure of nodes interconnected by fibrils.
  • the porous polytetrafluoroethylene has an average fibril length between 10 and 50 microns.
  • a tissue repair patch according to claim 7 wherein the porous polytetrafluoroethylene has an average fibril length less than 10 microns.
  • tissue repair patch according to claim 1 wherein the tissue repair patch is comprised of polypropylene.
  • a tissue repair patch according to claim 10 wherein the tissue repair patch is a hernia repair patch. 12. A tissue repair patch according to claim 10 wherein the tissue repair patch is a soft tissue closure patch. 13. A tissue repair patch according to claim 1 wherein the at least two flanges extend around the entire perimeter of the tissue repair patch. 14. A tissue repair patch according to claim 13 wherein the tissue repair patch is comprised of porous polytetrafluoroethylene. 15. A tissue repair patch according to claim 1 wherein the tissue repair patch has three flanges.
  • tissue repair patch according to claim 1 wherein the tissue repair patch is secured to living tissue by staples.

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Prostheses (AREA)

Abstract

Pièce pour la réparation de tissus, constituée d'une feuille de matière biocompatible et souple présentant une périphérie dont au moins une partie comporte au moins deux parties saillantes, un espace étant ménagé entre les parties saillantes voisines. Lors de la réparation d'un défaut dans un diaphragme tissulaire, on peut placer la pièce de sorte qu'elle recouvre une ouverture présente dans le diaphragme tissulaire, et que les parties saillantes de la pièce se situent des deux côtés du diaphragme tissulaire. Cette pièce assure une réparation plus résistante que les pièces classiques, et l'on s'attend à ce qu'elle soit utilisable dans la réparation des hernies, dans la réparation vasculaire, dans la réparation des muscles cardiaques, et dans la fermeture de différents types de tissus mous. On peut fixer ladite pièce par différents moyens connus, par exemple à l'aide de sutures et d'agrafes chirurgicales.
PCT/US1996/008916 1995-06-07 1996-06-04 Piece pour la reparation de tissus WO1996040307A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU62540/96A AU6254096A (en) 1995-06-07 1996-06-04 A tissue repair patch

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47993395A 1995-06-07 1995-06-07
US08/479,933 1995-06-07

Publications (1)

Publication Number Publication Date
WO1996040307A1 true WO1996040307A1 (fr) 1996-12-19

Family

ID=23906023

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/008916 WO1996040307A1 (fr) 1995-06-07 1996-06-04 Piece pour la reparation de tissus

Country Status (2)

Country Link
AU (1) AU6254096A (fr)
WO (1) WO1996040307A1 (fr)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063115A (en) * 1997-04-11 2000-05-16 Medtronic, Inc. Cardiac assistance system
WO2002019946A3 (fr) * 2000-09-07 2002-07-18 American Med Syst Procede et article implantable
WO2003011181A1 (fr) * 2001-08-03 2003-02-13 Bard De España, S.A. Prothese de paroi implantable dans le foyer d'une blessure, destinee a renforcer la fermeture d'une paroi abdominale
GB2397239A (en) * 2003-01-14 2004-07-21 Stephen George Edward Barker Implantable Hernia Repair Prosthesis
US7025063B2 (en) 2000-09-07 2006-04-11 Ams Research Corporation Coated sling material
US7101381B2 (en) 2002-08-02 2006-09-05 C.R. Bard, Inc. Implantable prosthesis
US7404819B1 (en) 2000-09-14 2008-07-29 C.R. Bard, Inc. Implantable prosthesis
WO2009003726A1 (fr) * 2007-07-02 2009-01-08 Loehde Eckhard Maillage tridimensionnel pour hernie
US7476255B2 (en) 2003-12-30 2009-01-13 Depuy Products, Inc. Soft tissue attachment system and method
US8123671B2 (en) 2005-08-04 2012-02-28 C.R. Bard, Inc. Pelvic implant systems and methods
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US8480559B2 (en) 2006-09-13 2013-07-09 C. R. Bard, Inc. Urethral support system
US8574149B2 (en) 2007-11-13 2013-11-05 C. R. Bard, Inc. Adjustable tissue support member
US8758373B2 (en) 2008-02-18 2014-06-24 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US8845512B2 (en) 2005-11-14 2014-09-30 C. R. Bard, Inc. Sling anchor system
US8906045B2 (en) 2009-08-17 2014-12-09 Covidien Lp Articulating patch deployment device and method of use
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
US9833240B2 (en) 2008-02-18 2017-12-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9999424B2 (en) 2009-08-17 2018-06-19 Covidien Lp Means and method for reversibly connecting an implant to a deployment device
US12036729B2 (en) 2020-07-01 2024-07-16 W. L. Gore & Associates, Inc. Process for forming porous three dimensional expanded polytetrafluoroethylene articles

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019029A1 (fr) * 1993-02-18 1994-09-01 W.L. Gore & Associates, Inc. Matiere en feuille stratifiee servant de piece pour la reparation de tissus vivants

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019029A1 (fr) * 1993-02-18 1994-09-01 W.L. Gore & Associates, Inc. Matiere en feuille stratifiee servant de piece pour la reparation de tissus vivants

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063115A (en) * 1997-04-11 2000-05-16 Medtronic, Inc. Cardiac assistance system
WO2002019946A3 (fr) * 2000-09-07 2002-07-18 American Med Syst Procede et article implantable
US6592515B2 (en) 2000-09-07 2003-07-15 Ams Research Corporation Implantable article and method
US8147478B2 (en) 2000-09-07 2012-04-03 Ams Research Corporation Coated sling material
US7025063B2 (en) 2000-09-07 2006-04-11 Ams Research Corporation Coated sling material
US7404819B1 (en) 2000-09-14 2008-07-29 C.R. Bard, Inc. Implantable prosthesis
WO2003011181A1 (fr) * 2001-08-03 2003-02-13 Bard De España, S.A. Prothese de paroi implantable dans le foyer d'une blessure, destinee a renforcer la fermeture d'une paroi abdominale
ES2183736A1 (es) * 2001-08-03 2003-03-16 Caneiro Juan Bellon Protesis de pared implantable en el foco de la herida para refuerzo de cierres de pared abdominal.
ES2183736B1 (es) * 2001-08-03 2004-06-16 Bard De España, S.A. Protesis de pared implantable en el foco de la herida para refuerzo de cierre de pared abdominal.
US9119698B2 (en) 2001-08-03 2015-09-01 Juan Manuel Bellon Caneiro Wall prosthesis that can be implanted in the center of a wound to reinforce abdominal wall closure
US7101381B2 (en) 2002-08-02 2006-09-05 C.R. Bard, Inc. Implantable prosthesis
US7785334B2 (en) 2002-08-02 2010-08-31 C.R. Bard, Inc. Implantable prosthesis
US7806905B2 (en) 2002-08-02 2010-10-05 C.R. Bard, Inc. Implantable prosthesis
US8956373B2 (en) 2002-08-02 2015-02-17 C.R. Bard, Inc. Implantable prosthesis
GB2397239B (en) * 2003-01-14 2006-03-08 Stephen George Edward Barker Umbilical or paraumbilical hernia repair prosthesis
GB2397239A (en) * 2003-01-14 2004-07-21 Stephen George Edward Barker Implantable Hernia Repair Prosthesis
US7476255B2 (en) 2003-12-30 2009-01-13 Depuy Products, Inc. Soft tissue attachment system and method
US8123671B2 (en) 2005-08-04 2012-02-28 C.R. Bard, Inc. Pelvic implant systems and methods
US8845512B2 (en) 2005-11-14 2014-09-30 C. R. Bard, Inc. Sling anchor system
US8480559B2 (en) 2006-09-13 2013-07-09 C. R. Bard, Inc. Urethral support system
WO2009003726A1 (fr) * 2007-07-02 2009-01-08 Loehde Eckhard Maillage tridimensionnel pour hernie
US8574149B2 (en) 2007-11-13 2013-11-05 C. R. Bard, Inc. Adjustable tissue support member
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US8758373B2 (en) 2008-02-18 2014-06-24 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
US10182898B2 (en) 2008-02-18 2019-01-22 Covidien Lp Clip for implant deployment device
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
US9833240B2 (en) 2008-02-18 2017-12-05 Covidien Lp Lock bar spring and clip for implant deployment device
US10159554B2 (en) 2008-02-18 2018-12-25 Covidien Lp Clip for implant deployment device
US9999424B2 (en) 2009-08-17 2018-06-19 Covidien Lp Means and method for reversibly connecting an implant to a deployment device
US8906045B2 (en) 2009-08-17 2014-12-09 Covidien Lp Articulating patch deployment device and method of use
US12036729B2 (en) 2020-07-01 2024-07-16 W. L. Gore & Associates, Inc. Process for forming porous three dimensional expanded polytetrafluoroethylene articles

Also Published As

Publication number Publication date
AU6254096A (en) 1996-12-30

Similar Documents

Publication Publication Date Title
WO1996040307A1 (fr) Piece pour la reparation de tissus
EP0684844B1 (fr) Matiere en feuille stratifiee servant de piece pour la reparation de tissus vivants
US5645915A (en) High strength porous PTFE sheet material
EP1738780B1 (fr) Support à base de collagène bioimplantable
EP1200015B1 (fr) Ensemble tuteur intravasculaire/greffe helicoidal
EP0932374B1 (fr) Membranes adaptees a l'usage medical
US6042666A (en) Prosthesis with in-wall modulation
KR20140132366A (ko) 향상된 생체적합성 표면 및 이러한 표면을 일체화한 장치
US10758355B2 (en) Orbital floor sheet
BR112013005614A2 (pt) método para aumentar a resistência ao cisalhamento de um filme
GB2095257A (en) Napper porous fluororesin materials and their manufacture
JPS645904B2 (fr)
JPS6041975Y2 (ja) 心臓外科用人工補綴材
RU2203685C2 (ru) Имплантат для восстановительной хирургии
JP3874205B2 (ja) 生体内移植材料及びその製造方法
EP1649828A1 (fr) Matiere pour la greffe in vivo
JP3497634B2 (ja) カイロ用積層体
US20240156583A1 (en) Flexible composite laminate with high suture retention strength and method of making same
JPS61103448A (ja) Ｘ線造影性を有する医療用シ−ト状補綴材料

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG UZ VN

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载