WO1995027209A1 - METHODE ET KIT DE DETECTION DE l'ACTIVATION DU RECEPTEUR DE THROMBINE DANS LES PLAQUETTES ET AUTRES CELLULES - Google Patents
METHODE ET KIT DE DETECTION DE l'ACTIVATION DU RECEPTEUR DE THROMBINE DANS LES PLAQUETTES ET AUTRES CELLULES Download PDFInfo
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- WO1995027209A1 WO1995027209A1 PCT/US1995/003796 US9503796W WO9527209A1 WO 1995027209 A1 WO1995027209 A1 WO 1995027209A1 US 9503796 W US9503796 W US 9503796W WO 9527209 A1 WO9527209 A1 WO 9527209A1
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- WIPO (PCT)
- Prior art keywords
- antibody
- peptide fragment
- cleaved peptide
- thrombin
- thrombin receptor
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Méthode de détection de l'activation des cellules induites par la thrombine à l'aide d'un système de détection permettant de déterminer la présence d'un fragment peptide clivé du récepteur de thrombine. Cette méthode permet de diagnostiquer et de traiter les états pathologiques pré-thrombotiques et thrombotiques. L'invention porte également sur les kits de détection utilisés pour l'application de cette méthode.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22037594A | 1994-03-31 | 1994-03-31 | |
| US08/220,375 | 1994-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1995027209A1 true WO1995027209A1 (fr) | 1995-10-12 |
Family
ID=22823307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/003796 WO1995027209A1 (fr) | 1994-03-31 | 1995-03-27 | METHODE ET KIT DE DETECTION DE l'ACTIVATION DU RECEPTEUR DE THROMBINE DANS LES PLAQUETTES ET AUTRES CELLULES |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO1995027209A1 (fr) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996010749A1 (fr) * | 1994-09-29 | 1996-04-11 | Mount Sinai School Of Medicine Of The City University Of New York | Test d'evaluation du blocage des plaquettes sanguines |
| WO2009098689A1 (fr) * | 2008-02-07 | 2009-08-13 | Hadasit Medical Research Services & Development Limited | Immunodétection d'un état cancéreux chez un sujet |
| US8574828B2 (en) | 2003-07-08 | 2013-11-05 | Accumetrics, Inc. | Controlled platelet activation to monitor therapy of ADP antagonists |
| US9506938B2 (en) | 2003-07-08 | 2016-11-29 | Accumetrics, Inc. | Methods for measuring platelet reactivity of individuals treated with drug eluting stents |
| CN107102134A (zh) * | 2017-03-02 | 2017-08-29 | 江苏华冠生物技术股份有限公司 | 一种适用于末梢血检测用的样品稀释液 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992014750A1 (fr) * | 1991-02-19 | 1992-09-03 | The Regents Of The University Of California | Recepteur de thrombine recombinant et produits pharmaceutiques correspondants |
| US5256766A (en) * | 1991-02-19 | 1993-10-26 | The Regents Of The University Of California | Recombinant thrombin receptor and related pharmaceuticals |
-
1995
- 1995-03-27 WO PCT/US1995/003796 patent/WO1995027209A1/fr active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992014750A1 (fr) * | 1991-02-19 | 1992-09-03 | The Regents Of The University Of California | Recepteur de thrombine recombinant et produits pharmaceutiques correspondants |
| US5256766A (en) * | 1991-02-19 | 1993-10-26 | The Regents Of The University Of California | Recombinant thrombin receptor and related pharmaceuticals |
Non-Patent Citations (4)
| Title |
|---|
| BLOOD, Volume 82, Number 7, issued 01 October 1993, K.J. NORTON et al., "Immunologic Analysis of the Cloned Platelet Thrombin Receptor Activation Mechanism: Evidence Supporting Receptor Cleavage, Release of the N-Terminal Peptide and Insertion of the Tethered Ligand Into a Protected Environment", pages 2125-2136. * |
| CLINICAL CHEMISTRY, Volume 36, Number 8, issued 1990, J.P. GOSLING, "A Decade of Development in Immunoassay Methodology", pages 1408-1427. * |
| JOURNAL OF BIOLOGICAL CHEMISTRY, Volume 267, Number 20, issued 15 July 1992, L.F. BRASS et al., "Structure and Function of the Human Platelet Thrombin Receptor. Studies Using Monoclonal Antibodies Directed Against a Defined Domain within the Receptor N Terminus", pages 13795-13798. * |
| SCIENCE, Volume 222, issued 09 December 1983, K.Y. HUI et al., "Monoclonal Antibodies to a Synthetic Fibrin-Like Peptide Bind to Human Fibrin But Not Fibrinogen", pages 1129-1132. * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996010749A1 (fr) * | 1994-09-29 | 1996-04-11 | Mount Sinai School Of Medicine Of The City University Of New York | Test d'evaluation du blocage des plaquettes sanguines |
| US5763199A (en) * | 1994-09-29 | 1998-06-09 | Mount Sinai School Of Medicine Of The City University Of New York | Platelet blockade assay |
| US5854005A (en) * | 1994-09-29 | 1998-12-29 | Mount Sinai School Of Medicine | Platelet blockade assay |
| US8574828B2 (en) | 2003-07-08 | 2013-11-05 | Accumetrics, Inc. | Controlled platelet activation to monitor therapy of ADP antagonists |
| US9341637B2 (en) | 2003-07-08 | 2016-05-17 | Accumetrics Inc. | Controlled platelet activation to monitor therapy of ADP antagonists |
| US9506938B2 (en) | 2003-07-08 | 2016-11-29 | Accumetrics, Inc. | Methods for measuring platelet reactivity of individuals treated with drug eluting stents |
| WO2009098689A1 (fr) * | 2008-02-07 | 2009-08-13 | Hadasit Medical Research Services & Development Limited | Immunodétection d'un état cancéreux chez un sujet |
| CN101999077A (zh) * | 2008-02-07 | 2011-03-30 | 哈达斯特医学服务与开发有限公司 | 受试者中癌状态的免疫检测 |
| CN107102134A (zh) * | 2017-03-02 | 2017-08-29 | 江苏华冠生物技术股份有限公司 | 一种适用于末梢血检测用的样品稀释液 |
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