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WO1995019359B1 - Procede de production de composes a base de xanthene ou de cubane et inhibitors de protease - Google Patents

Procede de production de composes a base de xanthene ou de cubane et inhibitors de protease

Info

Publication number
WO1995019359B1
WO1995019359B1 PCT/US1995/000344 US9500344W WO9519359B1 WO 1995019359 B1 WO1995019359 B1 WO 1995019359B1 US 9500344 W US9500344 W US 9500344W WO 9519359 B1 WO9519359 B1 WO 9519359B1
Authority
WO
WIPO (PCT)
Prior art keywords
molecule
molecules
core
group
library
Prior art date
Application number
PCT/US1995/000344
Other languages
English (en)
Other versions
WO1995019359A1 (fr
Filing date
Publication date
Application filed filed Critical
Priority to AU15628/95A priority Critical patent/AU1562895A/en
Publication of WO1995019359A1 publication Critical patent/WO1995019359A1/fr
Publication of WO1995019359B1 publication Critical patent/WO1995019359B1/fr

Links

Abstract

La présente invention concerne d'une part des procédés de constitution de bibliothèques combinatoires et d'autre part les bibliothèques ainsi obtenues. Selon l'un des aspects préférés de l'invention, un certain nombre de molécules noyaux, ces molécules étant des dérivés de xanthène ou de cubane, sont mises en réaction avec un certain nombre de molécules outils différentes pour constituer une bibliothèque de molécules caractérisée par une diversité moléculaire aux occurrences non naturelles. Ces bibliothèques servent également à identifier les composés au plomb modulant l'activité fonctionnelle des molécules biologiques. L'invention concerne également les inhibiteurs de protéases isolés de ces bibliothèques.
PCT/US1995/000344 1994-01-12 1995-01-11 Procede de production de composes a base de xanthene ou de cubane et inhibitors de protease WO1995019359A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU15628/95A AU1562895A (en) 1994-01-12 1995-01-11 Process for making xanthene or cubane based compounds, and protease inhibitors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18021594A 1994-01-12 1994-01-12
US08/180,215 1994-01-12
US28208394A 1994-07-28 1994-07-28
US08/282,083 1994-07-28

Publications (2)

Publication Number Publication Date
WO1995019359A1 WO1995019359A1 (fr) 1995-07-20
WO1995019359B1 true WO1995019359B1 (fr) 1995-08-10

Family

ID=26876096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/000344 WO1995019359A1 (fr) 1994-01-12 1995-01-11 Procede de production de composes a base de xanthene ou de cubane et inhibitors de protease

Country Status (3)

Country Link
US (1) US5877030A (fr)
AU (1) AU1562895A (fr)
WO (1) WO1995019359A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
GB9517661D0 (en) * 1995-08-30 1995-11-01 Smithkline Beecham Plc Novel compounds
DE19609272C2 (de) * 1996-02-27 2000-05-25 Schering Ag Verfahren zur Parallelsynthese großer Zahlen von 2,6-disubstituierten Chinolinderivaten
US6617114B1 (en) 1996-10-31 2003-09-09 Karo Bio Ab Identification of drug complementary combinatorial libraries
WO1998035923A1 (fr) * 1997-02-14 1998-08-20 Massachusetts Institute Of Technology Procede permettant de creer de la diversite moleculaire
US6207861B1 (en) 1998-01-05 2001-03-27 Neogenesis, Inc. Method for producing and screening mass coded combinatorial libraries for drug discovery and target validation
EP2241541A1 (fr) 1998-01-05 2010-10-20 Neogenesis, Inc. Procédé d'identification d'un élément d'une bibliothèque combinatoire codée en masse
US20020010550A1 (en) * 1998-09-14 2002-01-24 George M. Grass Pharmacokinetic-based drug design tool and method
US6939973B1 (en) 1999-02-09 2005-09-06 The Scripps Research Institute Glycoluril core molecules for combinatorial libraries
WO2002051775A2 (fr) * 2000-12-22 2002-07-04 Neogenesis Pharmaceuticals, Inc. Procédé de formation d'échantillothèques combinatoires par amination réductive
GB0125594D0 (en) * 2001-10-25 2001-12-19 Univ Sheffield Inhibitors for inactivating allergens
WO2004081531A2 (fr) * 2003-03-10 2004-09-23 Schering Corporation Analyse de ligands
CA2521766A1 (fr) * 2003-04-11 2004-10-28 Sgx Pharmaceuticals, Inc. Bibliotheques de composes et procedes de decouverte de medicaments
ATE462976T1 (de) * 2003-12-18 2010-04-15 Hoffmann La Roche Quantifizierung durch kombinatorische verdünnung
CN118005545B (zh) * 2024-01-04 2025-02-18 兰州大学 小分子抗菌肽模拟物及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109018A (en) * 1984-08-20 1992-04-28 Georgia Tech Research Corporation Use of heterocyclic inhibitors of serine proteases
US4694070A (en) * 1985-05-28 1987-09-15 Coulter Electronics, Inc. Water soluble xanthylium derivatives substrates
US5157019A (en) * 1986-03-18 1992-10-20 Monsanto Company Serine protease inhibitors
US4833332A (en) * 1987-06-12 1989-05-23 E. I. Du Pont De Nemours And Company Scanning fluorescent detection system
US5010175A (en) * 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US4963654A (en) * 1989-02-13 1990-10-16 Taisho Pharmaceutical Co., Ltd. Peptide serine protease inhibitor
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5071988A (en) * 1989-10-27 1991-12-10 American Home Products Corporation Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid derivatives
US5250677A (en) * 1990-06-04 1993-10-05 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5079254A (en) * 1990-06-04 1992-01-07 Merrell Dow Pharmaceuticals Inc. Derivatives of 6-aminooctahydroindolizinetriol
US5192668A (en) * 1990-10-11 1993-03-09 Merck & Co., Inc. Synthesis of protease inhibitor
EP1588761A3 (fr) * 1991-11-22 2005-11-23 Affymetrix, Inc. Procédé de préparation de matrices de polymères

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