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WO1995018530A1 - Procede d'inactivation de virus presents dans des constituants sanguins a l'aide de composes chimiquement actives - Google Patents

Procede d'inactivation de virus presents dans des constituants sanguins a l'aide de composes chimiquement actives Download PDF

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Publication number
WO1995018530A1
WO1995018530A1 PCT/US1995/000464 US9500464W WO9518530A1 WO 1995018530 A1 WO1995018530 A1 WO 1995018530A1 US 9500464 W US9500464 W US 9500464W WO 9518530 A1 WO9518530 A1 WO 9518530A1
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
dioxetane
moiety
compound
excited state
Prior art date
Application number
PCT/US1995/000464
Other languages
English (en)
Inventor
Charles M. Zepp
Donald L. Heefner
Original Assignee
Hemasure Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemasure Inc. filed Critical Hemasure Inc.
Priority to AU15658/95A priority Critical patent/AU1565895A/en
Priority to EP95907419A priority patent/EP0739163A1/fr
Publication of WO1995018530A1 publication Critical patent/WO1995018530A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/06—Inactivation or attenuation by chemical treatment

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne un procédé d'inactivation de molécules virales présentes dans un échantillon de sang et des composés destinés à être utilisés dans ce procédé. Pour inactiver des molécules virales on ajoute dans un échantillon de sang contenant un virus, une quantité efficace d'un composé qui présente une affinité pour un acide nucléique viral et qui peut être activé dans un état excité dans lequel le composé se lie de manière covalente à l'acide nucléique viral. On laisse au composé le temps de former un complexe avec l'aide nucléique viral puis on intensifie l'excitation du composé par activation chimique. Dans une première forme d'exécution on utilise du psoralène, de l'hypéricine ou un dérivé de psoralène ou d'hypéricine comme composé activable, inactivant les virus et l'activation chimique du composé résulte de la décomposition d'un dioxétane situé juste à côté du complexe acide nucléique/composé. Dans une deuxième forme d'exécution on incorpore le composé activable, inactivant les virus dans une molécule de dioxétane, et l'activation chimique du composé résulte de la décomposition du dioxétane en deux composés carbonyle.
PCT/US1995/000464 1994-01-10 1995-01-09 Procede d'inactivation de virus presents dans des constituants sanguins a l'aide de composes chimiquement actives WO1995018530A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU15658/95A AU1565895A (en) 1994-01-10 1995-01-09 Inactivation of viruses present in blood components using chemically-activated compounds
EP95907419A EP0739163A1 (fr) 1994-01-10 1995-01-09 Procede d'inactivation de virus presents dans des constituants sanguins a l'aide de composes chimiquement actives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17943794A 1994-01-10 1994-01-10
US08/179,437 1994-01-10

Publications (1)

Publication Number Publication Date
WO1995018530A1 true WO1995018530A1 (fr) 1995-07-13

Family

ID=22656595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/000464 WO1995018530A1 (fr) 1994-01-10 1995-01-09 Procede d'inactivation de virus presents dans des constituants sanguins a l'aide de composes chimiquement actives

Country Status (4)

Country Link
EP (1) EP0739163A1 (fr)
AU (1) AU1565895A (fr)
CA (1) CA2180854A1 (fr)
WO (1) WO1995018530A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410219B1 (en) 1994-11-14 2002-06-25 Cerus Corporation Treating blood or blood products with compounds which have a mustard, azirdinium or aziridine group and a nucleic acid binding group

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000695A1 (fr) * 1986-07-24 1988-01-28 Quest Systems, Inc. Procede de detection d'une substance utilisant une decomposition de dioxetanes induite par enzyme
US5068339A (en) * 1986-07-17 1991-11-26 Board Of Governors Of Wayne State University Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5068339A (en) * 1986-07-17 1991-11-26 Board Of Governors Of Wayne State University Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers
WO1988000695A1 (fr) * 1986-07-24 1988-01-28 Quest Systems, Inc. Procede de detection d'une substance utilisant une decomposition de dioxetanes induite par enzyme

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
TETRAHEDRON LETTERS, Volume 28, Number 11, issued 1987, SCHAAP et al., "Chemical and Enzymatic Triggering of 1,2-Dioxetanes. 2: Fluoride-Induced Chemiluminescence from Tert-Butyldimethylsilyloxy-Substituted Dioxetanes", pages 1155-1158. *
TETRAHEDRON LETTERS, Volume 28, Number 11, issued 1987, SCHAAP et al., "Chemical and Enzymatic Triggering of 1,2-Dioxetanes. 3: Alkaline Phosphatase-Catalyzed Chemiluminescence from an Aryl Phophate-Substituted Dioxetane", pages 1159-1162. *
TETRAHEDRON LETTERS, Volume 28, Number 9, issued 1987, SCHAAP et al., "Chemical and Enzymatic Triggering of 1,2-Dioxetanes. 1: Aryl Esterase-Catalyzed Chemiluminescence from a Naphthyl Acetate-Substituted Dioxetane", pages 935-938. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410219B1 (en) 1994-11-14 2002-06-25 Cerus Corporation Treating blood or blood products with compounds which have a mustard, azirdinium or aziridine group and a nucleic acid binding group

Also Published As

Publication number Publication date
AU1565895A (en) 1995-08-01
EP0739163A1 (fr) 1996-10-30
CA2180854A1 (fr) 1995-07-13

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