WO1995009005B1 - Methods for stimulating interleukin-6 synthesis and inducing thrombocytopoiesis using oncostatin m - Google Patents
Methods for stimulating interleukin-6 synthesis and inducing thrombocytopoiesis using oncostatin mInfo
- Publication number
- WO1995009005B1 WO1995009005B1 PCT/US1994/010923 US9410923W WO9509005B1 WO 1995009005 B1 WO1995009005 B1 WO 1995009005B1 US 9410923 W US9410923 W US 9410923W WO 9509005 B1 WO9509005 B1 WO 9509005B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- oncostatin
- interleukin
- methods
- cytokine
- Prior art date
Links
- 102000004889 Interleukin-6 Human genes 0.000 title abstract 4
- 108090001005 Interleukin-6 Proteins 0.000 title abstract 4
- 229940100601 interleukin-6 Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 title 1
- 102000004140 Oncostatin M Human genes 0.000 claims abstract 9
- 108090000630 Oncostatin M Proteins 0.000 claims abstract 9
- 206010033661 Pancytopenia Diseases 0.000 claims abstract 6
- 208000024389 cytopenia Diseases 0.000 claims abstract 6
- 102000004127 Cytokines Human genes 0.000 claims abstract 5
- 108090000695 Cytokines Proteins 0.000 claims abstract 5
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims abstract 3
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims abstract 3
- 102000000646 Interleukin-3 Human genes 0.000 claims abstract 3
- 108010002386 Interleukin-3 Proteins 0.000 claims abstract 3
- 229940076264 interleukin-3 Drugs 0.000 claims abstract 3
- 208000007502 anemia Diseases 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 11
- 210000000130 stem cell Anatomy 0.000 claims 3
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 210000000601 blood cell Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 231100000682 maximum tolerated dose Toxicity 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 206010043554 thrombocytopenia Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 102000003951 Erythropoietin Human genes 0.000 abstract 1
- 108090000394 Erythropoietin Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000036693 Thrombopoietin Human genes 0.000 abstract 1
- 108010041111 Thrombopoietin Proteins 0.000 abstract 1
- 230000033228 biological regulation Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 229940047120 colony stimulating factors Drugs 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 229940105423 erythropoietin Drugs 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Abstract
The present invention relates to methods of using oncostatin M (OM). In particular, it relates to the use of OM to stimulate interleukin 6 (IL-6) synthesis in target cells, especially human endothelial cells. The resultant IL-6, in turn, may perform a variety of functions such as cell growth regulation, leukocyte differentiation, and tumor inhibition. Furthermore, the present invention also relates to the use of OM to treat cytopenias, including anemia and thrombocytopoiesis, and to increase tolerance to irradiation and cytotoxic drugs. Therefore, the methods of the invention may have a wide range of applications, including, but not limited to, the inhibition of tumor growth, the treatment of cytopenias, and to increase the tolerance to radio- and chemotherapy. OM may be used in combination with various cytokines, including erythropoietin, colony-stimulating factors, interleukin-3 or thrombopoietin.
Claims
1. A composition comprising an effective amount of Oncostatin M for use in an individual to increase the number of blood cells to treat cytopenia.
2. The composition of claim 1, wherein the cytopenia is caused by transplantation of
hematopoeitic stem cells.
3. The composition, of claim 2, wherein the stem cells are from bone marrow.
4. The composition of claim 2, wherein the stem cells are from peripheral blood.
5. The composition of claim 1, wherein the cytopenia is caused by radiation or a cytotoxic drug.
6. The composition of claim 1, wherein the cytopenia is anemia or thrombocytopenia.
7. The composition of claim 1 , wherein Oncostatin M is combined by a cytokine.
8. The composition of claim 7, wherein the cytokine is erytbropoieten, granulocytc colony- stimulating factor, interleukin 3 and thrombopoieten.
9. A composition for use in increasing the maximum tolerated dose of radiation or cytotoxic drug comprising Oncostatin M.
10. The composition of claim 9, wherein Oncostatin M is combined with a cytokine.
11. The composition of claim 10, wherein the cytokine is erythropoieten, granulocyie colony- stimulating factor, interleukin 3 or thrombopoieten.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU78447/94A AU7844794A (en) | 1993-09-29 | 1994-09-27 | Methods for stimulating interleukin-6 synthesis and inducing thrombocytopoiesis using oncostatin m |
| EP94929361A EP0721344A1 (en) | 1993-09-29 | 1994-09-27 | Methods for stimulating interleukin-6 synthesis and inducing thrombocytopoiesis using oncostatin m |
| JP7510413A JPH09505560A (en) | 1993-09-29 | 1994-09-27 | Method for stimulating interleukin-6 synthesis using oncostatin M and method for inducing platelet production |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12923093A | 1993-09-29 | 1993-09-29 | |
| US08/312,205 | 1994-09-26 | ||
| US08/312,205 US5814307A (en) | 1989-04-10 | 1994-09-26 | Method for regulating cell growth, leukocyte differentiation and tumor cell growth using Oncostatin M to stimulate synthesis of IL-6 |
| US129,230 | 1994-09-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1995009005A1 WO1995009005A1 (en) | 1995-04-06 |
| WO1995009005B1 true WO1995009005B1 (en) | 1995-05-04 |
Family
ID=26827388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1994/010923 WO1995009005A1 (en) | 1993-09-29 | 1994-09-27 | Methods for stimulating interleukin-6 synthesis and inducing thrombocytopoiesis using oncostatin m |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5814307A (en) |
| EP (1) | EP0721344A1 (en) |
| JP (1) | JPH09505560A (en) |
| AU (1) | AU7844794A (en) |
| CA (1) | CA2172808A1 (en) |
| WO (1) | WO1995009005A1 (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000055319A1 (en) * | 1999-03-12 | 2000-09-21 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| CZ298790B6 (en) * | 1994-10-21 | 2008-01-30 | Kishimoto@Tadamitsu | Pharmaceutical composition for prevention or treatment of cachexia |
| CA2178256A1 (en) * | 1995-06-06 | 1996-12-07 | Christopher H. Clegg | Oncostatin m induced hematopoiesis |
| WO1997016202A1 (en) * | 1995-10-27 | 1997-05-09 | Amrad Operations Pty. Ltd. | Cytokines and their use in treatment and/or prophylaxis of breast cancer |
| WO2001049715A2 (en) * | 2000-01-06 | 2001-07-12 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| WO2000053751A1 (en) * | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| GB9806530D0 (en) | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
| PT1121439E (en) * | 1998-10-13 | 2006-12-29 | Genentech Inc | Methods and compositions for inhibiting neoplastic cell growth |
| EP1135491A2 (en) * | 1998-12-01 | 2001-09-26 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| CA2450402A1 (en) * | 1998-12-22 | 2000-06-29 | Genentech, Inc. | Methods and compositions for inhibiting cancer cell growth comprising pro224 |
| ATE353339T1 (en) * | 1998-12-22 | 2007-02-15 | Genentech Inc | METHOD AND COMPOSITION FOR INHIBITING NEOPLASTIC CELL GROWTH |
| EP1867719A3 (en) * | 1999-06-02 | 2008-03-19 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| AU3246100A (en) * | 1999-06-02 | 2000-12-28 | Genentech Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| AU2215300A (en) * | 1999-06-02 | 2000-12-28 | Genentech Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| DK1185648T3 (en) * | 1999-06-02 | 2007-07-30 | Genentech Inc | Methods and compositions for inhibiting neoplastic cell growth |
| IL160960A0 (en) * | 2001-09-24 | 2004-08-31 | Tosk Inc | Reduced toxicity cisplatin formulations and methods for using the same |
| US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| WO2007149328A1 (en) * | 2006-06-20 | 2007-12-27 | Genzyme Corporation | Serum-free media and their uses for chondrocyte expansion |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6463395A (en) * | 1987-05-04 | 1989-03-09 | Oncogen | Oncostatin m and novel composition having antitumor activity |
| IL112767A (en) * | 1989-04-10 | 1998-01-04 | Oncogen | Pharmaceutical compositions containing oncostatin m |
| US5202116A (en) * | 1989-04-10 | 1993-04-13 | Oncogen | Methods for controlling human endothelial cell proliferation and effector functions using oncostatin m |
| US5744442A (en) * | 1992-08-26 | 1998-04-28 | Bristol Meyers Squibb Company | Regulation of cellular invasiveness |
| US5460810A (en) * | 1992-09-02 | 1995-10-24 | Genetics Institute, Inc. | Method for maintaining gut epithelial cells by treatment with a cytokine such as interleukin 11 |
-
1994
- 1994-09-26 US US08/312,205 patent/US5814307A/en not_active Expired - Lifetime
- 1994-09-27 EP EP94929361A patent/EP0721344A1/en not_active Withdrawn
- 1994-09-27 JP JP7510413A patent/JPH09505560A/en active Pending
- 1994-09-27 WO PCT/US1994/010923 patent/WO1995009005A1/en not_active Application Discontinuation
- 1994-09-27 CA CA002172808A patent/CA2172808A1/en not_active Abandoned
- 1994-09-27 AU AU78447/94A patent/AU7844794A/en not_active Abandoned
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