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WO1995006728A3 - Epitopes de lymphocyte t pour l'allergene du ray-grass - Google Patents

Epitopes de lymphocyte t pour l'allergene du ray-grass Download PDF

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Publication number
WO1995006728A3
WO1995006728A3 PCT/US1994/009024 US9409024W WO9506728A3 WO 1995006728 A3 WO1995006728 A3 WO 1995006728A3 US 9409024 W US9409024 W US 9409024W WO 9506728 A3 WO9506728 A3 WO 9506728A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
lol
allergen
protein allergen
cell epitopes
Prior art date
Application number
PCT/US1994/009024
Other languages
English (en)
Other versions
WO1995006728A2 (fr
Inventor
Irwin J Griffith
Mei-Chang Kuo
Mohammad Luqman
Original Assignee
Immulogic Pharma Corp
Irwin J Griffith
Kuo Mei Chang
Mohammad Luqman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immulogic Pharma Corp, Irwin J Griffith, Kuo Mei Chang, Mohammad Luqman filed Critical Immulogic Pharma Corp
Priority to JP7508127A priority Critical patent/JPH09504167A/ja
Priority to NZ271818A priority patent/NZ271818A/en
Priority to EP94925803A priority patent/EP0714440A1/fr
Priority to AU75597/94A priority patent/AU7559794A/en
Priority to US08/737,904 priority patent/US7112333B1/en
Publication of WO1995006728A2 publication Critical patent/WO1995006728A2/fr
Publication of WO1995006728A3 publication Critical patent/WO1995006728A3/fr
Priority to NO960553A priority patent/NO960553L/no
Priority to FI960629A priority patent/FI960629L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention a pour objet des peptides isolés de Lol pV, un allergène protéique essentiel de l'espèce Lolium perenne. Les peptides thérapeutiques entrant dans le champ de l'invention comprennent au moins un épitope de lymphocyte T, ou de préférence au moins deux épitopes de lymphocyte T et un allergène protéique de Lol pV. Les peptides de diagnostic entrant dans le champ de l'invention lient l'IgE. L'invention prévoit également des peptides modifiés possédant les mêmes propriétés thérapeutiques que l'allergène naturel correspondant ou ses fragments, ou améliorées par rapport à ceux-ci, ou d'autres propriétés souhaitables de ceux-ci. L'invention prévoit en outre un codage de séquences d'acide nucléique pour les peptides selon l'invention. L'utilisation des compositions thérapeutiques comporant un ou plusieurs peptides selon l'inveniton dans la fabrication de médicaments destinés à traiter la sensibilité à Lol pV ou un allergène immunologiquement apparenté à Lol pV, ou la sensibilité générale au ray-grass chez un individu, est également prévue. L'invention décrit également un codage d'acides nucléiques pour l'allergène protéique Dac gV ainsi que la séquence d'acides aminés de l'allergène Dac gV.
PCT/US1994/009024 1993-08-13 1994-08-05 Epitopes de lymphocyte t pour l'allergene du ray-grass WO1995006728A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP7508127A JPH09504167A (ja) 1993-08-13 1994-08-05 ドクムギ花粉アレルゲンのｔ細胞エピトープ
NZ271818A NZ271818A (en) 1993-08-13 1994-08-05 T cell epitopes of ryegrass pollen antigen
EP94925803A EP0714440A1 (fr) 1993-08-13 1994-08-05 Epitopes de lymphocyte t pour l'allergene du ray-grass
AU75597/94A AU7559794A (en) 1993-08-13 1994-08-05 T cell epitopes of ryegrass pollen allergen
US08/737,904 US7112333B1 (en) 1994-08-05 1994-08-05 T cell epitopes of ryegrass pollen allergen
NO960553A NO960553L (no) 1993-08-13 1996-02-12 T-celle-epitoper av raigresspollen-allergen
FI960629A FI960629L (fi) 1993-08-13 1996-02-12 Raiheinäsiitepöly allergeenin T-soluepitoopit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10601693A 1993-08-13 1993-08-13
US08/106,016 1993-08-13

Publications (2)

Publication Number Publication Date
WO1995006728A2 WO1995006728A2 (fr) 1995-03-09
WO1995006728A3 true WO1995006728A3 (fr) 1995-05-04

Family

ID=22309029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/009024 WO1995006728A2 (fr) 1993-08-13 1994-08-05 Epitopes de lymphocyte t pour l'allergene du ray-grass

Country Status (10)

Country Link
EP (1) EP0714440A1 (fr)
JP (1) JPH09504167A (fr)
AU (1) AU7559794A (fr)
CA (1) CA2168565A1 (fr)
FI (1) FI960629L (fr)
IL (1) IL110619A0 (fr)
NO (1) NO960553L (fr)
NZ (1) NZ271818A (fr)
WO (1) WO1995006728A2 (fr)
ZA (1) ZA946068B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652485B2 (en) 2007-08-15 2014-02-18 Circassia Limited Peptide for vaccine

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112333B1 (en) * 1994-08-05 2006-09-26 Heska Corporation T cell epitopes of ryegrass pollen allergen
US6759234B1 (en) 1994-09-02 2004-07-06 Immulogic Pharmaceutical Corporation Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response
AU7726094A (en) * 1994-09-02 1996-03-27 Immulogic Pharmaceutical Corporation Peptide compositions capable of down regulating an antigen specific immune response
AT402505B (de) * 1995-08-02 1997-06-25 Biomay Prod & Handel Rekombinantes 60 kda pflanzliches panallergen (kofaktor-unabhängige phosphoglyceratmutase; e.c. 5.4.2.1.)
CA2247009C (fr) 1996-03-21 2009-08-04 Imperial College Of Science, Technology And Medicine Peptides cryptiques et leur procede d'identification
FR2809416B1 (fr) * 2000-05-29 2004-12-10 Tabacs & Allumettes Ind Clonage et sequencage de l'allergene dac g5 du pollen de dactilys glomerata, sa preparation et son utilisation
AUPR779201A0 (en) * 2001-09-20 2001-10-11 University Of Melbourne, The Immunotherapeutic and immunoprophylactic reagents
GB0710529D0 (en) 2007-06-01 2007-07-11 Circassia Ltd Vaccine
GB2469894B (en) * 2009-02-05 2011-09-07 Circassia Ltd Peptides for use in treating allergy to grass pollen
EP2249162A1 (fr) * 2009-04-30 2010-11-10 Stallergenes Sa Procédé pour l'identification d'espèces gazeuses
WO2017004561A1 (fr) 2015-07-01 2017-01-05 Alk-Abelló A/S Associations de peptides et leurs utilisations dans le traitement de l'allergie aux graminées
US11524019B2 (en) 2017-08-21 2022-12-13 Glycom A/S Synthetic composition for reducing allergy symptoms

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004174A1 (fr) * 1991-08-16 1993-03-04 The University Of Melbourne Allergene du pollen de raygrass
WO1994004564A1 (fr) * 1992-08-14 1994-03-03 The University Of Melbourne EPITOPES DE LYMPHOCYTES T DE l'ALLERGENE DE POLLEN DE L'IVRAIE VIVACE

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004174A1 (fr) * 1991-08-16 1993-03-04 The University Of Melbourne Allergene du pollen de raygrass
WO1994004564A1 (fr) * 1992-08-14 1994-03-03 The University Of Melbourne EPITOPES DE LYMPHOCYTES T DE l'ALLERGENE DE POLLEN DE L'IVRAIE VIVACE

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KLYSNER ET AL.: "Group V allergens in grass pollens:IV.Similarities in amino acid compositions and NH2-terminal sequences of the Group V allergenes from Lolium perenne, Poa pratensis and Dactylis glomerata", CLINICAL AND EXPERIMENTAL ALLERGY, vol. 22, no. 4, April 1992 (1992-04-01), OXFORD GB, pages 491 - 497 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652485B2 (en) 2007-08-15 2014-02-18 Circassia Limited Peptide for vaccine

Also Published As

Publication number Publication date
NO960553L (no) 1996-04-12
AU7559794A (en) 1995-03-22
FI960629L (fi) 1996-04-12
CA2168565A1 (fr) 1995-03-09
NO960553D0 (no) 1996-02-12
ZA946068B (en) 1995-03-28
NZ271818A (en) 1997-11-24
FI960629A0 (fi) 1996-02-12
WO1995006728A2 (fr) 1995-03-09
EP0714440A1 (fr) 1996-06-05
IL110619A0 (en) 1994-11-11
JPH09504167A (ja) 1997-04-28

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