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WO1995002370A2 - Catheter de tunnellisation - Google Patents

Catheter de tunnellisation Download PDF

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Publication number
WO1995002370A2
WO1995002370A2 PCT/GB1994/001536 GB9401536W WO9502370A2 WO 1995002370 A2 WO1995002370 A2 WO 1995002370A2 GB 9401536 W GB9401536 W GB 9401536W WO 9502370 A2 WO9502370 A2 WO 9502370A2
Authority
WO
WIPO (PCT)
Prior art keywords
cutting
basket
bars
tip
diathermic
Prior art date
Application number
PCT/GB1994/001536
Other languages
English (en)
Other versions
WO1995002370A3 (fr
Inventor
Aws Shakir Mustafa Salim
Original Assignee
Aws Shakir Mustafa Salim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aws Shakir Mustafa Salim filed Critical Aws Shakir Mustafa Salim
Priority to AU71909/94A priority Critical patent/AU7190994A/en
Publication of WO1995002370A2 publication Critical patent/WO1995002370A2/fr
Publication of WO1995002370A3 publication Critical patent/WO1995002370A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A61B17/320725—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with radially expandable cutting or abrading elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/148—Probes or electrodes therefor having a short, rigid shaft for accessing the inner body transcutaneously, e.g. for neurosurgery or arthroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A61B2017/00292—Surgical instruments, devices or methods for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/00267—Expandable means emitting energy, e.g. by elements carried thereon having a basket shaped structure

Definitions

  • TUNNELLING CATHETER This invention introduces a new oesophageal catheter for use endoscopically to tunnel through carcinomas thereby affording simple, effective and inexpensive palliation in cases of advanced oesophageal cancer causing dysphagia.
  • the catheter employs diathermy using high frequency electric current to achieve tunnelling and circumferential coring thus overcoming many of the limitations of LASER therapy. Repeated and frequent application of this form of tunnelling is safe and incurs no added inconvenience to the patient. The implications of this advantage in terms of sustaining palliation cannot be overemphasised.
  • Oesophageal carcinoma is usually diagnosed when symptons of malignant stenosis appear, which implies advanced disease with a poor prognosis.
  • the goal of treatment is therefore palliation with restoration of normal swai: owing and good quality of life over the remaining life span.
  • the present invention introduces a tunnelling catheter for diathermy current coring and cutting out of oesophageal carcinoma and which may be presented to the site of the carcinoma via the biopsy channel of a fibreoptic endoscope or by attachment to the body of this scope or via a rigid oesophagoscope.
  • the present invention provides a diathermy tunnelling catheter device having a remotely radially expandable basket means with a diathermic cutting and coagulating tip and a plurality of spaced apart diathermic cutting and coagulating bars extending rearwardly from said tip, whereby in use of the device the basket means may be initially advanced into a growth in a radially contracted condition by diathermic cutting with said basket tip, the basket then radially expanded whilst radially cutting diathermically with said cutting bars into said growth, and the basket then rotated whilst annularly cutting diathermically with said cutting bars.
  • the device of the invention is dimensioned so as to be useable via the biopsy channel of an endoscope and in use is introduced through the biopsy channel of the fibreoptic endoscope to afford two main actions: tunnelling and coring under direct vision.
  • the amount of diathermy tumour resection can be controlled directly by varying the degree of expansion and hence effective diameter of the device thereby allowing a good degree of precision in the application of the tunnelling. This advantage and that of low cost should enable a wide use of the present invention for palliating oesophageal cancer.
  • an electric current is applied to provide electrocoagulation at both the tip and basket bars to provide haemostasis if necessary.
  • this current may be unipolar or bipolar.
  • the size of the tunnelling catheter may be made in larger sizes for use with rigid oesophagoscopes or for being attached to but not through a fibreoptic endoscope i.e. with the latter being used primarily to provide vision at the site of operation of the tunneling catheter device.
  • the catheter can also be made in sizes to suit various veterinary uses.
  • the tunnelling catheter may be made in total or in part from metals such as steel, silver, aluminium, titanium etc, or alloys such as stainless steel. Conveniently some or all of the catheter may be made of plastics, silicones and/or natural or synthetic rubber materials. The most preferend substances to be used are Teflon, Dacron, (Trade Names) , latex, polyvinylchloride and biocompatible silicones.
  • an antibiotic and/or antiseptic may be incorporated into the catheter's substances and parts.
  • the tunnelling catheter device of the invention can be remotely controlled from outside of the patient's body to give a variable cutting/coagulating radius.
  • the catheter tip In use of the device the catheter tip is presented to the surface of the carcinoma with the basket in the collapsed state.
  • the catheter tip is heated by passing a high frequency electric current through its heating element, allowing the catheter to be pushed partially into the blockage.
  • the basket is then progressively expended, accompanied by rotation and backward/forward movement to provide a tunnelling action, ultimately leading to the creation of a complete passageway through the blockage.
  • the coagulating current delivered to the tip or basket bars may be used to arrest any haemorrhage.
  • Excised tissues may be removed by forceps or flushing into the stomach.
  • the tunnelling catheter may be in total or in part silver-impregnated or incorporate a silver-impregnated protective sheath.
  • the catheter may be manufactured so as to be suitable for single use (disposable) or several uses (re-useable) after sterilization by ethylene oxide gas or autoclaving.
  • the overall length of the tunnelling catheter is conveniently from 300mm to 2000mm, preferably 1500-1600mm for use with a fibreoptic scope and 500-600mm for use with a rigid scope.
  • the outer diameter of catheter generally ranges from 1.5mm to 30mm, preferably from 1.8mm to 2.8mm for use with a fibreoptic scope and 2 to 5mm for use with a rigid scope.
  • the outer sheath of the catheter may be made as a tube sheath type or coil sheath type.
  • a tube sheath can provide an extremely flexible catheter sheath particularly suitable for use in the upper oesophagus where much movement can be anticipated.
  • the catheter tip is generally a solid stiff structure, but if desired, can be made more or less flexible.
  • the overall length is preferably from 2mm to 30mm most preferably 5 to 10mm. It may be in the shape of a needle or have a round bodied end.
  • the needle can be pointed or bevelled having a diagonal slant of an angle ranging from 10 to 80°, preferably 30 to 45°.
  • the body of the catheter tip may be cylindrical, faceted having 3 to 10 surfaces, serrated or uneven with a roughened surface.
  • the tip may be conical or frusto-conical having a base larger than the end.
  • the handle of the catheter is desirably formed and arranged so as tc be substantially ergono ic and provide good grip and handling characteristics that will enable the mechanics of operating the catheter to be effectively applied.
  • the handle can range from 3cm to 20cm in length and 0.5 to 10cm in width. It can be in one or more parts. It can be made of two halves. Advantageously it can incorporate a sliding forward and backward movement mechanism.
  • the handle may also include hinges. When made of many parts, each or all may be fixed or allow the movement of one art onto the other.
  • the handle may have one to five fii.ger accommodating bars, ridges, grooves, holes, rings, or circular bands.
  • any or all parts of the handle may be cylindrical, circular, band shaped, coil shaped, triangular shaped, square shaped, rectangular shaped, or any other design to suit application.
  • any part of the handle may be solid or hollowed.
  • the handle may incorporate a piston that can be pushed backward and forward to open or close the basket.
  • This piston may have a ring shaped, spherical, rounded, circular, L-shaped, T-shaped or any of other suitably shaped handle for operating. It may be fitted onto the rear or side of the handle.
  • the handle conveniently incorporates the basket operating mechanism and can also be used to mount the electrical connections for delivering the diathermy operating electric current.
  • the handle may incor p orate one or more e.g. up to ten electrical plugs or sockets which may be flush with the surface or project above it. Alternatively all electric connections may be removed from the handle and built into the body of the catheter.
  • the basket is generally made up of form 2 to 12 wires or blades that open up circumferentially around a central support pole.
  • the blades may be strips or bands, triangular, rectangular or square shaped in cross section. The surface of these may be smooth, serated, saw-toothed, or roughened in any shape to facilitate cutting into tissues while providing a positive engagement with them.
  • the wires of the basket may be in the form of spring coils or rods.
  • the basket may incorporate both blades and wires.
  • the outer diameter of the collapsed basket is generally from 1.5mm to 10mm, preferably 1.5mm to 2.8mm for use with the fibreoptic scope.
  • the diameter of the fully opened-up basket is generally up to from 25mm to 30mm .
  • the length of the basket generally ranges from 5mm to 100mm, preferably 10 to 30mm, in its closed collapsed configuration.
  • the basket is normally operated from the handle and is introduced in its closed collapsed configuration, being then opened up under direct vision e.g. by displacement of the catheter sheath down towards the basket end and closed up again by withdrawing this sheath.
  • the basket will cut into the growth electrically when opened up and will cut off the growth electrically when rotated around optionally in combination with forward and backward movements.
  • diathermy operates by producing an alternating current with wavelengths in the radio frequency range.
  • This current passes through the patient's tissues from the active electrode, which may be of various shape?,to the i: afferent (neutral) electrode, which is usually a metal or foil plate approximately 15 X 15cm in size.
  • afferent (neutral) electrode which is usually a metal or foil plate approximately 15 X 15cm in size.
  • the indifferent electrode has a large contact area and therefore heating is reduced to a minimum and is dissipated rapidly.
  • the active electrode being small will concentrate heat in the tissues adjacent to it.
  • the current intensity determines whether a coagulating, fulguration or electro - sectioning effect is produced.
  • the circuit of the diathermy machine being generally similar to that of a simple radio tr ismitter will usually oscillate at a frequency between 400kHz (Kilocycles) and 3MHz (megacycles) .
  • Oscillators used in earlier diathermy machines incorporating the standard spark - gap principle which provide a frequency of around 500kHz may be used. This would provide excellent coagulation b would cut only by increasing the intensity to a high - power output.
  • valve oscillators of a frequency range of up to 3MHz may be used. This can be in the form of two circuits: with a cutting circuit operated by a valve oscillator and a coagulating ci it operated by a spark-gap oscillator.
  • Diathermy generators of power outputs up to 1 kW may be employed.
  • the use of transistors as oscillators rather than valves is generally preferred.
  • the quality of coagulation or cutting generally depends on the wave form presented by the diathermy machine, with a smooth sine wave giving the desired cutting while an interrupted burst of current provides the desired coagulation depending on the frequency of these bursts and the length of the gap between each burst.
  • the spark-gap machine generallly gives bursts of damped oscillation of a frequency of approximately 10kHz. When this interuption of current is superimposed on the sine wave oscillation, the coagulation quality is comparable to that of the spark-gap machine.
  • the amplitude of each wave should be increased in portion to the length of each burst of current.
  • the doubled circuit may be dispensed with.
  • Blending the current may be provided by a twin-circuit diathermy where the blender switch brings both circuits into action at the same time with the result that the active electrode produces a cutting effect as well as a coagulating effect as it passes through the tissues.
  • a solid state transistorised diathermy machine can be used to provide a blended current from a single circuit by taking the setting halfway between the pure sine wave for cutting and repeated short bursts for coagulation. This provides the advantage of subjecting the patient to only the normal power output of a single circuit.
  • electro-sectioning can be provided by cutting with a valve or transistorised oscillator to ensure minimal surrounding tissue damage or cutting with a blended current if moderate degrees of surrounding coagulation is desirable.
  • the diathermy machine should normally be earthed to the floor to avoid build up of electrical potential which could discharge in the form of a spark of static electricity. It may be advantageous to monitor the contact of the plate electrode to patient by measuring the potential difference between the input and output leads.
  • the overall power output of the diathermy machine is preferably restricted to from 400 to 500 kW.
  • the diathermy generator may conveniently be provided by valve oscillating machines, double - circuit spark and valve machines, transistorised solid state diathermies and spark-gap generators.
  • a foot pedal switch or finger switch may be used to activate the diathermy set, i.e. activating the operating electrode to start the diathermy.
  • earth-free circuits may also be used for the purposes of the present invention.
  • the electric connections to the diathermy machine may be placed on any part of the handle.
  • the active electrode may be plugged in, screwed-in, clipped-on or fitted into the socket in any convenient way through one or more points of contact.
  • the handle may have a finger switch to activate the diathermy set. Conversely this may be provided by a foot pedal.
  • the indifferent electrode plate is preferably stuck, strapped or attached in any way onto the patients lower limb, but other sites may also be used.
  • the tunnelling catheter is introduced into the oesophagus and placed in direct contact with the tumour.
  • the active electrode is connected to the catheter's handle then the diathermy machine is switched on.
  • the coagulating and cutting currents are generally set in the range from 20 to 90, preferably 30 to 60 standard diathermy apparatus cutting power units. During use the diathermy machine makes a noise which can be clearly heard to indicate it is working and the current is flowing. The coagulating and cutting currents are used as already described. Repeated sessions of tunnelling at three to seven day intervals may be necessary to achieve the desired tumour coring and tunnelling.
  • Fig.l is general view of a preferred embodiment
  • Fig.2 is a detail sectional view showing mounting of the basket.
  • Figs.3 to 5 show some alternative handles.
  • Patients suitable for this techinque are those who have advanced oesophageal cancer not suitable for surgery and who present with dysphagia thus requiring some form of intervention to enable them to swallow food comfortably.
  • the patient is endoscoped under parenteral sedation (using benzodiazepines or midazolam with or without narcotic analgesics such as pethidine) and a throat spray with xylocaine in the left lateral position.
  • Biopsies of the oesophageal lesion may be taken first, then the oesophageal tunnelling catheter 1 is introduced and placed in direct contact with the apparent oesophageal lumen and the cutting diathermy current switched on.
  • the tip 2 of the catheter while being heated by the passage of a high frequency electric current through its heating element is advanced through the lesion for a short distance sufficient to allow the bars 3 of the catheter's basket 4 to cut through tumour tissue when opened up.
  • the basket 4 is then expanded using the axial control wire 5 and operating handle 6 connected thereto, while cutting current is being applied, to advance the bars 3 redially outward into the tumour.
  • the basket 4 is then rotated to core out the tumour by cutting through the tissue between the basket bars 3 to cut away the tissue entrapped inside the basket 4. Sufficient tunnelling is carried out at the proximal end of the tumour before advancing the basket 4 down the growth and repeating the procedure.
  • the oseophageal lumen can be tunnelled through down to the stomach. Any obvious tissue mass lying free in the oesophageal lumen can be picked up by the forceps or flusehed down the into the stomach. Obviously bleeding points can be electrocoagulated by the tip or basket bars. Following this procedure and once the patient recovers from the sedation he/she is allowed oral intake of fluids for six hours and when these fluids have been well tolerated, solid food is permitted. The procedure may be repeated as frequently as deemed necessary.
  • Diathermy tunnelling of oesophageal cancer has been successfully applied to the clinical situation without Q any obvious morbidity or mortality.
  • the procedure should be open without any exclusions to all those oesophageal carcinoma patients who require palliation for their dysphagia.
  • This method is simple, safe, reliable, inexpensive and may be applied repeatedly. It incurs no additional inconvenience to the patient and enables an expeditious return to oral intake of food comfortably.
  • the further advantage of being much more inexpensive and simpler than LASER therapy should allow its wider use clinically.
  • remote control operations handle mechanisms may be used including: systems with first and second relatively displacable finger rings or other finger engagement formations which may simply be relatively displacable longitudinally of the device, so as to provide a more or less direct longitudinal compression of the basket resulting in radial expansion, or may be relatively displacable in other dimensions e.g. by compressing or pulling laterally towards each other, conveniently against a return force exerted by resilient biasing means, spaced apart finger engagement portions and use one or more of links, levers, gears and other well known mechanisms for converting relative displacement into a suitable form for transmission to the basket members.
  • hydraulic circuit means and/or electromechanical device may be used for transmitting required control movements to the basket in generally known manner.
  • the diathermic cutting and coagulating power supply control means are also provided on the handle means but this is not essential and they may be formed and arranged so as to be operable remotely from the handle means e.g. via a foot operated interface.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Otolaryngology (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention concerne un cathéter de tunnellisation diathermique (1). Ce dispositif (1) comprend un panier de perforation (4) à extension radiale télécommandée, muni d'une pointe (2) à couper par diathermie et à coaguler et de plusieurs tiges (3) espacées, ayant également pour fonction de couper par diathermie et de coaguler, qui remontent depuis la pointe (2) du panier vers l'arrière. Lors de l'utilisation, le panier pénètre d'abord, en position de contraction radiale, dans la tumeur en effectuant avec sa pointe (2) une coupe diathermique; le panier (4) est ensuite déployé radialement, ses tiges (3) effectuant dans la tumeur une coupe radiale diathermique; on fait alors tourner le panier (4) dont les tiges (3) effectuent la coupe diathermique selon un mouvement annulaire. Par commodité, on utilise avec ce dispositif (1) le canal de biopsie d'un endoscope.
PCT/GB1994/001536 1993-07-15 1994-07-15 Catheter de tunnellisation WO1995002370A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU71909/94A AU7190994A (en) 1993-07-15 1994-07-15 Tunnelling catheter

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9314640.5 1993-07-15
GB939314640A GB9314640D0 (en) 1993-07-15 1993-07-15 Tunnellimg catheter

Publications (2)

Publication Number Publication Date
WO1995002370A2 true WO1995002370A2 (fr) 1995-01-26
WO1995002370A3 WO1995002370A3 (fr) 1995-03-09

Family

ID=10738863

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1994/001536 WO1995002370A2 (fr) 1993-07-15 1994-07-15 Catheter de tunnellisation

Country Status (3)

Country Link
AU (1) AU7190994A (fr)
GB (1) GB9314640D0 (fr)
WO (1) WO1995002370A2 (fr)

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AU7190994A (en) 1995-02-13
GB9314640D0 (en) 1993-08-25
WO1995002370A3 (fr) 1995-03-09

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