WO1995000554A3 - Totipotent hematopoietic stem cell receptors and their ligands - Google Patents
Totipotent hematopoietic stem cell receptors and their ligands Download PDFInfo
- Publication number
- WO1995000554A3 WO1995000554A3 PCT/US1994/006944 US9406944W WO9500554A3 WO 1995000554 A3 WO1995000554 A3 WO 1995000554A3 US 9406944 W US9406944 W US 9406944W WO 9500554 A3 WO9500554 A3 WO 9500554A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ligands
- expressed
- receptor protein
- protein tyrosine
- hematopoietic cells
- Prior art date
Links
- 210000003958 hematopoietic stem cell Anatomy 0.000 title abstract 6
- 239000003446 ligand Substances 0.000 title abstract 4
- 102000004278 Receptor Protein-Tyrosine Kinases Human genes 0.000 abstract 4
- 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 241001529936 Murinae Species 0.000 abstract 2
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 101150088608 Kdr gene Proteins 0.000 abstract 1
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in Figure 1a (murine Flk2), Figure 1b (human Flk2) and Figure 2 (murine Flk1); the receptor protein tyrosine kinases having the amino acid sequences shown in Figure 1a, Figure 1b and Figure 2; ligands for the receptors; nucleic acids sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU72103/94A AU7210394A (en) | 1993-06-18 | 1994-06-17 | Totipotent hematopoietic stem cell receptors and their ligands |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8024493A | 1993-06-18 | 1993-06-18 | |
| US08/080,244 | 1993-06-18 | ||
| US8150893A | 1993-06-21 | 1993-06-21 | |
| US08/081,508 | 1993-06-21 | ||
| US15749093A | 1993-11-23 | 1993-11-23 | |
| US08/157,490 | 1993-11-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1995000554A2 WO1995000554A2 (en) | 1995-01-05 |
| WO1995000554A3 true WO1995000554A3 (en) | 1996-10-10 |
Family
ID=27373667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1994/006944 WO1995000554A2 (en) | 1993-06-18 | 1994-06-17 | Totipotent hematopoietic stem cell receptors and their ligands |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU7210394A (en) |
| WO (1) | WO1995000554A2 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6630143B1 (en) * | 1993-05-24 | 2003-10-07 | Immunex Corporation | Antibodies against flt3 ligand |
| US7150992B1 (en) | 1995-10-04 | 2006-12-19 | Innunex Corporation | Methods of preparing dendritic cells with flt3-ligand and antigen |
| US7361330B2 (en) | 1995-10-04 | 2008-04-22 | Immunex Corporation | Methods of using flt3-ligand in the treatment of fibrosarcoma |
| US6846630B2 (en) | 1996-10-18 | 2005-01-25 | Takara Shuzo Co., Ltd. | Nucleic acid encoding receptor type protein kinase |
| DK0959132T3 (en) * | 1996-10-18 | 2006-12-11 | Takara Bio Inc | Nucleic acid encoding receptor type protein kinase |
| US20020132017A1 (en) | 1996-12-09 | 2002-09-19 | Moore Jeffrey G. | Composition and method for preserving progenitor cells |
| US6084060A (en) * | 1996-12-09 | 2000-07-04 | Imclone Systems Incorporated | Composition and method for preserving progenitor cells |
| US6991794B1 (en) | 1997-06-24 | 2006-01-31 | Imclone Systems Incorporated | Progenitor cell preservation factors and methods for and products of their use |
| US6310195B1 (en) | 1997-06-24 | 2001-10-30 | Imclone Systems Incorporated | Nucleic acid encoding a lectin-derived progenitor cell preservation factor |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5185438A (en) * | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
-
1994
- 1994-06-17 WO PCT/US1994/006944 patent/WO1995000554A2/en active Application Filing
- 1994-06-17 AU AU72103/94A patent/AU7210394A/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5185438A (en) * | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
Non-Patent Citations (2)
| Title |
|---|
| ONCOGENE, Volume 6, issued September 1991, O. ROSNET et al., "Murine Flt3, a Gene Encoding a Novel Tyrosine Kinase Receptor of the PDGFR/CSF1R Family", pages 1641-1650. * |
| ONCOGENE, Volume 8, Number 4, issued April 1993, S.D. LYMAN et al., "Characterization of the Protein Encoded by the Flt3 (Flk2) Receptor-Like Tyrosine Kinase Gene", pages 815-822. * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU7210394A (en) | 1995-01-17 |
| WO1995000554A2 (en) | 1995-01-05 |
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