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WO1994027594A3 - Stable copper(i) complexes and methods related thereto - Google Patents

Stable copper(i) complexes and methods related thereto Download PDF

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Publication number
WO1994027594A3
WO1994027594A3 PCT/US1994/006247 US9406247W WO9427594A3 WO 1994027594 A3 WO1994027594 A3 WO 1994027594A3 US 9406247 W US9406247 W US 9406247W WO 9427594 A3 WO9427594 A3 WO 9427594A3
Authority
WO
WIPO (PCT)
Prior art keywords
copper
agents
complexes
stable
stable copper
Prior art date
Application number
PCT/US1994/006247
Other languages
French (fr)
Other versions
WO1994027594A2 (en
Inventor
Alexander J Pallenberg
Andrew Branca
Thomas M Marschner
Leonard M Patt
Original Assignee
Procyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procyte Corp filed Critical Procyte Corp
Priority to AU70517/94A priority Critical patent/AU7051794A/en
Priority to EP94919342A priority patent/EP0701439A1/en
Priority to JP7501073A priority patent/JPH08511006A/en
Priority to ZA949336A priority patent/ZA949336B/en
Publication of WO1994027594A2 publication Critical patent/WO1994027594A2/en
Publication of WO1994027594A3 publication Critical patent/WO1994027594A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

There is disclosed stable copper(I) complexes and methods relating thereto. The stable copper(I) complexes comprise a copper(I) ion complexed by a multi-dentate ligand which favors the +1 oxidation state for copper. Methods of this invention include the use of the stable copper(I) complexes as wound healing agents, anti-oxidative agents, anti-inflammatory agents, lipid modulating agents, signal transduction modulating agents, hair growth agents, and anti-viral agents. Exemplary stable copper(I) complexes include neocuproine copper(I) and bathocuproine disulfonic acid copper(I).
PCT/US1994/006247 1993-06-02 1994-06-02 Stable copper(i) complexes and methods related thereto WO1994027594A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU70517/94A AU7051794A (en) 1993-06-02 1994-06-02 Stable copper(1) complexes and methods related thereto
EP94919342A EP0701439A1 (en) 1993-06-02 1994-06-02 Stable copper(i) complexes and methods related thereto
JP7501073A JPH08511006A (en) 1993-06-02 1994-06-02 Stable copper (I) complexes and related methods
ZA949336A ZA949336B (en) 1994-06-02 1994-11-24 Stable copper (I) complexes and methods related thereto.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7144093A 1993-06-02 1993-06-02
US08/071,440 1993-06-02

Publications (2)

Publication Number Publication Date
WO1994027594A2 WO1994027594A2 (en) 1994-12-08
WO1994027594A3 true WO1994027594A3 (en) 1995-04-27

Family

ID=22101339

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/006247 WO1994027594A2 (en) 1993-06-02 1994-06-02 Stable copper(i) complexes and methods related thereto

Country Status (8)

Country Link
EP (1) EP0701439A1 (en)
JP (1) JPH08511006A (en)
AU (1) AU7051794A (en)
CA (1) CA2163640A1 (en)
OA (1) OA10198A (en)
TW (1) TW239077B (en)
WO (1) WO1994027594A2 (en)
ZA (1) ZA943857B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562854B2 (en) 1994-12-14 2003-05-13 Axys Pharmaceuticals, Inc. Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders
WO1996039144A1 (en) * 1995-06-06 1996-12-12 Procyte Corporation Stable copper(i) complexes as active therapeutic substances
US5637311A (en) * 1995-06-29 1997-06-10 Procyte Corporation Zinc(II) complexes and methods related thereto
US7045531B1 (en) 1997-03-11 2006-05-16 The General Hospital Corporation Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator
US6150379A (en) * 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
US6638711B1 (en) 1999-04-29 2003-10-28 The General Hospital Corporation Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation
US8829051B2 (en) * 2004-05-24 2014-09-09 Geoffrey C. GURTNER Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux
CN101203232A (en) * 2005-06-20 2008-06-18 德耐米克利尔集团有限公司 Composition for treating skin lesions
CA2735793C (en) * 2008-09-03 2019-07-09 Nbc Meshtec, Inc. Antiviral agent
US10098857B2 (en) 2008-10-10 2018-10-16 The Board Of Trustees Of The Leland Stanford Junior University Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds
TWI580787B (en) * 2012-12-28 2017-05-01 簡宏堅 Recombinant protein, pharmaceutical composition containing the same, and method of biosynthesizing thereof
WO2019055490A1 (en) 2017-09-14 2019-03-21 The Board Of Trustees Of The Leland Stanford Junior University Conditioning irradiated tissue for fat graft retention
KR20210087893A (en) * 2018-06-04 2021-07-13 케미스트리알엑스. Topical compositions for promoting hair growth

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6259213A (en) * 1985-09-10 1987-03-14 Eisai Co Ltd Superoxide remover
US4760051A (en) * 1985-01-24 1988-07-26 Pickart Loren R Use of GHL-Cu as a wound-healing and anti-inflammatory agent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760051A (en) * 1985-01-24 1988-07-26 Pickart Loren R Use of GHL-Cu as a wound-healing and anti-inflammatory agent
JPS6259213A (en) * 1985-09-10 1987-03-14 Eisai Co Ltd Superoxide remover

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIJLOO, G. J. ET AL: "Copper complexes of 1,10-phenanthroline and related compounds as superoxide dismutase mimetics", J. INORG. BIOCHEM., 1990, VOL. 40, PAGE(S) 237-44 *
BROWN DH ET AL: "Antiinflammatory effects of some copper complexes.", J MED CHEM (UNITED STATES), JUL 1980, VOL. 23, NO. 7, PAGE(S) 729-34, *
DATABASE WPI Week 8716, Derwent World Patents Index; AN 87-112954 *
DAVIS P.: "Penicillamine metal chelates and their possible importance in rheumatoid arthritis - A brief review", CLIN. INVEST. MED. (ENGLAND), 1984, VOL. 7, NO. 1, PAGE(S) 41-44, *
GAISSER, H. D. ET AL: "Determination of pKa values of 2,2'-bipyridyl analogs and stability constants of their copper(I) and copper(II) complexes;relationship to antimycoplasmal activity.", EUR. J. MED. CHEM.--CHIM. THER., 1986, VOL. 21, PAGES 285-9 *
SORENSON J.R.J. ET AL: "Antiulcer activities of D-penicillamine copper complexes", AGENTS ACTIONS (SWITZERLAND), 1982, VOL. 12, NO. 3, PAGE(S) 408-411, *

Also Published As

Publication number Publication date
EP0701439A1 (en) 1996-03-20
CA2163640A1 (en) 1994-12-08
AU7051794A (en) 1994-12-20
OA10198A (en) 1996-12-18
WO1994027594A2 (en) 1994-12-08
JPH08511006A (en) 1996-11-19
ZA943857B (en) 1995-02-01
TW239077B (en) 1995-01-21

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